|
US3598122A
(en)
|
1969-04-01 |
1971-08-10 |
Alza Corp |
Bandage for administering drugs
|
|
US4144317A
(en)
|
1975-05-30 |
1979-03-13 |
Alza Corporation |
Device consisting of copolymer having acetoxy groups for delivering drugs
|
|
US4262003A
(en)
|
1975-12-08 |
1981-04-14 |
Alza Corporation |
Method and therapeutic system for administering scopolamine transdermally
|
|
US4201211A
(en)
|
1977-07-12 |
1980-05-06 |
Alza Corporation |
Therapeutic system for administering clonidine transdermally
|
|
US4525586A
(en)
|
1980-02-28 |
1985-06-25 |
The Upjohn Company |
Composition and process
|
|
US4338457A
(en)
|
1980-02-28 |
1982-07-06 |
The Upjohn Company |
Composition and process
|
|
US4306075A
(en)
|
1980-03-28 |
1981-12-15 |
The Upjohn Company |
Composition and process
|
|
US4420632A
(en)
|
1980-04-15 |
1983-12-13 |
The Upjohn Company |
Composition and process
|
|
US4306076A
(en)
|
1980-04-23 |
1981-12-15 |
The Upjohn Company |
Inter-phenylene CBA compounds
|
|
US4349689A
(en)
|
1980-12-22 |
1982-09-14 |
The Upjohn Company |
Methano carbacyclin analogs
|
|
US4379454A
(en)
|
1981-02-17 |
1983-04-12 |
Alza Corporation |
Dosage for coadministering drug and percutaneous absorption enhancer
|
|
DE3333240A1
(de)
|
1983-09-12 |
1985-03-28 |
Schering AG, 1000 Berlin und 4709 Bergkamen |
Mittel zur transdermalen applikation von arzneimittelwirkstoffen
|
|
US4683330A
(en)
|
1984-03-08 |
1987-07-28 |
The Upjohn Company |
Interphenylene carbacyclin derivatives
|
|
US4668814A
(en)
|
1984-03-08 |
1987-05-26 |
The Upjohn Company |
Interphenylene carbacyclin derivatives
|
|
GB8814438D0
(en)
|
1988-06-17 |
1988-07-20 |
Wellcome Found |
Compounds for use in medicine
|
|
GB8824187D0
(en)
|
1988-10-14 |
1988-11-23 |
Wellcome Found |
Compounds for use in medicine
|
|
US5088977A
(en)
|
1988-12-21 |
1992-02-18 |
Drug Delivery Systems Inc. |
Electrical transdermal drug applicator with counteractor and method of drug delivery
|
|
CA2056039A1
(en)
|
1991-01-22 |
1992-07-23 |
Philip L. Fuchs |
Carbacyclin analogs
|
|
US5234690A
(en)
|
1991-08-23 |
1993-08-10 |
Cygnus Therapeutic Systems |
Transdermal drug delivery device using an unfilled microporous membrane to achieve delayed onset
|
|
US5869505A
(en)
|
1993-02-02 |
1999-02-09 |
Keenan; Robert M. |
Nicotine metabolites and nicotine dependence
|
|
US5853751A
(en)
|
1993-06-23 |
1998-12-29 |
Masiz; John J. |
Molecular transdermal transport system
|
|
US5797898A
(en)
|
1996-07-02 |
1998-08-25 |
Massachusetts Institute Of Technology |
Microchip drug delivery devices
|
|
IN184589B
(enExample)
|
1996-10-16 |
2000-09-09 |
Alza Corp |
|
|
CA2359652A1
(en)
*
|
1999-03-31 |
2000-10-05 |
United Therapeutics Corporation |
Novel prostaglandin compounds and derivatives thereof, compositions containing the same and method of using the same for the treatment of peripheral vascular disease and pulmonaryhypertension
|
|
AU3104301A
(en)
|
2000-01-20 |
2001-07-31 |
Noven Pharmaceuticals, Inc. |
Compositions and methods to effect the release profile in the transdermal administration of active agents
|
|
US6242482B1
(en)
*
|
2000-06-05 |
2001-06-05 |
United Therapeutics Corporation |
Prostaglandin compounds and derivatives thereof, compositions containing the same and method of using the same for the treatment of congestive heart failure
|
|
US6635274B1
(en)
|
2000-10-27 |
2003-10-21 |
Biochemics, Inc. |
Solution-based transdermal drug delivery system
|
|
US6700025B2
(en)
|
2001-01-05 |
2004-03-02 |
United Therapeutics Corporation |
Process for stereoselective synthesis of prostacyclin derivatives
|
|
US20030108512A1
(en)
|
2001-12-10 |
2003-06-12 |
Robert Shorr |
Modified prostaglandin compounds and analogs thereof, compositions containing the same useful for the treatment of cancer
|
|
US8246979B2
(en)
|
2002-07-30 |
2012-08-21 |
Ucb Pharma Gmbh |
Transdermal delivery system for the administration of rotigotine
|
|
ES2622471T5
(es)
|
2003-05-22 |
2020-07-23 |
United Therapeutics Corp |
Compuestos y procedimientos para la administración de análogos de prostaciclina
|
|
CA2530407A1
(en)
*
|
2003-07-23 |
2005-02-03 |
The Regents Of The University Of California |
Penetration enhancer combinations for transdermal delivery
|
|
US7375139B2
(en)
|
2003-08-18 |
2008-05-20 |
Aldred Katherine M |
Transdermal method and apparatus
|
|
JP2005120069A
(ja)
|
2003-10-13 |
2005-05-12 |
Anges Mg Inc |
炎症性疾患治療薬
|
|
ATE441418T1
(de)
|
2003-12-16 |
2009-09-15 |
United Therapeutics Corp |
Verwendung von treprostinil zur verbesserung der nierenfunktion
|
|
DE602004028155D1
(de)
|
2003-12-16 |
2010-08-26 |
United Therapeutics Corp |
Verwendung von treprostinil zur behandlung von ischämischen läsionen
|
|
WO2005099680A2
(en)
|
2004-04-12 |
2005-10-27 |
United Therapeutics, Inc. |
Use of treprostinil to treat neuropathic diabetic foot ulcers
|
|
WO2006015299A2
(en)
|
2004-07-30 |
2006-02-09 |
Microchips, Inc. |
Multi-reservoir device for transdermal drug delivery and sensing
|
|
EP1807033B1
(en)
|
2004-10-08 |
2016-07-20 |
Noven Pharmaceuticals, Inc. |
Transdermal drug delivery device including an occlusive backing
|
|
KR20130114229A
(ko)
|
2005-06-03 |
2013-10-16 |
애크럭스 디디에스 피티와이 리미티드 |
경피 약물 전달 방법 및 조성물
|
|
CA2633588A1
(en)
|
2005-12-20 |
2007-08-23 |
Teikoku Pharma Usa, Inc. |
Methods of transdermally administering an indole serotonin receptor agonist and transdermal compositions for use in the same
|
|
EP3222142A1
(en)
|
2006-02-28 |
2017-09-27 |
Kodiak Sciences Inc. |
Acryloyloxyethylphosphorylcholine containing polymer conjugates and their preparation
|
|
US8747897B2
(en)
|
2006-04-27 |
2014-06-10 |
Supernus Pharmaceuticals, Inc. |
Osmotic drug delivery system
|
|
EP2026816B1
(en)
|
2006-05-15 |
2018-10-24 |
United Therapeutics Corporation |
Treprostinil administration using a metered dose inhaler
|
|
WO2008002929A2
(en)
|
2006-06-26 |
2008-01-03 |
Inverseon, Inc. |
Heterologous cross-sensitization for improved agonist activity
|
|
US20090036465A1
(en)
|
2006-10-18 |
2009-02-05 |
United Therapeutics Corporation |
Combination therapy for pulmonary arterial hypertension
|
|
JP2010518122A
(ja)
|
2007-02-09 |
2010-05-27 |
ユナイテッド セラピューティクス コーポレーション |
間質性肺疾患および喘息のためのトレプロスチニル処置
|
|
US7875622B2
(en)
|
2007-07-11 |
2011-01-25 |
Lexicon Pharmaceuticals, Inc. |
Methods and compositions for treating pulmonary hypertension and related diseases and disorders
|
|
CN101903324B
(zh)
|
2007-12-17 |
2013-07-03 |
联合治疗公司 |
一种制备Remodulin中的活性成分曲前列素的改良方法
|
|
WO2009152160A1
(en)
|
2008-06-10 |
2009-12-17 |
Gilead Sciences, Inc. |
Inhaled carbaprostacyclin and prostacyclin prodrugs for the treatment of pulmonary arterial hypertension
|
|
WO2009158010A1
(en)
|
2008-06-27 |
2009-12-30 |
Concert Pharmaceuticals, Inc. |
Prostacyclin analogs
|
|
JP5764061B2
(ja)
|
2008-08-13 |
2015-08-12 |
アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ |
マシテンタン含有治療用組成物
|
|
MX2011006995A
(es)
|
2008-12-30 |
2011-09-27 |
Thrombologic Aps |
Metodos para identificar pacientes criticamente enfermos en riesgo incrementado de desarrollar nsuficiencia organica y compuestos para el tratamiento de la misma.
|
|
US8349892B2
(en)
|
2009-05-07 |
2013-01-08 |
United Therapeutics Corporation |
Solid formulations of prostacyclin analogs
|
|
JP6087147B2
(ja)
|
2009-06-22 |
2017-03-01 |
ジョンソン、マッセイ、パブリック、リミテッド、カンパニーＪｏｈｎｓｏｎ Ｍａｔｔｈｅｙ Ｐｕｂｌｉｃ Ｌｉｍｉｔｅｄ Ｃｏｍｐａｎｙ |
プロスタグランジンの精製方法
|
|
RS53234B
(sr)
|
2009-08-07 |
2014-08-29 |
Scipharm Sàrl |
Kompozicija za lečenje cistične fibroze
|
|
US9327105B2
(en)
*
|
2010-03-26 |
2016-05-03 |
Itrace Biomedical Inc. |
Active transdermal drug delivery system and the method thereof
|
|
US8557961B2
(en)
|
2010-04-02 |
2013-10-15 |
Amunix Operating Inc. |
Alpha 1-antitrypsin compositions and methods of making and using same
|
|
ES2993140T3
(en)
|
2010-04-02 |
2024-12-23 |
Amunix Pharmaceuticals Inc |
Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same
|
|
EP2563369A2
(en)
|
2010-04-29 |
2013-03-06 |
Thrombologic APS |
Methods of treatment of patients at increased risk of development of ischemic events and compounds hereof
|
|
JP6046034B2
(ja)
|
2010-06-03 |
2016-12-14 |
ユナイテッド セラピューティクス コーポレイション |
トレプロスチニルの製造
|
|
US20120010159A1
(en)
|
2010-07-09 |
2012-01-12 |
United Therapeutics Corporation |
Combination therapies with cox-2 inhibitors and treprostinil
|
|
CA2710726C
(en)
|
2010-07-22 |
2016-02-23 |
Alphora Research Inc. |
Synthesis of treprostinil and intermediates useful therein
|
|
CA2726599C
(en)
|
2010-12-30 |
2017-07-25 |
Alphora Research Inc. |
Process for treprostinil salt preparation
|
|
US10213464B2
(en)
|
2011-01-13 |
2019-02-26 |
Scipharm Sarl |
Method for enhancing engraftment of haematopoetic stem cells
|
|
WO2012107364A1
(en)
|
2011-02-07 |
2012-08-16 |
Scipharm Sàrl |
Novel composition for the treatment of cystic fibrosis
|
|
BR112013019335B1
(pt)
|
2011-02-07 |
2022-05-31 |
Scipharm Sàrl |
Nova composição, método para aumentar o nível de camp em um célula e combinação terapêutica, para o tratamento da fibrose cística
|
|
CA2832992A1
(en)
|
2011-04-19 |
2012-10-26 |
Rigshospitalet |
Prostacyclin and analogs thereof administered during surgery for prevention and treatment of capillary leakage
|
|
CN103987704A
(zh)
|
2011-08-05 |
2014-08-13 |
卡德尔治疗公司 |
类黄酮化合物
|
|
MX349950B
(es)
|
2011-08-12 |
2017-08-22 |
Ascendis Pharma As |
Profarmacos de treprostinil enlazados a un portador.
|
|
HK1198358A1
(en)
|
2011-08-12 |
2015-04-10 |
Ascendis Pharma A/S |
Sustained release composition of prostacyclin
|
|
CA2843506C
(en)
|
2011-08-12 |
2020-05-12 |
Ascendis Pharma A/S |
Carrier-linked prodrugs having reversible carboxylic ester linkages
|
|
US8524939B2
(en)
|
2011-08-24 |
2013-09-03 |
Chirogate International Inc. |
Intermediates for the synthesis of benzindene prostaglandins and preparations thereof
|
|
CN103193627B
(zh)
*
|
2012-01-10 |
2016-04-20 |
上海天伟生物制药有限公司 |
一种前列腺素类似物的晶型及其制备方法和用途
|
|
US9387214B2
(en)
|
2012-01-13 |
2016-07-12 |
United Therapeutics Corporation |
Method of identifying therapies for pulmonary hypertension
|
|
EP2834642A1
(en)
|
2012-03-30 |
2015-02-11 |
Rigshospitalet |
Compounds capable of modulating/preserving endothelial integrity for use in prevention or treatment of acute traumatic coagulopathy and resuscitated cardiac arrest
|
|
CA2868925C
(en)
|
2012-04-25 |
2020-01-21 |
Ascendis Pharma A/S |
Prodrugs of hydroxyl-comprising drugs
|
|
LT2674413T
(lt)
|
2012-06-15 |
2017-09-25 |
Scipharm Sąrl |
Treprostinilo ir jo darinių gavimo būdas
|
|
EP2879682B1
(en)
|
2012-08-01 |
2018-03-21 |
United Therapeutics Corporation |
Treatment of pulmonary arterial hypertension with mesenchymal stem cells
|
|
CN104837806A
(zh)
|
2012-12-07 |
2015-08-12 |
开曼化学股份有限公司 |
前列环素类似物的合成方法
|
|
EP2943069B1
(en)
|
2013-01-09 |
2018-08-15 |
United Therapeutics Corporation |
Treatment of vasculopathy with prostacyclin and mesenchymal stem cells
|
|
US9505737B2
(en)
|
2013-01-11 |
2016-11-29 |
Corsair Pharma, Inc. |
Treprostinil derivative compounds and methods of using same
|
|
EP3712142B1
(en)
|
2013-01-11 |
2022-07-06 |
Corsair Pharma, Inc. |
Prodrugs of treprostinil
|
|
CN109608326A
(zh)
|
2013-03-15 |
2019-04-12 |
联合治疗公司 |
曲前列环素的盐
|
|
JP6263604B2
(ja)
|
2013-03-25 |
2018-01-17 |
ユナイテッド セラピューティクス コーポレイション |
チオールリンカーを持つ、ペグ化型のプロスタサイクリン化合物の製造方法
|
|
US9758465B2
(en)
|
2013-04-30 |
2017-09-12 |
United Therapeutics Corporation |
Controlled release pharmaceutical formulations
|
|
WO2014203278A2
(en)
|
2013-06-19 |
2014-12-24 |
Msn Laboratories Private Limited |
NOVEL PROCESS FOR THE PREPARATION OF (1R,2R,3aS,9aS)-[[2,3,3a,4,9,9a-HEXAHYDRO-2-HYDROXY-1-[(3S)-3-HYDROXYOCTYL]-1H-BENZ[f]INDEN-5-YL]OXY]ACETIC ACID
|
|
ES2860975T3
(es)
|
2013-10-25 |
2021-10-05 |
Insmed Inc |
Compuestos de prostaciclina
|
|
CN105722812B
(zh)
|
2013-11-13 |
2018-11-16 |
开曼化学股份有限公司 |
前列环素类似物的胺盐
|
|
WO2015138423A1
(en)
|
2014-03-11 |
2015-09-17 |
Insmed Incorporated |
Prostacylin compositions and methods for using the same
|
|
JP6561109B2
(ja)
|
2014-07-16 |
2019-08-14 |
コルセア ファーマ インコーポレイテッド |
トレプロスチニル誘導体化合物およびその使用方法
|
|
HU231186B1
(hu)
|
2014-10-08 |
2021-06-28 |
CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. |
Új eljárás treprostinil és sói előállítására
|
|
AU2015349969B2
(en)
|
2014-11-18 |
2020-02-06 |
Insmed Incorporated |
Methods of manufacturing treprostinil and treprostinil derivative prodrugs
|
|
TWI540121B
(zh)
|
2014-12-01 |
2016-07-01 |
臺灣永光化學工業股份有限公司 |
曲前列環素二乙醇胺之合成方法及新穎中間體
|
|
SG11201705809QA
(en)
|
2015-01-27 |
2017-08-30 |
Scipharm Sàrl |
Composition for the treatment of hepatic veno-occlusive disease
|
|
US20160243064A1
(en)
|
2015-02-21 |
2016-08-25 |
Gavis Pharmaceuticals |
Novel oral pharmaceutical compositions of treprostinil
|
|
US20160318844A1
(en)
|
2015-04-29 |
2016-11-03 |
Insmed Incorporated |
Prostacyclin compounds, compositions and methods of use thereof
|
|
US9394227B1
(en)
|
2015-06-17 |
2016-07-19 |
Corsair Pharma, Inc. |
Treprostinil derivatives and compositions and uses thereof
|
|
US9643911B2
(en)
|
2015-06-17 |
2017-05-09 |
Corsair Pharma, Inc. |
Treprostinil derivatives and compositions and uses thereof
|
|
KR20190109399A
(ko)
|
2016-12-05 |
2019-09-25 |
코세어 파마 인코포레이티드 |
트레프로스티닐 및 이의 염의 피부 및 경피 투여
|