JP2013512910A5 - - Google Patents

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Publication number
JP2013512910A5
JP2013512910A5 JP2012542143A JP2012542143A JP2013512910A5 JP 2013512910 A5 JP2013512910 A5 JP 2013512910A5 JP 2012542143 A JP2012542143 A JP 2012542143A JP 2012542143 A JP2012542143 A JP 2012542143A JP 2013512910 A5 JP2013512910 A5 JP 2013512910A5
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JP
Japan
Prior art keywords
tert
butyl
benzimidazol
phenyl
pyrimidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012542143A
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English (en)
Japanese (ja)
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JP2013512910A (ja
JP5690839B2 (ja
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Publication date
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Priority claimed from PCT/US2010/058479 external-priority patent/WO2011068821A1/en
Publication of JP2013512910A publication Critical patent/JP2013512910A/ja
Publication of JP2013512910A5 publication Critical patent/JP2013512910A5/ja
Application granted granted Critical
Publication of JP5690839B2 publication Critical patent/JP5690839B2/ja
Active legal-status Critical Current
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JP2012542143A 2009-12-04 2010-12-01 ロイコトリエン産生のベンゾイミダゾール阻害薬 Active JP5690839B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26656209P 2009-12-04 2009-12-04
US61/266,562 2009-12-04
PCT/US2010/058479 WO2011068821A1 (en) 2009-12-04 2010-12-01 Benzimidazole inhibitors of leukotriene production

Publications (3)

Publication Number Publication Date
JP2013512910A JP2013512910A (ja) 2013-04-18
JP2013512910A5 true JP2013512910A5 (enExample) 2014-01-23
JP5690839B2 JP5690839B2 (ja) 2015-03-25

Family

ID=43530461

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012542143A Active JP5690839B2 (ja) 2009-12-04 2010-12-01 ロイコトリエン産生のベンゾイミダゾール阻害薬

Country Status (6)

Country Link
US (1) US8420655B2 (enExample)
EP (1) EP2509975B1 (enExample)
JP (1) JP5690839B2 (enExample)
AR (1) AR079260A1 (enExample)
TW (1) TW201130821A (enExample)
WO (1) WO2011068821A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2509975B1 (en) 2009-12-04 2014-04-23 Boehringer Ingelheim International GmbH Benzimidazole inhibitors of leukotriene production
ES2742195T3 (es) 2010-03-12 2020-02-13 Omeros Corp Inhibidores de PDE10 y composiciones y métodos relacionados
WO2012058254A1 (en) * 2010-10-29 2012-05-03 Boehringer Ingelheim International Gmbh Benzimidazole inhibitors of leukotriene production
EP2635566B1 (en) 2010-11-01 2018-05-16 Boehringer Ingelheim International GmbH Benzimidazole inhibitors of leukotriene production
CN102617495A (zh) * 2012-03-22 2012-08-01 盛世泰科生物医药技术(苏州)有限公司 一种2-(1-1,2,4-三氮唑)苯甲醛的制备方法
TWI644899B (zh) 2013-02-04 2018-12-21 健生藥品公司 Ｆｌａｐ調節劑
EP3495359A1 (en) * 2013-02-04 2019-06-12 Janssen Pharmaceutica NV Flap modulators
CN103804312B (zh) * 2014-02-17 2016-04-20 四川百利药业有限责任公司 一类氮杂环化合物及其制备方法和用途
EP2949653A1 (en) 2014-05-27 2015-12-02 Banoglu, Erden Isoxazole derivatives as leukotriene biosynthesis inhibitors
CA3003611C (en) 2015-11-04 2022-11-01 Omeros Corporation Solid state forms of a pde10 inhibitor
CN108299413A (zh) * 2018-01-22 2018-07-20 复旦大学 一种无金属催化制备2-(胺基苯基)苯并噁唑及其衍生物的方法
CN113801136B (zh) * 2020-06-16 2023-04-07 江苏恒瑞医药股份有限公司 咪唑并杂芳基类衍生物、其制备方法及其在医药上的应用
CR20230066A (es) 2020-08-06 2023-05-29 Gasherbrum Bio Inc Agonistas del glp-1 heterocíclicos
JP2023538949A (ja) 2020-08-28 2023-09-12 ガシャーブラム・バイオ・インコーポレイテッド ヘテロ環ｇｌｐ－１アゴニスト
US12227499B2 (en) * 2020-09-01 2025-02-18 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Fused imidazole derivative, preparation method therefor, and medical use thereof
US20230391760A1 (en) * 2020-10-13 2023-12-07 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3505609A1 (de) 1985-02-19 1986-08-21 Merck Patent Gmbh, 6100 Darmstadt Benzimidazolyl-pyridazinone
DE69924607T2 (de) * 1998-05-22 2006-02-02 Avanir Pharmaceuticals, San Diego Benzimidazol-derivate als ige-modulatoren
US6303645B1 (en) * 1998-05-22 2001-10-16 Avanir Pharmaceuticals Benzimidazole derivatives as modulators of IgE
DE60026312T2 (de) 1999-08-06 2006-12-21 Janssen Pharmaceutica N.V. Interleukin-5 hemmende 6-azauracil derivate
EP1529046A1 (en) * 2002-08-08 2005-05-11 Boehringer Ingelheim Pharmaceuticals Inc. Substituted benzimidazole compounds
EP1651631A1 (en) 2003-08-01 2006-05-03 Genelabs Technologies, Inc. Bicyclic imidazol derivatives against flaviviridae
US7319108B2 (en) 2004-01-25 2008-01-15 Sanofi-Aventis Deutschland Gmbh Aryl-substituted heterocycles, process for their preparation and their use as medicaments
CN101039938A (zh) 2004-10-18 2007-09-19 默克公司 作为flap抑制剂的二苯基取代的烷烃
US7405302B2 (en) * 2005-10-11 2008-07-29 Amira Pharmaceuticals, Inc. 5-lipoxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
CA2648555A1 (en) 2006-04-11 2007-10-25 Merck & Co., Inc. Diaryl substituted alkanes
US7495024B2 (en) 2006-08-07 2009-02-24 Via Pharmaceuticals, Inc. Phenylalkyl N-hydroxyureas for combating atherosclerotic plaque
ATE543810T1 (de) 2006-09-01 2012-02-15 Merck Sharp & Dohme Hemmer des 5-lipoxygenase aktivierenden proteins (flap)
WO2008067644A1 (en) 2006-12-04 2008-06-12 Boehringer Ingelheim International Gmbh Inhibitors of hiv replication
JP2010513253A (ja) * 2006-12-14 2010-04-30 ベーリンガー インゲルハイム インテルナショナール ゲーエムベーハー 炎症の治療に有用なベンゾオキサゾール類
WO2008084218A1 (en) * 2007-01-12 2008-07-17 Boehringer Ingelheim International Gmbh Benzazole derivatives for the treatment of inflammations
CA2683948A1 (en) 2007-04-20 2008-10-30 Merck Frosst Canada Ltd. Novel heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
AU2008266960A1 (en) 2007-06-20 2008-12-24 Merck Sharp & Dohme Corp. Diphenyl substituted alkanes
AU2008311375A1 (en) 2007-10-10 2009-04-16 Merck Sharp & Dohme Corp. Diphenyl substituted cycloalkanes
DE102009033208A1 (de) * 2009-07-15 2011-01-20 Merck Patent Gmbh Aminopyridinderivate
EP2509975B1 (en) 2009-12-04 2014-04-23 Boehringer Ingelheim International GmbH Benzimidazole inhibitors of leukotriene production
SG185414A1 (en) 2010-05-12 2012-12-28 Univ Vanderbilt Heterocyclic sulfone mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

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