CY1114850T1 - Αντικαρκινικη ενωση και η φαρμακευτικη συνθεση που την περιεχει - Google Patents

Αντικαρκινικη ενωση και η φαρμακευτικη συνθεση που την περιεχει

Info

Publication number
CY1114850T1
CY1114850T1 CY20131100920T CY131100920T CY1114850T1 CY 1114850 T1 CY1114850 T1 CY 1114850T1 CY 20131100920 T CY20131100920 T CY 20131100920T CY 131100920 T CY131100920 T CY 131100920T CY 1114850 T1 CY1114850 T1 CY 1114850T1
Authority
CY
Cyprus
Prior art keywords
cancer
union
pharmaceutical composition
composition containing
compound
Prior art date
Application number
CY20131100920T
Other languages
English (en)
Inventor
Jean-Christophe Carry
Michel Cheve
François Clerc
Cécile Combeau
Sylvie Gontier
Alain Krick
Sylvette Lachaud
Laurent Schio
Original Assignee
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi filed Critical Sanofi
Publication of CY1114850T1 publication Critical patent/CY1114850T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Η εφεύρεση σχετίζεται με την ένωση του τύπου (Ι) : πιο συγκεκριμένα με την αριστερόστροφη μορφή της (la), κυρίως αυτή που παρουσιάζει την περιστροφική ισχύ [[άλφα]] = -38,6+0,7 σε μια συγκέντρωση από 0,698 mg/ml μέσα σε μεθανόλη. Η ένωση μπορεί να υπάρχει με τη μορφή βάσης ή ενός άλατος προσθήκης σε ένα οξύ, κυρίως σε ένα φαρμακευτικώς αποδεκτό οξύ. Η ένωση αυτή είναι ένας επιλεκτικός αναστολέας των κινάσεων Αurora A και Β. Μπορεί να χρησιμοποιηθεί ως αντικαρκινικός παράγοντας.
CY20131100920T 2009-05-18 2013-10-17 Αντικαρκινικη ενωση και η φαρμακευτικη συνθεση που την περιεχει CY1114850T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0902392A FR2945535B1 (fr) 2009-05-18 2009-05-18 Compose anticancereux et composition pharmaceutique le contenant
EP10728768.2A EP2432766B1 (fr) 2009-05-18 2010-05-17 Composé anticancéreux et composition pharmaceutique le contenant

Publications (1)

Publication Number Publication Date
CY1114850T1 true CY1114850T1 (el) 2016-12-14

Family

ID=40973187

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131100920T CY1114850T1 (el) 2009-05-18 2013-10-17 Αντικαρκινικη ενωση και η φαρμακευτικη συνθεση που την περιεχει

Country Status (35)

Country Link
US (2) US9073917B2 (el)
EP (1) EP2432766B1 (el)
JP (1) JP5656981B2 (el)
KR (1) KR20120032483A (el)
CN (1) CN102459193B (el)
AR (1) AR076686A1 (el)
AU (1) AU2010251013B2 (el)
BR (1) BRPI1012201A2 (el)
CA (1) CA2762233C (el)
CL (1) CL2011002930A1 (el)
CO (1) CO6400138A2 (el)
CY (1) CY1114850T1 (el)
DK (1) DK2432766T3 (el)
EA (1) EA021084B1 (el)
ES (1) ES2430989T3 (el)
FR (1) FR2945535B1 (el)
HK (1) HK1167388A1 (el)
HR (1) HRP20130959T1 (el)
IL (1) IL216361A0 (el)
JO (1) JO2852B1 (el)
MA (1) MA33356B1 (el)
ME (1) ME01542B (el)
MX (1) MX2011012356A (el)
MY (1) MY152995A (el)
NZ (1) NZ596464A (el)
PL (1) PL2432766T3 (el)
PT (1) PT2432766E (el)
RS (1) RS53002B (el)
SG (1) SG176169A1 (el)
SI (1) SI2432766T1 (el)
SM (1) SMT201400005B (el)
TW (1) TWI441822B (el)
UY (1) UY32644A (el)
WO (1) WO2010133794A1 (el)
ZA (1) ZA201108447B (el)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2945535B1 (fr) 2009-05-18 2011-06-10 Sanofi Aventis Compose anticancereux et composition pharmaceutique le contenant
FR2967413A1 (fr) * 2010-11-17 2012-05-18 Sanofi Aventis Compose 8-oxo-9-[3-(1h-benzimidazol-2-yloxy)-phenyl]-4,5,6,7,8,9-hexahydro-2h-pyrrolo[3,4-b]quinoline-3-carboxylate d'ethyle, sel, forme cristalline, co-cristal, formulation, procedes de preparation, application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteur des kinases aurora.
PT2909204T (pt) 2012-10-12 2019-03-21 Dana Farber Cancer Inst Inc Inibidores de gsk3 e métodos de utilização dos mesmos
EP3164388A1 (en) 2014-07-01 2017-05-10 Takeda Pharmaceutical Company Limited Heterocyclic compounds and their use as retinoid-related orphan receptor (ror) gamma-t inhibitors
CN110958882B (zh) 2017-04-05 2023-08-29 布罗德研究所股份有限公司 作为糖原合酶激酶3(gsk3)抑制剂的三环化合物及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02005016A (es) 1999-11-19 2003-01-28 Abbott Lab Abridores de canal de potasio de dihidropirimidina triciclica.
KR20030076650A (ko) 2001-02-02 2003-09-26 미쯔비시 웰 파마 가부시키가이샤 디하이드로피라졸로피리딘 화합물 및 그의 약학적 용도
US7037902B2 (en) 2002-07-03 2006-05-02 Receptron, Inc. Affinity small molecules for the EPO receptor
CA2528938A1 (en) * 2003-06-13 2005-02-24 Zentaris Gmbh Compounds having inhibitive activity of phosphatidylinositol 3-kinase and methods of use thereof
SI1746097T1 (sl) 2005-07-20 2010-05-31 Aventis Pharma Sa dihidropiridin kondenzirani heterocikli postopek za njihovo pripravo njihova uporaba in sestavki ki jih vsebujejo
FR2945535B1 (fr) 2009-05-18 2011-06-10 Sanofi Aventis Compose anticancereux et composition pharmaceutique le contenant

Also Published As

Publication number Publication date
MX2011012356A (es) 2011-12-14
WO2010133794A1 (fr) 2010-11-25
JP5656981B2 (ja) 2015-01-21
DK2432766T3 (da) 2013-10-28
EP2432766B1 (fr) 2013-07-17
JO2852B1 (en) 2015-03-15
MA33356B1 (fr) 2012-06-01
HK1167388A1 (en) 2012-11-30
US9221817B2 (en) 2015-12-29
EP2432766A1 (fr) 2012-03-28
SG176169A1 (en) 2011-12-29
NZ596464A (en) 2014-01-31
CN102459193B (zh) 2014-08-27
CA2762233C (fr) 2017-11-28
SI2432766T1 (sl) 2013-11-29
MY152995A (en) 2014-12-31
CA2762233A1 (fr) 2010-11-25
AR076686A1 (es) 2011-06-29
HRP20130959T1 (hr) 2013-11-22
FR2945535B1 (fr) 2011-06-10
KR20120032483A (ko) 2012-04-05
US20120220621A1 (en) 2012-08-30
ME01542B (me) 2014-04-20
EA021084B1 (ru) 2015-04-30
TW201100418A (en) 2011-01-01
RS53002B (en) 2014-04-30
EA201171429A1 (ru) 2012-05-30
CL2011002930A1 (es) 2012-06-29
UY32644A (es) 2010-12-31
CN102459193A (zh) 2012-05-16
AU2010251013A1 (en) 2011-12-08
FR2945535A1 (fr) 2010-11-19
PL2432766T3 (pl) 2013-12-31
TWI441822B (zh) 2014-06-21
ES2430989T3 (es) 2013-11-22
BRPI1012201A2 (pt) 2016-04-05
CO6400138A2 (es) 2012-03-15
IL216361A0 (en) 2012-01-31
JP2012527436A (ja) 2012-11-08
PT2432766E (pt) 2013-10-23
US9073917B2 (en) 2015-07-07
SMT201400005B (it) 2014-03-07
AU2010251013B2 (en) 2015-08-20
ZA201108447B (en) 2013-01-30
US20150266877A1 (en) 2015-09-24

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