EA201100759A1 - Арилоазол-2-илцианоэтиламиносоединения противопаразитарного действия, обогащенные одним из энантиомеров - Google Patents

Арилоазол-2-илцианоэтиламиносоединения противопаразитарного действия, обогащенные одним из энантиомеров

Info

Publication number
EA201100759A1
EA201100759A1 EA201100759A EA201100759A EA201100759A1 EA 201100759 A1 EA201100759 A1 EA 201100759A1 EA 201100759 A EA201100759 A EA 201100759A EA 201100759 A EA201100759 A EA 201100759A EA 201100759 A1 EA201100759 A1 EA 201100759A1
Authority
EA
Eurasian Patent Office
Prior art keywords
ilcyanoethylamino
aryloazole
enantiomers
compound
antiparasitic activity
Prior art date
Application number
EA201100759A
Other languages
English (en)
Other versions
EA019606B1 (ru
Inventor
Марк Дейвид Солл
Лоик Патрик Лё Ир Де Фалуа
Скотт Кевин Хьюбер
Хьонг Ик Ли
Дуглас Эдвард Уилкинсон
Роберт Томс Джэкобс
Брент Кристофер Бек
Original Assignee
Мериал Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мериал Лимитед filed Critical Мериал Лимитед
Publication of EA201100759A1 publication Critical patent/EA201100759A1/ru
Publication of EA019606B1 publication Critical patent/EA019606B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
    • C07D249/20—Benzotriazoles with aryl radicals directly attached in position 2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к новым арилоазол-2-ил-цианоэтиламиносоединениям, в значительной степени обогащённым одним энантиомером формулы (I)и соединениям формулы (IH)где R, R, R, R, R, R, R, R, R, P, Q, V, W, X, Y, Z и a представляют собой группы, определённые в описании, их композициям, способам их получения и применению в качестве пестицидов.
EA201100759A 2008-11-14 2009-11-13 Арилоазол-2-илцианоэтиламино соединения противопаразитарного действия, обогащенные одним из энантиомеров EA019606B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11465608P 2008-11-14 2008-11-14
US11466508P 2008-11-14 2008-11-14
US17613609P 2009-05-07 2009-05-07
PCT/US2009/064392 WO2010056999A1 (en) 2008-11-14 2009-11-13 Enantiomerically enriched aryloazol- 2 -yl cyanoethylamino paraciticidal compounds

Publications (2)

Publication Number Publication Date
EA201100759A1 true EA201100759A1 (ru) 2011-12-30
EA019606B1 EA019606B1 (ru) 2014-04-30

Family

ID=41651188

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201100759A EA019606B1 (ru) 2008-11-14 2009-11-13 Арилоазол-2-илцианоэтиламино соединения противопаразитарного действия, обогащенные одним из энантиомеров

Country Status (30)

Country Link
US (1) US8461176B2 (ru)
EP (3) EP3498696A1 (ru)
JP (2) JP5730208B2 (ru)
KR (2) KR101825870B1 (ru)
CN (1) CN102272105B (ru)
AR (1) AR074024A1 (ru)
AU (1) AU2009313920B2 (ru)
BR (1) BRPI0921546A8 (ru)
CA (2) CA2743715C (ru)
CL (1) CL2011001123A1 (ru)
CY (1) CY1121908T1 (ru)
DK (1) DK3050874T3 (ru)
EA (1) EA019606B1 (ru)
ES (2) ES2551130T3 (ru)
HK (2) HK1157339A1 (ru)
HR (1) HRP20190498T1 (ru)
HU (1) HUE044046T2 (ru)
LT (1) LT3050874T (ru)
ME (1) ME03409B (ru)
MX (1) MX2011005011A (ru)
MY (1) MY153715A (ru)
NZ (1) NZ592980A (ru)
PL (1) PL3050874T3 (ru)
PT (1) PT3050874T (ru)
RS (1) RS58508B1 (ru)
SG (1) SG10201703698QA (ru)
SI (1) SI3050874T1 (ru)
TW (1) TWI516261B (ru)
WO (1) WO2010056999A1 (ru)
ZA (1) ZA201103483B (ru)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3498696A1 (en) * 2008-11-14 2019-06-19 Merial, Inc. Enantiomerically enriched aryloazol-2-yl cyanoethylamino parasiticidal compounds
US8389558B2 (en) * 2009-07-20 2013-03-05 Supratek Pharma Inc. Bendamustine amphiphilic anionic compositions
MX2014004743A (es) 2011-10-19 2014-08-01 Zoetis Llc Uso de derivados de aminoacetonitrilo contra endoparasitos.
LT2811998T (lt) 2012-02-06 2019-02-25 Merial, Inc. Paraziticidinės peroralinės veterinarinės kompozicijos, apimančios sistemiškai veikiančius aktyviuosius agentus, būdai ir jų panaudojimas
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
EP2833866B1 (en) 2012-04-04 2018-11-21 Intervet International B.V. Soft chewable pharmaceutical products
US9550749B2 (en) 2012-08-30 2017-01-24 The University Of Tokyo Endoparasite control agent and method for using the same
US8822689B2 (en) * 2012-09-19 2014-09-02 Merial Limited Aryloazol-2-yl cyanoethylamino compounds, method of making and method of using thereof
CN104230922B (zh) 2013-06-19 2016-12-28 中国科学院上海药物研究所 一类五元杂环并吡啶类化合物及其制备方法和用途
BR112017011656A2 (pt) * 2014-12-02 2019-05-14 Bayer Cropscience Aktiengesellschaft compostos bicíclicos como agentes de controle de pragas.
WO2016087363A1 (de) * 2014-12-02 2016-06-09 Bayer Cropscience Aktiengesellschaft Bicyclische verbindungen als schädlingsbekämpfungsmittel
CN107207497A (zh) * 2014-12-02 2017-09-26 拜耳作物科学股份公司 作为害虫防治剂的双环化合物
WO2017195173A1 (en) 2016-05-12 2017-11-16 Verdesian Life Sciences, U.S., Llc Compositions for controlling enzyme-induced urea decomposition
WO2018183562A1 (en) 2017-03-28 2018-10-04 Verdesian Life Sciences, U.S., Llc Triarylmethane compounds for controlling enzyme-induced urea decomposition
EP3688174A4 (en) * 2017-09-29 2021-09-08 Victoria Link Limited HETEROLOGICAL BIOSYNTHESIS OF NODULISPORIC ACID
WO2020112374A1 (en) 2018-11-20 2020-06-04 Boehringer Ingelheim Animal Health USA Inc. Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof
AU2020293021A1 (en) 2019-06-10 2021-12-23 Lupin Limited PRMT5 inhibitors

Family Cites Families (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL160809C (nl) 1970-05-15 1979-12-17 Duphar Int Res Werkwijze ter bereiding van benzoylureumverbindingen, alsmede werkwijze ter bereiding van insekticide prepara- ten op basis van benzoylureumverbindingen.
JPS4914624A (ru) 1972-06-08 1974-02-08
US3950360A (en) 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
US3818047A (en) 1972-08-07 1974-06-18 C Henrick Substituted pyrones
SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
CH604517A5 (ru) 1976-08-19 1978-09-15 Ciba Geigy Ag
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4134973A (en) 1977-04-11 1979-01-16 Merck & Co., Inc. Carbohydrate derivatives of milbemycin and processes therefor
US4199569A (en) 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
US4144352A (en) 1977-12-19 1979-03-13 Merck & Co., Inc. Milbemycin compounds as anthelmintic agents
US4203976A (en) 1978-08-02 1980-05-20 Merck & Co., Inc. Sugar derivatives of C-076 compounds
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
JPS57139012A (en) 1981-02-23 1982-08-27 Sankyo Co Ltd Anthelmintic composition
US4427663A (en) 1982-03-16 1984-01-24 Merck & Co., Inc. 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
US4683324A (en) 1982-05-25 1987-07-28 American Cyanamid Company Process for the resolution of certain racemic amino nitriles
DE3235931A1 (de) 1982-09-29 1984-03-29 Bayer Ag, 5090 Leverkusen Koeder zur bekaempfung von ungeziefer
JPS59199673A (ja) 1983-04-25 1984-11-12 Sumitomo Chem Co Ltd 含窒素複素環化合物、その製造法およびそれを有効成分とする有害生物防除剤
IL76708A (en) 1984-10-18 1990-01-18 Ciba Geigy Ag Substituted n-benzoyl-n'-(2,5-dichloro-4(1,1,2,3,3,3-hexafluoropropyloxy)-phenyl)ureas,their preparation and pesticidal compositions containing them
ATE67493T1 (de) 1985-02-04 1991-10-15 Bayer Agrochem Kk Heterocyclische verbindungen.
EP0237482A1 (de) 1986-03-06 1987-09-16 Ciba-Geigy Ag C(29)-Carbonyloxi-milbemycin-Derivate zur Bekämpfung von tier- und pflanzenparasitären Schädlingen
EP0342710B1 (en) 1986-03-25 1993-05-19 Sankyo Company Limited Macrolide compounds, their preparation and their use
EP0252879B1 (de) 1986-07-02 1992-05-06 Ciba-Geigy Ag Pestizide
US4855317A (en) 1987-03-06 1989-08-08 Ciba-Geigy Corporation Insecticides and parasiticides
US4871719A (en) 1987-03-24 1989-10-03 Ciba-Geigy Corporation Composition for controlling parasites in productive livestock
US4874749A (en) 1987-07-31 1989-10-17 Merck & Co., Inc. 4"-Deoxy-4-N-methylamino avermectin Bla/Blb
EP0319142B1 (en) 1987-11-03 1994-04-06 Beecham Group Plc Intermediates for the preparation of anthelmintic macrolide antibiotics
NZ232422A (en) 1989-02-16 1992-11-25 Merck & Co Inc 13-ketal milbemycin derivatives and parasiticides
IE904606A1 (en) 1989-12-21 1991-07-03 Beecham Group Plc Novel products
NZ247278A (en) 1991-02-12 1995-03-28 Ancare Distributors Veterinary anthelmintic drench comprising a suspension of praziquantel in a liquid carrier
WO1992022555A1 (en) 1991-06-17 1992-12-23 Beecham Group Plc Paraherquamide derivatives, precursor thereof, processes for their preparation, microorganism used and their use as antiparasitic agents
US5345377A (en) 1992-10-30 1994-09-06 Electric Power Research Institute, Inc. Harmonic controller for an active power line conditioner
GB9300883D0 (en) 1993-01-18 1993-03-10 Pfizer Ltd Antiparasitic agents
US5399582A (en) 1993-11-01 1995-03-21 Merck & Co., Inc. Antiparasitic agents
AUPM969994A0 (en) 1994-11-28 1994-12-22 Virbac S.A. Equine anthelmintic formulations
JPH08311036A (ja) * 1995-03-14 1996-11-26 Takeda Chem Ind Ltd ピラゾール誘導体、その用途
US5962499A (en) 1995-03-20 1999-10-05 Merck & Co., Inc. Nodulisporic acid derivatives
US6221894B1 (en) 1995-03-20 2001-04-24 Merck & Co., Inc. Nodulisporic acid derivatives
DE19520613A1 (de) 1995-06-06 1996-12-12 Bayer Ag Phenylpyridazinone
TW334436B (en) 1995-07-21 1998-06-21 Upjohn Co Antiparasitic marcfortines and paraherquamides
FR2739255B1 (fr) 1995-09-29 1998-09-04 Rhone Merieux Composition antiparasitaire pour le traitement et la protection des animaux de compagnie
US5885607A (en) 1996-03-29 1999-03-23 Rhone Merieux N-phenylpyrazole-based anti-flea and anti-tick external device for cats and dogs
FR2752525B1 (fr) 1996-08-20 2000-05-05 Rhone Merieux Procede de lutte contre les myiases des cheptels bovins et ovins et compositions pour la mise en oeuvre de ce procede
IE80657B1 (en) 1996-03-29 1998-11-04 Merial Sas Insecticidal combination to control mammal fleas in particular fleas on cats and dogs
US6010710A (en) 1996-03-29 2000-01-04 Merial Direct pour-on skin solution for antiparasitic use in cattle and sheep
FR2753377B1 (fr) 1996-09-19 1999-09-24 Rhone Merieux Nouvelle association parasiticide a base de 1-n-phenylpyra- zoles et de lactones macrocycliques endectocides
US6998131B2 (en) 1996-09-19 2006-02-14 Merial Limited Spot-on formulations for combating parasites
US6426333B1 (en) 1996-09-19 2002-07-30 Merial Spot-on formulations for combating parasites
US6289076B1 (en) 1997-05-06 2001-09-11 Sumitomo Heavy Industries, Ltd. Transmission system for synchrotron radiation light
US6207647B1 (en) 1997-07-18 2001-03-27 Smithkline Beecham Corporation RatA
US6239077B1 (en) 1998-05-01 2001-05-29 Nihon Nohyaku Co., Ltd. Aminoacetonitrile derivative agricultural and horticultural insecticide containing the same and use thereof
DE19823396A1 (de) 1998-05-26 1999-12-02 Bayer Ag Synergistische insektizide Mischungen
US6174540B1 (en) 1998-09-14 2001-01-16 Merck & Co., Inc. Long acting injectable formulations containing hydrogenated caster oil
US6346649B1 (en) 1999-12-28 2002-02-12 Basf Aktiengesellschaft Process for the recovery and recycle of D-tartaric acid
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
PE20011289A1 (es) 2000-04-07 2001-12-21 Upjohn Co Composiciones antihelminticas que comprenden lactonas macrociclicas y espirodioxepinoindoles
US6399786B1 (en) 2000-07-14 2002-06-04 Merck & Co., Inc. Nonacyclic nodulisporic acid derivatives
EP1392281B1 (en) 2000-12-20 2007-02-21 Novartis AG Anti-endoparasitic amidoacetonitrils
AU2002224942A1 (en) 2000-12-20 2002-07-01 Syngenta Participations Ag N-acyl aminoacetonitriles having pesticidal properties
AR035531A1 (es) 2001-01-22 2004-06-02 Novartis Ag Composicion para el control de plagas endoparasiticas en ganados y animales domesticos, un metodo para su control y el uso de dicha composicion para la preparacion de medicamentos
EP1390344B1 (en) 2001-05-15 2006-12-27 Novartis AG Benzamidoacetonitrile derivatives and their use as antiparasitics
AR036054A1 (es) 2001-06-15 2004-08-04 Novartis Ag Uso de compuestos de aminoacetonitrilo para el control de plagas, una composicion y un proceso para dicho control y una composicion farmaceutica contra parasitos
BR0213066A (pt) 2001-10-04 2004-09-28 Novartis Ag Compostos de cianoacetila
WO2003031393A2 (en) 2001-10-04 2003-04-17 Novartis Ag Carbonyloxy-cyanomethyl compounds as antiparasitic agents
TW200300140A (en) 2001-11-14 2003-05-16 Novartis Ag Organic compounds
TWI261053B (en) 2001-12-06 2006-09-01 Novartis Ag Amidoacetonitrile compounds, their preparation, compositions and use as pesticides
AR038156A1 (es) 2002-01-21 2004-12-29 Novartis Ag Compuestos de amidoacetonitrilo, proceso para su preparacion, composicion para controlar los parasitos, y uso de estos compuestos para preparar una composicion farmaceutica
TW200305556A (en) 2002-03-21 2003-11-01 Novartis Ag Organic compounds
EP1352894A1 (en) 2002-04-09 2003-10-15 DSM IP Assets B.V. Process for the preparation of enantiomerically enriched compounds
TW200400004A (en) 2002-05-22 2004-01-01 Novartis Ag Organic compounds
TW200400931A (en) 2002-05-22 2004-01-16 Novartis Ag Organic compounds
AR039961A1 (es) 2002-06-06 2005-03-09 Novartis Ag Derivados de amidoacetonitrilo y su uso como pesticida
AR040149A1 (es) 2002-06-07 2005-03-16 Novartis Ag Compuestos de aminoacetonitrilo, un proceso para su preparacion, composicion, y uso del compuesto
GB0214117D0 (en) 2002-06-19 2002-07-31 Syngenta Participations Ag N-sulphonylaminoacetonitriles having pesticidal properties
TW200400932A (en) 2002-06-19 2004-01-16 Novartis Ag Organic compounds
US7001889B2 (en) 2002-06-21 2006-02-21 Merial Limited Anthelmintic oral homogeneous veterinary pastes
AR042420A1 (es) * 2002-09-11 2005-06-22 Novartis Ag Benzotriazolil- aminoacetonitril compuestos, proceso para su preparacion, metodo y uso de los mismos en el control de endo- y ecto-parasitos dentro y sobre ganado productor de sangre caliente y animales domesticos y plantas, y en la preparacion de una composicion farmaceutica
BR0316747A (pt) 2002-12-18 2005-10-18 Fmc Corp Piperidinas n-(arilmetil substituìdas)-4-(metil dissubstituìdas) e piperazinas
US6883320B2 (en) 2003-07-08 2005-04-26 G. W. Lisk Company, Inc. Control system regulating air flow to engine intake
DE10331675A1 (de) 2003-07-14 2005-02-10 Bayer Cropscience Ag Hetarylsubstituierte Pyrazolidindion-Derivate
CA2535406A1 (en) 2003-08-14 2005-02-24 F. Hoffmann-La Roche Ag Gabanergic modulators
BRPI0416159A (pt) 2003-11-03 2007-01-16 Bayer Cropscience Gmbh agente de eficácia herbicida
GB0402677D0 (en) 2003-11-06 2004-03-10 Novartis Ag Organic compounds
AR046757A1 (es) 2003-12-10 2005-12-21 Novartis Ag Amidoacetonitrilos utiles como pesticidas
CN102532048B (zh) 2004-03-05 2015-06-24 日产化学工业株式会社 异噁唑啉取代苯甲酰胺化合物的制备中间体
TW200613251A (en) 2004-06-10 2006-05-01 Novartis Ag Organic compounds
WO2006043654A1 (ja) * 2004-10-22 2006-04-27 Nihon Nohyaku Co., Ltd. アセトニトリル誘導体及び有害生物防除剤並びにその使用方法
NZ553887A (en) 2004-11-09 2010-09-30 Novartis Ag Process for the preparation of enantiomers of amidoacetonitrile compounds from their racemates
US20080261999A1 (en) 2005-03-04 2008-10-23 Fionna Mitchell Martin Azabicycloalkane Derivatives Useful as Nicotinic Acetylcholine Receptor Agonists
JP2008534565A (ja) 2005-03-31 2008-08-28 アストラゼネカ アクチボラグ Ｔｉｅ２阻害活性のあるアミノピリミジン誘導体
AU2006278867A1 (en) 2005-07-25 2007-02-15 Novartis Ag Amidonitrile compounds
DE102005053680A1 (de) 2005-11-10 2007-05-16 Bayer Cropscience Ag Synergistische insektizide Mischungen zur Behandlung von Saatgut
JP2009519937A (ja) 2005-12-14 2009-05-21 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 無脊椎有害生物防除用イソオキサゾリン
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
CN101155036A (zh) * 2006-09-30 2008-04-02 Thomson宽带研发（北京）有限公司 有线接入网络系统头端设备
WO2008062005A1 (en) 2006-11-24 2008-05-29 Novartis Ag The use of aminoacetonitril compounds in the control of endoparasites in warm- blood animals.
ES2344279T3 (es) 2006-12-01 2010-08-23 Syngenta Participations Ag N-cianoalquilantranilamidas como insecticidas.
US20100027495A1 (en) 2007-02-05 2010-02-04 Nokia Corporation Method and Apparatus for Providing Acknowledgment Signaling
WO2008096231A1 (en) 2007-02-09 2008-08-14 Pfizer Limited Antiparasitic agents
NZ580241A (en) 2007-04-10 2011-02-25 Bayer Cropscience Ag Insecticidal aryl isoxazoline derivatives
ES2825198T3 (es) 2007-05-15 2021-05-14 Boehringer Ingelheim Animal Health Usa Inc Compuestos de ariloazol-2-il cianoetilamino, procedimiento de fabricación y procedimiento de utilización de los mismos
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
RU2508102C2 (ru) 2007-06-27 2014-02-27 Е.И.Дюпон Де Немур Энд Компани Способ борьбы с вредителями животных
NZ581859A (en) 2007-06-29 2012-06-29 Pfizer Anthelmintic combination comprising 2-desoxoparaherquamide and abamectin
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
EP3498696A1 (en) * 2008-11-14 2019-06-19 Merial, Inc. Enantiomerically enriched aryloazol-2-yl cyanoethylamino parasiticidal compounds

Also Published As

Publication number Publication date
EP3050874B1 (en) 2019-01-09
EP2364301A1 (en) 2011-09-14
MY153715A (en) 2015-03-13
ES2551130T3 (es) 2015-11-16
TW201019935A (en) 2010-06-01
SG10201703698QA (en) 2017-06-29
ES2729854T3 (es) 2019-11-06
MX2011005011A (es) 2011-07-29
KR101715414B1 (ko) 2017-03-10
ZA201103483B (en) 2012-10-31
KR101825870B1 (ko) 2018-02-05
JP5730208B2 (ja) 2015-06-03
JP6010846B2 (ja) 2016-10-19
CA2945453A1 (en) 2010-05-20
KR20160145204A (ko) 2016-12-19
CY1121908T1 (el) 2020-10-14
LT3050874T (lt) 2019-04-10
JP2012508767A (ja) 2012-04-12
ME03409B (me) 2020-01-20
NZ592980A (en) 2013-03-28
DK3050874T3 (en) 2019-04-01
PL3050874T3 (pl) 2019-07-31
EP3050874A1 (en) 2016-08-03
US20100125089A1 (en) 2010-05-20
CA2945453C (en) 2021-03-02
HK1222645A1 (zh) 2017-07-07
AU2009313920A1 (en) 2010-05-20
BRPI0921546A8 (pt) 2022-08-16
CA2743715C (en) 2016-12-13
BRPI0921546A2 (pt) 2015-08-18
CA2743715A1 (en) 2010-05-20
KR20110084323A (ko) 2011-07-21
HRP20190498T1 (hr) 2019-05-03
SI3050874T1 (sl) 2019-04-30
PT3050874T (pt) 2019-05-09
HK1157339A1 (en) 2012-06-29
TWI516261B (zh) 2016-01-11
JP2015098480A (ja) 2015-05-28
EP2364301B1 (en) 2015-09-02
AR074024A1 (es) 2010-12-15
US8461176B2 (en) 2013-06-11
CL2011001123A1 (es) 2011-09-02
HUE044046T2 (hu) 2019-09-30
EA019606B1 (ru) 2014-04-30
AU2009313920B2 (en) 2014-10-23
CN102272105B (zh) 2016-09-14
RS58508B1 (sr) 2019-04-30
WO2010056999A1 (en) 2010-05-20
WO2010056999A9 (en) 2018-06-07
EP3498696A1 (en) 2019-06-19
CN102272105A (zh) 2011-12-07

Similar Documents

Publication Publication Date Title
EA201100759A1 (ru) Арилоазол-2-илцианоэтиламиносоединения противопаразитарного действия, обогащенные одним из энантиомеров
EA200901529A1 (ru) Производные арилоазол-2-илцианоэтиламина, способ их получения и способ их применения
EA201100666A1 (ru) Тиоамидные соединения, способ их получения и способ их применения
EA201001205A1 (ru) Соединения, содержащие циклобутоксигруппу
EA201200018A1 (ru) Триазольные соединения, несущие серосодержащий заместитель
GEP20156266B (en) Spiroheterocyclic n-oxypiperidines as pesticides
CO6361989A2 (es) Proceso para la preparacion de derivados de l-alanina protegidos
EA201190235A1 (ru) Замещенные 1-цианоэтилгетероциклилкарбоксамидные соединения 750
SV2010003617A (es) Fungicidas
EA201500652A1 (ru) Дифторметилникотиновые инданилкарбоксамиды
ATE543854T1 (de) Neue polycarbonat-polyorganosiloxan- und/oder polyurethan-polyorganosiloxan-verbindungen
EA200702329A1 (ru) Замещенные пирролпиридины, содержащие их композиции, способ получения и применение
MX2009010071A (es) Derivados de aril isoxazolina insecticidas.
TN2012000575A1 (en) Compositions and methods for modulating the wnt signaling pathway
ATE459622T1 (de) Tropanverbindungen
EA201201377A1 (ru) Определенные аминопиридазины, композиции на их основе и способы их использования
EA200870514A1 (ru) Ацетиленовые гетероарильные соединения
UY31750A (es) Compuestos y composiciones como inhibidores de quinasa
EA201170282A1 (ru) Фунгицидные n-циколоалкил-n-бифенилметилкарбоксамидные производные
EA200971140A1 (ru) Триарильные соединения и композиции, их содержащие
EA200900090A1 (ru) Бензиламины, способ их получения и их применение в качестве противовоспалительных средств
MX2014011752A (es) Compuestos heterobiciclicos n-sustituidos y derivados para combatir plagas de animales ii.
SV2010003501A (es) Fungicidas novedosos
EA200900397A1 (ru) Новые соединения диосметина, способ их получения и фармацевтические композиции, которые их содержат
MX343893B (es) Nuevos derivados de aril-quinolina.

Legal Events

Date Code Title Description
PC4A Registration of transfer of a eurasian patent by assignment