EA201171429A1 - Противораковое соединение и содержащая его фармацевтическая композиция - Google Patents
Противораковое соединение и содержащая его фармацевтическая композицияInfo
- Publication number
- EA201171429A1 EA201171429A1 EA201171429A EA201171429A EA201171429A1 EA 201171429 A1 EA201171429 A1 EA 201171429A1 EA 201171429 A EA201171429 A EA 201171429A EA 201171429 A EA201171429 A EA 201171429A EA 201171429 A1 EA201171429 A1 EA 201171429A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compound
- pharmaceutical composition
- composition containing
- tract
- tract compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Изобретение относится к соединению формулы (I), более конкретно, в его левовращающей форме (1а), в частности, имеющему удельное вращение [α] D=-38, 6±0,7 при концентрации 0,698 мг/мл в метаноле. Соединение может существовать в виде основания или соли присоединения кислоты, в частности фармацевтически приемлемой кислоты. Это соединение является селективным ингибитором киназ Aurora А и В. Оно может также применяться в качестве противоракового средства.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0902392A FR2945535B1 (fr) | 2009-05-18 | 2009-05-18 | Compose anticancereux et composition pharmaceutique le contenant |
| PCT/FR2010/050948 WO2010133794A1 (fr) | 2009-05-18 | 2010-05-17 | Compose anticancéreux et composition pharmaceutique le contenant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201171429A1 true EA201171429A1 (ru) | 2012-05-30 |
| EA021084B1 EA021084B1 (ru) | 2015-04-30 |
Family
ID=40973187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201171429A EA021084B1 (ru) | 2009-05-18 | 2010-05-17 | Противораковое соединение и содержащая его фармацевтическая композиция |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US9073917B2 (ru) |
| EP (1) | EP2432766B1 (ru) |
| JP (1) | JP5656981B2 (ru) |
| KR (1) | KR20120032483A (ru) |
| CN (1) | CN102459193B (ru) |
| AR (1) | AR076686A1 (ru) |
| AU (1) | AU2010251013B2 (ru) |
| BR (1) | BRPI1012201A2 (ru) |
| CA (1) | CA2762233C (ru) |
| CL (1) | CL2011002930A1 (ru) |
| CO (1) | CO6400138A2 (ru) |
| CY (1) | CY1114850T1 (ru) |
| DK (1) | DK2432766T3 (ru) |
| EA (1) | EA021084B1 (ru) |
| ES (1) | ES2430989T3 (ru) |
| FR (1) | FR2945535B1 (ru) |
| HK (1) | HK1167388A1 (ru) |
| HR (1) | HRP20130959T1 (ru) |
| IL (1) | IL216361A0 (ru) |
| JO (1) | JO2852B1 (ru) |
| MA (1) | MA33356B1 (ru) |
| ME (1) | ME01542B (ru) |
| MX (1) | MX2011012356A (ru) |
| MY (1) | MY152995A (ru) |
| NZ (1) | NZ596464A (ru) |
| PL (1) | PL2432766T3 (ru) |
| PT (1) | PT2432766E (ru) |
| RS (1) | RS53002B (ru) |
| SG (1) | SG176169A1 (ru) |
| SI (1) | SI2432766T1 (ru) |
| SM (1) | SMT201400005B (ru) |
| TW (1) | TWI441822B (ru) |
| UY (1) | UY32644A (ru) |
| WO (1) | WO2010133794A1 (ru) |
| ZA (1) | ZA201108447B (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2945535B1 (fr) | 2009-05-18 | 2011-06-10 | Sanofi Aventis | Compose anticancereux et composition pharmaceutique le contenant |
| FR2967413A1 (fr) * | 2010-11-17 | 2012-05-18 | Sanofi Aventis | Compose 8-oxo-9-[3-(1h-benzimidazol-2-yloxy)-phenyl]-4,5,6,7,8,9-hexahydro-2h-pyrrolo[3,4-b]quinoline-3-carboxylate d'ethyle, sel, forme cristalline, co-cristal, formulation, procedes de preparation, application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteur des kinases aurora. |
| PT2909204T (pt) | 2012-10-12 | 2019-03-21 | Dana Farber Cancer Inst Inc | Inibidores de gsk3 e métodos de utilização dos mesmos |
| EP3164388A1 (en) | 2014-07-01 | 2017-05-10 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds and their use as retinoid-related orphan receptor (ror) gamma-t inhibitors |
| CN110958882B (zh) | 2017-04-05 | 2023-08-29 | 布罗德研究所股份有限公司 | 作为糖原合酶激酶3(gsk3)抑制剂的三环化合物及其用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA02005016A (es) | 1999-11-19 | 2003-01-28 | Abbott Lab | Abridores de canal de potasio de dihidropirimidina triciclica. |
| KR20030076650A (ko) | 2001-02-02 | 2003-09-26 | 미쯔비시 웰 파마 가부시키가이샤 | 디하이드로피라졸로피리딘 화합물 및 그의 약학적 용도 |
| US7037902B2 (en) | 2002-07-03 | 2006-05-02 | Receptron, Inc. | Affinity small molecules for the EPO receptor |
| CA2528938A1 (en) * | 2003-06-13 | 2005-02-24 | Zentaris Gmbh | Compounds having inhibitive activity of phosphatidylinositol 3-kinase and methods of use thereof |
| SI1746097T1 (sl) | 2005-07-20 | 2010-05-31 | Aventis Pharma Sa | dihidropiridin kondenzirani heterocikli postopek za njihovo pripravo njihova uporaba in sestavki ki jih vsebujejo |
| FR2945535B1 (fr) | 2009-05-18 | 2011-06-10 | Sanofi Aventis | Compose anticancereux et composition pharmaceutique le contenant |
-
2009
- 2009-05-18 FR FR0902392A patent/FR2945535B1/fr not_active Expired - Fee Related
-
2010
- 2010-05-16 JO JO2010163A patent/JO2852B1/en active
- 2010-05-17 TW TW099115713A patent/TWI441822B/zh not_active IP Right Cessation
- 2010-05-17 MX MX2011012356A patent/MX2011012356A/es active IP Right Grant
- 2010-05-17 NZ NZ596464A patent/NZ596464A/en not_active IP Right Cessation
- 2010-05-17 US US13/320,965 patent/US9073917B2/en not_active Expired - Fee Related
- 2010-05-17 SG SG2011085529A patent/SG176169A1/en unknown
- 2010-05-17 CN CN201080032327.7A patent/CN102459193B/zh not_active Expired - Fee Related
- 2010-05-17 PT PT107287682T patent/PT2432766E/pt unknown
- 2010-05-17 EA EA201171429A patent/EA021084B1/ru not_active IP Right Cessation
- 2010-05-17 MA MA34441A patent/MA33356B1/fr unknown
- 2010-05-17 ES ES10728768T patent/ES2430989T3/es active Active
- 2010-05-17 WO PCT/FR2010/050948 patent/WO2010133794A1/fr active Application Filing
- 2010-05-17 AU AU2010251013A patent/AU2010251013B2/en not_active Ceased
- 2010-05-17 MY MYPI2011005531 patent/MY152995A/en unknown
- 2010-05-17 RS RS20130444A patent/RS53002B/en unknown
- 2010-05-17 AR ARP100101705A patent/AR076686A1/es unknown
- 2010-05-17 JP JP2012511323A patent/JP5656981B2/ja not_active Expired - Fee Related
- 2010-05-17 KR KR1020117030136A patent/KR20120032483A/ko active Search and Examination
- 2010-05-17 CA CA2762233A patent/CA2762233C/fr not_active Expired - Fee Related
- 2010-05-17 EP EP10728768.2A patent/EP2432766B1/fr active Active
- 2010-05-17 PL PL10728768T patent/PL2432766T3/pl unknown
- 2010-05-17 SI SI201030384T patent/SI2432766T1/sl unknown
- 2010-05-17 BR BRPI1012201A patent/BRPI1012201A2/pt not_active IP Right Cessation
- 2010-05-17 DK DK10728768.2T patent/DK2432766T3/da active
- 2010-05-17 ME MEP-2013-121A patent/ME01542B/me unknown
- 2010-05-18 UY UY0001032644A patent/UY32644A/es not_active Application Discontinuation
-
2011
- 2011-11-14 IL IL216361A patent/IL216361A0/en unknown
- 2011-11-17 ZA ZA2011/08447A patent/ZA201108447B/en unknown
- 2011-11-18 CO CO11157425A patent/CO6400138A2/es active IP Right Grant
- 2011-11-18 CL CL2011002930A patent/CL2011002930A1/es unknown
-
2012
- 2012-08-15 HK HK12108002.5A patent/HK1167388A1/xx not_active IP Right Cessation
-
2013
- 2013-10-09 HR HRP20130959AT patent/HRP20130959T1/hr unknown
- 2013-10-17 CY CY20131100920T patent/CY1114850T1/el unknown
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2014
- 2014-01-16 SM SM201400005T patent/SMT201400005B/xx unknown
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2015
- 2015-06-02 US US14/728,846 patent/US9221817B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |