DK2854814T3 - Heteroberl ketone condensed azadecaline as modulators of glucocorticoid receptors - Google Patents

Heteroberl ketone condensed azadecaline as modulators of glucocorticoid receptors Download PDF

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Publication number
DK2854814T3
DK2854814T3 DK13793417.0T DK13793417T DK2854814T3 DK 2854814 T3 DK2854814 T3 DK 2854814T3 DK 13793417 T DK13793417 T DK 13793417T DK 2854814 T3 DK2854814 T3 DK 2854814T3
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Prior art keywords
fluorophenyl
hexahydro
methanone
sulfonyl
isoquinolin
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DK13793417.0T
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Danish (da)
English (en)
Inventor
Hazel Hunt
Tony Johnson
Nicholas Ray
Iain Walters
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Corcept Therapeutics Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53831,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Electroluminescent Light Sources (AREA)
DK13793417.0T 2012-05-25 2013-05-24 Heteroberl ketone condensed azadecaline as modulators of glucocorticoid receptors DK2854814T3 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201261651669P 2012-05-25 2012-05-25
US201261691083P 2012-08-20 2012-08-20
US201261715907P 2012-10-19 2012-10-19
US201361759520P 2013-02-01 2013-02-01
US201361781629P 2013-03-14 2013-03-14
PCT/US2013/042732 WO2013177559A2 (en) 2012-05-25 2013-05-24 Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators

Publications (1)

Publication Number Publication Date
DK2854814T3 true DK2854814T3 (en) 2018-03-12

Family

ID=49624542

Family Applications (5)

Application Number Title Priority Date Filing Date
DK13793417.0T DK2854814T3 (en) 2012-05-25 2013-05-24 Heteroberl ketone condensed azadecaline as modulators of glucocorticoid receptors
DK21154665.0T DK3851107T3 (da) 2012-05-25 2013-05-24 Heteroaryl-ketonkondenseret azadecalin som glucocorticoidreceptormodulatorer
DK18154256T DK3338781T3 (da) 2012-05-25 2013-05-24 Heteroaryl-keton-kondenseret azadecalin som modulatorer af glucocorticoidreceptorer
DK22193438.3T DK4119561T3 (da) 2012-05-25 2013-05-24 Heteroaryl-ketonkondenserede azadecalin-glucocorticoidreceptormodulatorer
DK19188885.8T DK3590517T3 (da) 2012-05-25 2013-05-24 Heteroaryl-ketonkondenserede azadecalin som modulatorer af glucocorticoidreceptorer

Family Applications After (4)

Application Number Title Priority Date Filing Date
DK21154665.0T DK3851107T3 (da) 2012-05-25 2013-05-24 Heteroaryl-ketonkondenseret azadecalin som glucocorticoidreceptormodulatorer
DK18154256T DK3338781T3 (da) 2012-05-25 2013-05-24 Heteroaryl-keton-kondenseret azadecalin som modulatorer af glucocorticoidreceptorer
DK22193438.3T DK4119561T3 (da) 2012-05-25 2013-05-24 Heteroaryl-ketonkondenserede azadecalin-glucocorticoidreceptormodulatorer
DK19188885.8T DK3590517T3 (da) 2012-05-25 2013-05-24 Heteroaryl-ketonkondenserede azadecalin som modulatorer af glucocorticoidreceptorer

Country Status (24)

Country Link
EP (6) EP2854814B1 (enExample)
JP (1) JP6172871B2 (enExample)
KR (1) KR102062640B1 (enExample)
CN (1) CN104619328B (enExample)
AU (1) AU2013266110C1 (enExample)
BR (1) BR112014028857B1 (enExample)
CA (1) CA2872260C (enExample)
CL (1) CL2014003173A1 (enExample)
DK (5) DK2854814T3 (enExample)
ES (5) ES2665338T3 (enExample)
FI (1) FI4119561T3 (enExample)
HK (1) HK1250014B (enExample)
IL (1) IL235868A (enExample)
MX (1) MX365423B (enExample)
MY (1) MY172739A (enExample)
NZ (1) NZ701469A (enExample)
PE (1) PE20150352A1 (enExample)
PH (1) PH12014502584A1 (enExample)
PL (5) PL4119561T3 (enExample)
PT (5) PT2854814T (enExample)
RU (1) RU2639867C2 (enExample)
SG (1) SG11201407682TA (enExample)
WO (1) WO2013177559A2 (enExample)
ZA (1) ZA201408182B (enExample)

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US8859774B2 (en) 2012-05-25 2014-10-14 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
US12226412B2 (en) 2012-05-25 2025-02-18 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
US10047082B2 (en) * 2013-11-25 2018-08-14 Corcept Therapeutics, Inc. Octahydro fused azadecalin glucocorticoid receptor modulators
EP3265127B1 (en) * 2015-03-02 2024-02-21 Corcept Therapeutics, Inc. Mifepristone and octreotide for use in the treatment of cushing's syndrome in a patient having an adrenocorticotropic hormone (acth)-secreting pancreatic neuroendocrine tumor
US10610534B2 (en) * 2015-03-30 2020-04-07 Corcept Therapeutics, Inc. Use of glucocorticoid receptor antagonists in combination with glucocorticoids to treat adrenal insufficiency
KR102876869B1 (ko) 2015-05-18 2025-10-27 코어셉트 쎄라퓨틱스 인코포레이티드 쿠싱 증후군을 진단하고 이에 대한 치료를 평가하는 방법
ES2865334T3 (es) 2015-08-13 2021-10-15 Corcept Therapeutics Inc Método de diagnóstico diferencial de síndrome de Cushing dependiente de ACTH
IL297201A (en) * 2016-03-01 2022-12-01 Corcept Therapeutics Inc Use of glucocorticoid receptor modulators to increase the activity of checkpoint inhibitors
US9943505B2 (en) 2016-09-09 2018-04-17 Corcept Therapeutics, Inc. Glucocorticoid receptor modulators to treat pancreatic cancer
UA127409C2 (uk) 2017-03-31 2023-08-16 Корцепт Терап'Ютікс, Інк. Модулятори глюкокортикоїдного рецептора для лікування раку шийки матки
ES3043682T3 (en) 2017-06-20 2025-11-25 Corcept Therapeutics Inc Treatment of neuroepithelial tumors using selective glucocorticoid receptor modulators
IL278125B (en) * 2018-04-23 2022-09-01 Corcept Therapeutics Inc Methods for the preparation of regioselective n-alkyl triazoles
AU2019377864B2 (en) 2018-11-09 2023-03-16 Corcept Therapeutics Incorporated Methods for shrinking pituitary tumors
WO2020132046A1 (en) 2018-12-19 2020-06-25 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
IL284061B2 (en) 2018-12-19 2025-02-01 Corcept Therapeutics Inc A preparation containing a relaxant
US11234971B2 (en) 2018-12-19 2022-02-01 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
KR102832262B1 (ko) * 2018-12-20 2025-07-10 코어셉트 쎄라퓨틱스 인코포레이티드 소마토스타틴 수용체 양성 종양의 영상화 및 치료 방법
CN113490496A (zh) * 2019-02-22 2021-10-08 科赛普特治疗学股份有限公司 一种杂芳基-酮稠合氮杂萘烷糖皮质激素受体调节剂瑞拉可兰的治疗用途
KR102845522B1 (ko) 2019-10-16 2025-08-12 코어셉트 쎄라퓨틱스 인코포레이티드 선택적 글루코코르티코이드 수용체 길항제로 암 환자의 호중구 대 림프구 비율을 정상화시키는 방법
AU2020400061B2 (en) 2019-12-11 2025-02-13 Corcept Therapeutics Incorporated Methods of treating antipsychotic-induced weight gain with miricorilant
WO2021127376A1 (en) 2019-12-21 2021-06-24 Corcept Therapeutics Incorporated Treatment of, and differential diagnosis between, acth-dependent cushing's syndrome and acth-independent cushing's syndrome
MX2022009781A (es) * 2020-02-10 2022-09-09 Corcept Therapeutics Inc Metodos para estimular una respuesta antitumoral utilizando un modulador selectivo del receptor de glucocorticoides.
WO2022134033A1 (en) * 2020-12-25 2022-06-30 Corcept Therapeutics Incorporated Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
CN116829556A (zh) * 2021-02-03 2023-09-29 江苏恒瑞医药股份有限公司 稠合的氮杂三环类衍生物、其制备方法及其在医药上的应用
WO2024077169A1 (en) * 2022-10-06 2024-04-11 Corcept Therapeutics Incorporated Formulations of glucocorticoid receptor modulators
KR20250102046A (ko) 2022-10-28 2025-07-04 코어셉트 쎄라퓨틱스 인코포레이티드 다주코릴란트를 이용한 근위축성 측삭경화증의 치료
US20250360125A1 (en) * 2023-02-17 2025-11-27 Corcept Therapeutics Incorporated Methods and compositions for treating huntington's disease and its symptoms

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CA2806900A1 (en) * 2010-08-27 2012-03-01 Corcept Therapeutics, Inc. Pyridyl-amine fused azadecalin modulators

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JP6172871B2 (ja) 2017-08-02
MY172739A (en) 2019-12-11
AU2013266110C1 (en) 2018-07-12
KR102062640B1 (ko) 2020-01-06
JP2015517580A (ja) 2015-06-22
WO2013177559A2 (en) 2013-11-28
DK3590517T3 (da) 2021-05-03
PH12014502584B1 (en) 2015-01-21
EP4434584A3 (en) 2024-11-20
RU2014152625A (ru) 2016-07-20
PT3851107T (pt) 2022-10-28
WO2013177559A3 (en) 2014-01-16
EP4119561B1 (en) 2024-09-11
EP4434584A2 (en) 2024-09-25
ES2995026T3 (en) 2025-02-05
PL3338781T3 (pl) 2020-03-31
EP3851107A1 (en) 2021-07-21
NZ701469A (en) 2017-06-30
ES2753816T3 (es) 2020-04-14
PT3338781T (pt) 2019-11-29
EP3338781B1 (en) 2019-09-11
PE20150352A1 (es) 2015-03-16
HK1208818A1 (en) 2016-03-18
IL235868A0 (en) 2015-01-29
CA2872260C (en) 2020-12-22
IL235868A (en) 2017-12-31
MX2014014239A (es) 2015-08-05
PH12014502584A1 (en) 2015-01-21
RU2639867C2 (ru) 2017-12-25
CN104619328A (zh) 2015-05-13
EP2854814A2 (en) 2015-04-08
CN104619328B (zh) 2018-10-02
DK3338781T3 (da) 2019-12-09
PT3590517T (pt) 2021-04-07
PL3851107T3 (pl) 2023-03-06
PL4119561T3 (pl) 2024-11-25
AU2013266110B2 (en) 2017-04-20
CA2872260A1 (en) 2013-11-28
KR20150021955A (ko) 2015-03-03
SG11201407682TA (en) 2014-12-30
EP3338781A1 (en) 2018-06-27
EP2854814B1 (en) 2018-01-31
ES2873949T3 (es) 2021-11-04
ES2930298T3 (es) 2022-12-09
PL3590517T3 (pl) 2021-09-20
EP2854814A4 (en) 2016-01-27
FI4119561T3 (fi) 2024-11-01
PT4119561T (pt) 2024-09-30
CL2014003173A1 (es) 2015-02-27
MX365423B (es) 2019-06-03
BR112014028857A2 (pt) 2017-08-15
PT2854814T (pt) 2018-03-15
HK1250014B (en) 2020-06-12
EP3590517A1 (en) 2020-01-08
EP4119561A1 (en) 2023-01-18
DK4119561T3 (da) 2024-09-30
PL2854814T3 (pl) 2018-07-31
EP3851107B1 (en) 2022-10-19
DK3851107T3 (da) 2022-11-21
EP3590517B1 (en) 2021-03-17
AU2013266110A1 (en) 2014-11-20
ES2665338T3 (es) 2018-04-25
BR112014028857B1 (pt) 2021-09-28
ZA201408182B (en) 2017-09-27

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