NO20001045L - Nye cycliske tetrapeptidderivater og medisinsk anvendelse derav - Google Patents

Nye cycliske tetrapeptidderivater og medisinsk anvendelse derav

Info

Publication number
NO20001045L
NO20001045L NO20001045A NO20001045A NO20001045L NO 20001045 L NO20001045 L NO 20001045L NO 20001045 A NO20001045 A NO 20001045A NO 20001045 A NO20001045 A NO 20001045A NO 20001045 L NO20001045 L NO 20001045L
Authority
NO
Norway
Prior art keywords
group
chain
bivalent
cyclic tetrapeptide
carbon atoms
Prior art date
Application number
NO20001045A
Other languages
English (en)
Other versions
NO20001045D0 (no
Inventor
Norikazu Nishino
Minoru Yoshida
Sueharu Horinouchi
Yasuhiko Komatsu
Tsutomu Mimoto
Original Assignee
Japan Energy Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Energy Corp filed Critical Japan Energy Corp
Publication of NO20001045D0 publication Critical patent/NO20001045D0/no
Publication of NO20001045L publication Critical patent/NO20001045L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/126—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cyklisk tetrapeptidderivat representert ved generelle formel (I): ^22 NH ^ O R4 0= NH HO (I) hvori: RII,' Ri2, R2i og R22 uavhengig angir en enverdig gruppe valgt fra hydrogen, en lineær eller forgrenet alkylgruppe med 6 eller mindre karbonatomer, benzylgruppe, 4-metoksybenzylgruppe, 3-indolylmetylgruppe, (N-metoksy-3-indolyl) metylgruppe, (N-formyl-3-indolyl) metylgruppe osv.; RS angir en toverdig gruppe valgt fra en lineær kjedet hydrokarbongruppe med 3 eller 4 karbonatomer, eller nevnte lineære forgrenete hydrokarbongruppe har en forgrenet kjede tilsatt til kjeden, eller en toverdig gruppe substituert med et heteroatom; R4 angir en toverdig kjedet hydrokarbongruppe med 4 til 6 karbonatomer, eller en toverdig gruppe avledet fra nevnte hydrokarbongruppe ved tilsetning osv. av en forgrenet kjede på nevnte kjede; og et farmasøytisk akseptabelt salt derav, eller en analog cyklisk tetrapeptidderivatforbindelse; samt en histondeacetylaseenzym- inhibitor, et MHC klasse-l molekylekspresjonsfremmende middel og en farmasøytisk blanding som omfatter nevnte cykliske tetrapeptidderivat som et effektivt ingrediens.
NO20001045A 1997-09-02 2000-03-01 Nye cycliske tetrapeptidderivater og medisinsk anvendelse derav NO20001045L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP23748197 1997-09-02
JP6327098 1998-03-13
PCT/JP1998/003893 WO1999011659A1 (fr) 1997-09-02 1998-09-01 Derives tetrapeptides cycliques et leur utilisation medicinale

Publications (2)

Publication Number Publication Date
NO20001045D0 NO20001045D0 (no) 2000-03-01
NO20001045L true NO20001045L (no) 2000-04-27

Family

ID=26404362

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20001045A NO20001045L (no) 1997-09-02 2000-03-01 Nye cycliske tetrapeptidderivater og medisinsk anvendelse derav

Country Status (9)

Country Link
US (1) US6399568B1 (no)
EP (1) EP1010705A4 (no)
JP (1) JP3494624B2 (no)
KR (1) KR20010023449A (no)
AU (1) AU732299B2 (no)
CA (1) CA2302451A1 (no)
NO (1) NO20001045L (no)
NZ (1) NZ503061A (no)
WO (1) WO1999011659A1 (no)

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JP2003505417A (ja) * 1999-07-23 2003-02-12 メルク エンド カムパニー インコーポレーテッド アピシジン誘導環状テトラペプチド類
EP1231919B1 (en) 1999-09-08 2015-09-30 Sloan-Kettering Institute For Cancer Research Derivatives of 1-amino-1-(hetero)arylaminocarbonyl-6-hydroxyaminocarbonylhexane useful in the treatment of tumors
US6828302B1 (en) 1999-12-08 2004-12-07 Xcyte Therapies, Inc. Therapeutic uses of depsipeptides and congeners thereof
EP1438966B1 (en) 1999-12-08 2007-02-14 Cyclacel Pharmaceuticals, Inc. Use of depsipeptide and congeners thereof as immunosuppressants for treating an infectious disease, an autoimmune disease, allergic reactions or a hyperproliferative skin disease.
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
MXPA04001612A (es) * 2001-08-21 2004-07-08 Fujisawa Pharmaceutical Co Uso medicinal de inhibidor de la histona desacetilasa y metodo para evaluar el efecto antitumoral del mismo.
CA2471957A1 (en) * 2001-12-28 2003-07-17 Fujisawa Pharmaceutical Co., Ltd. Cyclic tetrapeptide compound and use thereof
WO2003070754A1 (fr) * 2002-02-20 2003-08-28 Minoru Yoshida Inhibiteurs d'histone desacetylase et procede de production de ces inhibiteurs
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7250514B1 (en) 2002-10-21 2007-07-31 Takeda San Diego, Inc. Histone deacetylase inhibitors
WO2004046312A2 (en) * 2002-11-15 2004-06-03 The Board Of Trustees Of The University Of Illinois Methods for in vitro expansion of hematopoietic stem cells
EP1608628A2 (en) 2003-03-17 2005-12-28 Takeda San Diego, Inc. Histone deacetylase inhibitors
WO2004113366A1 (ja) 2003-06-20 2004-12-29 Riken ヒストン脱アセチル化酵素阻害剤およびその製造方法
JP2008524246A (ja) 2004-12-16 2008-07-10 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼ阻害剤
WO2006122319A2 (en) 2005-05-11 2006-11-16 Takeda San Diego, Inc. Histone deacetylase inhibitors
EA200800321A1 (ru) 2005-07-14 2008-06-30 Такеда Сан Диего, Инк. Ингибиторы гистондеацетилазы
EP1801115A1 (en) * 2005-12-23 2007-06-27 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Cyclic peptides and their use in treating advanced stage neuroblastoma
JP2007262058A (ja) * 2006-03-03 2007-10-11 Tokyo Univ Of Science 糸状菌の分化抑制剤
WO2007145704A2 (en) 2006-04-24 2007-12-21 Gloucester Pharmaceuticals Gemcitabine combination therapy
US8957027B2 (en) 2006-06-08 2015-02-17 Celgene Corporation Deacetylase inhibitor therapy
KR101114970B1 (ko) 2006-09-05 2012-03-13 도꾸리쯔교세이호징 리가가쿠 겐큐소 히스톤 탈아세틸화효소 저해 활성을 갖는 화합물, 및 이 화합물을 활성 성분으로 포함하는 의약
JP4887427B2 (ja) * 2006-12-06 2012-02-29 北海道公立大学法人 札幌医科大学 ヒストン脱アセチル化酵素阻害活性を有する物質を用いた細胞性免疫増強剤
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CA2574531C (en) * 2007-01-19 2016-10-25 The University Of British Columbia Hat acetylation promoters and uses of compositions thereof in promoting immunogenicity
KR100909867B1 (ko) * 2007-04-16 2009-07-29 주식회사바이오러넥스 골대사성 질환의 예방 및 치료를 위한 조성물
WO2010006267A2 (en) * 2008-07-11 2010-01-14 University Of Kansas Cyclic tetrapeptides
CN103108648A (zh) 2010-07-12 2013-05-15 细胞基因公司 罗米地辛固体形式及其用途
US8859502B2 (en) 2010-09-13 2014-10-14 Celgene Corporation Therapy for MLL-rearranged leukemia
WO2012074180A1 (ko) * 2010-12-01 2012-06-07 주식회사바이오러넥스 신규한 테트라아자사이클로도데칸-테트라온 유도체 또는 이의 약학적으로 허용 가능한 염, 및 이를 함유하는 암 예방 또는 치료용 약학적 조성물
AU2013202506B2 (en) 2012-09-07 2015-06-18 Celgene Corporation Resistance biomarkers for hdac inhibitors
AU2013202507B9 (en) 2012-11-14 2015-08-13 Celgene Corporation Inhibition of drug resistant cancer cells
NZ630311A (en) 2013-12-27 2016-03-31 Celgene Corp Romidepsin formulations and uses thereof
US11325944B2 (en) 2017-06-16 2022-05-10 University Of Florida Research Foundation, Incorporated Macrocyclic peptides and derivatives thereof with opioid activity
EP3461480A1 (en) 2017-09-27 2019-04-03 Onxeo Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer
EP3461488A1 (en) 2017-09-27 2019-04-03 Onxeo Combination of a dbait molecule and a hdac inhibitor for treating cancer
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2023041805A1 (en) 2021-09-20 2023-03-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for improving the efficacy of hdac inhibitor therapy and predicting the response to treatment with hdac inhibitor
WO2023194441A1 (en) 2022-04-05 2023-10-12 Istituto Nazionale Tumori Irccs - Fondazione G. Pascale Combination of hdac inhibitors and statins for use in the treatment of pancreatic cancer

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JPH0334991A (ja) * 1989-06-30 1991-02-14 Shionogi & Co Ltd 環状テトラペプチドおよびその製造法
AU712801B2 (en) * 1995-09-20 1999-11-18 Merck Sharp & Dohme Corp. Histone deacetylase as target for antiprotozoal agents
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US6777217B1 (en) * 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto

Also Published As

Publication number Publication date
AU732299B2 (en) 2001-04-12
NO20001045D0 (no) 2000-03-01
JP3494624B2 (ja) 2004-02-09
EP1010705A1 (en) 2000-06-21
AU8888598A (en) 1999-03-22
CA2302451A1 (en) 1999-03-11
NZ503061A (en) 2001-08-31
US6399568B1 (en) 2002-06-04
KR20010023449A (ko) 2001-03-26
WO1999011659A1 (fr) 1999-03-11
EP1010705A4 (en) 2004-09-15

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