CA3076214A1 - Use of metformin and analogs thereof to reduce ran protein levels in the treatment of neurological disorders - Google Patents
Use of metformin and analogs thereof to reduce ran protein levels in the treatment of neurological disorders Download PDFInfo
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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- C12Y207/11—Protein-serine/threonine kinases (2.7.11)
- C12Y207/11001—Non-specific serine/threonine protein kinase (2.7.11.1), i.e. casein kinase or checkpoint kinase
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
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| US201762563588P | 2017-09-26 | 2017-09-26 | |
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| PCT/US2018/052913 WO2019067587A1 (en) | 2017-09-26 | 2018-09-26 | USE OF METFORMIN AND ANALOGUES THEREOF TO REDUCE RAN PROTEIN RATES DURING TREATMENT OF NEUROLOGICAL DISORDERS |
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| AU (1) | AU2018342105B2 (enExample) |
| CA (1) | CA3076214A1 (enExample) |
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| WO2014159247A1 (en) | 2013-03-14 | 2014-10-02 | University Of Florida Research Foundation, Inc. | Di-amino acid repeat-containing proteins associated with als |
| WO2016196324A1 (en) | 2015-05-29 | 2016-12-08 | University Of Floridia Research Foundation, Inc. | Methods for diagnosing huntington's disease |
| EP3440100A4 (en) | 2016-04-04 | 2020-01-22 | University of Florida Research Foundation, Incorporated | HANDLING EIF3 TO MODULATE A NON-ATG TRANSLATION ASSOCIATED WITH A REPETITION (RAN) |
| JP7526455B2 (ja) | 2017-04-17 | 2024-08-01 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | ＰＫＲおよびｅＩＦ２Ａ－Ｐ経路によるＲＡＮタンパク質翻訳の調節 |
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| JP7579589B2 (ja) * | 2019-07-05 | 2024-11-08 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | Ｒａｎタンパク質関連神経学的疾患を処置するための方法 |
| EP4031562A4 (en) | 2019-09-20 | 2023-11-01 | University of Florida Research Foundation, Incorporated | DETECTION OF ANTIBODIES AGAINST RAN PROTEINS FROM SERUM AND TISSUE LYSATES |
| CN115335058B (zh) * | 2020-03-27 | 2024-12-06 | 国立大学法人京都大学 | 神经细胞变性抑制剂 |
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| US7481997B1 (en) | 2004-02-12 | 2009-01-27 | Montana State University | Snow mountain virus genome sequence, virus-like particles and methods of use |
| JP4878551B2 (ja) | 2004-04-08 | 2012-02-15 | 貞和 相磯 | 運動ニューロン疾患治療薬 |
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| CA2596588C (en) | 2005-01-31 | 2017-06-27 | University Of Iowa Research Foundation | Nucleic acid silencing of huntington's disease gene |
| US20090074721A1 (en) | 2005-06-06 | 2009-03-19 | Vgx Pharmaceuticals, Inc. | Methods for treating viral infection with oral or injectibel drug solution |
| JP2009515885A (ja) | 2005-11-11 | 2009-04-16 | オーロゲン インコーポレイテッド | 組織の収縮又は萎縮に関連する成人中枢神経系の疾病又は障害をインスリン投与によって治療する方法 |
| EP2082225B1 (en) | 2006-09-20 | 2014-01-01 | The Queen's University of Belfast | Method to determine whether a tumour cell has invasive and/or metastatic potential and modulating agents of malignant transformation |
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| US20090143418A1 (en) | 2007-11-30 | 2009-06-04 | The Regents Of The University Of Michigan | Compositions and Methods for Preventing and Treating Hair Growth Cycle-Related Conditions |
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| US20130115603A9 (en) | 2009-04-02 | 2013-05-09 | Regents Of The University Of Minnesota | Nucleotide repeat expansion-associated polypeptides and uses thereof |
| CN102497887A (zh) | 2009-04-17 | 2012-06-13 | Isis创新公司 | 递送遗传物质的组合物 |
| WO2010132982A1 (en) | 2009-05-18 | 2010-11-25 | Ottawa Hospital Research Institute | Treatment of muscle disease characterized by insulin resistance |
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| US20130085169A1 (en) | 2010-04-02 | 2013-04-04 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and compositions comprising ampk activator (metformin/troglitazone) for the treatment of myotonic dystrophy type 1 (dm1) |
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