BR9909440A - Derivados de indol - Google Patents
Derivados de indolInfo
- Publication number
- BR9909440A BR9909440A BR9909440-1A BR9909440A BR9909440A BR 9909440 A BR9909440 A BR 9909440A BR 9909440 A BR9909440 A BR 9909440A BR 9909440 A BR9909440 A BR 9909440A
- Authority
- BR
- Brazil
- Prior art keywords
- group
- aryl
- lower alkyl
- alkyl group
- alkenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Patente de Invenção: <B>"DERIVADOS DE INDOL"<D>. é fornecido um novo derivado de indol ou um sal do mesmo, que é representado pela fórmula: em que R~ 1~ representa um grupo aril alquila inferior, o referido grupo arila podendo ser substituído com um ou mais grupos selecionados do grupo que consiste em um átomo de halogênio, um grupo arila, um grupo heterocíclico, um grupo aril alquila inferior, um grupo aril alquenila inferior, um grupo halo - alquila inferior, um grupo cicloalquila inferior - alcóxi inferior, um grupo cicloalcóxi inferior - alquila inferior, um grupo aril alquinila inferior, um grupo arilóxi alquila inferior, um grupo aril alcóxi inferior, um grupo alquiltio inferior, um grupo alcóxi inferior, e um grupo alquenila; e R~ 2~ representa um grupo alquila inferior, um grupo alquenila inferior, um grupo arila, ou um grupo heterocíclico, cada um dos quais pode ser substituído com um átomo de hidrogênio, um grupo alquila inferior, um grupo alquenila inferior, ou um grupo arila. O composto da presente invenção possui atividade depressora de açúcar no sangue e atividade inibidora de PDE~ 5~, e é útil em medicina
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9362598 | 1998-04-06 | ||
PCT/JP1999/001798 WO1999051574A1 (fr) | 1998-04-06 | 1999-04-05 | Derives d'indole |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9909440A true BR9909440A (pt) | 2000-12-26 |
Family
ID=14087520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9909440-1A BR9909440A (pt) | 1998-04-06 | 1999-04-05 | Derivados de indol |
Country Status (8)
Country | Link |
---|---|
US (1) | US20050171185A1 (pt) |
EP (1) | EP1070705A4 (pt) |
KR (1) | KR20010052235A (pt) |
CN (1) | CN1150167C (pt) |
BR (1) | BR9909440A (pt) |
CA (1) | CA2327397A1 (pt) |
HK (1) | HK1037619A1 (pt) |
WO (1) | WO1999051574A1 (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000028991A1 (fr) * | 1998-11-13 | 2000-05-25 | Fujisawa Pharmaceutical Co., Ltd. | Remedes contre le syndrome des ovaires polykystiques |
IL154158A0 (en) * | 2000-08-11 | 2003-07-31 | Pfizer | Treatment of the insulin resistance syndrome with selective cgmp pde5 inhibitors |
US6638965B2 (en) | 2000-11-01 | 2003-10-28 | Boehringer Ingelheim Pharma Kg | Substituted indolinones, preparation thereof and their use as pharmaceutical compositions |
BR0206847A (pt) * | 2001-02-02 | 2004-02-25 | Pfizer | Tratamento do diabete melito |
ATE380028T1 (de) * | 2001-09-05 | 2007-12-15 | Eisai R&D Man Co Ltd | Mittel zur anregung des appetits und mittel zur behandlung von anorexie |
TW200533336A (en) * | 2004-03-02 | 2005-10-16 | Fujisawa Pharmaceutical Co | Concomitant drugs |
AU2015328174B2 (en) | 2014-10-06 | 2020-05-21 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
WO2017173274A1 (en) | 2016-03-31 | 2017-10-05 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
KR102531491B1 (ko) | 2016-09-30 | 2023-05-10 | 버텍스 파마슈티칼스 인코포레이티드 | 낭포성 섬유증 막횡단 전도 조절자의 조절제, 제약 조성물, 치료 방법, 및 상기 조절제의 제조 방법 |
JOP20190125B1 (ar) | 2016-12-09 | 2022-03-14 | Vertex Pharma | مُعدِّل لمنظم موصلية التليف الكيسي عبر الغشاء، وتركيبات صيدلانية، وطرق للعلاج، وعملية لتصنيع المُعدِّل |
AU2018279646B2 (en) | 2017-06-08 | 2023-04-06 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
BR112020000941A2 (pt) | 2017-07-17 | 2020-07-21 | Vertex Pharmaceuticals Incorporated | métodos de tratamento para fibrose cística |
AU2018309043B2 (en) | 2017-08-02 | 2022-03-31 | Vertex Pharmaceuticals Incorporated | Processes for preparing pyrrolidine compounds |
AU2018351533B2 (en) | 2017-10-19 | 2023-02-02 | Vertex Pharmaceuticals Incorporated | Crystalline forms and compositions of CFTR modulators |
JP7245834B2 (ja) | 2017-12-08 | 2023-03-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | 嚢胞性線維症膜コンダクタンス制御因子のモジュレーターを作成するためのプロセス |
TWI810243B (zh) | 2018-02-05 | 2023-08-01 | 美商維泰克斯製藥公司 | 用於治療囊腫纖化症之醫藥組合物 |
US11414439B2 (en) | 2018-04-13 | 2022-08-16 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
US11681922B2 (en) * | 2019-11-26 | 2023-06-20 | Numenta, Inc. | Performing inference and training using sparse neural network |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8916774D0 (en) * | 1989-07-21 | 1989-09-06 | Bayer Ag | New indole derivatives,a process for their preparation and their use in medicaments |
GB9122590D0 (en) * | 1991-10-24 | 1991-12-04 | Lilly Industries Ltd | Pharmaceutical compounds |
NZ324834A (en) * | 1995-12-28 | 2001-11-30 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives and their use in reducing blood sugar or as inhibitors of PDE5 activity |
WO1998015530A1 (fr) * | 1996-10-08 | 1998-04-16 | Fujisawa Pharmaceutical Co., Ltd. | Derives d'indol |
TW453999B (en) * | 1997-06-27 | 2001-09-11 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
DE69826286T2 (de) * | 1997-06-27 | 2005-11-24 | Fujisawa Pharmaceutical Co., Ltd. | Derivate mit einem aromatischen ring |
IL133575A0 (en) * | 1997-06-27 | 2001-04-30 | Fujisawa Pharmaceutical Co | Sulfonamide compounds, a method for producing same and pharmaceutical compositions containing same |
US6046199A (en) * | 1998-01-14 | 2000-04-04 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with tetracyclic pyrido[3,4-B]indole derivatives |
-
1999
- 1999-04-05 CN CNB998068829A patent/CN1150167C/zh not_active Expired - Fee Related
- 1999-04-05 KR KR1020007011056A patent/KR20010052235A/ko not_active Application Discontinuation
- 1999-04-05 BR BR9909440-1A patent/BR9909440A/pt not_active IP Right Cessation
- 1999-04-05 CA CA002327397A patent/CA2327397A1/en not_active Abandoned
- 1999-04-05 EP EP99912110A patent/EP1070705A4/en not_active Withdrawn
- 1999-04-05 WO PCT/JP1999/001798 patent/WO1999051574A1/ja not_active Application Discontinuation
-
2001
- 2001-11-28 HK HK01108363A patent/HK1037619A1/xx not_active IP Right Cessation
-
2005
- 2005-03-29 US US11/092,398 patent/US20050171185A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20050171185A1 (en) | 2005-08-04 |
CA2327397A1 (en) | 1999-10-14 |
KR20010052235A (ko) | 2001-06-25 |
WO1999051574A1 (fr) | 1999-10-14 |
CN1303371A (zh) | 2001-07-11 |
CN1150167C (zh) | 2004-05-19 |
EP1070705A4 (en) | 2002-04-17 |
EP1070705A1 (en) | 2001-01-24 |
HK1037619A1 (en) | 2002-02-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25A | Requested transfer of rights approved |
Owner name: YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) Free format text: TRANSFERIDO POR FUSAO DE: FUJISAWA PHARMACEUTICAL CO., LTD. |
|
B25D | Requested change of name of applicant approved |
Owner name: ASTELLAS PHARMA INC. (JP) Free format text: ALTERADO DE: YAMANOUCHI PHARMACEUTICAL CO., LTD. |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A E 9A ANUIDADES |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1945 DE 15 - 04 - 2008. |