JP2015523546A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015523546A5 JP2015523546A5 JP2015509271A JP2015509271A JP2015523546A5 JP 2015523546 A5 JP2015523546 A5 JP 2015523546A5 JP 2015509271 A JP2015509271 A JP 2015509271A JP 2015509271 A JP2015509271 A JP 2015509271A JP 2015523546 A5 JP2015523546 A5 JP 2015523546A5
- Authority
- JP
- Japan
- Prior art keywords
- amd
- compound
- formula
- alkyl
- rate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 13
- 206010064930 age-related macular degeneration Diseases 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 4
- 208000002780 macular degeneration Diseases 0.000 claims 4
- 208000011325 dry age related macular degeneration Diseases 0.000 claims 3
- 208000008069 Geographic Atrophy Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 210000004127 vitreous body Anatomy 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261640854P | 2012-05-01 | 2012-05-01 | |
| US61/640,854 | 2012-05-01 | ||
| US201261641393P | 2012-05-02 | 2012-05-02 | |
| US61/641,393 | 2012-05-02 | ||
| US201261693226P | 2012-08-24 | 2012-08-24 | |
| US61/693,226 | 2012-08-24 | ||
| US201361792436P | 2013-03-15 | 2013-03-15 | |
| US61/792,436 | 2013-03-15 | ||
| PCT/CA2013/050335 WO2013163758A1 (en) | 2012-05-01 | 2013-04-30 | Methods for treating and diagnosing blinding eye diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017028425A Division JP2017114894A (ja) | 2012-05-01 | 2017-02-17 | 失明性疾患を処置および診断するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015523546A JP2015523546A (ja) | 2015-08-13 |
| JP2015523546A5 true JP2015523546A5 (enExample) | 2016-06-16 |
Family
ID=49514154
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015509271A Pending JP2015523546A (ja) | 2012-05-01 | 2013-04-30 | 失明性疾患を処置および診断するための方法 |
| JP2017028425A Pending JP2017114894A (ja) | 2012-05-01 | 2017-02-17 | 失明性疾患を処置および診断するための方法 |
| JP2019125032A Active JP6837522B2 (ja) | 2012-05-01 | 2019-07-04 | 失明性疾患を処置および診断するための方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017028425A Pending JP2017114894A (ja) | 2012-05-01 | 2017-02-17 | 失明性疾患を処置および診断するための方法 |
| JP2019125032A Active JP6837522B2 (ja) | 2012-05-01 | 2019-07-04 | 失明性疾患を処置および診断するための方法 |
Country Status (9)
| Country | Link |
|---|---|
| EP (2) | EP2844250B1 (enExample) |
| JP (3) | JP2015523546A (enExample) |
| CN (2) | CN107050020A (enExample) |
| AU (2) | AU2013255050B2 (enExample) |
| CA (2) | CA3095012C (enExample) |
| DK (1) | DK2844250T3 (enExample) |
| ES (1) | ES2656292T3 (enExample) |
| IL (3) | IL235395A (enExample) |
| WO (1) | WO2013163758A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8999292B2 (en) | 2012-05-01 | 2015-04-07 | Translatum Medicus Inc. | Methods for treating and diagnosing blinding eye diseases |
| HUE049518T2 (hu) * | 2014-05-15 | 2020-09-28 | Translatum Medicus Inc | Készítmények és eljárások a szem megbetegedéseinek kezelésére és diagnosztizálására |
| US20180221339A1 (en) * | 2015-06-16 | 2018-08-09 | Translatum Medicus, Inc. | Compositions and methods for treating and diagnosing ocular disorders |
| JP6664115B2 (ja) * | 2016-03-15 | 2020-03-13 | 原 英彰 | アフリベルセプトによる網膜保護作用 |
| EP3474762A4 (en) * | 2016-06-24 | 2019-08-07 | Lumenis Ltd. | SELECTIVE SKIN TREATMENTS WITH LASER EQUIVALENTS OF HIGHERGETIC PULSE LIGHT EQUIPMENT |
| US11610311B2 (en) | 2016-10-13 | 2023-03-21 | Translatum Medicus, Inc. | Systems and methods for detection of ocular disease |
| KR102713615B1 (ko) * | 2016-12-05 | 2024-10-04 | 더 잭슨 래보라토리 | 인간에서의 신경퇴화 및 녹내장에 대한 진단적 마커로서의 망막 및 시신경 내 지방 알갱이 |
| US20210060017A1 (en) * | 2018-02-27 | 2021-03-04 | Shilpa Medicare Ltd | Methotrexate ophthalmic solution |
| DE112019002024T5 (de) * | 2018-04-18 | 2021-01-07 | Nikon Corporation | Bildverarbeitungsverfahren, Programm und Bildverarbeitungsvorrichtung |
| CN112004457B (zh) * | 2018-04-18 | 2024-06-21 | 株式会社尼康 | 图像处理方法、程序、图像处理装置及眼科系统 |
| CN109222890A (zh) * | 2018-08-24 | 2019-01-18 | 微云（武汉）科技有限公司 | 一种眼睛健康情况确定方法、装置和存储介质 |
| CN109585017B (zh) * | 2019-01-31 | 2023-12-12 | 上海宝藤生物医药科技股份有限公司 | 一种年龄相关性黄斑变性的风险预测算法模型和装置 |
| EP3990433A4 (en) | 2019-06-25 | 2023-07-26 | Translatum Medicus Inc. | METHODS FOR THE MANUFACTURE OF 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES |
| AU2021225926A1 (en) | 2020-02-26 | 2022-10-20 | Case Western Reserve University | Compositions and methods for treating misfolded protein ocular disorders |
| JP7406403B2 (ja) * | 2020-02-28 | 2023-12-27 | 浜松ホトニクス株式会社 | 眼底画像処理方法、眼底画像処理装置、眼底画像処理プログラム、及びそのプログラムを記録する記録媒体 |
| CN114099515A (zh) * | 2021-12-27 | 2022-03-01 | 中山大学中山眼科中心 | 氨甲蝶呤在制备治疗视网膜色素变性的药物方面的应用 |
| EP4662203A1 (en) * | 2023-02-10 | 2025-12-17 | Translatum Medicus Inc. | Bindarit conjugates, compositions and methods for treating ocular diseases or disorders |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US4080325A (en) | 1976-11-17 | 1978-03-21 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Synthesis of methotrexate |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| US5138069A (en) | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
| US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| IT1230441B (it) | 1989-02-07 | 1991-10-23 | Acraf | Eteri della serie dell'indazolo |
| IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
| US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
| ATE134624T1 (de) | 1990-02-19 | 1996-03-15 | Ciba Geigy Ag | Acylverbindungen |
| US5270317A (en) | 1990-03-20 | 1993-12-14 | Elf Sanofi | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present |
| US5196444A (en) | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
| US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
| ES2219679T3 (es) | 1995-10-18 | 2004-12-01 | Akzo Nobel N.V. | Vacuna de combinacion contra la enfermedad de newcastle. |
| IT1276031B1 (it) * | 1995-10-31 | 1997-10-24 | Angelini Ricerche Spa | Composizione farmaceutica per il trattamento delle malattie autoimmuni |
| US6362371B1 (en) | 1998-06-08 | 2002-03-26 | Advanced Medicine, Inc. | β2- adrenergic receptor agonists |
| CN1171872C (zh) | 1999-06-30 | 2004-10-20 | 图拉列克股份有限公司 | 调节PPARγ活性的化合物 |
| WO2001064749A2 (en) | 2000-02-28 | 2001-09-07 | Idec Pharmaceuticals Corporation | Method for preparing anti-mif antibodies |
| WO2001084149A2 (en) * | 2000-04-29 | 2001-11-08 | University Of Iowa Research Foundation | Diagnostics and therapeutics for macular degeneration-related disorders |
| WO2002068386A2 (en) | 2001-02-27 | 2002-09-06 | The Johns Hopkins University | Tools and methods for identifying ppar$g(d)-specific agonists and antagonists |
| UY27304A1 (es) | 2001-05-24 | 2002-12-31 | Avanir Pharmaceuticals | Inhibidores del factor inhibidor de la migración de los macrófagos y métodos para su identificación |
| EP1511736A4 (en) | 2002-06-07 | 2006-06-07 | Cortical Pty Ltd | THERAPEUTIC MOLECULES AND METHOD 1 |
| WO2004069809A1 (en) | 2003-02-03 | 2004-08-19 | Janssen Pharmaceutica N.V. | Mercaptoimidazoles as ccr2 receptor antagonists |
| US7083802B2 (en) * | 2003-07-31 | 2006-08-01 | Advanced Ocular Systems Limited | Treatment of ocular disease |
| NZ552173A (en) | 2004-06-25 | 2010-07-30 | Janssen Pharmaceutica Nv | Quaternary salt CCR2 antagonists |
| AU2005290028A1 (en) | 2004-09-28 | 2006-04-06 | Janssen Pharmaceutica, N.V. | Substituted dipiperdine CCR2 antagonists |
| JP4897690B2 (ja) * | 2004-10-12 | 2012-03-14 | ジェネンテック， インコーポレイテッド | 補体関連障害の予防および処置のためのＣＲＩｇポリペプチド |
| US7622583B2 (en) | 2005-01-14 | 2009-11-24 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2 |
| WO2007053499A2 (en) | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
| US20090130165A1 (en) | 2005-12-21 | 2009-05-21 | Cortical Pty Ltd | MIF Inhibitors |
| US20070197590A1 (en) | 2006-01-31 | 2007-08-23 | Demong Duane E | Substituted dipiperidine ccr2 antagonists |
| DE102006030382A1 (de) * | 2006-06-29 | 2008-01-03 | Carl Zeiss Meditec Ag | Verfahren und Vorrichtung zur optischen Detektion am Auge |
| PL2254870T3 (pl) * | 2008-03-07 | 2016-07-29 | Acraf | Pochodne 1-benzylo-3-hydroksymetyloindazolu i ich zastosowanie w leczeniu chorób opartych na ekspresji MCP-1, CX3CR1 |
| US20110044988A1 (en) | 2008-03-20 | 2011-02-24 | Carolus Therpeutics, Inc. | Methods of treatment using anti-mif antibodies |
| TW201105667A (en) | 2009-05-08 | 2011-02-16 | Cytopathfinder Inc | Dihydronaphthyridinyl and related compounds for use in treating ophthalmological disorders |
| TW201201808A (en) * | 2010-01-06 | 2012-01-16 | Glaxo Wellcome Mfg Pte Ltd | Treatment method |
| JP2012006918A (ja) * | 2010-05-27 | 2012-01-12 | Santen Pharmaceut Co Ltd | イソキノリンスルホニル誘導体を有効成分として含有する網脈絡膜変性疾患の予防または治療剤 |
| TW201202214A (en) * | 2010-05-27 | 2012-01-16 | Santen Pharmaceutical Co Ltd | Novel indazole derivative or salt thereof, production intermediate thereof, and prophylactic or therapeutic agent for chorioretinal degeneratire disease using the same |
| AU2011279250B2 (en) * | 2010-07-12 | 2014-12-04 | California Institute Of Technology | Biocompatible substrate for facilitating interconnections between stem cells and target tissues and methods for implanting same |
-
2013
- 2013-04-30 EP EP13785144.0A patent/EP2844250B1/en active Active
- 2013-04-30 DK DK13785144.0T patent/DK2844250T3/en active
- 2013-04-30 WO PCT/CA2013/050335 patent/WO2013163758A1/en not_active Ceased
- 2013-04-30 CN CN201710228552.1A patent/CN107050020A/zh active Pending
- 2013-04-30 EP EP17200123.2A patent/EP3338776A1/en active Pending
- 2013-04-30 CA CA3095012A patent/CA3095012C/en active Active
- 2013-04-30 AU AU2013255050A patent/AU2013255050B2/en active Active
- 2013-04-30 ES ES13785144.0T patent/ES2656292T3/es active Active
- 2013-04-30 CA CA2911041A patent/CA2911041C/en active Active
- 2013-04-30 JP JP2015509271A patent/JP2015523546A/ja active Pending
- 2013-04-30 CN CN201380027856.1A patent/CN104334173B/zh active Active
-
2014
- 2014-10-29 IL IL235395A patent/IL235395A/en active IP Right Grant
-
2016
- 2016-08-26 AU AU2016219703A patent/AU2016219703B2/en active Active
-
2017
- 2017-02-17 JP JP2017028425A patent/JP2017114894A/ja active Pending
- 2017-10-15 IL IL254995A patent/IL254995B/en active IP Right Grant
-
2018
- 2018-07-22 IL IL260714A patent/IL260714B/en active IP Right Grant
-
2019
- 2019-07-04 JP JP2019125032A patent/JP6837522B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015523546A5 (enExample) | ||
| CN116249683A8 (zh) | 氘甲基取代吡嗪并吡嗪并喹啉酮类衍生物、其制备方法及其在医药上的应用 | |
| JP2013519645A5 (enExample) | ||
| CN110248926A (zh) | Lsd1抑制剂及其制备方法和应用 | |
| JP2014500861A5 (enExample) | ||
| JP2015155440A5 (enExample) | ||
| JP2017537066A5 (enExample) | ||
| JP2012041349A5 (enExample) | ||
| JP2015537020A5 (enExample) | ||
| JP2013534248A5 (enExample) | ||
| JP2014515351A5 (enExample) | ||
| JP2016540749A5 (enExample) | ||
| JP2015025011A5 (enExample) | ||
| JP2016503797A5 (enExample) | ||
| EA201391263A1 (ru) | Комбинированные терапии гематологических опухолей | |
| JP2015057437A5 (enExample) | ||
| JP2018135343A5 (enExample) | ||
| JP2013515752A5 (enExample) | ||
| RU2012103538A (ru) | Композиции и способы ингибирования пути jak | |
| RU2013150861A (ru) | Фармацевтическая композиция, содержащая производные глутаримидов, и их применение для лечения эозинофильных заболеваний | |
| JP2019516739A5 (enExample) | ||
| JP2019535723A5 (enExample) | ||
| JP2016537338A5 (enExample) | ||
| CN115315423A (zh) | 取代芳基类化合物 | |
| CN109689652A (zh) | 稠杂环类衍生物、其制备方法及其在医学上的应用 |