JP2013512910A5 - - Google Patents

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Publication number
JP2013512910A5
JP2013512910A5 JP2012542143A JP2012542143A JP2013512910A5 JP 2013512910 A5 JP2013512910 A5 JP 2013512910A5 JP 2012542143 A JP2012542143 A JP 2012542143A JP 2012542143 A JP2012542143 A JP 2012542143A JP 2013512910 A5 JP2013512910 A5 JP 2013512910A5
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JP
Japan
Prior art keywords
tert
butyl
benzimidazol
phenyl
pyrimidin
Prior art date
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Application number
JP2012542143A
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English (en)
Japanese (ja)
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JP2013512910A (ja
JP5690839B2 (ja
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Priority claimed from PCT/US2010/058479 external-priority patent/WO2011068821A1/en
Publication of JP2013512910A publication Critical patent/JP2013512910A/ja
Publication of JP2013512910A5 publication Critical patent/JP2013512910A5/ja
Application granted granted Critical
Publication of JP5690839B2 publication Critical patent/JP5690839B2/ja
Active legal-status Critical Current
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JP2012542143A 2009-12-04 2010-12-01 ロイコトリエン産生のベンゾイミダゾール阻害薬 Active JP5690839B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26656209P 2009-12-04 2009-12-04
US61/266,562 2009-12-04
PCT/US2010/058479 WO2011068821A1 (en) 2009-12-04 2010-12-01 Benzimidazole inhibitors of leukotriene production

Publications (3)

Publication Number Publication Date
JP2013512910A JP2013512910A (ja) 2013-04-18
JP2013512910A5 true JP2013512910A5 (enExample) 2014-01-23
JP5690839B2 JP5690839B2 (ja) 2015-03-25

Family

ID=43530461

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012542143A Active JP5690839B2 (ja) 2009-12-04 2010-12-01 ロイコトリエン産生のベンゾイミダゾール阻害薬

Country Status (6)

Country Link
US (1) US8420655B2 (enExample)
EP (1) EP2509975B1 (enExample)
JP (1) JP5690839B2 (enExample)
AR (1) AR079260A1 (enExample)
TW (1) TW201130821A (enExample)
WO (1) WO2011068821A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2509975B1 (en) 2009-12-04 2014-04-23 Boehringer Ingelheim International GmbH Benzimidazole inhibitors of leukotriene production
NZ601967A (en) * 2010-03-12 2015-03-27 Omeros Corp Pde10 inhibitors and related compositions and methods
JP5928958B2 (ja) * 2010-10-29 2016-06-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成のベンゾイミダゾールインヒビター
JP5789888B2 (ja) 2010-11-01 2015-10-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成のベンゾイミダゾールインヒビター
CN102617495A (zh) * 2012-03-22 2012-08-01 盛世泰科生物医药技术(苏州)有限公司 一种2-(1-1,2,4-三氮唑)苯甲醛的制备方法
TWI644899B (zh) 2013-02-04 2018-12-21 健生藥品公司 Ｆｌａｐ調節劑
WO2014121055A2 (en) * 2013-02-04 2014-08-07 Janssen Pharmaceutica Nv Flap modulators
CN103804312B (zh) * 2014-02-17 2016-04-20 四川百利药业有限责任公司 一类氮杂环化合物及其制备方法和用途
EP2949653A1 (en) 2014-05-27 2015-12-02 Banoglu, Erden Isoxazole derivatives as leukotriene biosynthesis inhibitors
WO2017079678A1 (en) 2015-11-04 2017-05-11 Omeros Corporation Solid state forms of a pde10 inhibitor
CN108299413A (zh) * 2018-01-22 2018-07-20 复旦大学 一种无金属催化制备2-(胺基苯基)苯并噁唑及其衍生物的方法
EP4143183B1 (en) 2020-04-29 2025-10-22 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
CN113801136B (zh) * 2020-06-16 2023-04-07 江苏恒瑞医药股份有限公司 咪唑并杂芳基类衍生物、其制备方法及其在医药上的应用
WO2022028572A1 (en) 2020-08-06 2022-02-10 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
CN116406360A (zh) 2020-08-28 2023-07-07 加舒布鲁姆生物公司 杂环glp-1激动剂
CN119930605A (zh) * 2020-09-01 2025-05-06 江苏恒瑞医药股份有限公司 稠合咪唑类衍生物、其制备方法及其在医药上的应用
CN116547279A (zh) * 2020-10-13 2023-08-04 加舒布鲁姆生物公司 杂环glp-1激动剂

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3505609A1 (de) 1985-02-19 1986-08-21 Merck Patent Gmbh, 6100 Darmstadt Benzimidazolyl-pyridazinone
WO1999061013A2 (en) * 1998-05-22 1999-12-02 Avanir Pharmaceuticals COMPOUNDS HAVING IgE AFFECTING PROPERTIES
US6303645B1 (en) * 1998-05-22 2001-10-16 Avanir Pharmaceuticals Benzimidazole derivatives as modulators of IgE
TR200200310T2 (tr) 1999-08-06 2002-08-21 Janssen Pharmaceutica N.V. Interlökin-5 inhibe eden 6-azaurasil türevleri.
EP1529046A1 (en) * 2002-08-08 2005-05-11 Boehringer Ingelheim Pharmaceuticals Inc. Substituted benzimidazole compounds
CA2534649A1 (en) 2003-08-01 2005-02-10 Genelabs Technologies, Inc. Bicyclic imidazol derivatives against flaviviridae
US7319108B2 (en) 2004-01-25 2008-01-15 Sanofi-Aventis Deutschland Gmbh Aryl-substituted heterocycles, process for their preparation and their use as medicaments
WO2006044602A2 (en) 2004-10-18 2006-04-27 Merck & Co., Inc. Diphenyl substituted alkanes as flap inhiibitors
US7405302B2 (en) * 2005-10-11 2008-07-29 Amira Pharmaceuticals, Inc. 5-lipoxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
EP2013174B1 (en) 2006-04-11 2013-05-08 Merck Sharp & Dohme Corp. Diaryl substituted alkanes
US7495024B2 (en) 2006-08-07 2009-02-24 Via Pharmaceuticals, Inc. Phenylalkyl N-hydroxyureas for combating atherosclerotic plaque
JP2010502615A (ja) 2006-09-01 2010-01-28 メルク エンド カムパニー インコーポレーテッド ５−リポキシゲナーゼ活性化タンパク質（ｆｌａｐ）の阻害剤
EP2099789A4 (en) 2006-12-04 2012-02-15 Boehringer Ingelheim Int INHIBITORS OF HIV REPLICATION
JP2010513253A (ja) * 2006-12-14 2010-04-30 ベーリンガー インゲルハイム インテルナショナール ゲーエムベーハー 炎症の治療に有用なベンゾオキサゾール類
WO2008084218A1 (en) * 2007-01-12 2008-07-17 Boehringer Ingelheim International Gmbh Benzazole derivatives for the treatment of inflammations
CA2683948A1 (en) 2007-04-20 2008-10-30 Merck Frosst Canada Ltd. Novel heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
AU2008266960A1 (en) 2007-06-20 2008-12-24 Merck Sharp & Dohme Corp. Diphenyl substituted alkanes
EP2209761A4 (en) 2007-10-10 2012-01-04 Merck Sharp & Dohme DIPHENYL-SUBSTITUTED CYCLOAL CANS
DE102009033208A1 (de) * 2009-07-15 2011-01-20 Merck Patent Gmbh Aminopyridinderivate
EP2509975B1 (en) 2009-12-04 2014-04-23 Boehringer Ingelheim International GmbH Benzimidazole inhibitors of leukotriene production
RU2012154447A (ru) 2010-05-12 2014-06-20 Вандербилт Юниверсити Гетероциклические сульфоновые аллостерические потенциаторы mglur4, композиции и способы лечения неврологических дисфункций

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