CN110891950A - 一种三嗪化合物及其药学上可接受的盐 - Google Patents

一种三嗪化合物及其药学上可接受的盐 Download PDF

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Publication number
CN110891950A
CN110891950A CN201880031520.5A CN201880031520A CN110891950A CN 110891950 A CN110891950 A CN 110891950A CN 201880031520 A CN201880031520 A CN 201880031520A CN 110891950 A CN110891950 A CN 110891950A
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compound
pharmaceutically acceptable
amino
acceptable salt
egfr
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CN201880031520.5A
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CN110891950B (zh
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朱程刚
徐良亮
约翰·J·塔利
杨铉
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Zhongguancun Technology Leasing Co ltd
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Shenzhen Forward Pharmaceuticals Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明公开了一种三嗪类衍生物及其药学上可接受的盐、药物组合物和用途。具体地，本发明公开了式(I)化合物或其药学上可接受的盐，其中，R1、R2、R3和R4的定义如说明书和权利要求书中所述。本发明所述化合物或其盐可通过调节某些突变形式的表皮生长因子受体而用于治疗或预防疾病或病症。本发明还公开了包含所述化合物或其盐的药物组合物，以及使用所述化合物及其盐治疗由各种不同形式的EGFR所介导的多种疾病的方法，包括非小细胞肺癌。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN201880031520.5A 2017-05-15 2018-05-15 一种三嗪化合物及其药学上可接受的盐 Active CN110891950B (zh)

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CN201710339199.4A CN108864079B (zh) 2017-05-15 2017-05-15 一种三嗪化合物及其药学上可接受的盐
CN2017103391994 2017-05-15
PCT/CN2018/086929 WO2018210246A1 (zh) 2017-05-15 2018-05-15 一种三嗪化合物及其药学上可接受的盐

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CN110891950A true CN110891950A (zh) 2020-03-17
CN110891950B CN110891950B (zh) 2023-04-07

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CN111747950B (zh) * 2019-03-29 2024-01-23 深圳福沃药业有限公司 用于治疗癌症的嘧啶衍生物
CN111925366B (zh) * 2019-05-13 2024-04-09 广东阿格蕾雅光电材料有限公司 一种咪唑并氮杂环化合物及其应用
CN113179640B (zh) * 2019-11-26 2024-06-25 上海翰森生物医药科技有限公司 含氮多环类衍生物抑制剂、其制备方法和应用
KR20230026383A (ko) * 2020-06-23 2023-02-24 선전 포워드 파머수티컬즈 코 엘티디 화합물의 염 및 염을 포함하는 약학적 조성물
CN115836064B (zh) * 2020-08-13 2024-08-27 上海和誉生物医药科技有限公司 具有egfr抑制活性的三嗪衍生物及其制备方法和应用
CN115867539A (zh) * 2020-12-02 2023-03-28 上海和誉生物医药科技有限公司 2,3-二氢-1H-吡咯并[3,2-b]吡啶衍生物、其制备方法和应用
WO2022237825A1 (zh) * 2021-05-13 2022-11-17 上海和誉生物医药科技有限公司 具有egfr抑制活性的氮杂芳基衍生物、其制备方法和应用

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CN104860941A (zh) * 2014-02-25 2015-08-26 上海海雁医药科技有限公司 2,4-二取代苯-1,5-二胺衍生物及其应用以及由其制备的药物组合物和药用组合物
CN105175349A (zh) * 2014-06-12 2015-12-23 南京圣和药业股份有限公司 作为egfr抑制剂的苯基取代的三嗪类化合物及其应用
CN105461695A (zh) * 2014-09-29 2016-04-06 齐鲁制药有限公司 嘧啶或三嗪衍生物及其制备方法和用途
CN106132957A (zh) * 2015-08-31 2016-11-16 无锡双良生物科技有限公司 2‑芳胺基吡啶、嘧啶或三嗪衍生物及其制备方法和用途
CN106559991A (zh) * 2014-06-19 2017-04-05 阿里亚德医药股份有限公司 用于激酶抑制的杂芳基化合物
CN106928200A (zh) * 2015-12-30 2017-07-07 湖南福沃药业有限公司 用于治疗癌症的三嗪衍生物

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CN105175349A (zh) * 2014-06-12 2015-12-23 南京圣和药业股份有限公司 作为egfr抑制剂的苯基取代的三嗪类化合物及其应用
CN106559991A (zh) * 2014-06-19 2017-04-05 阿里亚德医药股份有限公司 用于激酶抑制的杂芳基化合物
CN105461695A (zh) * 2014-09-29 2016-04-06 齐鲁制药有限公司 嘧啶或三嗪衍生物及其制备方法和用途
CN106132957A (zh) * 2015-08-31 2016-11-16 无锡双良生物科技有限公司 2‑芳胺基吡啶、嘧啶或三嗪衍生物及其制备方法和用途
CN106928200A (zh) * 2015-12-30 2017-07-07 湖南福沃药业有限公司 用于治疗癌症的三嗪衍生物

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Publication number Publication date
EP3705478B1 (en) 2023-10-04
EP3705478A1 (en) 2020-09-09
CN108864079B (zh) 2021-04-09
EP3705478A4 (en) 2020-10-28
MA50506A (fr) 2020-09-09
CN108864079A (zh) 2018-11-23
CN110891950B (zh) 2023-04-07
WO2018210246A1 (zh) 2018-11-22

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