BRPI0921546A8 - Compostos de arilazol-2-il cianoetilamina enriquecidos enantiomericamente, método para fabricação e método de uso dos mesmos - Google Patents

Compostos de arilazol-2-il cianoetilamina enriquecidos enantiomericamente, método para fabricação e método de uso dos mesmos

Info

Publication number
BRPI0921546A8
BRPI0921546A8 BRPI0921546A BRPI0921546A BRPI0921546A8 BR PI0921546 A8 BRPI0921546 A8 BR PI0921546A8 BR PI0921546 A BRPI0921546 A BR PI0921546A BR PI0921546 A BRPI0921546 A BR PI0921546A BR PI0921546 A8 BRPI0921546 A8 BR PI0921546A8
Authority
BR
Brazil
Prior art keywords
cyanoethylamine
compounds
manufacturing
enantiomerically enriched
arilazole
Prior art date
Application number
BRPI0921546A
Other languages
English (en)
Inventor
David Soll Mark
Patrick Le Hir De Fallois Loïc
Kevin Huber Scot
Ik Lee Hyoung
Edward Wilkinson Douglas
Toms Jacobs Robert
Christopher Beck Brent
Original Assignee
Merial Ltd
Merial Inc
Boehringer Ingelheim Animal Health Usa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Ltd, Merial Inc, Boehringer Ingelheim Animal Health Usa Inc filed Critical Merial Ltd
Publication of BRPI0921546A2 publication Critical patent/BRPI0921546A2/pt
Publication of BRPI0921546A8 publication Critical patent/BRPI0921546A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
    • C07D249/20—Benzotriazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPOSTOS DE ARILAZOL2-IL CIANOETILAMINA ENRIQUECIDOS ENANTIOMERICAMENTE, MÉTODO PARA FABRICAÇÃO E MÉTODO DE USO DOS MESMOS. A presente invenção se refere aos novos derivados de arilazol-2-il-cianoetilamina substancialmente enriquecidos em um enantiômero da fórmula (I): e aos compostos da fórmula (IH): onde Ras, Ra, Rs, Re, Ry, Rizar Risp, Riga, Rip, P, Q, V, Wo X Y, 2Z e a são conforme definidos na descrição, composições dos mesmos, processos para sua preparação e seus usos como pesticidas.
BRPI0921546A 2008-11-14 2009-11-13 Compostos de arilazol-2-il cianoetilamina enriquecidos enantiomericamente, método para fabricação e método de uso dos mesmos BRPI0921546A8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11465608P 2008-11-14 2008-11-14
US11466508P 2008-11-14 2008-11-14
US17613609P 2009-05-07 2009-05-07
PCT/US2009/064392 WO2010056999A1 (en) 2008-11-14 2009-11-13 Enantiomerically enriched aryloazol- 2 -yl cyanoethylamino paraciticidal compounds

Publications (2)

Publication Number Publication Date
BRPI0921546A2 BRPI0921546A2 (pt) 2015-08-18
BRPI0921546A8 true BRPI0921546A8 (pt) 2022-08-16

Family

ID=41651188

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0921546A BRPI0921546A8 (pt) 2008-11-14 2009-11-13 Compostos de arilazol-2-il cianoetilamina enriquecidos enantiomericamente, método para fabricação e método de uso dos mesmos

Country Status (30)

Country Link
US (1) US8461176B2 (pt)
EP (3) EP3050874B1 (pt)
JP (2) JP5730208B2 (pt)
KR (2) KR101715414B1 (pt)
CN (1) CN102272105B (pt)
AR (1) AR074024A1 (pt)
AU (1) AU2009313920B2 (pt)
BR (1) BRPI0921546A8 (pt)
CA (2) CA2743715C (pt)
CL (1) CL2011001123A1 (pt)
CY (1) CY1121908T1 (pt)
DK (1) DK3050874T3 (pt)
EA (1) EA019606B1 (pt)
ES (2) ES2729854T3 (pt)
HK (2) HK1157339A1 (pt)
HR (1) HRP20190498T1 (pt)
HU (1) HUE044046T2 (pt)
LT (1) LT3050874T (pt)
ME (1) ME03409B (pt)
MX (1) MX2011005011A (pt)
MY (1) MY153715A (pt)
NZ (1) NZ592980A (pt)
PL (1) PL3050874T3 (pt)
PT (1) PT3050874T (pt)
RS (1) RS58508B1 (pt)
SG (1) SG10201703698QA (pt)
SI (1) SI3050874T1 (pt)
TW (1) TWI516261B (pt)
WO (1) WO2010056999A1 (pt)
ZA (1) ZA201103483B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0921546A8 (pt) * 2008-11-14 2022-08-16 Merial Ltd Compostos de arilazol-2-il cianoetilamina enriquecidos enantiomericamente, método para fabricação e método de uso dos mesmos
US8389558B2 (en) * 2009-07-20 2013-03-05 Supratek Pharma Inc. Bendamustine amphiphilic anionic compositions
US8962681B2 (en) 2011-10-19 2015-02-24 Zoetis Llc Use of aminoacetonitrile derivatives against endoparasites
NZ731588A (en) 2012-02-06 2018-11-30 Boehringer Ingelheim Animal Health Usa Inc Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
CA2868381C (en) 2012-04-04 2020-07-07 Intervet International B.V. Soft chewable pharmaceutical products
EP2891489B1 (en) * 2012-08-30 2018-01-10 The University of Tokyo Endoparasite control agent and use thereof
US8822689B2 (en) * 2012-09-19 2014-09-02 Merial Limited Aryloazol-2-yl cyanoethylamino compounds, method of making and method of using thereof
CN104230922B (zh) 2013-06-19 2016-12-28 中国科学院上海药物研究所 一类五元杂环并吡啶类化合物及其制备方法和用途
WO2016087422A1 (de) * 2014-12-02 2016-06-09 Bayer Cropscience Aktiengesellschaft Bicyclische verbindungen als schädlingsbekämpfungsmittel
US20170260183A1 (en) * 2014-12-02 2017-09-14 Bayer Cropscience Aktiengesellschaft Bicyclic compounds as pest control agents
WO2016087363A1 (de) * 2014-12-02 2016-06-09 Bayer Cropscience Aktiengesellschaft Bicyclische verbindungen als schädlingsbekämpfungsmittel
US11384032B2 (en) 2016-05-12 2022-07-12 Verdesian Life Sciences, U.S., Llc Compositions for controlling enzyme-induced urea decomposition
WO2018183562A1 (en) 2017-03-28 2018-10-04 Verdesian Life Sciences, U.S., Llc Triarylmethane compounds for controlling enzyme-induced urea decomposition
AU2018343310B2 (en) * 2017-09-29 2023-11-30 Victoria Link Limited Heterologous biosynthesis of nodulisporic acid
CN113260419A (zh) * 2018-11-20 2021-08-13 勃林格殷格翰动物保健美国公司 吲唑基氰基乙基氨基化合物、其组合物、其制备方法和其使用方法
PE20230245A1 (es) 2019-06-10 2023-02-07 Lupin Ltd Inhibidores de prmt5

Family Cites Families (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL160809C (nl) 1970-05-15 1979-12-17 Duphar Int Res Werkwijze ter bereiding van benzoylureumverbindingen, alsmede werkwijze ter bereiding van insekticide prepara- ten op basis van benzoylureumverbindingen.
JPS4914624A (pt) 1972-06-08 1974-02-08
US3950360A (en) 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
US3818047A (en) 1972-08-07 1974-06-18 C Henrick Substituted pyrones
SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
CH604517A5 (pt) 1976-08-19 1978-09-15 Ciba Geigy Ag
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4134973A (en) 1977-04-11 1979-01-16 Merck & Co., Inc. Carbohydrate derivatives of milbemycin and processes therefor
US4199569A (en) 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
US4144352A (en) 1977-12-19 1979-03-13 Merck & Co., Inc. Milbemycin compounds as anthelmintic agents
US4203976A (en) 1978-08-02 1980-05-20 Merck & Co., Inc. Sugar derivatives of C-076 compounds
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
JPS57139012A (en) 1981-02-23 1982-08-27 Sankyo Co Ltd Anthelmintic composition
US4427663A (en) 1982-03-16 1984-01-24 Merck & Co., Inc. 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
US4683324A (en) 1982-05-25 1987-07-28 American Cyanamid Company Process for the resolution of certain racemic amino nitriles
DE3235931A1 (de) 1982-09-29 1984-03-29 Bayer Ag, 5090 Leverkusen Koeder zur bekaempfung von ungeziefer
JPS59199673A (ja) 1983-04-25 1984-11-12 Sumitomo Chem Co Ltd 含窒素複素環化合物、その製造法およびそれを有効成分とする有害生物防除剤
DE3580444D1 (en) 1984-10-18 1990-12-13 Ciba Geigy Ag Benzoylphenylharnstoffe.
EP0192060B1 (de) 1985-02-04 1991-09-18 Nihon Bayer Agrochem K.K. Heterocyclische Verbindungen
EP0237482A1 (de) 1986-03-06 1987-09-16 Ciba-Geigy Ag C(29)-Carbonyloxi-milbemycin-Derivate zur Bekämpfung von tier- und pflanzenparasitären Schädlingen
RU2024527C1 (ru) 1986-03-25 1994-12-15 Санкио Компани Лимитед Способ получения макролидных соединений
DE3778768D1 (de) 1986-07-02 1992-06-11 Ciba Geigy Ag Pestizide.
US4855317A (en) 1987-03-06 1989-08-08 Ciba-Geigy Corporation Insecticides and parasiticides
US4871719A (en) 1987-03-24 1989-10-03 Ciba-Geigy Corporation Composition for controlling parasites in productive livestock
US4874749A (en) 1987-07-31 1989-10-17 Merck & Co., Inc. 4"-Deoxy-4-N-methylamino avermectin Bla/Blb
EP0319142B1 (en) 1987-11-03 1994-04-06 Beecham Group Plc Intermediates for the preparation of anthelmintic macrolide antibiotics
NZ232422A (en) 1989-02-16 1992-11-25 Merck & Co Inc 13-ketal milbemycin derivatives and parasiticides
IE904606A1 (en) 1989-12-21 1991-07-03 Beecham Group Plc Novel products
NZ247278A (en) 1991-02-12 1995-03-28 Ancare Distributors Veterinary anthelmintic drench comprising a suspension of praziquantel in a liquid carrier
WO1992022555A1 (en) 1991-06-17 1992-12-23 Beecham Group Plc Paraherquamide derivatives, precursor thereof, processes for their preparation, microorganism used and their use as antiparasitic agents
US5345377A (en) 1992-10-30 1994-09-06 Electric Power Research Institute, Inc. Harmonic controller for an active power line conditioner
GB9300883D0 (en) 1993-01-18 1993-03-10 Pfizer Ltd Antiparasitic agents
US5399582A (en) 1993-11-01 1995-03-21 Merck & Co., Inc. Antiparasitic agents
AUPM969994A0 (en) 1994-11-28 1994-12-22 Virbac S.A. Equine anthelmintic formulations
JPH08311036A (ja) * 1995-03-14 1996-11-26 Takeda Chem Ind Ltd ピラゾール誘導体、その用途
US5962499A (en) 1995-03-20 1999-10-05 Merck & Co., Inc. Nodulisporic acid derivatives
US6221894B1 (en) 1995-03-20 2001-04-24 Merck & Co., Inc. Nodulisporic acid derivatives
DE19520613A1 (de) 1995-06-06 1996-12-12 Bayer Ag Phenylpyridazinone
MY113806A (en) 1995-07-21 2002-05-31 Upjohn Co Antiparasitic marcfortines and paraherquamides
FR2739255B1 (fr) 1995-09-29 1998-09-04 Rhone Merieux Composition antiparasitaire pour le traitement et la protection des animaux de compagnie
US6010710A (en) 1996-03-29 2000-01-04 Merial Direct pour-on skin solution for antiparasitic use in cattle and sheep
US5885607A (en) 1996-03-29 1999-03-23 Rhone Merieux N-phenylpyrazole-based anti-flea and anti-tick external device for cats and dogs
FR2752525B1 (fr) 1996-08-20 2000-05-05 Rhone Merieux Procede de lutte contre les myiases des cheptels bovins et ovins et compositions pour la mise en oeuvre de ce procede
IE80657B1 (en) 1996-03-29 1998-11-04 Merial Sas Insecticidal combination to control mammal fleas in particular fleas on cats and dogs
FR2753377B1 (fr) 1996-09-19 1999-09-24 Rhone Merieux Nouvelle association parasiticide a base de 1-n-phenylpyra- zoles et de lactones macrocycliques endectocides
US6426333B1 (en) 1996-09-19 2002-07-30 Merial Spot-on formulations for combating parasites
US6998131B2 (en) 1996-09-19 2006-02-14 Merial Limited Spot-on formulations for combating parasites
US6289076B1 (en) 1997-05-06 2001-09-11 Sumitomo Heavy Industries, Ltd. Transmission system for synchrotron radiation light
US6207647B1 (en) 1997-07-18 2001-03-27 Smithkline Beecham Corporation RatA
US6239077B1 (en) 1998-05-01 2001-05-29 Nihon Nohyaku Co., Ltd. Aminoacetonitrile derivative agricultural and horticultural insecticide containing the same and use thereof
DE19823396A1 (de) 1998-05-26 1999-12-02 Bayer Ag Synergistische insektizide Mischungen
US6174540B1 (en) 1998-09-14 2001-01-16 Merck & Co., Inc. Long acting injectable formulations containing hydrogenated caster oil
US6346649B1 (en) 1999-12-28 2002-02-12 Basf Aktiengesellschaft Process for the recovery and recycle of D-tartaric acid
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
PE20011289A1 (es) 2000-04-07 2001-12-21 Upjohn Co Composiciones antihelminticas que comprenden lactonas macrociclicas y espirodioxepinoindoles
US6399786B1 (en) 2000-07-14 2002-06-04 Merck & Co., Inc. Nonacyclic nodulisporic acid derivatives
WO2002050052A1 (en) 2000-12-20 2002-06-27 Syngenta Participations Ag N-acyl aminoacetonitriles having pesticidal properties
BR0116326A (pt) 2000-12-20 2004-07-06 Novartis Ag Compostos orgânicos
AR035531A1 (es) 2001-01-22 2004-06-02 Novartis Ag Composicion para el control de plagas endoparasiticas en ganados y animales domesticos, un metodo para su control y el uso de dicha composicion para la preparacion de medicamentos
RU2284990C2 (ru) 2001-05-15 2006-10-10 Новартис Аг Производные бензамидоацетонитрила, способ их получения, содержащая их композиция для борьбы с нематодами и их применение
AR036054A1 (es) 2001-06-15 2004-08-04 Novartis Ag Uso de compuestos de aminoacetonitrilo para el control de plagas, una composicion y un proceso para dicho control y una composicion farmaceutica contra parasitos
EP1436250A1 (en) 2001-10-04 2004-07-14 Novartis AG Cyanoacetyl compounds
WO2003031393A2 (en) 2001-10-04 2003-04-17 Novartis Ag Carbonyloxy-cyanomethyl compounds as antiparasitic agents
TW200300140A (en) 2001-11-14 2003-05-16 Novartis Ag Organic compounds
AR037746A1 (es) 2001-12-06 2004-12-01 Novartis Ag Compuestos derivados de amidoacetonitrilo, un procedimiento para su preparacion, un procedimiento para la preparacion de compuestos intermediarios, una composicion para combatir parasitos, un procedimiento para combatir dichos parasitos, y el empleo de dichos derivados para la preparacion de una com
AR038156A1 (es) 2002-01-21 2004-12-29 Novartis Ag Compuestos de amidoacetonitrilo, proceso para su preparacion, composicion para controlar los parasitos, y uso de estos compuestos para preparar una composicion farmaceutica
TW200305556A (en) 2002-03-21 2003-11-01 Novartis Ag Organic compounds
EP1352894A1 (en) 2002-04-09 2003-10-15 DSM IP Assets B.V. Process for the preparation of enantiomerically enriched compounds
TW200400931A (en) 2002-05-22 2004-01-16 Novartis Ag Organic compounds
TW200400004A (en) 2002-05-22 2004-01-01 Novartis Ag Organic compounds
AR039961A1 (es) 2002-06-06 2005-03-09 Novartis Ag Derivados de amidoacetonitrilo y su uso como pesticida
AR040149A1 (es) 2002-06-07 2005-03-16 Novartis Ag Compuestos de aminoacetonitrilo, un proceso para su preparacion, composicion, y uso del compuesto
TW200400932A (en) 2002-06-19 2004-01-16 Novartis Ag Organic compounds
GB0214117D0 (en) 2002-06-19 2002-07-31 Syngenta Participations Ag N-sulphonylaminoacetonitriles having pesticidal properties
US7001889B2 (en) 2002-06-21 2006-02-21 Merial Limited Anthelmintic oral homogeneous veterinary pastes
TW200409760A (en) * 2002-09-11 2004-06-16 Novartis Ag Organic compounds
AU2003296373A1 (en) 2002-12-18 2004-07-29 Bayer Cropscience Ag N-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and piperazines
US6883320B2 (en) 2003-07-08 2005-04-26 G. W. Lisk Company, Inc. Control system regulating air flow to engine intake
DE10331675A1 (de) 2003-07-14 2005-02-10 Bayer Cropscience Ag Hetarylsubstituierte Pyrazolidindion-Derivate
KR100742014B1 (ko) 2003-08-14 2007-07-23 에프. 호프만-라 로슈 아게 Ｇａｂａ계 조절제
EA012521B1 (ru) 2003-11-03 2009-10-30 Байер Кропсайенс Аг Жидкий препарат, его применение, способ его получения и способ борьбы с сорными растениями
GB0402677D0 (en) 2003-11-06 2004-03-10 Novartis Ag Organic compounds
AR046757A1 (es) 2003-12-10 2005-12-21 Novartis Ag Amidoacetonitrilos utiles como pesticidas
WO2005085216A1 (ja) 2004-03-05 2005-09-15 Nissan Chemical Industries, Ltd. イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤
AR049391A1 (es) 2004-06-10 2006-07-26 Novartis Ag Derivados de aminoacetonitrilo y su uso para controlar parasitos en animales de sangre caliente
WO2006043654A1 (ja) 2004-10-22 2006-04-27 Nihon Nohyaku Co., Ltd. アセトニトリル誘導体及び有害生物防除剤並びにその使用方法
CA2580247C (en) 2004-11-09 2014-06-17 Novartis Ag Process for the preparation of enantiomers of amidoacetonitrile compounds from their racemates
US20080261999A1 (en) 2005-03-04 2008-10-23 Fionna Mitchell Martin Azabicycloalkane Derivatives Useful as Nicotinic Acetylcholine Receptor Agonists
EP1893605A2 (en) 2005-03-31 2008-03-05 AstraZeneca AB Saminopyrimidine derivates with tie2 inhibiting activity
US20080227863A1 (en) 2005-07-25 2008-09-18 Novartis Ag Organic Compounds
DE102005053680A1 (de) 2005-11-10 2007-05-16 Bayer Cropscience Ag Synergistische insektizide Mischungen zur Behandlung von Saatgut
JP2009519937A (ja) 2005-12-14 2009-05-21 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 無脊椎有害生物防除用イソオキサゾリン
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
CN101155036A (zh) * 2006-09-30 2008-04-02 Thomson宽带研发（北京）有限公司 有线接入网络系统头端设备
WO2008062005A1 (en) 2006-11-24 2008-05-29 Novartis Ag The use of aminoacetonitril compounds in the control of endoparasites in warm- blood animals.
ATE468333T1 (de) 2006-12-01 2010-06-15 Syngenta Participations Ag N-cyanoalkylanthranilamide als insektizide
WO2008096232A1 (en) 2007-02-05 2008-08-14 Nokia Corporation Method and apparatus for providing acknowledgment signaling
BRPI0807137A2 (pt) 2007-02-09 2014-04-15 Pfizer Ltd Agentes antiparasitários
RU2009141185A (ru) 2007-04-10 2011-05-20 Байер КропСайенс АГ (DE) Инсектицидные производные арилизоксазолина
RS58416B1 (sr) 2007-05-15 2019-04-30 Merial Inc Ariloazol-2-il cijanoetilamino jedinjenja, postupci dobijanja i postupci njihove primene
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
CN101743000A (zh) 2007-06-27 2010-06-16 杜邦公司 动物虫害控制方法
CN101686962B (zh) 2007-06-29 2012-05-23 辉瑞大药厂 驱虫药联合用药
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
BRPI0921546A8 (pt) * 2008-11-14 2022-08-16 Merial Ltd Compostos de arilazol-2-il cianoetilamina enriquecidos enantiomericamente, método para fabricação e método de uso dos mesmos

Also Published As

Publication number Publication date
MY153715A (en) 2015-03-13
CY1121908T1 (el) 2020-10-14
HK1157339A1 (en) 2012-06-29
KR101825870B1 (ko) 2018-02-05
JP5730208B2 (ja) 2015-06-03
PT3050874T (pt) 2019-05-09
US8461176B2 (en) 2013-06-11
CN102272105A (zh) 2011-12-07
HK1222645A1 (zh) 2017-07-07
JP2015098480A (ja) 2015-05-28
CA2945453A1 (en) 2010-05-20
TW201019935A (en) 2010-06-01
AR074024A1 (es) 2010-12-15
CL2011001123A1 (es) 2011-09-02
KR20160145204A (ko) 2016-12-19
KR20110084323A (ko) 2011-07-21
JP6010846B2 (ja) 2016-10-19
AU2009313920A1 (en) 2010-05-20
DK3050874T3 (en) 2019-04-01
US20100125089A1 (en) 2010-05-20
SG10201703698QA (en) 2017-06-29
JP2012508767A (ja) 2012-04-12
TWI516261B (zh) 2016-01-11
HRP20190498T1 (hr) 2019-05-03
EP2364301B1 (en) 2015-09-02
LT3050874T (lt) 2019-04-10
EA201100759A1 (ru) 2011-12-30
CA2743715A1 (en) 2010-05-20
EP2364301A1 (en) 2011-09-14
EP3498696A1 (en) 2019-06-19
ES2729854T3 (es) 2019-11-06
BRPI0921546A2 (pt) 2015-08-18
AU2009313920B2 (en) 2014-10-23
EP3050874A1 (en) 2016-08-03
HUE044046T2 (hu) 2019-09-30
WO2010056999A1 (en) 2010-05-20
WO2010056999A9 (en) 2018-06-07
CA2743715C (en) 2016-12-13
ME03409B (me) 2020-01-20
ES2551130T3 (es) 2015-11-16
PL3050874T3 (pl) 2019-07-31
CA2945453C (en) 2021-03-02
RS58508B1 (sr) 2019-04-30
MX2011005011A (es) 2011-07-29
NZ592980A (en) 2013-03-28
CN102272105B (zh) 2016-09-14
ZA201103483B (en) 2012-10-31
EA019606B1 (ru) 2014-04-30
KR101715414B1 (ko) 2017-03-10
SI3050874T1 (sl) 2019-04-30
EP3050874B1 (en) 2019-01-09

Similar Documents

Publication Publication Date Title
BRPI0921546A8 (pt) Compostos de arilazol-2-il cianoetilamina enriquecidos enantiomericamente, método para fabricação e método de uso dos mesmos
BRPI0612957B8 (pt) composto, processos de preparação de compostos, composição farmacêutica e uso de um composto
BR112013018515A2 (pt) derivados de pirrol tricíclico, processo para preparação e seu uso como inibidores da quinase
BRPI0519674A2 (pt) sulfonil pirrolidinas, mÉtodo para produzir as mesmas e seu uso como drogas
CL2015001304A1 (es) Compuestos derivados de 5-fluoro-n-(piridin-2-il)piridin-2-amina que contienen un grupo sulfoximina; composicion farmaceutica; combinacion farmaceutica; y metodo para la preparacion de compuestos.
EA200901529A1 (ru) Производные арилоазол-2-илцианоэтиламина, способ их получения и способ их применения
UA107951C2 (en) Imidazopyridine derivatives as inhibitors of jak
BRPI0513901A (pt) derivados de uréia cìclicos substituìdos, preparação dos mesmos e uso farmacêutico dos mesmos como inibidores de cinase
BR112016007356A2 (pt) compostos herbicidas
UY30444A1 (es) Derivados de pirimidina, procesos para su preparacinn, composiciones farmaccuticos y usos de los mismos.
CR11623A (es) Compuestos
BRPI1009235B8 (pt) acetamidas substituídas por 2-(hetero)arila, n-(hetero)arila, e composição farmacêutica
CL2009002206A1 (es) Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales.
CL2010001407A1 (es) Compuestos derivados de purina y pirimidina sustituidos; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar enfermedades virales tales como hepatitis c, dengue, fiebre amarilla, polio, hepatitis a, entre otras.
BRPI0916286B8 (pt) amidofenóxi-indazóis úteis como inibidores de c-met, seus usos, e composição farmacêutica
EA200970247A1 (ru) Способ получения оптического активного n-защищенного 3-аминопирролидина или оптически активного n-защищенного 3-аминопиперидина и соответствующих кетонов путем оптического разделения рацемических смесей аминов с использованием бактериальной омега-трансаминазы
BRPI0712631A8 (pt) compostos, processos para a preparação de um composto, composição farmacêutica, uso de um composto e combinações
BR112017023263A2 (pt) compostos antivirais rsv de pirazolo e triazolopirimidina
EA201201677A1 (ru) Производные гетероарилимидазолона в качестве ингибиторов jak
BR112012011328A2 (pt) inibidores de akt
BR112013022671A2 (pt) processo para a preparação de aminas primárias, e, uso de um catalisador complexo
EA200900397A1 (ru) Новые соединения диосметина, способ их получения и фармацевтические композиции, которые их содержат
BR112012009310A2 (pt) composto, e, composição farmacêutica
ECSP11010992A (es) Derivados de anilina-pirimidina sustituidos con sulfoximina como inhibidores de quinasas dependientes de ciclina (cdk), producción y uso de los mismos como productos medicinales
BR112013004662B8 (pt) Composto, composição farmacêutica, usos de um composto, e método para preparar uma composição farmacêutica

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: MERIAL, INC. (US)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B25A Requested transfer of rights approved

Owner name: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC. (US)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 14A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2748 DE 05-09-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.