CN110891950A - 一种三嗪化合物及其药学上可接受的盐 - Google Patents
一种三嗪化合物及其药学上可接受的盐 Download PDFInfo
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- CN110891950A CN110891950A CN201880031520.5A CN201880031520A CN110891950A CN 110891950 A CN110891950 A CN 110891950A CN 201880031520 A CN201880031520 A CN 201880031520A CN 110891950 A CN110891950 A CN 110891950A
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- pharmaceutically acceptable
- amino
- acceptable salt
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (10)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710339199.4A CN108864079B (zh) | 2017-05-15 | 2017-05-15 | 一种三嗪化合物及其药学上可接受的盐 |
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PCT/CN2018/086929 WO2018210246A1 (zh) | 2017-05-15 | 2018-05-15 | 一种三嗪化合物及其药学上可接受的盐 |
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CN111747950B (zh) * | 2019-03-29 | 2024-01-23 | 深圳福沃药业有限公司 | 用于治疗癌症的嘧啶衍生物 |
CN111925366B (zh) * | 2019-05-13 | 2024-04-09 | 广东阿格蕾雅光电材料有限公司 | 一种咪唑并氮杂环化合物及其应用 |
CN113179640B (zh) * | 2019-11-26 | 2024-06-25 | 上海翰森生物医药科技有限公司 | 含氮多环类衍生物抑制剂、其制备方法和应用 |
KR20230026383A (ko) * | 2020-06-23 | 2023-02-24 | 선전 포워드 파머수티컬즈 코 엘티디 | 화합물의 염 및 염을 포함하는 약학적 조성물 |
CN115836064B (zh) * | 2020-08-13 | 2024-08-27 | 上海和誉生物医药科技有限公司 | 具有egfr抑制活性的三嗪衍生物及其制备方法和应用 |
CN115867539A (zh) * | 2020-12-02 | 2023-03-28 | 上海和誉生物医药科技有限公司 | 2,3-二氢-1H-吡咯并[3,2-b]吡啶衍生物、其制备方法和应用 |
WO2022237825A1 (zh) * | 2021-05-13 | 2022-11-17 | 上海和誉生物医药科技有限公司 | 具有egfr抑制活性的氮杂芳基衍生物、其制备方法和应用 |
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EP3705478B1 (en) | 2023-10-04 |
EP3705478A1 (en) | 2020-09-09 |
CN108864079B (zh) | 2021-04-09 |
EP3705478A4 (en) | 2020-10-28 |
MA50506A (fr) | 2020-09-09 |
CN108864079A (zh) | 2018-11-23 |
CN110891950B (zh) | 2023-04-07 |
WO2018210246A1 (zh) | 2018-11-22 |
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