JP2009536196A5 - - Google Patents
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- JP2009536196A5 JP2009536196A5 JP2009509485A JP2009509485A JP2009536196A5 JP 2009536196 A5 JP2009536196 A5 JP 2009536196A5 JP 2009509485 A JP2009509485 A JP 2009509485A JP 2009509485 A JP2009509485 A JP 2009509485A JP 2009536196 A5 JP2009536196 A5 JP 2009536196A5
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- Prior art keywords
- alkyl
- substituted
- formula
- phenyl
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 18
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 125000001153 fluoro group Chemical group F* 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 11
- -1 C 1 -C 6 alkoxy Chemical group 0.000 claims 10
- 229910052760 oxygen Inorganic materials 0.000 claims 10
- 125000001424 substituent group Chemical group 0.000 claims 10
- 229910052799 carbon Inorganic materials 0.000 claims 9
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- 125000005842 heteroatom Chemical group 0.000 claims 7
- 239000001301 oxygen Chemical group 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 229910052717 sulfur Chemical group 0.000 claims 6
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 4
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 4
- 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 claims 4
- 208000027418 Wounds and injury Diseases 0.000 claims 4
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims 4
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 4
- 208000006673 asthma Diseases 0.000 claims 4
- 206010006451 bronchitis Diseases 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 239000011593 sulfur Chemical group 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 206010006458 Bronchitis chronic Diseases 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 2
- 206010014561 Emphysema Diseases 0.000 claims 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims 2
- 108010028275 Leukocyte Elastase Proteins 0.000 claims 2
- 102000016799 Leukocyte elastase Human genes 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000008469 Peptic Ulcer Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 206010063837 Reperfusion injury Diseases 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 206010052428 Wound Diseases 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 230000009286 beneficial effect Effects 0.000 claims 2
- 201000009267 bronchiectasis Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 208000007451 chronic bronchitis Diseases 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000002496 gastric effect Effects 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 208000012947 ischemia reperfusion injury Diseases 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 201000008482 osteoarthritis Diseases 0.000 claims 2
- 208000011906 peptic ulcer disease Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000002815 pulmonary hypertension Diseases 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 206010039083 rhinitis Diseases 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 1
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- XMJYJGDTXWJZOJ-UHFFFAOYSA-N 1-(3-chloro-4-fluorophenyl)-5-[2-(4-cyanophenyl)pyrazol-3-yl]-n,6-dimethyl-2-oxopyridine-3-carboxamide Chemical compound CC=1N(C=2C=C(Cl)C(F)=CC=2)C(=O)C(C(=O)NC)=CC=1C1=CC=NN1C1=CC=C(C#N)C=C1 XMJYJGDTXWJZOJ-UHFFFAOYSA-N 0.000 claims 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- XTMYKZUDOSTQFY-UHFFFAOYSA-N 5-[2-(4-chlorophenyl)pyrazol-3-yl]-n,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]pyridine-3-carboxamide Chemical compound CC=1N(C=2C=C(C=CC=2)C(F)(F)F)C(=O)C(C(=O)NC)=CC=1C1=CC=NN1C1=CC=C(Cl)C=C1 XTMYKZUDOSTQFY-UHFFFAOYSA-N 0.000 claims 1
- QZVIXMNTGHGVEI-UHFFFAOYSA-N 5-[2-(4-cyanophenyl)-1,2,4-triazol-3-yl]-n,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]pyridine-3-carboxamide Chemical compound CC=1N(C=2C=C(C=CC=2)C(F)(F)F)C(=O)C(C(=O)NC)=CC=1C1=NC=NN1C1=CC=C(C#N)C=C1 QZVIXMNTGHGVEI-UHFFFAOYSA-N 0.000 claims 1
- KIMZBWYHGGXELV-UHFFFAOYSA-N 5-[2-(4-cyanophenyl)pyrazol-3-yl]-6-methyl-n-[(4-methylsulfonylphenyl)methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]pyridine-3-carboxamide Chemical compound O=C1N(C=2C=C(C=CC=2)C(F)(F)F)C(C)=C(C=2N(N=CC=2)C=2C=CC(=CC=2)C#N)C=C1C(=O)NCC1=CC=C(S(C)(=O)=O)C=C1 KIMZBWYHGGXELV-UHFFFAOYSA-N 0.000 claims 1
- IVORQAQKBHVZHS-UHFFFAOYSA-N 5-[2-(4-cyanophenyl)pyrazol-3-yl]-n,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]pyridine-3-carboxamide Chemical compound CC=1N(C=2C=C(C=CC=2)C(F)(F)F)C(=O)C(C(=O)NC)=CC=1C1=CC=NN1C1=CC=C(C#N)C=C1 IVORQAQKBHVZHS-UHFFFAOYSA-N 0.000 claims 1
- ATCWZNNQWJCJKS-UHFFFAOYSA-N 5-[2-(4-fluorophenyl)pyrazol-3-yl]-n,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]pyridine-3-carboxamide Chemical compound CC=1N(C=2C=C(C=CC=2)C(F)(F)F)C(=O)C(C(=O)NC)=CC=1C1=CC=NN1C1=CC=C(F)C=C1 ATCWZNNQWJCJKS-UHFFFAOYSA-N 0.000 claims 1
- ALLZACDKHLHGPV-UHFFFAOYSA-N 5-[2-amino-5-(4-chlorophenyl)-1,3-thiazol-4-yl]-n,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]pyridine-3-carboxamide Chemical compound CC=1N(C=2C=C(C=CC=2)C(F)(F)F)C(=O)C(C(=O)NC)=CC=1C=1N=C(N)SC=1C1=CC=C(Cl)C=C1 ALLZACDKHLHGPV-UHFFFAOYSA-N 0.000 claims 1
- QFKFSRSXKCLKOE-UHFFFAOYSA-N 5-[2-amino-5-(4-cyanophenyl)-1,3-thiazol-4-yl]-n,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]pyridine-3-carboxamide Chemical compound CC=1N(C=2C=C(C=CC=2)C(F)(F)F)C(=O)C(C(=O)NC)=CC=1C=1N=C(N)SC=1C1=CC=C(C#N)C=C1 QFKFSRSXKCLKOE-UHFFFAOYSA-N 0.000 claims 1
- JBDNBHUJCALBPG-UHFFFAOYSA-N 5-[3-(4-cyanophenyl)triazol-4-yl]-n,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]pyridine-3-carboxamide Chemical compound CC=1N(C=2C=C(C=CC=2)C(F)(F)F)C(=O)C(C(=O)NC)=CC=1C1=CN=NN1C1=CC=C(C#N)C=C1 JBDNBHUJCALBPG-UHFFFAOYSA-N 0.000 claims 1
- VMYAMXXMGCFFCI-UHFFFAOYSA-N 5-[4-(4-chlorophenyl)-1,3-oxazol-5-yl]-n,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]pyridine-3-carboxamide Chemical compound CC=1N(C=2C=C(C=CC=2)C(F)(F)F)C(=O)C(C(=O)NC)=CC=1C=1OC=NC=1C1=CC=C(Cl)C=C1 VMYAMXXMGCFFCI-UHFFFAOYSA-N 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000012038 nucleophile Substances 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical group OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79878606P | 2006-05-08 | 2006-05-08 | |
| PCT/SE2007/000441 WO2007129962A1 (en) | 2006-05-08 | 2007-05-07 | 2-pyridone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009536196A JP2009536196A (ja) | 2009-10-08 |
| JP2009536196A5 true JP2009536196A5 (enExample) | 2010-06-03 |
Family
ID=38667997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009509485A Withdrawn JP2009536196A (ja) | 2006-05-08 | 2007-05-07 | 好中球エラスターゼ活性の阻害が有益である疾患または状態の処置のための２−ピリドン誘導体 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7998984B2 (enExample) |
| EP (1) | EP2018375B1 (enExample) |
| JP (1) | JP2009536196A (enExample) |
| KR (1) | KR20090017573A (enExample) |
| CN (1) | CN101490033A (enExample) |
| AR (1) | AR060875A1 (enExample) |
| AT (1) | ATE459615T1 (enExample) |
| AU (1) | AU2007248950B2 (enExample) |
| BR (1) | BRPI0711357A2 (enExample) |
| CA (1) | CA2649813A1 (enExample) |
| CL (1) | CL2007001282A1 (enExample) |
| DE (1) | DE602007005120D1 (enExample) |
| ES (1) | ES2339607T3 (enExample) |
| IL (1) | IL194948A0 (enExample) |
| MX (1) | MX2008013836A (enExample) |
| NO (1) | NO20084872L (enExample) |
| TW (1) | TW200808763A (enExample) |
| UY (1) | UY30328A1 (enExample) |
| WO (1) | WO2007129962A1 (enExample) |
| ZA (1) | ZA200809024B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0302486D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| TW200808771A (en) * | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
| TW200808763A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds I |
| EP2066662B1 (en) * | 2006-09-21 | 2012-12-05 | Kyorin Pharmaceutical Co., Ltd. | Serine hydrolase inhibitors |
| DE102007031397A1 (de) | 2007-07-05 | 2009-01-08 | D2O Bioscience Group Ltd. | Verwendung von Deuteriumoxid zur Behandlung von Virus-basierten Erkrankungen der Haut |
| EA017297B1 (ru) * | 2007-11-06 | 2012-11-30 | Астразенека Аб | Некоторые производные 2-пиразинона и их применение в качестве ингибиторов нейтрофильной эластазы |
| EP2508189A3 (de) * | 2008-04-20 | 2012-11-07 | D2 Bioscience Group Ltd | Verwendung von Deuteriumoxid als Elastase-Inhibitor |
| DE102009003942A1 (de) * | 2009-01-07 | 2010-07-08 | D2O Biosience Group Ltd., Hamilton | Verwendung von Deuteriumoxid zur Behandlung Virus-basierter Erkrankungen des Auges |
| TW201036957A (en) * | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
| AR076590A1 (es) * | 2009-05-19 | 2011-06-22 | Vivia Biotech Sl | Metodos para proveer pruebas medicinales personalizada ex vivo para neoplasmas hematologicos |
| AU2010302420B2 (en) | 2009-10-02 | 2013-07-04 | Astrazeneca Ab | 2-pyridone compounds used as inhibitors of neutrophil elastase |
| DE102010030187A1 (de) | 2010-06-16 | 2011-12-22 | Bayer Schering Pharma Aktiengesellschaft | 4-Cyan-2-sulfonylphenyl)pyrazolyl-substituierte Pyridinone und Pyrazinone und ihre Verwendung |
| JP2013177318A (ja) * | 2010-06-30 | 2013-09-09 | Dainippon Sumitomo Pharma Co Ltd | ジヒドロピリミジノン誘導体およびその医薬用途 |
| EP2740728A4 (en) | 2011-08-01 | 2015-04-01 | Sumitomo Dainippon Pharma Co Ltd | URACIL DERIVATIVE AND ITS USE FOR MEDICAL PURPOSES |
| US20140057920A1 (en) | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| US20140057926A1 (en) | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| US9102624B2 (en) | 2012-08-23 | 2015-08-11 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| US9409870B2 (en) * | 2014-12-15 | 2016-08-09 | Chiesi Farmaceutici S.P.A. | Compounds |
| AR105875A1 (es) | 2015-09-02 | 2017-11-15 | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (Nº 2) LTD | Derivados de 2-oxo-1,2-dihidropiridina como inhibidores de bromodominio |
| CN106674098B (zh) * | 2016-12-23 | 2019-07-02 | 中国医科大学 | N-(3-氰基-4-烷氧基苯基)吡啶甲酰胺类化合物及其用途 |
| CN111683976B (zh) | 2018-02-05 | 2022-11-18 | 生物辐射实验室股份有限公司 | 具有阴离子交换-疏水混合模式配体的色谱树脂 |
| AU2020349353A1 (en) | 2019-09-17 | 2022-04-14 | Duke University | Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease |
| ES2962498T3 (es) | 2020-04-16 | 2024-03-19 | Mereo Biopharma 4 Ltd | Métodos que implican el inhibidor de elastasa de neutrófilos alvelestat para el tratamiento de enfermedades respiratorias mediadas por deficiencia de alfa-1 antitripsina |
| KR20240090272A (ko) | 2021-10-20 | 2024-06-21 | 메레오 바이오파마 4 리미티드 | 섬유화 치료에 사용하기 위한 호중구 엘라스테이스 억제제 |
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| CA1067079A (en) | 1976-07-22 | 1979-11-27 | Yamanouchi Pharmaceutical Co. | Nitrogen-containing heterobicyclic compounds |
| DE2706977A1 (de) | 1977-02-18 | 1978-08-24 | Hoechst Ag | Benzoesaeuren und deren derivate sowie verfahren zu ihrer herstellung |
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| SE0302324D0 (sv) | 2003-08-28 | 2003-08-28 | Astrazeneca Ab | Novel compounds |
| SE0302323D0 (sv) | 2003-08-28 | 2003-08-28 | Astrazeneca Ab | Novel compounds |
| SE0302487D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| SE0302486D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
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| JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
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| GB0605469D0 (en) | 2006-03-17 | 2006-04-26 | Argenta Discovery Ltd | Multimers of heterocyclic compounds and their use |
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| TW200808771A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
| TW200808763A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds I |
| WO2008030158A1 (en) | 2006-09-04 | 2008-03-13 | Astrazeneca Ab | Multimeric heterocyclic compounds useful as neutrophil elastase inhibitors |
| WO2008104752A1 (en) | 2007-02-26 | 2008-09-04 | Astrazeneca Ab | Dihydropyridones as elastase inhibitors |
| WO2009058076A1 (en) | 2007-11-02 | 2009-05-07 | Astrazeneca Ab | 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase |
| EA017297B1 (ru) | 2007-11-06 | 2012-11-30 | Астразенека Аб | Некоторые производные 2-пиразинона и их применение в качестве ингибиторов нейтрофильной эластазы |
| TW201036957A (en) | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
-
2007
- 2007-04-27 TW TW096115047A patent/TW200808763A/zh unknown
- 2007-05-07 WO PCT/SE2007/000441 patent/WO2007129962A1/en not_active Ceased
- 2007-05-07 AT AT07748105T patent/ATE459615T1/de not_active IP Right Cessation
- 2007-05-07 KR KR1020087029811A patent/KR20090017573A/ko not_active Ceased
- 2007-05-07 DE DE602007005120T patent/DE602007005120D1/de active Active
- 2007-05-07 US US12/299,879 patent/US7998984B2/en not_active Expired - Fee Related
- 2007-05-07 MX MX2008013836A patent/MX2008013836A/es active IP Right Grant
- 2007-05-07 JP JP2009509485A patent/JP2009536196A/ja not_active Withdrawn
- 2007-05-07 CA CA002649813A patent/CA2649813A1/en not_active Abandoned
- 2007-05-07 EP EP07748105A patent/EP2018375B1/en active Active
- 2007-05-07 CN CNA2007800259071A patent/CN101490033A/zh active Pending
- 2007-05-07 AU AU2007248950A patent/AU2007248950B2/en not_active Ceased
- 2007-05-07 CL CL2007001282A patent/CL2007001282A1/es unknown
- 2007-05-07 BR BRPI0711357-9A patent/BRPI0711357A2/pt not_active IP Right Cessation
- 2007-05-07 ES ES07748105T patent/ES2339607T3/es active Active
- 2007-05-07 UY UY30328A patent/UY30328A1/es not_active Application Discontinuation
- 2007-05-08 AR ARP070101994A patent/AR060875A1/es unknown
-
2008
- 2008-10-21 ZA ZA200809024A patent/ZA200809024B/xx unknown
- 2008-10-27 IL IL194948A patent/IL194948A0/en unknown
- 2008-11-19 NO NO20084872A patent/NO20084872L/no not_active Application Discontinuation
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