JP2018524304A5 - - Google Patents

Download PDF

Info

Publication number
JP2018524304A5
JP2018524304A5 JP2017564668A JP2017564668A JP2018524304A5 JP 2018524304 A5 JP2018524304 A5 JP 2018524304A5 JP 2017564668 A JP2017564668 A JP 2017564668A JP 2017564668 A JP2017564668 A JP 2017564668A JP 2018524304 A5 JP2018524304 A5 JP 2018524304A5
Authority
JP
Japan
Prior art keywords
independently
hydrogen
case
cycloalkyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017564668A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018524304A (ja
JP7013245B2 (ja
Filing date
Publication date
Priority claimed from US14/742,544 external-priority patent/US9394227B1/en
Priority claimed from US14/829,180 external-priority patent/US9643911B2/en
Application filed filed Critical
Publication of JP2018524304A publication Critical patent/JP2018524304A/ja
Publication of JP2018524304A5 publication Critical patent/JP2018524304A5/ja
Priority to JP2021151659A priority Critical patent/JP2022003057A/ja
Application granted granted Critical
Publication of JP7013245B2 publication Critical patent/JP7013245B2/ja
Priority to JP2023209782A priority patent/JP2024019523A/ja
Priority to JP2025194875A priority patent/JP2026021603A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017564668A 2015-06-17 2016-06-14 トレプロスチニル誘導体ならびにその組成物および使用 Active JP7013245B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2021151659A JP2022003057A (ja) 2015-06-17 2021-09-17 トレプロスチニル誘導体ならびにその組成物および使用
JP2023209782A JP2024019523A (ja) 2015-06-17 2023-12-13 トレプロスチニル誘導体ならびにその組成物および使用
JP2025194875A JP2026021603A (ja) 2015-06-17 2025-11-14 トレプロスチニル誘導体ならびにその組成物および使用

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201514742579A 2015-06-17 2015-06-17
US14/742,544 2015-06-17
US14/742,544 US9394227B1 (en) 2015-06-17 2015-06-17 Treprostinil derivatives and compositions and uses thereof
US14/742,579 2015-06-17
US14/829,180 2015-08-18
US14/829,180 US9643911B2 (en) 2015-06-17 2015-08-18 Treprostinil derivatives and compositions and uses thereof
PCT/US2016/037383 WO2016205202A1 (en) 2015-06-17 2016-06-14 Treprostinil derivatives and compositions and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021151659A Division JP2022003057A (ja) 2015-06-17 2021-09-17 トレプロスチニル誘導体ならびにその組成物および使用

Publications (3)

Publication Number Publication Date
JP2018524304A JP2018524304A (ja) 2018-08-30
JP2018524304A5 true JP2018524304A5 (enExample) 2019-07-11
JP7013245B2 JP7013245B2 (ja) 2022-01-31

Family

ID=56204034

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2017564668A Active JP7013245B2 (ja) 2015-06-17 2016-06-14 トレプロスチニル誘導体ならびにその組成物および使用
JP2021151659A Pending JP2022003057A (ja) 2015-06-17 2021-09-17 トレプロスチニル誘導体ならびにその組成物および使用
JP2023209782A Pending JP2024019523A (ja) 2015-06-17 2023-12-13 トレプロスチニル誘導体ならびにその組成物および使用
JP2025194875A Pending JP2026021603A (ja) 2015-06-17 2025-11-14 トレプロスチニル誘導体ならびにその組成物および使用

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2021151659A Pending JP2022003057A (ja) 2015-06-17 2021-09-17 トレプロスチニル誘導体ならびにその組成物および使用
JP2023209782A Pending JP2024019523A (ja) 2015-06-17 2023-12-13 トレプロスチニル誘導体ならびにその組成物および使用
JP2025194875A Pending JP2026021603A (ja) 2015-06-17 2025-11-14 トレプロスチニル誘導体ならびにその組成物および使用

Country Status (10)

Country Link
US (11) US9643911B2 (enExample)
EP (3) EP3835291A1 (enExample)
JP (4) JP7013245B2 (enExample)
KR (2) KR20240149440A (enExample)
CN (1) CN108349926A (enExample)
CA (1) CA2989317A1 (enExample)
ES (2) ES2859749T3 (enExample)
HK (1) HK1258913A1 (enExample)
IL (4) IL305157B2 (enExample)
WO (1) WO2016205202A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9505737B2 (en) 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US9371264B2 (en) 2013-01-11 2016-06-21 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US9643911B2 (en) 2015-06-17 2017-05-09 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US9394227B1 (en) 2015-06-17 2016-07-19 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
IL319790A (en) 2016-05-05 2025-05-01 Liquidia Tech Inc Terpostinil in dry powder form for the treatment of pulmonary hypertension
EP3515430A1 (en) 2016-09-26 2019-07-31 United Therapeutics Corporation Treprostinil prodrugs
US20190099383A1 (en) * 2017-09-30 2019-04-04 Samos Pharmaceuticals, Inc. Transdermal Delivery of Selexipag Metabolite
EP3498283A1 (en) 2017-12-14 2019-06-19 Ipsol AG Glycosidic derivatives of treprostinil
JP2022546314A (ja) * 2019-08-23 2022-11-04 ユナイテッド セラピューティクス コーポレイション トレプロスチニルプロドラッグ
US11826327B2 (en) 2020-04-17 2023-11-28 United Therapeutics Corporation Treatment for interstitial lung disease
JP7826317B2 (ja) 2020-12-14 2026-03-09 ユナイテッド セラピューティクス コーポレイション トレプロスチニルプロドラッグで疾患を治療する方法
EP4301372A1 (en) 2021-03-03 2024-01-10 United Therapeutics Corporation A dry powder composition of trestinil and its prodrug thereof and further comprising comprising (e)-3,6-bis[4-(n-carbonyl-2-propenyl)amidobutyl]-2,5-diketopiperazine (fdkp)
WO2022194195A1 (zh) * 2021-03-16 2022-09-22 江苏恒瑞医药股份有限公司 一种曲前列环素衍生物及其用途
JP2025506019A (ja) 2022-02-08 2025-03-05 ユナイテッド セラピューティクス コーポレイション トレプロスチニルイロプロスト併用療法
CN115448839B (zh) * 2022-10-14 2025-02-14 广州楷石医药有限公司 一种曲前列尼尔的前体药物
CN115894240B9 (zh) * 2022-10-14 2026-03-13 广州楷石医药有限公司 曲前列尼尔的前体药物及其应用
AU2024208919A1 (en) * 2023-01-19 2025-07-17 United Therapeutics Corporation Treprostinil analogs
CN117800845A (zh) * 2023-03-28 2024-04-02 广州楷石医药有限公司 一种羟基取代曲前列尼尔衍生物、合成方法及其应用
TW202502721A (zh) * 2023-07-03 2025-01-16 香港商長風藥業(香港)有限公司 一種曲前列環素衍生物、其製備方法及應用

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3598122A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US4144317A (en) 1975-05-30 1979-03-13 Alza Corporation Device consisting of copolymer having acetoxy groups for delivering drugs
US4262003A (en) 1975-12-08 1981-04-14 Alza Corporation Method and therapeutic system for administering scopolamine transdermally
US4201211A (en) 1977-07-12 1980-05-06 Alza Corporation Therapeutic system for administering clonidine transdermally
US4338457A (en) 1980-02-28 1982-07-06 The Upjohn Company Composition and process
US4525586A (en) 1980-02-28 1985-06-25 The Upjohn Company Composition and process
US4306075A (en) 1980-03-28 1981-12-15 The Upjohn Company Composition and process
US4420632A (en) 1980-04-15 1983-12-13 The Upjohn Company Composition and process
US4306076A (en) 1980-04-23 1981-12-15 The Upjohn Company Inter-phenylene CBA compounds
US4349689A (en) 1980-12-22 1982-09-14 The Upjohn Company Methano carbacyclin analogs
US4379454A (en) 1981-02-17 1983-04-12 Alza Corporation Dosage for coadministering drug and percutaneous absorption enhancer
DE3333240A1 (de) 1983-09-12 1985-03-28 Schering AG, 1000 Berlin und 4709 Bergkamen Mittel zur transdermalen applikation von arzneimittelwirkstoffen
US4683330A (en) 1984-03-08 1987-07-28 The Upjohn Company Interphenylene carbacyclin derivatives
US4668814A (en) 1984-03-08 1987-05-26 The Upjohn Company Interphenylene carbacyclin derivatives
GB8824187D0 (en) 1988-10-14 1988-11-23 Wellcome Found Compounds for use in medicine
GB8814438D0 (en) 1988-06-17 1988-07-20 Wellcome Found Compounds for use in medicine
US5088977A (en) 1988-12-21 1992-02-18 Drug Delivery Systems Inc. Electrical transdermal drug applicator with counteractor and method of drug delivery
CA2056039A1 (en) 1991-01-22 1992-07-23 Philip L. Fuchs Carbacyclin analogs
US5234690A (en) 1991-08-23 1993-08-10 Cygnus Therapeutic Systems Transdermal drug delivery device using an unfilled microporous membrane to achieve delayed onset
US5869505A (en) 1993-02-02 1999-02-09 Keenan; Robert M. Nicotine metabolites and nicotine dependence
US5853751A (en) 1993-06-23 1998-12-29 Masiz; John J. Molecular transdermal transport system
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
IN184589B (enExample) 1996-10-16 2000-09-09 Alza Corp
AU4327300A (en) 1999-03-31 2000-10-16 United Therapeutics Corporation Prostaglandin compounds, compositions and methods of treating peripheral vascular disease and pulmonary hypertension
WO2001052823A2 (en) 2000-01-20 2001-07-26 Noven Pharmaceuticals, Inc. Compositions to effect the release profile in the transdermal administration of drugs
US6242482B1 (en) 2000-06-05 2001-06-05 United Therapeutics Corporation Prostaglandin compounds and derivatives thereof, compositions containing the same and method of using the same for the treatment of congestive heart failure
US6635274B1 (en) 2000-10-27 2003-10-21 Biochemics, Inc. Solution-based transdermal drug delivery system
US6700025B2 (en) 2001-01-05 2004-03-02 United Therapeutics Corporation Process for stereoselective synthesis of prostacyclin derivatives
US20030108512A1 (en) 2001-12-10 2003-06-12 Robert Shorr Modified prostaglandin compounds and analogs thereof, compositions containing the same useful for the treatment of cancer
US8246979B2 (en) 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system for the administration of rotigotine
WO2005007081A2 (en) 2003-05-22 2005-01-27 United Therapeutics Corporation Compounds and methods for delivery of prostacyclin analogs
CA2530407A1 (en) * 2003-07-23 2005-02-03 The Regents Of The University Of California Penetration enhancer combinations for transdermal delivery
US7375139B2 (en) 2003-08-18 2008-05-20 Aldred Katherine M Transdermal method and apparatus
JP2005120069A (ja) 2003-10-13 2005-05-12 Anges Mg Inc 炎症性疾患治療薬
ES2331187T3 (es) 2003-12-16 2009-12-23 United Therapeutics Corporation Utilizacion de treprostinil para mejorar las funciones renales.
DE602004028155D1 (de) * 2003-12-16 2010-08-26 United Therapeutics Corp Verwendung von treprostinil zur behandlung von ischämischen läsionen
CN101287457B (zh) 2004-04-12 2011-11-16 联合治疗公司 Treprostinil用于治疗神经性糖尿病的足部溃疡的用途
US7537590B2 (en) 2004-07-30 2009-05-26 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
WO2006044206A2 (en) 2004-10-08 2006-04-27 Noven Pharmaceuticals, Inc. Transdermal drug delivery device including an occlusive backing
KR20130114229A (ko) 2005-06-03 2013-10-16 애크럭스 디디에스 피티와이 리미티드 경피 약물 전달 방법 및 조성물
WO2007094876A2 (en) 2005-12-20 2007-08-23 Teikoku Pharma Usa, Inc. Methods of transdermally administering an indole serotonin receptor agonist and transdermal compositions for use in the same
ES2657628T3 (es) 2006-02-28 2018-03-06 Kodiak Sciences Inc. Conjugados poliméricos que contienen acriloiloxietilfosforilcolina y su preparación
US8747897B2 (en) 2006-04-27 2014-06-10 Supernus Pharmaceuticals, Inc. Osmotic drug delivery system
WO2007134292A2 (en) 2006-05-15 2007-11-22 United Therapeutics Corporation Treprostinil administration using a metered dose inhaler
WO2008002929A2 (en) 2006-06-26 2008-01-03 Inverseon, Inc. Heterologous cross-sensitization for improved agonist activity
WO2008049000A2 (en) 2006-10-18 2008-04-24 United Therapeutics Corporation Combination therapy for pulmonary arterial hypertension
CN101678033A (zh) 2007-02-09 2010-03-24 联合治疗公司 用于间质性肺病和哮喘的曲前列尼治疗
EA201070127A1 (ru) 2007-07-11 2010-08-30 Лексикон Фармасьютикалз , Инк. Способы лечения легочной гипертензии, родственных заболеваний и нарушений и композиции для их осуществления
EP2252570B1 (en) 2007-12-17 2017-04-05 United Therapeutics Corporation An improved process to prepare treprostinil, the active ingredient in remodulin ®
WO2009152160A1 (en) 2008-06-10 2009-12-17 Gilead Sciences, Inc. Inhaled carbaprostacyclin and prostacyclin prodrugs for the treatment of pulmonary arterial hypertension
WO2009158010A1 (en) 2008-06-27 2009-12-30 Concert Pharmaceuticals, Inc. Prostacyclin analogs
MX350011B (es) 2008-08-13 2017-08-22 Actelion Pharmaceuticals Ltd Composiciones terapeuticas que contienen macitentan.
KR20110115578A (ko) 2008-12-30 2011-10-21 트롬보로직 에이피에스 장기 부전이 발달할 증가된 위험이 있는 중증 질환 환자의 확인 방법 및 이의 치료를 위한 화합물
CN102421288B (zh) 2009-05-07 2015-04-22 联合治疗公司 前列环素类似物的固体剂型
WO2011005505A2 (en) 2009-06-22 2011-01-13 Johnson Matthey Public Limited Company Method for the purification of prostaglandins
ES2451790T3 (es) 2009-08-07 2014-03-28 Scipharm Sàrl Composición para el tratamiento de la fibrosis quística
US9327105B2 (en) * 2010-03-26 2016-05-03 Itrace Biomedical Inc. Active transdermal drug delivery system and the method thereof
EP3372617B1 (en) 2010-04-02 2024-07-24 Amunix Pharmaceuticals, Inc. Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same
WO2011123830A2 (en) 2010-04-02 2011-10-06 Amunix Operating Inc. Alpha 1-antitrypsin compositions and methods of making and using same
WO2011134478A2 (en) 2010-04-29 2011-11-03 Thrombologic Aps Methods of treatment of patients at increased risk of development of ischemic events and compounds hereof
EP2576492B1 (en) 2010-06-03 2017-09-20 United Therapeutics Corporation Treprostinil production
US20120010159A1 (en) 2010-07-09 2012-01-12 United Therapeutics Corporation Combination therapies with cox-2 inhibitors and treprostinil
CA2710726C (en) 2010-07-22 2016-02-23 Alphora Research Inc. Synthesis of treprostinil and intermediates useful therein
CA2726599C (en) 2010-12-30 2017-07-25 Alphora Research Inc. Process for treprostinil salt preparation
WO2012095511A1 (en) 2011-01-13 2012-07-19 Scipharm Sàrl Method for enhancing engraftment of haematopoetic stem cells
WO2012107364A1 (en) 2011-02-07 2012-08-16 Scipharm Sàrl Novel composition for the treatment of cystic fibrosis
AU2012215606B2 (en) 2011-02-07 2016-12-22 Scipharm Sarl Novel composition for the treatment of cystic fibrosis
EP2699243A1 (en) 2011-04-19 2014-02-26 Rigshospitalet Prostacyclin and analogs thereof administered during surgery for prevention and treatment of capillary leakage
CN103987704A (zh) 2011-08-05 2014-08-13 卡德尔治疗公司 类黄酮化合物
JP6092867B2 (ja) 2011-08-12 2017-03-08 アセンディス ファーマ エー/エス 担体連結しているトレプロスチニルプロドラッグ
US20140249093A1 (en) 2011-08-12 2014-09-04 Ascendis Pharma A/S Carrier-Linked Prodrugs Having Reversible Carboxylic Ester Linkages
MX2014001496A (es) 2011-08-12 2014-04-30 Ascendis Pharma As Composicion de liberacion sostenida de prostaciclina.
US8524939B2 (en) 2011-08-24 2013-09-03 Chirogate International Inc. Intermediates for the synthesis of benzindene prostaglandins and preparations thereof
CN103193627B (zh) * 2012-01-10 2016-04-20 上海天伟生物制药有限公司 一种前列腺素类似物的晶型及其制备方法和用途
US9387214B2 (en) 2012-01-13 2016-07-12 United Therapeutics Corporation Method of identifying therapies for pulmonary hypertension
US20150057325A1 (en) 2012-03-30 2015-02-26 Rigshospitalet Compounds capable of modulating/preserving endothelial integrity for use in prevention or treatment of acute traumatic coagulopathy and resuscitated cardiac arrest
EP2841109A1 (en) 2012-04-25 2015-03-04 Ascendis Pharma A/S Prodrugs of hydroxyl-comprising drugs
PL2674413T3 (pl) 2012-06-15 2018-05-30 Scipharm Sàrl Sposób wytwarzania treprostynilu i jego pochodnych
EP2879682B1 (en) 2012-08-01 2018-03-21 United Therapeutics Corporation Treatment of pulmonary arterial hypertension with mesenchymal stem cells
PE20160090A1 (es) 2012-12-07 2016-02-20 Cayman Chemical Co Inc Metodos para sintetizar un analogo de la prostaciclina
ES2963968T3 (es) 2013-01-09 2024-04-03 United Therapeutics Corp Tratamiento de la vasculopatía con prostaciclina y células madre mesenquimatosas
US9505737B2 (en) * 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US9371264B2 (en) 2013-01-11 2016-06-21 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
JP2016516693A (ja) 2013-03-15 2016-06-09 ユナイテッド セラピューティクス コーポレイション トレプロスチニルの塩
CN105228451B (zh) 2013-03-25 2018-03-30 联合治疗公司 制备具有硫醇连接子和聚乙二醇化形式的前列环素化合物的方法
CN105407883A (zh) 2013-04-30 2016-03-16 联合治疗学有限公司 控释药物制剂
WO2014203278A2 (en) 2013-06-19 2014-12-24 Msn Laboratories Private Limited NOVEL PROCESS FOR THE PREPARATION OF (1R,2R,3aS,9aS)-[[2,3,3a,4,9,9a-HEXAHYDRO-2-HYDROXY-1-[(3S)-3-HYDROXYOCTYL]-1H-BENZ[f]INDEN-5-YL]OXY]ACETIC ACID
PL3060041T3 (pl) 2013-10-25 2021-08-02 Insmed Incorporated Związki prostacykliny
WO2015073314A1 (en) 2013-11-13 2015-05-21 Cayman Chemical Company Incorporated Amine salts of a prostacyclin analog
WO2015138423A1 (en) 2014-03-11 2015-09-17 Insmed Incorporated Prostacylin compositions and methods for using the same
EP3828160A1 (en) 2014-07-16 2021-06-02 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
HU231186B1 (hu) 2014-10-08 2021-06-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás treprostinil és sói előállítására
ES2873873T3 (es) 2014-11-18 2021-11-04 Insmed Inc Métodos de fabricación de treprostinilo y profármacos derivados de treprostinilo
TWI540121B (zh) 2014-12-01 2016-07-01 臺灣永光化學工業股份有限公司 曲前列環素二乙醇胺之合成方法及新穎中間體
AU2016212091A1 (en) 2015-01-27 2017-08-03 Scipharm Sàrl Composition for the treatment of hepatic veno-occlusive disease
US20160243064A1 (en) 2015-02-21 2016-08-25 Gavis Pharmaceuticals Novel oral pharmaceutical compositions of treprostinil
US20160318844A1 (en) 2015-04-29 2016-11-03 Insmed Incorporated Prostacyclin compounds, compositions and methods of use thereof
US9643911B2 (en) 2015-06-17 2017-05-09 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US9394227B1 (en) 2015-06-17 2016-07-19 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
KR20190109399A (ko) 2016-12-05 2019-09-25 코세어 파마 인코포레이티드 트레프로스티닐 및 이의 염의 피부 및 경피 투여

Similar Documents

Publication Publication Date Title
JP2018524304A5 (enExample)
KR102093608B1 (ko) 이미다조피리딘 화합물
ES2626390T3 (es) Moduladores del receptor gamma huérfano relacionado con retinoide (ROR-gamma) para uso en el tratamiento de enfermedades autoinmunitarias e inflamatorias
JP6859323B2 (ja) カルボキシ置換(ヘテロ)芳香環誘導体並びにその調製方法及び使用
JP2016512531A5 (enExample)
JP2019094345A5 (enExample)
JP2020507589A5 (enExample)
JP2016512823A5 (enExample)
JP2903040B2 (ja) ピラゾロピリジン化合物の用途
JP2016519165A5 (enExample)
JP2019518050A5 (enExample)
JP2020520946A5 (enExample)
JP2015051983A5 (enExample)
JP2011506588A5 (enExample)
JP2012502048A5 (enExample)
JP6983416B2 (ja) エトミデート誘導体ならびにその中間体、調製方法および使用
JP2010090149A5 (enExample)
JP2013040178A (ja) Hivプロテアーゼ阻害薬のプロドラッグ
US10710961B2 (en) Method for preparing intermediate of 4-methoxypyrrole derivative
JP2018513832A5 (enExample)
JP2018529690A5 (enExample)
JP2022539126A (ja) ベンゾジアゼピン系化合物及びその製造方法並びに医薬における作用
JP2017520528A (ja) ホルミルペプチド受容体調節物質としてのイミダゾール誘導体
CN110156674A (zh) 一种作为吲哚胺-2,3-双加氧酶抑制剂的螺环化合物
JP2013512199A (ja) アジルサルタン有機アミン塩、その製造方法及び使用