JP7013245B2 - トレプロスチニル誘導体ならびにその組成物および使用 - Google Patents
トレプロスチニル誘導体ならびにその組成物および使用 Download PDFInfo
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- JP7013245B2 JP7013245B2 JP2017564668A JP2017564668A JP7013245B2 JP 7013245 B2 JP7013245 B2 JP 7013245B2 JP 2017564668 A JP2017564668 A JP 2017564668A JP 2017564668 A JP2017564668 A JP 2017564668A JP 7013245 B2 JP7013245 B2 JP 7013245B2
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- compound
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- treprostinil
- hydrogen
- independently
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- 0 CC(OCC(O1)=C(*)OC1=O)=O Chemical compound CC(OCC(O1)=C(*)OC1=O)=O 0.000 description 37
- MCYXXAZQNRGYGE-UHFFFAOYSA-N COC1CCC(CC(O)=O)CC1 Chemical compound COC1CCC(CC(O)=O)CC1 MCYXXAZQNRGYGE-UHFFFAOYSA-N 0.000 description 1
- QNJXFGTUERFVSU-UHFFFAOYSA-N COCC(CC1)CCC1C(O)=O Chemical compound COCC(CC1)CCC1C(O)=O QNJXFGTUERFVSU-UHFFFAOYSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
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- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
- C07C69/28—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with dihydroxylic compounds
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- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
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Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021151659A JP2022003057A (ja) | 2015-06-17 | 2021-09-17 | トレプロスチニル誘導体ならびにその組成物および使用 |
| JP2023209782A JP2024019523A (ja) | 2015-06-17 | 2023-12-13 | トレプロスチニル誘導体ならびにその組成物および使用 |
| JP2025194875A JP2026021603A (ja) | 2015-06-17 | 2025-11-14 | トレプロスチニル誘導体ならびにその組成物および使用 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201514742579A | 2015-06-17 | 2015-06-17 | |
| US14/742,544 | 2015-06-17 | ||
| US14/742,544 US9394227B1 (en) | 2015-06-17 | 2015-06-17 | Treprostinil derivatives and compositions and uses thereof |
| US14/742,579 | 2015-06-17 | ||
| US14/829,180 | 2015-08-18 | ||
| US14/829,180 US9643911B2 (en) | 2015-06-17 | 2015-08-18 | Treprostinil derivatives and compositions and uses thereof |
| PCT/US2016/037383 WO2016205202A1 (en) | 2015-06-17 | 2016-06-14 | Treprostinil derivatives and compositions and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021151659A Division JP2022003057A (ja) | 2015-06-17 | 2021-09-17 | トレプロスチニル誘導体ならびにその組成物および使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018524304A JP2018524304A (ja) | 2018-08-30 |
| JP2018524304A5 JP2018524304A5 (enExample) | 2019-07-11 |
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| JP2003523935A (ja) | 1999-03-31 | 2003-08-12 | ユナイテッド セラピューティクス コーポレイション | 末梢血管疾患と肺高血圧症を治療するためのプロスタグランジン化合物、組成物および方法 |
| JP2003535132A (ja) | 2000-06-05 | 2003-11-25 | ユナイテッド セラピューティクス コーポレーション | うっ血性心不全治療用プロスタグランジン化合物 |
| WO2003049676A2 (en) | 2001-12-10 | 2003-06-19 | United Therapeutics Corporation | Modified prostaglandin compounds and analogs thereof, compositions containing the same useful for the teatment of cancer |
| JP2007501281A (ja) | 2003-05-22 | 2007-01-25 | ユナイテッド セラピューティクス コーポレイション | プロスタサイクリン類似体の送達のための化合物及び方法 |
| JP2014527050A (ja) | 2011-08-12 | 2014-10-09 | アセンディス ファーマ エー/エス | 担体連結しているトレプロスチニルプロドラッグ |
| WO2014110491A1 (en) | 2013-01-11 | 2014-07-17 | Theratrophix Llc | Prodrugs of treprostinil |
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