JP2015517580A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015517580A5 JP2015517580A5 JP2015514233A JP2015514233A JP2015517580A5 JP 2015517580 A5 JP2015517580 A5 JP 2015517580A5 JP 2015514233 A JP2015514233 A JP 2015514233A JP 2015514233 A JP2015514233 A JP 2015514233A JP 2015517580 A5 JP2015517580 A5 JP 2015517580A5
- Authority
- JP
- Japan
- Prior art keywords
- fluorophenyl
- pyrazolo
- methanone
- hexahydro
- sulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261651669P | 2012-05-25 | 2012-05-25 | |
| US61/651,669 | 2012-05-25 | ||
| US201261691083P | 2012-08-20 | 2012-08-20 | |
| US61/691,083 | 2012-08-20 | ||
| US201261715907P | 2012-10-19 | 2012-10-19 | |
| US61/715,907 | 2012-10-19 | ||
| US201361759520P | 2013-02-01 | 2013-02-01 | |
| US61/759,520 | 2013-02-01 | ||
| US201361781629P | 2013-03-14 | 2013-03-14 | |
| US61/781,629 | 2013-03-14 | ||
| PCT/US2013/042732 WO2013177559A2 (en) | 2012-05-25 | 2013-05-24 | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015517580A JP2015517580A (ja) | 2015-06-22 |
| JP2015517580A5 true JP2015517580A5 (enExample) | 2016-06-23 |
| JP6172871B2 JP6172871B2 (ja) | 2017-08-02 |
Family
ID=49624542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015514233A Active JP6172871B2 (ja) | 2012-05-25 | 2013-05-24 | ヘテロアリール‐ケトン縮合アザデカリン糖質コルチコイドレセプター調節因子 |
Country Status (24)
| Country | Link |
|---|---|
| EP (6) | EP2854814B1 (enExample) |
| JP (1) | JP6172871B2 (enExample) |
| KR (1) | KR102062640B1 (enExample) |
| CN (1) | CN104619328B (enExample) |
| AU (1) | AU2013266110C1 (enExample) |
| BR (1) | BR112014028857B1 (enExample) |
| CA (1) | CA2872260C (enExample) |
| CL (1) | CL2014003173A1 (enExample) |
| DK (5) | DK3590517T3 (enExample) |
| ES (5) | ES2995026T3 (enExample) |
| FI (1) | FI4119561T3 (enExample) |
| HK (1) | HK1250014B (enExample) |
| IL (1) | IL235868A (enExample) |
| MX (1) | MX365423B (enExample) |
| MY (1) | MY172739A (enExample) |
| NZ (1) | NZ701469A (enExample) |
| PE (1) | PE20150352A1 (enExample) |
| PH (1) | PH12014502584A1 (enExample) |
| PL (5) | PL3338781T3 (enExample) |
| PT (5) | PT3338781T (enExample) |
| RU (1) | RU2639867C2 (enExample) |
| SG (1) | SG11201407682TA (enExample) |
| WO (1) | WO2013177559A2 (enExample) |
| ZA (1) | ZA201408182B (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| US12226412B2 (en) | 2012-05-25 | 2025-02-18 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| EP4219494B1 (en) | 2013-11-25 | 2026-03-25 | Corcept Therapeutics Incorporated | Octahydro fused azadecalin glucocorticoid receptor modulators |
| WO2016140867A1 (en) * | 2015-03-02 | 2016-09-09 | Corcept Therapeutics, Inc. | Use of glucocorticoid receptor antagonist and somatostatin analogues to treat acth-secreting tumors |
| US10610534B2 (en) * | 2015-03-30 | 2020-04-07 | Corcept Therapeutics, Inc. | Use of glucocorticoid receptor antagonists in combination with glucocorticoids to treat adrenal insufficiency |
| CA2984623C (en) | 2015-05-18 | 2023-05-02 | Corcept Therapeutics, Inc. | Methods for diagnosing and assessing treatment for cushing's syndrome |
| KR20180052120A (ko) | 2015-08-13 | 2018-05-17 | 코어셉트 쎄라퓨틱스, 잉크. | Acth-의존성 쿠싱 증후군을 감별 진단하는 방법 |
| MX390517B (es) * | 2016-03-01 | 2025-03-20 | Corcept Therapeutics Inc | Uso de moduladores del receptor de glucocorticoides para potenciar inhibidores de puntos de regulacion. |
| US9943505B2 (en) | 2016-09-09 | 2018-04-17 | Corcept Therapeutics, Inc. | Glucocorticoid receptor modulators to treat pancreatic cancer |
| SG11201908790PA (en) | 2017-03-31 | 2019-10-30 | Corcept Therapeutics Inc | Glucocorticoid receptor modulators to treat cervical cancer |
| MX393313B (es) | 2017-06-20 | 2025-03-24 | Corcept Therapeutics Inc | Metodos de tratamiento de tumores neuroepiteliales usando moduladores selectivos del receptor de glucocorticoide. |
| CN112004803B (zh) * | 2018-04-23 | 2023-11-03 | 科赛普特治疗公司 | 区域选择的n-烷基三唑的制备方法 |
| BR112021008719A2 (pt) * | 2018-11-09 | 2021-08-03 | Corcept Therapeutics, Inc. | método para reduzir o tamanho de um tumor pituitário visível em um paciente |
| AU2019404026B2 (en) * | 2018-12-19 | 2023-06-08 | Corcept Therapeutics Incorporated | Pharmaceutical formulations containing relacorilant, a heteroaryl-ketone fused azadecalin compound |
| US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| WO2020132046A1 (en) | 2018-12-19 | 2020-06-25 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
| WO2020132171A1 (en) * | 2018-12-20 | 2020-06-25 | Corcept Therapeutics Incorporated | Methods for imaging and treatment of somatostatin-receptor positive tumors |
| CA3131263C (en) * | 2019-02-22 | 2024-01-02 | Corcept Therapeutics Incorporated | Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator |
| CN114650820A (zh) * | 2019-10-16 | 2022-06-21 | 科赛普特治疗学股份有限公司 | 通过选择性糖皮质激素受体拮抗剂使癌症患者的中性粒细胞对淋巴细胞比例正常化的方法 |
| US11903945B2 (en) | 2019-12-11 | 2024-02-20 | Corcept Therapeutics Incorporated | Methods of treating antipsychotic-induced weight gain with miricorilant |
| WO2021127376A1 (en) | 2019-12-21 | 2021-06-24 | Corcept Therapeutics Incorporated | Treatment of, and differential diagnosis between, acth-dependent cushing's syndrome and acth-independent cushing's syndrome |
| EP4103180A4 (en) * | 2020-02-10 | 2024-03-13 | Corcept Therapeutics Incorporated | METHOD FOR STIMULATING AN ANTI-TUMOR RESPONSE USING A SELECTIVE GLUCOCORTICOID RECEPTOR MODULATOR |
| CN115916202A (zh) | 2020-05-27 | 2023-04-04 | 科赛普特治疗学股份有限公司 | 糖皮质激素受体调节剂瑞拉可兰和cyp2c9底物的并行给药 |
| KR20230017829A (ko) | 2020-05-27 | 2023-02-06 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 글루코코르티코이드 수용체 조절제 렐라코릴란트 및 cyp2c8과 cyp3a4의 이중 기질인 파클리탁셀의 병용 투여 |
| WO2022134033A1 (en) * | 2020-12-25 | 2022-06-30 | Corcept Therapeutics Incorporated | Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| WO2022166810A1 (zh) * | 2021-02-03 | 2022-08-11 | 江苏恒瑞医药股份有限公司 | 稠合的氮杂三环类衍生物、其制备方法及其在医药上的应用 |
| CN114907340A (zh) * | 2021-02-09 | 2022-08-16 | 江苏恒瑞医药股份有限公司 | 稠合的氮杂三环类衍生物、其制备方法及其在医药上的应用 |
| CN114907349A (zh) * | 2021-02-10 | 2022-08-16 | 江苏恒瑞医药股份有限公司 | 稠合的氮杂三环类衍生物、其制备方法及其在医药上的应用 |
| US12616698B2 (en) | 2021-05-05 | 2026-05-05 | Corcept Therapeutics Incorporated | Methods for reducing liver fat and for treating fatty liver disorders |
| CN117510490A (zh) * | 2022-08-03 | 2024-02-06 | 江苏恒瑞医药股份有限公司 | 一种稠合氮杂萘烷类衍生物的晶型及其制备方法 |
| WO2024077169A1 (en) * | 2022-10-06 | 2024-04-11 | Corcept Therapeutics Incorporated | Formulations of glucocorticoid receptor modulators |
| US12433882B2 (en) | 2022-10-28 | 2025-10-07 | Corcept Therapeutics Incorporated | Treatments for amyotrophic lateral sclerosis using dazucorilant |
| WO2024173745A1 (en) * | 2023-02-17 | 2024-08-22 | Corcept Therapeutics Incorporated | Methods and compositions for treating huntington's disease and its symptoms |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4391904A (en) | 1979-12-26 | 1983-07-05 | Syva Company | Test strip kits in immunoassays and compositions therein |
| GB8828669D0 (en) | 1988-12-08 | 1989-01-11 | Lilly Industries Ltd | Organic compounds |
| AU2005222421B2 (en) | 2004-03-09 | 2010-09-23 | Corcept Therapeutics, Inc. | Fused ring azadecalin glucocorticoid receptor modulators |
| US7640389B2 (en) | 2006-02-28 | 2009-12-29 | Freescale Semiconductor, Inc. | Non-volatile memory having a multiple block erase mode and method therefor |
| EP1932843A1 (en) * | 2006-12-14 | 2008-06-18 | sanofi-aventis | Sulfonyl-phenyl-2H-(1,2,4) oxadiazole-5-one derivatives, processes for their preparation and their use as pharmaceuticals |
| MX2013002186A (es) * | 2010-08-27 | 2013-06-28 | Corcept Therapeutics Inc | Moduladores de azadecalina de piridil-amina fusionada. |
-
2013
- 2013-05-24 PT PT181542564T patent/PT3338781T/pt unknown
- 2013-05-24 PE PE2014002054A patent/PE20150352A1/es active IP Right Grant
- 2013-05-24 EP EP13793417.0A patent/EP2854814B1/en active Active
- 2013-05-24 PT PT211546650T patent/PT3851107T/pt unknown
- 2013-05-24 ES ES22193438T patent/ES2995026T3/es active Active
- 2013-05-24 EP EP18154256.4A patent/EP3338781B1/en active Active
- 2013-05-24 ES ES19188885T patent/ES2873949T3/es active Active
- 2013-05-24 MX MX2014014239A patent/MX365423B/es active IP Right Grant
- 2013-05-24 MY MYPI2014003289A patent/MY172739A/en unknown
- 2013-05-24 DK DK19188885.8T patent/DK3590517T3/da active
- 2013-05-24 EP EP24192650.0A patent/EP4434584A3/en active Pending
- 2013-05-24 PT PT221934383T patent/PT4119561T/pt unknown
- 2013-05-24 EP EP21154665.0A patent/EP3851107B1/en active Active
- 2013-05-24 PL PL18154256T patent/PL3338781T3/pl unknown
- 2013-05-24 CN CN201380039218.1A patent/CN104619328B/zh active Active
- 2013-05-24 ES ES18154256T patent/ES2753816T3/es active Active
- 2013-05-24 DK DK13793417.0T patent/DK2854814T3/en active
- 2013-05-24 NZ NZ701469A patent/NZ701469A/en unknown
- 2013-05-24 PL PL22193438.3T patent/PL4119561T3/pl unknown
- 2013-05-24 WO PCT/US2013/042732 patent/WO2013177559A2/en not_active Ceased
- 2013-05-24 BR BR112014028857-7A patent/BR112014028857B1/pt active IP Right Grant
- 2013-05-24 AU AU2013266110A patent/AU2013266110C1/en active Active
- 2013-05-24 CA CA2872260A patent/CA2872260C/en active Active
- 2013-05-24 DK DK22193438.3T patent/DK4119561T3/da active
- 2013-05-24 PL PL21154665.0T patent/PL3851107T3/pl unknown
- 2013-05-24 ES ES21154665T patent/ES2930298T3/es active Active
- 2013-05-24 DK DK21154665.0T patent/DK3851107T3/da active
- 2013-05-24 ES ES13793417.0T patent/ES2665338T3/es active Active
- 2013-05-24 RU RU2014152625A patent/RU2639867C2/ru active
- 2013-05-24 PL PL19188885T patent/PL3590517T3/pl unknown
- 2013-05-24 PT PT191888858T patent/PT3590517T/pt unknown
- 2013-05-24 PL PL13793417T patent/PL2854814T3/pl unknown
- 2013-05-24 EP EP22193438.3A patent/EP4119561B1/en active Active
- 2013-05-24 EP EP19188885.8A patent/EP3590517B1/en active Active
- 2013-05-24 SG SG11201407682TA patent/SG11201407682TA/en unknown
- 2013-05-24 PT PT137934170T patent/PT2854814T/pt unknown
- 2013-05-24 FI FIEP22193438.3T patent/FI4119561T3/fi active
- 2013-05-24 JP JP2015514233A patent/JP6172871B2/ja active Active
- 2013-05-24 KR KR1020147036405A patent/KR102062640B1/ko active Active
- 2013-05-24 DK DK18154256T patent/DK3338781T3/da active
-
2014
- 2014-11-10 ZA ZA2014/08182A patent/ZA201408182B/en unknown
- 2014-11-19 PH PH12014502584A patent/PH12014502584A1/en unknown
- 2014-11-21 CL CL2014003173A patent/CL2014003173A1/es unknown
- 2014-11-23 IL IL235868A patent/IL235868A/en active IP Right Grant
-
2018
- 2018-07-23 HK HK18109510.2A patent/HK1250014B/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2014152625A (ru) | Конденсированные с гетероарилкетонами азадекалины - модуляторы глюкокортикоидных рецепторов | |
| JP2010533158A5 (enExample) | ||
| JP2008501673A5 (enExample) | ||
| JP2018535999A5 (enExample) | ||
| RU2018143324A (ru) | Применение 1H-пиразоло[4,3-b]пиридинов в качестве ингибиторов PDE1 | |
| JP2007523905A5 (enExample) | ||
| JP2007523142A5 (enExample) | ||
| JP2009536196A5 (enExample) | ||
| EP2736904B1 (en) | Oxazole and thiazole derivatives as selective protein kinase inhibitors (c-kit) | |
| JP2006503009A5 (enExample) | ||
| CA2747419A1 (en) | Sulfonamide derivatives | |
| IL196129A (en) | Human protein tyrosine phosphatase inhibitors, compositions comprising such compounds and uses thereof in the preparation of medicaments for regulating angiogenesis | |
| RU2004121029A (ru) | Производные пиримидина в качестве модуляторов рецептора инсулинподобного фактора роста 1 (igf-1) | |
| JP2007519735A5 (enExample) | ||
| HRP20191327T1 (hr) | 4-hidroksi-3-(heteroaril)piridin-2-on apj agonisti za primjenju u liječenju kardiovaskularnih poremećaja | |
| JP2014518214A5 (enExample) | ||
| RU2015132181A (ru) | Фтор-[1,3]-оксазины в качестве ингибиторов васе1 | |
| RU2005106844A (ru) | [1,2,4]оксодиазолы (варианты), способ их получения, и фармацевтическая композиция и способ (варианты) ингибирования активации метаботропных глютаматных рецепторов-5 | |
| HRP20211960T1 (hr) | Alosterični modulatori nikotinskih acetilcolinskih receptora | |
| JP2017532364A5 (enExample) | ||
| JP2017500364A5 (enExample) | ||
| JP2019516737A5 (enExample) | ||
| JP2017508766A5 (enExample) | ||
| JP2014523400A5 (enExample) | ||
| RU2017118562A (ru) | Соединения-антагонисты дофаминового d3-рецептора |