HK1258913A1 - 曲前列環素衍生物及其組合物和用途 - Google Patents
曲前列環素衍生物及其組合物和用途Info
- Publication number
- HK1258913A1 HK1258913A1 HK19101390.3A HK19101390A HK1258913A1 HK 1258913 A1 HK1258913 A1 HK 1258913A1 HK 19101390 A HK19101390 A HK 19101390A HK 1258913 A1 HK1258913 A1 HK 1258913A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- compositions
- treprostinil derivatives
- treprostinil
- derivatives
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- PAJMKGZZBBTTOY-ZFORQUDYSA-N treprostinil Chemical class C1=CC=C(OCC(O)=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 PAJMKGZZBBTTOY-ZFORQUDYSA-N 0.000 title 1
Classifications
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
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- C—CHEMISTRY; METALLURGY
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- C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
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- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
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- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
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- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
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Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Furan Compounds (AREA)
- Epoxy Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201514742579A | 2015-06-17 | 2015-06-17 | |
US14/742,544 US9394227B1 (en) | 2015-06-17 | 2015-06-17 | Treprostinil derivatives and compositions and uses thereof |
US14/829,180 US9643911B2 (en) | 2015-06-17 | 2015-08-18 | Treprostinil derivatives and compositions and uses thereof |
PCT/US2016/037383 WO2016205202A1 (en) | 2015-06-17 | 2016-06-14 | Treprostinil derivatives and compositions and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1258913A1 true HK1258913A1 (zh) | 2019-11-22 |
Family
ID=56204034
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK19101390.3A HK1258913A1 (zh) | 2015-06-17 | 2019-01-28 | 曲前列環素衍生物及其組合物和用途 |
Country Status (10)
Country | Link |
---|---|
US (11) | US9643911B2 (zh) |
EP (3) | EP3456715B1 (zh) |
JP (3) | JP7013245B2 (zh) |
KR (1) | KR20180027517A (zh) |
CN (1) | CN108349926A (zh) |
CA (1) | CA2989317A1 (zh) |
ES (2) | ES2897721T3 (zh) |
HK (1) | HK1258913A1 (zh) |
IL (3) | IL289276B2 (zh) |
WO (1) | WO2016205202A1 (zh) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
JP6542128B2 (ja) | 2013-01-11 | 2019-07-10 | コルセア ファーマ インコーポレイテッド | トレプロスチニルのプロドラッグ |
US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
IL310250A (en) | 2016-05-05 | 2024-03-01 | Liquidia Tech Inc | Terfostinil in dry powder form for the treatment of pulmonary hypertension |
KR102541885B1 (ko) | 2016-09-26 | 2023-06-12 | 유나이티드 쎄러퓨틱스 코포레이션 | 트레프로스티닐 프로드럭 |
US20190099383A1 (en) * | 2017-09-30 | 2019-04-04 | Samos Pharmaceuticals, Inc. | Transdermal Delivery of Selexipag Metabolite |
EP3498283A1 (en) * | 2017-12-14 | 2019-06-19 | Ipsol AG | Glycosidic derivatives of treprostinil |
WO2021041320A1 (en) | 2019-08-23 | 2021-03-04 | United Therapeutics Corporation | Treprostinil prodrugs |
AU2021255621A1 (en) | 2020-04-17 | 2022-10-20 | United Therapeutics Corporation | Treprostinil for use in the treatment of intersitial lung disease |
JP2023553989A (ja) | 2020-12-14 | 2023-12-26 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルプロドラッグで疾患を治療する方法 |
KR20240012354A (ko) | 2021-03-03 | 2024-01-29 | 유나이티드 쎄러퓨틱스 코포레이션 | (e)-3,6-비스[4-(n-카보닐-2-프로페닐)아미도부틸]-2,5-디케토피페라진(fdkp)을 추가로 포함하는, 트레프로스티닐 및 이의 프로드러그의 건조 분말 조성물 |
CN117015524A (zh) * | 2021-03-16 | 2023-11-07 | 江苏恒瑞医药股份有限公司 | 一种曲前列环素衍生物及其用途 |
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