EA201070603A1 - Лекарственное средство, активное в отношении невропатической боли - Google Patents

Лекарственное средство, активное в отношении невропатической боли

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Publication number
EA201070603A1
EA201070603A1 EA201070603A EA201070603A EA201070603A1 EA 201070603 A1 EA201070603 A1 EA 201070603A1 EA 201070603 A EA201070603 A EA 201070603A EA 201070603 A EA201070603 A EA 201070603A EA 201070603 A1 EA201070603 A1 EA 201070603A1
Authority
EA
Eurasian Patent Office
Prior art keywords
neuropathic pain
compound
relation
relates
drug active
Prior art date
Application number
EA201070603A
Other languages
English (en)
Other versions
EA019405B1 (ru
Inventor
Мария Алессандра Ализи
Никола Каццолла
Гвидо Фурлотти
Анджело Гульельмотти
Лоренцо Поленцани
Original Assignee
Ацьенде Кимике Рьюните Анджелини Франческо A.K.P.A.Ф. С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ацьенде Кимике Рьюните Анджелини Франческо A.K.P.A.Ф. С.П.А. filed Critical Ацьенде Кимике Рьюните Анджелини Франческо A.K.P.A.Ф. С.П.А.
Publication of EA201070603A1 publication Critical patent/EA201070603A1/ru
Publication of EA019405B1 publication Critical patent/EA019405B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Настоящее изобретение относится к соединению формулы (I), в которой R представляет собой линейную или разветвленную алкильную группу, содержащую от 1 до 3 атомов углерода, Y представляет собой СН или N и р представляет собой целое число от 0 до 3 и предпочтительно 0 и 1, и к его солям, либо солям присоединения фармацевтически приемлемых органических или неорганических кислот, либо солям присоединения фармацевтически приемлемых органических или неорганических оснований. Изобретение также относится к способу получения соединения формулы (I) и к фармацевтической композиции, содержащей это соединение. Изобретение также относится к применению индазола для приготовления фармацевтической композиции, которая является активной в лечении невропатической боли.
EA201070603A 2007-11-12 2008-11-06 Лекарственное средство, активное в отношении невропатической боли EA019405B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07425709 2007-11-12
PCT/EP2008/065081 WO2009062883A1 (en) 2007-11-12 2008-11-06 Drug active in neuropathic pain

Publications (2)

Publication Number Publication Date
EA201070603A1 true EA201070603A1 (ru) 2010-10-29
EA019405B1 EA019405B1 (ru) 2014-03-31

Family

ID=39312937

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070603A EA019405B1 (ru) 2007-11-12 2008-11-06 Лекарственное средство, активное в отношении невропатической боли

Country Status (25)

Country Link
US (1) US8455519B2 (ru)
EP (1) EP2207776B9 (ru)
JP (1) JP5443372B2 (ru)
KR (1) KR101555626B1 (ru)
CN (1) CN101855220B (ru)
AR (1) AR069249A1 (ru)
AU (1) AU2008323026B2 (ru)
CA (1) CA2702874C (ru)
CY (1) CY1118131T1 (ru)
DK (1) DK2207776T3 (ru)
EA (1) EA019405B1 (ru)
ES (1) ES2601250T3 (ru)
GE (1) GEP20125526B (ru)
HK (1) HK1142884A1 (ru)
HR (1) HRP20161497T1 (ru)
HU (1) HUE031676T2 (ru)
IL (1) IL205309A (ru)
LT (1) LT2207776T (ru)
MX (1) MX2010005267A (ru)
PL (1) PL2207776T3 (ru)
PT (1) PT2207776T (ru)
SG (1) SG185982A1 (ru)
SI (1) SI2207776T1 (ru)
UA (1) UA99927C2 (ru)
WO (1) WO2009062883A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2817301T1 (sl) 2012-02-21 2016-03-31 Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. - S.P.A Uporaba 1H-indazol-3-karboksamidnih spojin kot inhibitorjev glikogen sintaza-kinaze-3beta
SG10201701649YA (en) 2012-02-21 2017-04-27 Acraf 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
MX2021001110A (es) * 2018-07-31 2021-03-31 Ono Pharmaceutical Co Derivado de benceno.
JP7384179B2 (ja) * 2020-01-29 2023-11-21 小野薬品工業株式会社 ベンゼン誘導体を含有する医薬組成物
KR20220132537A (ko) * 2020-01-29 2022-09-30 오노 야꾸힝 고교 가부시키가이샤 벤젠 유도체의 신규 결정형
KR102374820B1 (ko) 2020-11-04 2022-03-16 전남대학교병원 프레가발린 및 티아넵틴을 포함하는 신경병성 통증 치료용 약학적 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996038420A1 (fr) * 1995-05-31 1996-12-05 Nisshin Flour Milling Co., Ltd. Derives de l'indazole a groupe amino monocyclique
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
CA2369695A1 (en) * 1999-04-09 2000-10-19 Manabu Itoh Agent for treating neuropathic pain
ITMI20030972A1 (it) * 2003-05-15 2004-11-16 Acraf Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.
ITMI20031468A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
ATE457309T1 (de) * 2003-12-23 2010-02-15 Serodus As Modulatoren von peripheren 5-ht-rezeptoren

Also Published As

Publication number Publication date
HK1142884A1 (zh) 2010-12-17
US8455519B2 (en) 2013-06-04
CY1118131T1 (el) 2017-06-28
WO2009062883A1 (en) 2009-05-22
DK2207776T3 (en) 2016-10-31
SI2207776T1 (sl) 2016-11-30
UA99927C2 (ru) 2012-10-25
AR069249A1 (es) 2010-01-06
CA2702874C (en) 2015-12-29
SG185982A1 (en) 2012-12-28
MX2010005267A (es) 2010-05-24
CN101855220A (zh) 2010-10-06
ES2601250T3 (es) 2017-02-14
CN101855220B (zh) 2014-07-30
AU2008323026B2 (en) 2014-06-19
EA019405B1 (ru) 2014-03-31
US20100215742A1 (en) 2010-08-26
EP2207776A1 (en) 2010-07-21
HRP20161497T1 (hr) 2016-12-16
JP2011503030A (ja) 2011-01-27
JP5443372B2 (ja) 2014-03-19
HUE031676T2 (en) 2017-07-28
LT2207776T (lt) 2016-11-10
IL205309A (en) 2015-04-30
KR20100082359A (ko) 2010-07-16
GEP20125526B (en) 2012-05-25
IL205309A0 (en) 2010-12-30
PT2207776T (pt) 2016-11-08
KR101555626B1 (ko) 2015-09-24
CA2702874A1 (en) 2009-05-22
AU2008323026A1 (en) 2009-05-22
EP2207776B1 (en) 2016-08-17
PL2207776T3 (pl) 2017-01-31
EP2207776B9 (en) 2016-12-21

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU