ME02861B - Postupak za pripremu treprostinila i njegovih derivata - Google Patents
Postupak za pripremu treprostinila i njegovih derivataInfo
- Publication number
- ME02861B ME02861B MEP-2017-203A MEP2017203A ME02861B ME 02861 B ME02861 B ME 02861B ME P2017203 A MEP2017203 A ME P2017203A ME 02861 B ME02861 B ME 02861B
- Authority
- ME
- Montenegro
- Prior art keywords
- preparation
- treprostinil
- derivatives
- formula
- dichlorobenzyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/56—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups
- C07C47/565—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups all hydroxy groups bound to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P31/00—Preparation of compounds containing a five-membered ring having two side-chains in ortho position to each other, and having at least one oxygen atom directly bound to the ring in ortho position to one of the side-chains, one side-chain containing, not directly bound to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having at least one oxygen atom bound in gamma-position to the ring, e.g. prostaglandins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/14—Benz[f]indenes; Hydrogenated benz[f]indenes
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Alcoholic Beverages (AREA)
- Epoxy Compounds (AREA)
Claims (4)
1. Jedinjenje formule I, ili formule II, gde X je Br; Y je H i PG1 je metil, metoksimetil, benzoiloksimetil, metoksietoksimetil, benzil, 4-metoksibenzil, 2-6-dihlorobenzil, 3,4-dihlorobenzil -CH2COOH, CH2COORx i CH2CH2OPG2; PG2 je terc-butil-dimetilsilil; i Ra je hidroksi Rx je C1-4 alkil ili aril.
2. Postupak za pripremu jedinjenja formule (II), koji sadrži sledeći korak: gde X, Y, Ra, PG1 i PG2 su kao što su definisani u patentnom zahtevu 1.
3. Postupak za pripremu treprostinila (18) prema patentnom zahtevu 2 koji sadrži sledeće korake:
4. Novo intermedijerno jedinjenje izabrano iz grupe koja se sastoji od .
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12172191.4A EP2674413B1 (en) | 2012-06-15 | 2012-06-15 | Process for the preparation of treprostinil and derivatives thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME02861B true ME02861B (me) | 2018-04-20 |
Family
ID=46262002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2017-203A ME02861B (me) | 2012-06-15 | 2012-06-15 | Postupak za pripremu treprostinila i njegovih derivata |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US9346738B2 (me) |
| EP (2) | EP2674413B1 (me) |
| JP (1) | JP6219376B2 (me) |
| KR (1) | KR102080264B1 (me) |
| CN (2) | CN104350035B (me) |
| AU (1) | AU2013265351B2 (me) |
| BR (1) | BR112014028969B1 (me) |
| CA (2) | CA2873280C (me) |
| CL (1) | CL2014003165A1 (me) |
| CO (1) | CO7240368A2 (me) |
| CR (1) | CR20140534A (me) |
| CU (1) | CU24274B1 (me) |
| DK (2) | DK2674413T3 (me) |
| DO (1) | DOP2014000266A (me) |
| EA (1) | EA027202B1 (me) |
| EC (1) | ECSP14028230A (me) |
| ES (2) | ES2639823T3 (me) |
| GE (2) | GEP201606548B (me) |
| GT (1) | GT201400262A (me) |
| HR (1) | HRP20171340T1 (me) |
| HU (2) | HUE034485T2 (me) |
| IL (1) | IL235734B (me) |
| LT (1) | LT2674413T (me) |
| MA (1) | MA37611B1 (me) |
| ME (1) | ME02861B (me) |
| MX (1) | MX358418B (me) |
| MY (1) | MY174852A (me) |
| NI (1) | NI201400135A (me) |
| NZ (1) | NZ701041A (me) |
| PE (1) | PE20150712A1 (me) |
| PH (1) | PH12014502604A1 (me) |
| PL (2) | PL2674413T3 (me) |
| PT (2) | PT2674413T (me) |
| RS (1) | RS56304B1 (me) |
| SG (1) | SG11201407662WA (me) |
| SI (1) | SI2674413T1 (me) |
| SM (1) | SMT201700496T1 (me) |
| TN (1) | TN2014000486A1 (me) |
| UA (1) | UA118337C2 (me) |
| WO (1) | WO2013174848A2 (me) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| US9371264B2 (en) | 2013-01-11 | 2016-06-21 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| PL3060041T3 (pl) | 2013-10-25 | 2021-08-02 | Insmed Incorporated | Związki prostacykliny |
| CN104892555B (zh) * | 2014-03-04 | 2019-03-08 | 江苏豪森药业集团有限公司 | 曲前列尼尔中间体的制备方法 |
| HU231186B1 (hu) * | 2014-10-08 | 2021-06-28 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Új eljárás treprostinil és sói előállítására |
| ES2873873T3 (es) | 2014-11-18 | 2021-11-04 | Insmed Inc | Métodos de fabricación de treprostinilo y profármacos derivados de treprostinilo |
| TWI540121B (zh) | 2014-12-01 | 2016-07-01 | 臺灣永光化學工業股份有限公司 | 曲前列環素二乙醇胺之合成方法及新穎中間體 |
| US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| KR101830693B1 (ko) * | 2016-04-28 | 2018-02-21 | 연성정밀화학(주) | 트레프로스티닐의 제조방법 및 이를 위한 중간체 |
| EP3515430A1 (en) | 2016-09-26 | 2019-07-31 | United Therapeutics Corporation | Treprostinil prodrugs |
| EP3498283A1 (en) | 2017-12-14 | 2019-06-19 | Ipsol AG | Glycosidic derivatives of treprostinil |
| CN108875295A (zh) * | 2018-06-21 | 2018-11-23 | 华北电力科学研究院有限责任公司 | 一种利用析因实验设计指导有机物分子修饰改性的方法 |
| JP7455144B2 (ja) | 2019-04-29 | 2024-03-25 | インスメッド インコーポレイテッド | トレプロスチニルプロドラッグの乾燥粉末組成物およびその使用方法 |
| JP2022546314A (ja) | 2019-08-23 | 2022-11-04 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルプロドラッグ |
| US11826327B2 (en) | 2020-04-17 | 2023-11-28 | United Therapeutics Corporation | Treatment for interstitial lung disease |
| KR20250057075A (ko) | 2020-06-09 | 2025-04-28 | 유나이티드 쎄러퓨틱스 코포레이션 | 트레프로스티닐의 푸마릴 디케토피페리딘 프로드러그 |
| JP7826317B2 (ja) | 2020-12-14 | 2026-03-09 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルプロドラッグで疾患を治療する方法 |
| EP4301372A1 (en) | 2021-03-03 | 2024-01-10 | United Therapeutics Corporation | A dry powder composition of trestinil and its prodrug thereof and further comprising comprising (e)-3,6-bis[4-(n-carbonyl-2-propenyl)amidobutyl]-2,5-diketopiperazine (fdkp) |
| JP2025506019A (ja) | 2022-02-08 | 2025-03-05 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニルイロプロスト併用療法 |
| AU2024208919A1 (en) | 2023-01-19 | 2025-07-17 | United Therapeutics Corporation | Treprostinil analogs |
| US20250197338A1 (en) | 2023-11-09 | 2025-06-19 | United Therapeutics Corporation | Syntheses of compounds useful for producing treprostinil |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6242842B1 (en) | 1996-12-16 | 2001-06-05 | Siemens Matsushita Components Gmbh & Co. Kg | Electrical component, in particular saw component operating with surface acoustic waves, and a method for its production |
| US6441245B1 (en) * | 1997-10-24 | 2002-08-27 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| US6242482B1 (en) * | 2000-06-05 | 2001-06-05 | United Therapeutics Corporation | Prostaglandin compounds and derivatives thereof, compositions containing the same and method of using the same for the treatment of congestive heart failure |
| US6700025B2 (en) * | 2001-01-05 | 2004-03-02 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| WO2005007081A2 (en) * | 2003-05-22 | 2005-01-27 | United Therapeutics Corporation | Compounds and methods for delivery of prostacyclin analogs |
| EP2576492B1 (en) * | 2010-06-03 | 2017-09-20 | United Therapeutics Corporation | Treprostinil production |
| CA2710726C (en) * | 2010-07-22 | 2016-02-23 | Alphora Research Inc. | Synthesis of treprostinil and intermediates useful therein |
-
2012
- 2012-06-15 PL PL12172191T patent/PL2674413T3/pl unknown
- 2012-06-15 LT LTEP12172191.4T patent/LT2674413T/lt unknown
- 2012-06-15 EP EP12172191.4A patent/EP2674413B1/en active Active
- 2012-06-15 ME MEP-2017-203A patent/ME02861B/me unknown
- 2012-06-15 ES ES12172191.4T patent/ES2639823T3/es active Active
- 2012-06-15 DK DK12172191.4T patent/DK2674413T3/en active
- 2012-06-15 PT PT121721914T patent/PT2674413T/pt unknown
- 2012-06-15 HU HUE12172191A patent/HUE034485T2/en unknown
- 2012-06-15 SM SM20170496T patent/SMT201700496T1/it unknown
- 2012-06-15 RS RS20170871A patent/RS56304B1/sr unknown
- 2012-06-15 SI SI201231051T patent/SI2674413T1/sl unknown
-
2013
- 2013-05-22 PT PT13724809T patent/PT2861554T/pt unknown
- 2013-05-22 ES ES13724809T patent/ES2702347T3/es active Active
- 2013-05-22 PE PE2014002058A patent/PE20150712A1/es active IP Right Grant
- 2013-05-22 DK DK13724809.2T patent/DK2861554T3/en active
- 2013-05-22 HU HUE13724809A patent/HUE042516T2/hu unknown
- 2013-05-22 SG SG11201407662WA patent/SG11201407662WA/en unknown
- 2013-05-22 MX MX2014014237A patent/MX358418B/es active IP Right Grant
- 2013-05-22 EA EA201401293A patent/EA027202B1/ru not_active IP Right Cessation
- 2013-05-22 CA CA2873280A patent/CA2873280C/en active Active
- 2013-05-22 MY MYPI2014003255A patent/MY174852A/en unknown
- 2013-05-22 MA MA37611A patent/MA37611B1/fr unknown
- 2013-05-22 KR KR1020147031805A patent/KR102080264B1/ko active Active
- 2013-05-22 CA CA3118552A patent/CA3118552C/en active Active
- 2013-05-22 AU AU2013265351A patent/AU2013265351B2/en active Active
- 2013-05-22 CN CN201380026921.9A patent/CN104350035B/zh active Active
- 2013-05-22 UA UAA201413808A patent/UA118337C2/uk unknown
- 2013-05-22 CU CUP2014000135A patent/CU24274B1/xx unknown
- 2013-05-22 JP JP2015513152A patent/JP6219376B2/ja active Active
- 2013-05-22 CN CN201711097647.0A patent/CN107963962A/zh active Pending
- 2013-05-22 EP EP13724809.2A patent/EP2861554B1/en active Active
- 2013-05-22 PL PL13724809T patent/PL2861554T3/pl unknown
- 2013-05-22 GE GEAP201313668A patent/GEP201606548B/en unknown
- 2013-05-22 US US14/401,826 patent/US9346738B2/en active Active
- 2013-05-22 BR BR112014028969-7A patent/BR112014028969B1/pt active IP Right Grant
- 2013-05-22 WO PCT/EP2013/060472 patent/WO2013174848A2/en not_active Ceased
- 2013-05-22 NZ NZ701041A patent/NZ701041A/en unknown
- 2013-05-22 GE GEAP201714111A patent/GEP20186826B/en unknown
-
2014
- 2014-11-17 IL IL235734A patent/IL235734B/en active IP Right Grant
- 2014-11-21 DO DO2014000266A patent/DOP2014000266A/es unknown
- 2014-11-21 CO CO14256345A patent/CO7240368A2/es unknown
- 2014-11-21 PH PH12014502604A patent/PH12014502604A1/en unknown
- 2014-11-21 EC ECIEPI201428230A patent/ECSP14028230A/es unknown
- 2014-11-21 GT GT201400262A patent/GT201400262A/es unknown
- 2014-11-21 NI NI201400135A patent/NI201400135A/es unknown
- 2014-11-21 CL CL2014003165A patent/CL2014003165A1/es unknown
- 2014-11-21 TN TN2014000486A patent/TN2014000486A1/fr unknown
- 2014-11-21 CR CR20140534A patent/CR20140534A/es unknown
-
2017
- 2017-09-06 HR HRP20171340TT patent/HRP20171340T1/hr unknown
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