JP2015523546A5 - - Google Patents
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- JP2015523546A5 JP2015523546A5 JP2015509271A JP2015509271A JP2015523546A5 JP 2015523546 A5 JP2015523546 A5 JP 2015523546A5 JP 2015509271 A JP2015509271 A JP 2015509271A JP 2015509271 A JP2015509271 A JP 2015509271A JP 2015523546 A5 JP2015523546 A5 JP 2015523546A5
- Authority
- JP
- Japan
- Prior art keywords
- amd
- compound
- formula
- alkyl
- rate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 238000000034 method Methods 0.000 claims 13
- 206010064930 age-related macular degeneration Diseases 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 4
- 208000002780 macular degeneration Diseases 0.000 claims 4
- 208000011325 dry age related macular degeneration Diseases 0.000 claims 3
- 208000008069 Geographic Atrophy Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 210000004127 vitreous body Anatomy 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261640854P | 2012-05-01 | 2012-05-01 | |
| US61/640,854 | 2012-05-01 | ||
| US201261641393P | 2012-05-02 | 2012-05-02 | |
| US61/641,393 | 2012-05-02 | ||
| US201261693226P | 2012-08-24 | 2012-08-24 | |
| US61/693,226 | 2012-08-24 | ||
| US201361792436P | 2013-03-15 | 2013-03-15 | |
| US61/792,436 | 2013-03-15 | ||
| PCT/CA2013/050335 WO2013163758A1 (en) | 2012-05-01 | 2013-04-30 | Methods for treating and diagnosing blinding eye diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017028425A Division JP2017114894A (ja) | 2012-05-01 | 2017-02-17 | 失明性疾患を処置および診断するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015523546A JP2015523546A (ja) | 2015-08-13 |
| JP2015523546A5 true JP2015523546A5 (enExample) | 2016-06-16 |
Family
ID=49514154
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015509271A Pending JP2015523546A (ja) | 2012-05-01 | 2013-04-30 | 失明性疾患を処置および診断するための方法 |
| JP2017028425A Pending JP2017114894A (ja) | 2012-05-01 | 2017-02-17 | 失明性疾患を処置および診断するための方法 |
| JP2019125032A Active JP6837522B2 (ja) | 2012-05-01 | 2019-07-04 | 失明性疾患を処置および診断するための方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017028425A Pending JP2017114894A (ja) | 2012-05-01 | 2017-02-17 | 失明性疾患を処置および診断するための方法 |
| JP2019125032A Active JP6837522B2 (ja) | 2012-05-01 | 2019-07-04 | 失明性疾患を処置および診断するための方法 |
Country Status (9)
| Country | Link |
|---|---|
| EP (2) | EP3338776A1 (enExample) |
| JP (3) | JP2015523546A (enExample) |
| CN (2) | CN104334173B (enExample) |
| AU (2) | AU2013255050B2 (enExample) |
| CA (2) | CA3095012C (enExample) |
| DK (1) | DK2844250T3 (enExample) |
| ES (1) | ES2656292T3 (enExample) |
| IL (3) | IL235395A (enExample) |
| WO (1) | WO2013163758A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8999292B2 (en) | 2012-05-01 | 2015-04-07 | Translatum Medicus Inc. | Methods for treating and diagnosing blinding eye diseases |
| EP3142664B1 (en) * | 2014-05-15 | 2019-12-04 | Translatum Medicus Inc. | Compositions and methods for treating and diagnosing ocular disorders |
| US20180221339A1 (en) * | 2015-06-16 | 2018-08-09 | Translatum Medicus, Inc. | Compositions and methods for treating and diagnosing ocular disorders |
| JP6664115B2 (ja) * | 2016-03-15 | 2020-03-13 | 原 英彰 | アフリベルセプトによる網膜保護作用 |
| CN109788946B (zh) * | 2016-06-24 | 2023-02-03 | 鲁美斯Be有限公司 | 利用激光等效强脉冲光装置的选择性皮肤处理 |
| CA3040419A1 (en) * | 2016-10-13 | 2018-04-19 | Translatum Medicus, Inc. | Systems and methods for detection of ocular disease |
| US11369695B2 (en) | 2016-12-05 | 2022-06-28 | The Jackson Laboratory | Fat droplets in retina and optic nerve as a diagnostic marker for neurodegeneration and glaucoma in humans |
| US20210060017A1 (en) * | 2018-02-27 | 2021-03-04 | Shilpa Medicare Ltd | Methotrexate ophthalmic solution |
| JP7279711B2 (ja) * | 2018-04-18 | 2023-05-23 | 株式会社ニコン | 画像処理方法、プログラム、画像処理装置、及び眼科システム |
| DE112019002024T5 (de) * | 2018-04-18 | 2021-01-07 | Nikon Corporation | Bildverarbeitungsverfahren, Programm und Bildverarbeitungsvorrichtung |
| CN109222890A (zh) * | 2018-08-24 | 2019-01-18 | 微云（武汉）科技有限公司 | 一种眼睛健康情况确定方法、装置和存储介质 |
| CN109585017B (zh) * | 2019-01-31 | 2023-12-12 | 上海宝藤生物医药科技股份有限公司 | 一种年龄相关性黄斑变性的风险预测算法模型和装置 |
| AU2019441740B2 (en) | 2019-04-18 | 2025-12-18 | Tracery Ophthalmics Inc. | Detection, prediction, and classification for ocular disease |
| EP3990433B1 (en) | 2019-06-25 | 2026-05-20 | Translatum Medicus Inc. | PROCESSES FOR THE MANUFACTURE OF 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES |
| US12678440B2 (en) | 2020-02-26 | 2026-07-14 | Case Western Reserve University | Compositions and methods for treating misfolded protein ocular disorders |
| JP7406403B2 (ja) * | 2020-02-28 | 2023-12-27 | 浜松ホトニクス株式会社 | 眼底画像処理方法、眼底画像処理装置、眼底画像処理プログラム、及びそのプログラムを記録する記録媒体 |
| CN114099515A (zh) * | 2021-12-27 | 2022-03-01 | 中山大学中山眼科中心 | 氨甲蝶呤在制备治疗视网膜色素变性的药物方面的应用 |
| EP4662203A1 (en) * | 2023-02-10 | 2025-12-17 | Translatum Medicus Inc. | Bindarit conjugates, compositions and methods for treating ocular diseases or disorders |
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| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US4080325A (en) | 1976-11-17 | 1978-03-21 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Synthesis of methotrexate |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| US5138069A (en) | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
| US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| IT1230441B (it) | 1989-02-07 | 1991-10-23 | Acraf | Eteri della serie dell'indazolo |
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| EP0443983B1 (de) | 1990-02-19 | 1996-02-28 | Ciba-Geigy Ag | Acylverbindungen |
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| EP0770397B1 (en) | 1995-10-18 | 2004-04-21 | Akzo Nobel N.V. | Newcastle disease virus combination vaccine |
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| DK1287364T3 (da) * | 2000-04-29 | 2009-03-02 | Univ Iowa Res Found | Diagnostisk og terapi til makulære degenerationsrelaterede lidelser |
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| JP4897690B2 (ja) * | 2004-10-12 | 2012-03-14 | ジェネンテック， インコーポレイテッド | 補体関連障害の予防および処置のためのＣＲＩｇポリペプチド |
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| US20070197590A1 (en) | 2006-01-31 | 2007-08-23 | Demong Duane E | Substituted dipiperidine ccr2 antagonists |
| DE102006030382A1 (de) * | 2006-06-29 | 2008-01-03 | Carl Zeiss Meditec Ag | Verfahren und Vorrichtung zur optischen Detektion am Auge |
| DK2254869T3 (en) * | 2008-03-07 | 2017-09-04 | Acraf | 1-BENZYL-3-HYDROXYMETHYL INDAZOLE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF CX3CR1 AND P40 |
| KR20110014141A (ko) | 2008-03-20 | 2011-02-10 | 카롤러스 테라퓨틱스, 인코포레이티드 | 염증을 치료하는 방법 |
| US20100286136A1 (en) * | 2009-05-08 | 2010-11-11 | Simon Jones | Dihydronaphthyridinyl and related compounds for use in treating ophthalmological disorders |
| UY33164A (es) * | 2010-01-06 | 2011-08-31 | Glaxo Wellcome Mfg Pte Ltd | Metodo de tratamiento |
| WO2011149012A1 (ja) * | 2010-05-27 | 2011-12-01 | 参天製薬株式会社 | イソキノリンスルホニル誘導体を有効成分として含有する網脈絡膜変性疾患の予防または治療剤、網脈絡膜変性疾患の予防または治療方法、イソキノリンスルホニル誘導体またはその医薬的に許容される塩、ならびにその使用 |
| TW201202214A (en) * | 2010-05-27 | 2012-01-16 | Santen Pharmaceutical Co Ltd | Novel indazole derivative or salt thereof, production intermediate thereof, and prophylactic or therapeutic agent for chorioretinal degeneratire disease using the same |
| AU2011279250B2 (en) * | 2010-07-12 | 2014-12-04 | California Institute Of Technology | Biocompatible substrate for facilitating interconnections between stem cells and target tissues and methods for implanting same |
-
2013
- 2013-04-30 CA CA3095012A patent/CA3095012C/en active Active
- 2013-04-30 CA CA2911041A patent/CA2911041C/en active Active
- 2013-04-30 AU AU2013255050A patent/AU2013255050B2/en active Active
- 2013-04-30 JP JP2015509271A patent/JP2015523546A/ja active Pending
- 2013-04-30 CN CN201380027856.1A patent/CN104334173B/zh active Active
- 2013-04-30 ES ES13785144.0T patent/ES2656292T3/es active Active
- 2013-04-30 EP EP17200123.2A patent/EP3338776A1/en not_active Ceased
- 2013-04-30 DK DK13785144.0T patent/DK2844250T3/en active
- 2013-04-30 CN CN201710228552.1A patent/CN107050020A/zh active Pending
- 2013-04-30 EP EP13785144.0A patent/EP2844250B1/en active Active
- 2013-04-30 WO PCT/CA2013/050335 patent/WO2013163758A1/en not_active Ceased
-
2014
- 2014-10-29 IL IL235395A patent/IL235395A/en active IP Right Grant
-
2016
- 2016-08-26 AU AU2016219703A patent/AU2016219703B2/en active Active
-
2017
- 2017-02-17 JP JP2017028425A patent/JP2017114894A/ja active Pending
- 2017-10-15 IL IL254995A patent/IL254995B/en active IP Right Grant
-
2018
- 2018-07-22 IL IL260714A patent/IL260714B/en active IP Right Grant
-
2019
- 2019-07-04 JP JP2019125032A patent/JP6837522B2/ja active Active
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