|
US3598122A
(en)
|
1969-04-01 |
1971-08-10 |
Alza Corp |
Bandage for administering drugs
|
|
US4144317A
(en)
|
1975-05-30 |
1979-03-13 |
Alza Corporation |
Device consisting of copolymer having acetoxy groups for delivering drugs
|
|
US4262003A
(en)
|
1975-12-08 |
1981-04-14 |
Alza Corporation |
Method and therapeutic system for administering scopolamine transdermally
|
|
US4201211A
(en)
|
1977-07-12 |
1980-05-06 |
Alza Corporation |
Therapeutic system for administering clonidine transdermally
|
|
US4338457A
(en)
|
1980-02-28 |
1982-07-06 |
The Upjohn Company |
Composition and process
|
|
US4525586A
(en)
|
1980-02-28 |
1985-06-25 |
The Upjohn Company |
Composition and process
|
|
US4306075A
(en)
|
1980-03-28 |
1981-12-15 |
The Upjohn Company |
Composition and process
|
|
US4420632A
(en)
|
1980-04-15 |
1983-12-13 |
The Upjohn Company |
Composition and process
|
|
US4306076A
(en)
|
1980-04-23 |
1981-12-15 |
The Upjohn Company |
Inter-phenylene CBA compounds
|
|
US4349689A
(en)
|
1980-12-22 |
1982-09-14 |
The Upjohn Company |
Methano carbacyclin analogs
|
|
US4379454A
(en)
|
1981-02-17 |
1983-04-12 |
Alza Corporation |
Dosage for coadministering drug and percutaneous absorption enhancer
|
|
DE3333240A1
(de)
|
1983-09-12 |
1985-03-28 |
Schering AG, 1000 Berlin und 4709 Bergkamen |
Mittel zur transdermalen applikation von arzneimittelwirkstoffen
|
|
US4668814A
(en)
|
1984-03-08 |
1987-05-26 |
The Upjohn Company |
Interphenylene carbacyclin derivatives
|
|
US4683330A
(en)
|
1984-03-08 |
1987-07-28 |
The Upjohn Company |
Interphenylene carbacyclin derivatives
|
|
GB8814438D0
(en)
|
1988-06-17 |
1988-07-20 |
Wellcome Found |
Compounds for use in medicine
|
|
GB8824187D0
(en)
|
1988-10-14 |
1988-11-23 |
Wellcome Found |
Compounds for use in medicine
|
|
US5088977A
(en)
|
1988-12-21 |
1992-02-18 |
Drug Delivery Systems Inc. |
Electrical transdermal drug applicator with counteractor and method of drug delivery
|
|
CA2056039A1
(en)
|
1991-01-22 |
1992-07-23 |
Philip L. Fuchs |
Carbacyclin analogs
|
|
US5234690A
(en)
|
1991-08-23 |
1993-08-10 |
Cygnus Therapeutic Systems |
Transdermal drug delivery device using an unfilled microporous membrane to achieve delayed onset
|
|
US5869505A
(en)
|
1993-02-02 |
1999-02-09 |
Keenan; Robert M. |
Nicotine metabolites and nicotine dependence
|
|
US5853751A
(en)
|
1993-06-23 |
1998-12-29 |
Masiz; John J. |
Molecular transdermal transport system
|
|
US5797898A
(en)
|
1996-07-02 |
1998-08-25 |
Massachusetts Institute Of Technology |
Microchip drug delivery devices
|
|
IN184589B
(enExample)
|
1996-10-16 |
2000-09-09 |
Alza Corp |
|
|
KR20020012169A
(ko)
*
|
1999-03-31 |
2002-02-15 |
유나이티드 쎄러퓨틱스 코포레이션 |
프로스타글란딘 화합물, 조성물 및 말초혈관질병 및폐고혈압증의 치료방법
|
|
US20020004065A1
(en)
|
2000-01-20 |
2002-01-10 |
David Kanios |
Compositions and methods to effect the release profile in the transdermal administration of active agents
|
|
US6242482B1
(en)
|
2000-06-05 |
2001-06-05 |
United Therapeutics Corporation |
Prostaglandin compounds and derivatives thereof, compositions containing the same and method of using the same for the treatment of congestive heart failure
|
|
US6635274B1
(en)
|
2000-10-27 |
2003-10-21 |
Biochemics, Inc. |
Solution-based transdermal drug delivery system
|
|
US6700025B2
(en)
|
2001-01-05 |
2004-03-02 |
United Therapeutics Corporation |
Process for stereoselective synthesis of prostacyclin derivatives
|
|
US20030108512A1
(en)
|
2001-12-10 |
2003-06-12 |
Robert Shorr |
Modified prostaglandin compounds and analogs thereof, compositions containing the same useful for the treatment of cancer
|
|
US8246979B2
(en)
|
2002-07-30 |
2012-08-21 |
Ucb Pharma Gmbh |
Transdermal delivery system for the administration of rotigotine
|
|
CN102697790A
(zh)
|
2003-05-22 |
2012-10-03 |
联合治疗公司 |
化合物和释放前列环素类似物的方法
|
|
CA2530407A1
(en)
*
|
2003-07-23 |
2005-02-03 |
The Regents Of The University Of California |
Penetration enhancer combinations for transdermal delivery
|
|
US7375139B2
(en)
|
2003-08-18 |
2008-05-20 |
Aldred Katherine M |
Transdermal method and apparatus
|
|
JP2005120069A
(ja)
|
2003-10-13 |
2005-05-12 |
Anges Mg Inc |
炎症性疾患治療薬
|
|
CN1917866B
(zh)
*
|
2003-12-16 |
2010-12-15 |
联合治疗公司 |
曲前列环素或它的衍生物,或其药学上可接受的盐在制备治疗和预防缺血性损害的药物中的用途
|
|
US7199157B2
(en)
|
2003-12-16 |
2007-04-03 |
United Therapeutics Corporation |
Use of treprostinil to improve kidney functions
|
|
DE602005020269D1
(de)
|
2004-04-12 |
2010-05-12 |
United Therapeutics Corp |
Verwendung von treprostinil zur behandlung von neuropathischen diabetischen fussgeschwüren
|
|
WO2006015299A2
(en)
|
2004-07-30 |
2006-02-09 |
Microchips, Inc. |
Multi-reservoir device for transdermal drug delivery and sensing
|
|
ES2596809T3
(es)
|
2004-10-08 |
2017-01-12 |
Noven Pharmaceuticals, Inc. |
Dispositivo de administración transdérmica de fármacos que incluye un refuerzo oclusivo
|
|
KR20130114229A
(ko)
|
2005-06-03 |
2013-10-16 |
애크럭스 디디에스 피티와이 리미티드 |
경피 약물 전달 방법 및 조성물
|
|
EP1962837A4
(en)
|
2005-12-20 |
2011-12-14 |
Teikoku Pharma Usa Inc |
METHODS OF PERCUTANEOUS DELIVERY OF INDOLIC SEROTONIN RECEPTOR AGONIST AND PERCUTANEOUS COMPOSITIONS FOR USE THEREIN
|
|
SI1988910T1
(en)
|
2006-02-28 |
2018-02-28 |
Kodiak Sciences Inc. |
Polymeric conjugates containing acryloyloxyethylphosphorylcholine and their preparations
|
|
US8747897B2
(en)
|
2006-04-27 |
2014-06-10 |
Supernus Pharmaceuticals, Inc. |
Osmotic drug delivery system
|
|
CA2654492C
(en)
|
2006-05-15 |
2017-06-27 |
United Therapeutics Corporation |
Treprostinil administration using a metered dose inhaler
|
|
WO2008002929A2
(en)
|
2006-06-26 |
2008-01-03 |
Inverseon, Inc. |
Heterologous cross-sensitization for improved agonist activity
|
|
US20090036465A1
(en)
|
2006-10-18 |
2009-02-05 |
United Therapeutics Corporation |
Combination therapy for pulmonary arterial hypertension
|
|
CA2678258A1
(en)
|
2007-02-09 |
2008-08-14 |
United Therapeutics Corporation |
Treprostinil treatment for interstitial lung disease and asthma
|
|
CN101815534A
(zh)
|
2007-07-11 |
2010-08-25 |
莱西肯医药有限公司 |
用于治疗肺动脉高压以及相关疾病和病症的方法和组合物
|
|
WO2009078965A1
(en)
|
2007-12-17 |
2009-06-25 |
United Therapeutics Corporation |
An improved process to prepare treprostinil, the active ingredient in remodulin
|
|
WO2009152160A1
(en)
|
2008-06-10 |
2009-12-17 |
Gilead Sciences, Inc. |
Inhaled carbaprostacyclin and prostacyclin prodrugs for the treatment of pulmonary arterial hypertension
|
|
WO2009158010A1
(en)
|
2008-06-27 |
2009-12-30 |
Concert Pharmaceuticals, Inc. |
Prostacyclin analogs
|
|
MX350011B
(es)
|
2008-08-13 |
2017-08-22 |
Actelion Pharmaceuticals Ltd |
Composiciones terapeuticas que contienen macitentan.
|
|
CN102271685A
(zh)
|
2008-12-30 |
2011-12-07 |
斯若姆博洛捷克有限公司 |
鉴定发展成器官功能衰竭的风险提高的危重患者的方法及用于其治疗的化合物
|
|
CN102421288B
(zh)
|
2009-05-07 |
2015-04-22 |
联合治疗公司 |
前列环素类似物的固体剂型
|
|
US8519178B2
(en)
|
2009-06-22 |
2013-08-27 |
Johnson Matthey Public Limited Company |
Method for the purification of prostaglandins
|
|
AU2010280684B2
(en)
|
2009-08-07 |
2016-07-28 |
Scipharm Sarl |
Composition for the treatment of cystic fibrosis
|
|
US9327105B2
(en)
*
|
2010-03-26 |
2016-05-03 |
Itrace Biomedical Inc. |
Active transdermal drug delivery system and the method thereof
|
|
WO2011123830A2
(en)
|
2010-04-02 |
2011-10-06 |
Amunix Operating Inc. |
Alpha 1-antitrypsin compositions and methods of making and using same
|
|
EP4450523A3
(en)
|
2010-04-02 |
2025-03-12 |
Amunix Pharmaceuticals, Inc. |
Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same
|
|
US20130040898A1
(en)
|
2010-04-29 |
2013-02-14 |
Pär Johansson |
Methods of treatment of patients at increased risk of development of ischemic events and compounds hereof
|
|
CN103261142B
(zh)
|
2010-06-03 |
2014-12-10 |
联合治疗公司 |
曲前列环素的制备
|
|
US20120010159A1
(en)
|
2010-07-09 |
2012-01-12 |
United Therapeutics Corporation |
Combination therapies with cox-2 inhibitors and treprostinil
|
|
CA2710726C
(en)
|
2010-07-22 |
2016-02-23 |
Alphora Research Inc. |
Synthesis of treprostinil and intermediates useful therein
|
|
CA2726599C
(en)
|
2010-12-30 |
2017-07-25 |
Alphora Research Inc. |
Process for treprostinil salt preparation
|
|
PL2663313T3
(pl)
|
2011-01-13 |
2019-01-31 |
SciPharm S.à r.l. |
Sposób zwiększania wszczepiania hematopoetycznych komórek macierzystych
|
|
WO2012107364A1
(en)
|
2011-02-07 |
2012-08-16 |
Scipharm Sàrl |
Novel composition for the treatment of cystic fibrosis
|
|
RS55624B1
(sr)
|
2011-02-07 |
2017-06-30 |
Scipharm Sàrl |
Nova kompozicija za lečenje cistične fibroze
|
|
KR20140053881A
(ko)
|
2011-04-19 |
2014-05-08 |
릭스하스피탈렛 |
모세관 누출의 예방 및 치료를 위한 수술 동안 투여되는 프로스타시클린 및 그 유사체
|
|
JP2014521702A
(ja)
|
2011-08-05 |
2014-08-28 |
カーデロ セラピューティクス インコーポレイテッド |
フラボノイド化合物
|
|
BR112014003225A2
(pt)
|
2011-08-12 |
2017-03-01 |
Ascendis Pharma As |
profármacos de treprostinil ligados a veículo
|
|
AU2012296953B2
(en)
|
2011-08-12 |
2016-10-20 |
Ascendis Pharma A/S |
Sustained release composition of prostacyclin
|
|
EP3643306A3
(en)
|
2011-08-12 |
2020-08-26 |
Ascendis Pharma A/S |
Carrier-linked prodrugs having reversible carboxylic ester linkages
|
|
US8524939B2
(en)
|
2011-08-24 |
2013-09-03 |
Chirogate International Inc. |
Intermediates for the synthesis of benzindene prostaglandins and preparations thereof
|
|
CN103193627B
(zh)
*
|
2012-01-10 |
2016-04-20 |
上海天伟生物制药有限公司 |
一种前列腺素类似物的晶型及其制备方法和用途
|
|
US9387214B2
(en)
|
2012-01-13 |
2016-07-12 |
United Therapeutics Corporation |
Method of identifying therapies for pulmonary hypertension
|
|
EP2834642A1
(en)
|
2012-03-30 |
2015-02-11 |
Rigshospitalet |
Compounds capable of modulating/preserving endothelial integrity for use in prevention or treatment of acute traumatic coagulopathy and resuscitated cardiac arrest
|
|
EP2841109B1
(en)
|
2012-04-25 |
2026-04-15 |
Ascendis Pharma A/S |
Prodrugs of hydroxyl-comprising drugs
|
|
SI2674413T1
(sl)
|
2012-06-15 |
2017-10-30 |
Scipharm Sarl |
Postopek za pripravo treprostinila in derivatov le-tega
|
|
CN104684561A
(zh)
|
2012-08-01 |
2015-06-03 |
联合治疗公司 |
利用间充质干细胞的肺动脉高血压的治疗
|
|
CN104837806A
(zh)
|
2012-12-07 |
2015-08-12 |
开曼化学股份有限公司 |
前列环素类似物的合成方法
|
|
KR102466885B1
(ko)
|
2013-01-09 |
2022-11-11 |
유나이티드 세러퓨틱스 코오포레이션 |
프로스타시클린 및 중간엽 줄기 세포를 사용한 혈관병증의 치료
|
|
EP3712142B1
(en)
|
2013-01-11 |
2022-07-06 |
Corsair Pharma, Inc. |
Prodrugs of treprostinil
|
|
US9505737B2
(en)
|
2013-01-11 |
2016-11-29 |
Corsair Pharma, Inc. |
Treprostinil derivative compounds and methods of using same
|
|
EP2970081A4
(en)
|
2013-03-15 |
2016-10-12 |
United Therapeutics Corp |
SALTS OF TREPROSTINIL
|
|
WO2014160638A1
(en)
|
2013-03-25 |
2014-10-02 |
United Therapeutics Corporation |
Process of making prostacyclin compounds with linker thiol and pegylated forms
|
|
CA2911172C
(en)
|
2013-04-30 |
2021-10-19 |
United Therapeutics Corporation |
Controlled release pharmaceutical formulations
|
|
WO2014203278A2
(en)
|
2013-06-19 |
2014-12-24 |
Msn Laboratories Private Limited |
NOVEL PROCESS FOR THE PREPARATION OF (1R,2R,3aS,9aS)-[[2,3,3a,4,9,9a-HEXAHYDRO-2-HYDROXY-1-[(3S)-3-HYDROXYOCTYL]-1H-BENZ[f]INDEN-5-YL]OXY]ACETIC ACID
|
|
US9469600B2
(en)
|
2013-10-25 |
2016-10-18 |
Insmed Incorporated |
Prostacyclin compounds, compositions and methods of use thereof
|
|
WO2015073314A1
(en)
|
2013-11-13 |
2015-05-21 |
Cayman Chemical Company Incorporated |
Amine salts of a prostacyclin analog
|
|
WO2015138423A1
(en)
|
2014-03-11 |
2015-09-17 |
Insmed Incorporated |
Prostacylin compositions and methods for using the same
|
|
EP3169660A1
(en)
|
2014-07-16 |
2017-05-24 |
Corsair Pharma, Inc. |
Treprostinil derivative compounds and methods of using same
|
|
HU231184B1
(hu)
|
2014-10-08 |
2021-07-28 |
CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. |
Treprostinil-nátrium-monohidrát és eljárás ennek előállítására
|
|
US10343979B2
(en)
|
2014-11-18 |
2019-07-09 |
Insmed Incorporated |
Methods of manufacturing treprostinil and treprostinil derivative prodrugs
|
|
TWI540121B
(zh)
|
2014-12-01 |
2016-07-01 |
臺灣永光化學工業股份有限公司 |
曲前列環素二乙醇胺之合成方法及新穎中間體
|
|
JP2018503654A
(ja)
|
2015-01-27 |
2018-02-08 |
サイファーム ソシエテ ア レスポンサビリテ リミテSciPharmS.a r.l. |
肝静脈閉塞症の処置のための組成物
|
|
US20160243064A1
(en)
|
2015-02-21 |
2016-08-25 |
Gavis Pharmaceuticals |
Novel oral pharmaceutical compositions of treprostinil
|
|
WO2016176555A1
(en)
|
2015-04-29 |
2016-11-03 |
Insmed Incorporated |
Prostacyclin compounds, compositions and methods of use thereof
|
|
US9394227B1
(en)
|
2015-06-17 |
2016-07-19 |
Corsair Pharma, Inc. |
Treprostinil derivatives and compositions and uses thereof
|
|
US9643911B2
(en)
|
2015-06-17 |
2017-05-09 |
Corsair Pharma, Inc. |
Treprostinil derivatives and compositions and uses thereof
|
|
CN110381930A
(zh)
|
2016-12-05 |
2019-10-25 |
康赛制药公司 |
曲前列环素及其盐的经皮和透皮施用
|