EA200600270A1 - Применение производных 2h-[1,3]-оксазино[3,2-a]индола для лечения невропатической боли - Google Patents

Применение производных 2h-[1,3]-оксазино[3,2-a]индола для лечения невропатической боли

Info

Publication number
EA200600270A1
EA200600270A1 EA200600270A EA200600270A EA200600270A1 EA 200600270 A1 EA200600270 A1 EA 200600270A1 EA 200600270 A EA200600270 A EA 200600270A EA 200600270 A EA200600270 A EA 200600270A EA 200600270 A1 EA200600270 A1 EA 200600270A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
neuropathic pain
oxasino
application
indol derivatives
Prior art date
Application number
EA200600270A
Other languages
English (en)
Other versions
EA008927B1 (ru
Inventor
Анджело Гульельмотти
Лоренцо Поленцани
Алессандра Ализи
Никола Каццолла
Original Assignee
Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А. filed Critical Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А.
Publication of EA200600270A1 publication Critical patent/EA200600270A1/ru
Publication of EA008927B1 publication Critical patent/EA008927B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Применение соединения формулы (I), в которой R представляет Н, линейную или разветвленную алкильную цепь, имеющую от 1 до 12 атомов углерода, или арилалкильную группу, и его кислотно-аддитивных солей с фармацевтически приемлемыми органическими или неорганическими кислотами для приготовления фармацевтической композиции, активной при лечении невропатической боли.
EA200600270A 2003-07-18 2004-07-08 Применение производных 2h-[1,3]оксазино[3,2-a]индола для лечения невропатической боли EA008927B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001467A ITMI20031467A1 (it) 2003-07-18 2003-07-18 Farmaco attivo nel dolore neuropatico
PCT/EP2004/007633 WO2005014001A1 (en) 2003-07-18 2004-07-08 Use of 2h- [1, 3] - oxazino [3, 2-a] indole derivatives for the treatment of neuropathic pain

Publications (2)

Publication Number Publication Date
EA200600270A1 true EA200600270A1 (ru) 2006-06-30
EA008927B1 EA008927B1 (ru) 2007-08-31

Family

ID=34131193

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600270A EA008927B1 (ru) 2003-07-18 2004-07-08 Применение производных 2h-[1,3]оксазино[3,2-a]индола для лечения невропатической боли

Country Status (21)

Country Link
US (1) US20060211691A1 (ru)
EP (1) EP1646391B1 (ru)
JP (1) JP2006528142A (ru)
KR (1) KR20060033784A (ru)
CN (1) CN100409850C (ru)
AR (1) AR045993A1 (ru)
AT (1) ATE345137T1 (ru)
AU (1) AU2004262876B2 (ru)
CA (1) CA2526852C (ru)
DE (1) DE602004003252T2 (ru)
DK (1) DK1646391T3 (ru)
EA (1) EA008927B1 (ru)
ES (1) ES2276317T3 (ru)
GE (1) GEP20084307B (ru)
HK (1) HK1087027A1 (ru)
IL (1) IL172156A0 (ru)
IT (1) ITMI20031467A1 (ru)
PL (1) PL1646391T3 (ru)
PT (1) PT1646391E (ru)
UA (1) UA81050C2 (ru)
WO (1) WO2005014001A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2103305B1 (en) * 2006-12-26 2011-09-28 Taiho Pharmaceutical Co., Ltd. Therapeutic agent for diabetic neuropathy
DE102007058504A1 (de) 2007-12-05 2009-07-09 Acino Ag Transdermales therapeutisches System mit einem Gehalt an einem Modulator für nikotinische Acetylcholinrezeptoren (nAChR)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5189041A (en) * 1990-11-16 1993-02-23 Syntex (U.S.A.) Inc. Tricyclic 5-ht3 receptor antagonists
GB9120628D0 (en) * 1991-09-27 1991-11-06 Fujisawa Pharmaceutical Co Pyrrolobenzoxazine derivatives and process for preparation thereof
RU2104279C1 (ru) * 1992-03-12 1998-02-10 Смитклайн Бичам Плс Конденсированное индольное производное или его фармацевтически приемлемая соль, фармацевтическая композиция, проявляющая активность антагониста 5-нт*004-рецептора
IL117438A (en) * 1995-03-16 2001-12-23 Lilly Co Eli Indazolecarboxamides, their preparation and pharmaceutical compositions containing them
BR0012934A (pt) * 1999-08-04 2003-07-29 Icagen Inc Processos para a redução de dor e de ansiedade
US20040038874A1 (en) * 2002-08-22 2004-02-26 Osemwota Omoigui Method of treatment of persistent pain

Also Published As

Publication number Publication date
HK1087027A1 (en) 2006-10-06
WO2005014001A1 (en) 2005-02-17
KR20060033784A (ko) 2006-04-19
WO2005014001A9 (en) 2005-05-26
EA008927B1 (ru) 2007-08-31
CA2526852C (en) 2011-08-30
ES2276317T3 (es) 2007-06-16
JP2006528142A (ja) 2006-12-14
CA2526852A1 (en) 2005-02-17
DE602004003252T2 (de) 2007-05-03
CN1809361A (zh) 2006-07-26
US20060211691A1 (en) 2006-09-21
ATE345137T1 (de) 2006-12-15
DE602004003252D1 (de) 2006-12-28
EP1646391B1 (en) 2006-11-15
DK1646391T3 (da) 2007-03-19
PT1646391E (pt) 2007-01-31
AU2004262876A1 (en) 2005-02-17
ITMI20031467A1 (it) 2005-01-19
CN100409850C (zh) 2008-08-13
PL1646391T3 (pl) 2007-04-30
AU2004262876B2 (en) 2010-05-20
EP1646391A1 (en) 2006-04-19
AR045993A1 (es) 2005-11-23
IL172156A0 (en) 2006-04-10
UA81050C2 (en) 2007-11-26
GEP20084307B (en) 2008-02-11

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU