CN109689652A - 稠杂环类衍生物、其制备方法及其在医学上的应用 - Google Patents

稠杂环类衍生物、其制备方法及其在医学上的应用 Download PDF

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CN109689652A
CN109689652A CN201780051580.9A CN201780051580A CN109689652A CN 109689652 A CN109689652 A CN 109689652A CN 201780051580 A CN201780051580 A CN 201780051580A CN 109689652 A CN109689652 A CN 109689652A
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CN109689652B (zh
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陈向阳
高英祥
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Beijing Innocare Pharma Tech Co Ltd
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Beijing Innocare Pharma Tech Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

一种通式(I')所示的新的衍生物或其可药用的盐、含有所述衍生物或其可药用的盐的药物组合物及所述衍生物或其可药用的盐的制备方法。所述衍生物或其可药用的盐或含有所述衍生物或其可药用的盐的药物组合物在制备药物，特别是IDO抑制剂药物和治疗和/或预防肿瘤的药物中的用途。其中通式(I')的各取代基同说明书中的定义相同。

Description

PCT国内申请，说明书已公开。

Claims (22)

  1. PCT国内申请，权利要求书已公开。
CN201780051580.9A 2016-08-23 2017-08-16 稠杂环类衍生物、其制备方法及其在医学上的应用 Active CN109689652B (zh)

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CN201610705318 2016-08-23
CN2016107053189 2016-08-23
PCT/CN2017/097660 WO2018036414A1 (zh) 2016-08-23 2017-08-16 稠杂环类衍生物、其制备方法及其在医学上的应用

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CN109689652A true CN109689652A (zh) 2019-04-26
CN109689652B CN109689652B (zh) 2022-04-26

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US (1) US11046682B2 (zh)
EP (1) EP3505517A4 (zh)
JP (1) JP7035301B2 (zh)
CN (1) CN109689652B (zh)
AU (1) AU2017315572B2 (zh)
WO (1) WO2018036414A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110382500A (zh) * 2017-03-21 2019-10-25 正大天晴药业集团股份有限公司 用于ido和tdo双重抑制剂的脲类化合物

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3668880B1 (en) 2017-08-17 2021-10-06 Idorsia Pharmaceuticals Ltd Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase
ES2907282T3 (es) 2018-01-15 2022-04-22 Idorsia Pharmaceuticals Ltd Inhibidores de la indoleamina 2,3-dioxigenasa y/o de la triptófano dioxigenasa
CN113498352A (zh) 2019-01-23 2021-10-12 施万生物制药研发Ip有限责任公司 作为jak抑制剂的咪唑并[1,5-a]吡啶、1,2,4-三唑并[4,3-a]吡啶和咪唑并[1,5-a]吡嗪
CA3146406A1 (en) 2019-07-11 2021-01-14 Idorsia Pharmaceuticals Ltd Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase
WO2024117205A1 (ja) * 2022-11-30 2024-06-06 北興化学工業株式会社 双環式ピリジン誘導体およびその塩、並びに、当該誘導体又はその塩を有効成分として含有することを特徴とする有害生物防除剤

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050137243A1 (en) * 2003-12-23 2005-06-23 Souers Andrew J. Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor
CN101932325A (zh) * 2007-11-30 2010-12-29 新联基因公司 Ido抑制剂
US20110183973A1 (en) * 2008-06-05 2011-07-28 Ian Robert Baldwin Novel Compounds
US20120245171A1 (en) * 2009-12-03 2012-09-27 Glaxo Group Limited Benzpyrazole derivatives as inhibitors of pi3 kinases
CN103635458A (zh) * 2011-03-25 2014-03-12 艾伯维公司 Trpv1拮抗剂
CN105358547A (zh) * 2013-02-28 2016-02-24 百时美施贵宝公司 作为强效rock1和rock2抑制剂的苯基吡唑衍生物
WO2016044585A1 (en) * 2014-09-17 2016-03-24 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
WO2016071293A2 (en) * 2014-11-03 2016-05-12 Iomet Pharma Ltd Pharmaceutical compound
WO2016102493A1 (en) * 2014-12-22 2016-06-30 Bayer Pharma Aktiengesellschaft Imidazopyridine ezh2 inhibitors
WO2016126570A1 (en) * 2015-02-06 2016-08-11 Merck Sharp & Dohme Corp. Aminoquinazoline compounds as a2a antagonist
WO2016161960A1 (en) * 2015-04-10 2016-10-13 Beigene, Ltd. NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1, 5-a] PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2378291A1 (en) 1999-07-07 2001-01-18 Astrazeneca Uk Limited Quinazoline derivatives
TWI382974B (zh) 2005-12-20 2013-01-21 Incyte Corp 作為吲哚胺２，３-二氧化酶調節劑之ｎ-羥基甲脒基雜環化物
MX2010006800A (es) * 2007-12-19 2010-10-05 Genentech Inc 5-anilinoimidazopiridinas y metodos de uso de las mismas.
SG178854A1 (en) 2009-08-28 2012-04-27 Array Biopharma Inc Raf inhibitor compounds and methods of use thereof
ES2601226T3 (es) 2009-10-28 2017-02-14 Newlink Genetics Corporation Derivados de imidazol como inhibidores de IDO
KR20140095325A (ko) 2013-01-24 2014-08-01 크리스탈지노믹스(주) Lyn 키나제에 대하여 저해 활성을 갖는 아미노퀴나졸린 유도체
EA201591610A1 (ru) 2013-03-14 2015-12-30 Курадев Фарма Прайвит Лтд. Ингибиторы кинуренинового пути
SG11201506918WA (en) 2013-03-15 2015-09-29 Bristol Myers Squibb Co Inhibitors of indoleamine 2,3-dioxygenase (ido)
JP6313415B2 (ja) 2013-03-15 2018-04-18 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｉｄｏ阻害剤
EA029981B1 (ru) 2013-08-27 2018-06-29 Бристол-Майерс Сквибб Компани Ингибиторы ido
TWI696618B (zh) 2013-11-08 2020-06-21 美商英塞特控股公司 用於合成吲哚胺2,3-雙加氧酶抑制劑之方法
EP3082802B1 (en) 2013-12-03 2020-02-26 Iomet Pharma Ltd. Tryptophan-2,3-dioxygenase (tdo) and/or indolamine-2,3-dioxygenase (ido) inhibitors and their use
GB201414730D0 (en) 2014-08-19 2014-10-01 Tpp Global Dev Ltd Pharmaceutical compound
AU2015311826B2 (en) 2014-09-05 2019-05-23 Merck Patent Gmbh Cyclohexyl-ethyl substituted diaza- and triaza-tricyclic compounds as indole-amine-2,3-dioxygenase (IDO) antagonists for the treatment of cancer
GB201417369D0 (en) 2014-10-01 2014-11-12 Redx Pharma Ltd Compounds
JP2017538678A (ja) 2014-11-05 2017-12-28 フレクサス・バイオサイエンシーズ・インコーポレイテッドＦｌｅｘｕｓ Ｂｉｏｓｃｉｅｎｃｅｓ， Ｉｎｃ． 免疫調節剤
AR102537A1 (es) 2014-11-05 2017-03-08 Flexus Biosciences Inc Agentes inmunomoduladores
CN110382500B (zh) * 2017-03-21 2021-08-10 正大天晴药业集团股份有限公司 用于ido和tdo双重抑制剂的脲类化合物

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050137243A1 (en) * 2003-12-23 2005-06-23 Souers Andrew J. Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor
CN101932325A (zh) * 2007-11-30 2010-12-29 新联基因公司 Ido抑制剂
US20110183973A1 (en) * 2008-06-05 2011-07-28 Ian Robert Baldwin Novel Compounds
US20120245171A1 (en) * 2009-12-03 2012-09-27 Glaxo Group Limited Benzpyrazole derivatives as inhibitors of pi3 kinases
CN103635458A (zh) * 2011-03-25 2014-03-12 艾伯维公司 Trpv1拮抗剂
CN105358547A (zh) * 2013-02-28 2016-02-24 百时美施贵宝公司 作为强效rock1和rock2抑制剂的苯基吡唑衍生物
WO2016044585A1 (en) * 2014-09-17 2016-03-24 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
WO2016071293A2 (en) * 2014-11-03 2016-05-12 Iomet Pharma Ltd Pharmaceutical compound
WO2016102493A1 (en) * 2014-12-22 2016-06-30 Bayer Pharma Aktiengesellschaft Imidazopyridine ezh2 inhibitors
WO2016126570A1 (en) * 2015-02-06 2016-08-11 Merck Sharp & Dohme Corp. Aminoquinazoline compounds as a2a antagonist
WO2016161960A1 (en) * 2015-04-10 2016-10-13 Beigene, Ltd. NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1, 5-a] PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACT SERVICE: "《STN REGISTRY数据库》", 16 October 2012 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110382500A (zh) * 2017-03-21 2019-10-25 正大天晴药业集团股份有限公司 用于ido和tdo双重抑制剂的脲类化合物
CN110382500B (zh) * 2017-03-21 2021-08-10 正大天晴药业集团股份有限公司 用于ido和tdo双重抑制剂的脲类化合物
CN113651820A (zh) * 2017-03-21 2021-11-16 正大天晴药业集团股份有限公司 用于ido和tdo双重抑制剂的脲类化合物

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JP7035301B2 (ja) 2022-03-15
JP2019524895A (ja) 2019-09-05
AU2017315572A1 (en) 2019-03-07
US11046682B2 (en) 2021-06-29
EP3505517A1 (en) 2019-07-03
EP3505517A4 (en) 2020-01-15
WO2018036414A1 (zh) 2018-03-01
AU2017315572B2 (en) 2021-07-15
CN109689652B (zh) 2022-04-26
US20190185472A1 (en) 2019-06-20

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