JP2015533157A5 - - Google Patents

Info

Publication number

JP2015533157A5

JP2015533157A5 JP2015536264A JP2015536264A JP2015533157A5 JP 2015533157 A5 JP2015533157 A5 JP 2015533157A5 JP 2015536264 A JP2015536264 A JP 2015536264A JP 2015536264 A JP2015536264 A JP 2015536264A JP 2015533157 A5 JP2015533157 A5 JP 2015533157A5

Authority

JP

Japan

Prior art keywords

phenyl

triazol

methanone

pyrrolidin

methyl

Prior art date

2013-10-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• -1 benzo [1,3] dioxolyl group Chemical group 0.000 claims 42
• 125000001424 substituent group Chemical group 0.000 claims 31
• 125000000217 alkyl group Chemical group 0.000 claims 28
• 150000001875 compounds Chemical class 0.000 claims 18
• 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 15
• 150000003839 salts Chemical class 0.000 claims 15
• 229910052736 halogen Inorganic materials 0.000 claims 13
• 150000002367 halogens Chemical class 0.000 claims 13
• 125000001072 heteroaryl group Chemical group 0.000 claims 12
• 125000003709 fluoroalkyl group Chemical group 0.000 claims 11
• 125000004428 fluoroalkoxy group Chemical group 0.000 claims 10
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
• 125000004093 cyano group Chemical group *C#N 0.000 claims 8
• 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
• 125000000753 cycloalkyl group Chemical group 0.000 claims 5
• 125000001153 fluoro group Chemical group F* 0.000 claims 5
• 125000003545 alkoxy group Chemical group 0.000 claims 4
• ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 4
• 125000005842 heteroatom Chemical group 0.000 claims 4
• 229910052757 nitrogen Inorganic materials 0.000 claims 4
• 125000005549 heteroarylene group Chemical group 0.000 claims 3
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
• 208000019901 Anxiety disease Diseases 0.000 claims 2
• RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 2
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
• KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 claims 2
• 239000004480 active ingredient Substances 0.000 claims 2
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
• 235000010290 biphenyl Nutrition 0.000 claims 2
• 229910052799 carbon Inorganic materials 0.000 claims 2
• 125000004432 carbon atom Chemical group C* 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000035475 disorder Diseases 0.000 claims 2
• 229910052739 hydrogen Inorganic materials 0.000 claims 2
• 239000001257 hydrogen Substances 0.000 claims 2
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
• 229910052760 oxygen Inorganic materials 0.000 claims 2
• 239000001301 oxygen Substances 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• 125000003226 pyrazolyl group Chemical group 0.000 claims 2
• 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
• 208000019116 sleep disease Diseases 0.000 claims 2
• 208000020685 sleep-wake disease Diseases 0.000 claims 2
• 229910052717 sulfur Inorganic materials 0.000 claims 2
• 239000011593 sulfur Substances 0.000 claims 2
• 125000001425 triazolyl group Chemical group 0.000 claims 2
• AQBWFIUDEKGTJW-IBGZPJMESA-N (4,5-dimethyl-2-pyrazol-1-ylphenyl)-[(2s)-2-[3-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]methanone Chemical compound N=1OC([C@@H]2CCCN2C(=O)C=2C=C(C(=CC=2N2N=CC=C2)C)C)=NC=1C1=CC=CC=C1OC(F)(F)F AQBWFIUDEKGTJW-IBGZPJMESA-N 0.000 claims 1
• KFAYFXBNCHFRIM-QFIPXVFZSA-N (5-methoxy-2-phenylphenyl)-[(2s)-2-[3-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]methanone Chemical compound N1([C@@H](CCC1)C=1ON=C(N=1)C=1C(=CC=CC=1)OC(F)(F)F)C(=O)C1=CC(OC)=CC=C1C1=CC=CC=C1 KFAYFXBNCHFRIM-QFIPXVFZSA-N 0.000 claims 1
• JJLSTITYUOAKRB-QFIPXVFZSA-N (5-methyl-2-phenylphenyl)-[(2s)-2-[3-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]methanone Chemical compound N1([C@@H](CCC1)C=1ON=C(N=1)C=1C(=CC=CC=1)OC(F)(F)F)C(=O)C1=CC(C)=CC=C1C1=CC=CC=C1 JJLSTITYUOAKRB-QFIPXVFZSA-N 0.000 claims 1
• HRQHDSAGTVVGDG-IBGZPJMESA-N (5-methyl-2-pyrazol-1-ylphenyl)-[(2s)-2-[3-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]methanone Chemical compound N=1OC([C@@H]2CCCN2C(=O)C=2C(=CC=C(C=2)C)N2N=CC=C2)=NC=1C1=CC=CC=C1OC(F)(F)F HRQHDSAGTVVGDG-IBGZPJMESA-N 0.000 claims 1
• SFMKLYCXWKPTSF-NRFANRHFSA-N (5-methyl-2-pyridin-2-ylphenyl)-[(2s)-2-[3-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]methanone Chemical compound N1([C@@H](CCC1)C=1ON=C(N=1)C=1C(=CC=CC=1)OC(F)(F)F)C(=O)C1=CC(C)=CC=C1C1=CC=CC=N1 SFMKLYCXWKPTSF-NRFANRHFSA-N 0.000 claims 1
• 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
• 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims 1
• 208000027559 Appetite disease Diseases 0.000 claims 1
• WNOBZVLDCLHESG-QFIPXVFZSA-N C(C)OC1=C(C=CC=C1)C1=CN=C(N1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)C)N1N=CC=N1 Chemical compound C(C)OC1=C(C=CC=C1)C1=CN=C(N1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)C)N1N=CC=N1 WNOBZVLDCLHESG-QFIPXVFZSA-N 0.000 claims 1
• SHWGJZBKQDDROG-SFHVURJKSA-N C(C)OC1=C(C=CC=C1F)C1=NC(=NO1)[C@H]1N(CCC1)C(=O)C1=C(C=C(C(=C1)OC)F)N1N=CC=N1 Chemical compound C(C)OC1=C(C=CC=C1F)C1=NC(=NO1)[C@H]1N(CCC1)C(=O)C1=C(C=C(C(=C1)OC)F)N1N=CC=N1 SHWGJZBKQDDROG-SFHVURJKSA-N 0.000 claims 1
• XYHCBJMEXWMNOV-KRWDZBQOSA-N C(C)OC1=NC=CC=C1C1=NC(=NO1)[C@H]1N(CCC1)C(=O)C1=C(C=C(C(=C1)OC)F)N1N=CC=N1 Chemical compound C(C)OC1=NC=CC=C1C1=NC(=NO1)[C@H]1N(CCC1)C(=O)C1=C(C=C(C(=C1)OC)F)N1N=CC=N1 XYHCBJMEXWMNOV-KRWDZBQOSA-N 0.000 claims 1
• RNKHDMIFBGJSRQ-SFHVURJKSA-N C(C)OC1=NC=CC=C1C1=NOC(=N1)[C@H]1N(CCC1)C(=O)C1=C(C=C(C=C1)C)N1N=CC=N1 Chemical compound C(C)OC1=NC=CC=C1C1=NOC(=N1)[C@H]1N(CCC1)C(=O)C1=C(C=C(C=C1)C)N1N=CC=N1 RNKHDMIFBGJSRQ-SFHVURJKSA-N 0.000 claims 1
• GRTBTKHDHJBIBE-IBGZPJMESA-N C(C)OC1=NC=CC=C1C=1NC(=NN1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)C)N1N=CC=N1 Chemical compound C(C)OC1=NC=CC=C1C=1NC(=NN1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)C)N1N=CC=N1 GRTBTKHDHJBIBE-IBGZPJMESA-N 0.000 claims 1
• 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 1
• IWZYKLXJSHEIAN-KRWDZBQOSA-N CC1=CC(=C(C=C1)C(=O)N1[C@@H](CCC1)C1=NN=C(N1)C1=C(C=CC=C1)OC(F)(F)F)N1N=CC=N1 Chemical compound CC1=CC(=C(C=C1)C(=O)N1[C@@H](CCC1)C1=NN=C(N1)C1=C(C=CC=C1)OC(F)(F)F)N1N=CC=N1 IWZYKLXJSHEIAN-KRWDZBQOSA-N 0.000 claims 1
• WLJCQLXKJHJGOS-IBGZPJMESA-N CC1=CC(=C(C=C1)C(=O)N1[C@@H](CCC1)C1=NOC(=C1)C1=C(C=CC=C1)OC(F)(F)F)N1N=CC=N1 Chemical compound CC1=CC(=C(C=C1)C(=O)N1[C@@H](CCC1)C1=NOC(=C1)C1=C(C=CC=C1)OC(F)(F)F)N1N=CC=N1 WLJCQLXKJHJGOS-IBGZPJMESA-N 0.000 claims 1
• ZFBTXWPCJCOJHZ-IBGZPJMESA-N CC1=CC(=C(C=C1)C(=O)N1[C@@H](CCC1)C=1NC(=CN1)C1=C(C=CC=C1)OC(F)(F)F)N1N=CC=N1 Chemical compound CC1=CC(=C(C=C1)C(=O)N1[C@@H](CCC1)C=1NC(=CN1)C1=C(C=CC=C1)OC(F)(F)F)N1N=CC=N1 ZFBTXWPCJCOJHZ-IBGZPJMESA-N 0.000 claims 1
• NGHOTNWDFFRERR-IBGZPJMESA-N CC1=CC(=C(C=C1C)C(=O)N1[C@@H](CCC1)C1=NC(=NO1)C1=C(C=CC=C1)C(F)(F)F)N1N=CC=N1 Chemical compound CC1=CC(=C(C=C1C)C(=O)N1[C@@H](CCC1)C1=NC(=NO1)C1=C(C=CC=C1)C(F)(F)F)N1N=CC=N1 NGHOTNWDFFRERR-IBGZPJMESA-N 0.000 claims 1
• JIXLYZFMWGQCJO-IBGZPJMESA-N CC1=CC(=C(C=C1C)C(=O)N1[C@@H](CCC1)C1=NN=C(N1)C1=C(C(=CC=C1)F)OC)N1N=CC=N1 Chemical compound CC1=CC(=C(C=C1C)C(=O)N1[C@@H](CCC1)C1=NN=C(N1)C1=C(C(=CC=C1)F)OC)N1N=CC=N1 JIXLYZFMWGQCJO-IBGZPJMESA-N 0.000 claims 1
• OWTICHBQSWXRQS-IBGZPJMESA-N CC1=CC(=C(C=C1C)C(=O)N1[C@@H](CCC1)C1=NN=C(N1)C1=C(C=CC=C1)OC)N1N=CC=N1 Chemical compound CC1=CC(=C(C=C1C)C(=O)N1[C@@H](CCC1)C1=NN=C(N1)C1=C(C=CC=C1)OC)N1N=CC=N1 OWTICHBQSWXRQS-IBGZPJMESA-N 0.000 claims 1
• TVSGVYBYINFSEV-IBGZPJMESA-N CC1=CC(=C(C=C1C)C(=O)N1[C@@H](CCC1)C1=NN=C(N1)C=1C(=NC=CC1)OCC)N1N=CC=N1 Chemical compound CC1=CC(=C(C=C1C)C(=O)N1[C@@H](CCC1)C1=NN=C(N1)C=1C(=NC=CC1)OCC)N1N=CC=N1 TVSGVYBYINFSEV-IBGZPJMESA-N 0.000 claims 1
• BRUXZKWUDDEDNK-IBGZPJMESA-N CC1=CC(=C(C=C1C)C(=O)N1[C@@H](CCC1)C1=NOC(=N1)C1=C(C(=CC=C1)F)OC)N1N=CC=N1 Chemical compound CC1=CC(=C(C=C1C)C(=O)N1[C@@H](CCC1)C1=NOC(=N1)C1=C(C(=CC=C1)F)OC)N1N=CC=N1 BRUXZKWUDDEDNK-IBGZPJMESA-N 0.000 claims 1
• QBOJPAJALJSCPZ-FQEVSTJZSA-N CC1=CC(=C(C=C1C)C(=O)N1[C@@H](CCC1)C1=NOC(=N1)C1=C(C(=CC=C1)OC)C)N1N=CC=N1 Chemical compound CC1=CC(=C(C=C1C)C(=O)N1[C@@H](CCC1)C1=NOC(=N1)C1=C(C(=CC=C1)OC)C)N1N=CC=N1 QBOJPAJALJSCPZ-FQEVSTJZSA-N 0.000 claims 1
• ZFAOCDJDWJPATF-FQEVSTJZSA-N CC1=CC(=C(C=C1C)C(=O)N1[C@@H](CCC1)C1=NOC(=N1)C1=C(C=CC(=C1)C)OC)N1N=CC=N1 Chemical compound CC1=CC(=C(C=C1C)C(=O)N1[C@@H](CCC1)C1=NOC(=N1)C1=C(C=CC(=C1)C)OC)N1N=CC=N1 ZFAOCDJDWJPATF-FQEVSTJZSA-N 0.000 claims 1
• NTNSUMPZQLAAMK-DEOSSOPVSA-N CC1=CC(=C(C=C1C)C(=O)N1[C@@](CCC1)(C1=NN=C(N1)C1=C(C=CC=C1)OC(F)(F)F)C)N1N=CC=N1 Chemical compound CC1=CC(=C(C=C1C)C(=O)N1[C@@](CCC1)(C1=NN=C(N1)C1=C(C=CC=C1)OC(F)(F)F)C)N1N=CC=N1 NTNSUMPZQLAAMK-DEOSSOPVSA-N 0.000 claims 1
• QVGFYLOJQRXNMV-QHCPKHFHSA-N CC=1C=CC(=C(C(=O)N2[C@@H](CCC2)C2=NC(=NO2)C2=CN(C3=CC=CC=C23)C(C)=O)C1)N1N=CC=N1 Chemical compound CC=1C=CC(=C(C(=O)N2[C@@H](CCC2)C2=NC(=NO2)C2=CN(C3=CC=CC=C23)C(C)=O)C1)N1N=CC=N1 QVGFYLOJQRXNMV-QHCPKHFHSA-N 0.000 claims 1
• SLBSYBMINGTPCZ-IBGZPJMESA-N CC=1C=CC(=C(C1)C(=O)N1[C@@H](CCC1)C1=NC(=NO1)C1=C(C=CC=C1)C(F)(F)F)N1N=CC=N1 Chemical compound CC=1C=CC(=C(C1)C(=O)N1[C@@H](CCC1)C1=NC(=NO1)C1=C(C=CC=C1)C(F)(F)F)N1N=CC=N1 SLBSYBMINGTPCZ-IBGZPJMESA-N 0.000 claims 1
• QNLNRUKDTPQCQF-IBGZPJMESA-N CC=1C=CC(=C(C1)C(=O)N1[C@@H](CCC1)C1=NC(=NO1)C1=CC(=CC=C1)OC(F)(F)F)N1N=CC=N1 Chemical compound CC=1C=CC(=C(C1)C(=O)N1[C@@H](CCC1)C1=NC(=NO1)C1=CC(=CC=C1)OC(F)(F)F)N1N=CC=N1 QNLNRUKDTPQCQF-IBGZPJMESA-N 0.000 claims 1
• YSALRRJZLXWJIR-FQEVSTJZSA-N CC=1C=CC(=C(C1)C(=O)N1[C@@H](CCC1)C1=NC(=NO1)C=1C=C(C=CC1)C)N1N=CC=N1 Chemical compound CC=1C=CC(=C(C1)C(=O)N1[C@@H](CCC1)C1=NC(=NO1)C=1C=C(C=CC1)C)N1N=CC=N1 YSALRRJZLXWJIR-FQEVSTJZSA-N 0.000 claims 1
• PGHJKLNWJBQMBU-SFHVURJKSA-N CC=1C=CC(=C(C1)C(=O)N1[C@@H](CCC1)C1=NN=C(N1)C1=C(C=CC=C1)OC(F)(F)F)N1N=CC=N1 Chemical compound CC=1C=CC(=C(C1)C(=O)N1[C@@H](CCC1)C1=NN=C(N1)C1=C(C=CC=C1)OC(F)(F)F)N1N=CC=N1 PGHJKLNWJBQMBU-SFHVURJKSA-N 0.000 claims 1
• QDJYAIHQXTVGKK-FQEVSTJZSA-N CC=1C=CC(=C(C1)C(=O)N1[C@@H](CCC1)C=1NC(=CN1)C1=C(C=CC=C1)OC(F)(F)F)N1N=CC=N1 Chemical compound CC=1C=CC(=C(C1)C(=O)N1[C@@H](CCC1)C=1NC(=CN1)C1=C(C=CC=C1)OC(F)(F)F)N1N=CC=N1 QDJYAIHQXTVGKK-FQEVSTJZSA-N 0.000 claims 1
• SGCLCURYCKUVAD-IBGZPJMESA-N CCOc1c(F)cccc1-c1nc(no1)[C@@H]1CCCN1C(=O)c1cc(OC)c(C)cc1-n1nccn1 Chemical compound CCOc1c(F)cccc1-c1nc(no1)[C@@H]1CCCN1C(=O)c1cc(OC)c(C)cc1-n1nccn1 SGCLCURYCKUVAD-IBGZPJMESA-N 0.000 claims 1
• MYWPKJICHKTMDN-SFHVURJKSA-N CCOc1c(F)cccc1-c1nc(no1)[C@@H]1CCCN1C(=O)c1cc(OC)c(Cl)cc1-n1nccn1 Chemical compound CCOc1c(F)cccc1-c1nc(no1)[C@@H]1CCCN1C(=O)c1cc(OC)c(Cl)cc1-n1nccn1 MYWPKJICHKTMDN-SFHVURJKSA-N 0.000 claims 1
• WGOKCSOLQVLCKP-FQEVSTJZSA-N CCOc1c(F)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(C)c(C)cc1-n1nccn1 Chemical compound CCOc1c(F)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(C)c(C)cc1-n1nccn1 WGOKCSOLQVLCKP-FQEVSTJZSA-N 0.000 claims 1
• HHPIGCNBOVWVJD-IBGZPJMESA-N CCOc1c(F)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(Cl)c(C)cc1-n1nccn1 Chemical compound CCOc1c(F)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(Cl)c(C)cc1-n1nccn1 HHPIGCNBOVWVJD-IBGZPJMESA-N 0.000 claims 1
• LYLJJUAAANDBTD-IBGZPJMESA-N CCOc1c(F)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(OC)c(C)cc1-n1nccn1 Chemical compound CCOc1c(F)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(OC)c(C)cc1-n1nccn1 LYLJJUAAANDBTD-IBGZPJMESA-N 0.000 claims 1
• XPAFAIBIIHHQBR-SFHVURJKSA-N CCOc1c(F)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(OC)c(Cl)cc1-n1nccn1 Chemical compound CCOc1c(F)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(OC)c(Cl)cc1-n1nccn1 XPAFAIBIIHHQBR-SFHVURJKSA-N 0.000 claims 1
• QUMNHSLYCANEIS-IBGZPJMESA-N CCOc1c(F)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1ccc(C)cc1-n1nccn1 Chemical compound CCOc1c(F)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1ccc(C)cc1-n1nccn1 QUMNHSLYCANEIS-IBGZPJMESA-N 0.000 claims 1
• MUHYLIWIJWRUEE-NRFANRHFSA-N CCOc1ccccc1-c1cnc([nH]1)[C@@H]1CCCN1C(=O)c1ccc(C)cc1-n1nccn1 Chemical compound CCOc1ccccc1-c1cnc([nH]1)[C@@H]1CCCN1C(=O)c1ccc(C)cc1-n1nccn1 MUHYLIWIJWRUEE-NRFANRHFSA-N 0.000 claims 1
• SZPPVOKLJAHBNZ-IBGZPJMESA-N CCOc1ccccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cccc(F)c1-c1ccn[nH]1 Chemical compound CCOc1ccccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cccc(F)c1-c1ccn[nH]1 SZPPVOKLJAHBNZ-IBGZPJMESA-N 0.000 claims 1
• OLOZJJINZBPHSF-IBGZPJMESA-N CCOc1cnccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(C)ccc1-n1nccn1 Chemical compound CCOc1cnccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(C)ccc1-n1nccn1 OLOZJJINZBPHSF-IBGZPJMESA-N 0.000 claims 1
• NLURUCYGOQWQKJ-NRFANRHFSA-N CCOc1ncccc1-c1cc(on1)[C@@H]1CCCN1C(=O)c1cc(C)ccc1-n1nccn1 Chemical compound CCOc1ncccc1-c1cc(on1)[C@@H]1CCCN1C(=O)c1cc(C)ccc1-n1nccn1 NLURUCYGOQWQKJ-NRFANRHFSA-N 0.000 claims 1
• GNQFOWZBJSCIJQ-SFHVURJKSA-N CCOc1ncccc1-c1nnc([nH]1)[C@@H]1CCCN1C(=O)c1cc(Cl)c(C)cc1-n1nccn1 Chemical compound CCOc1ncccc1-c1nnc([nH]1)[C@@H]1CCCN1C(=O)c1cc(Cl)c(C)cc1-n1nccn1 GNQFOWZBJSCIJQ-SFHVURJKSA-N 0.000 claims 1
• QCLSFIKPJILTAA-SFHVURJKSA-N CCOc1ncccc1-c1nnc([nH]1)[C@@H]1CCCN1C(=O)c1cc(OC)c(C)cc1-n1nccn1 Chemical compound CCOc1ncccc1-c1nnc([nH]1)[C@@H]1CCCN1C(=O)c1cc(OC)c(C)cc1-n1nccn1 QCLSFIKPJILTAA-SFHVURJKSA-N 0.000 claims 1
• QPSRSPZUAGXOPN-KRWDZBQOSA-N CCOc1ncccc1-c1nnc([nH]1)[C@@H]1CCCN1C(=O)c1cc(OC)c(Cl)cc1-n1nccn1 Chemical compound CCOc1ncccc1-c1nnc([nH]1)[C@@H]1CCCN1C(=O)c1cc(OC)c(Cl)cc1-n1nccn1 QPSRSPZUAGXOPN-KRWDZBQOSA-N 0.000 claims 1
• LOYJVOHUKOEBNR-IBGZPJMESA-N CCOc1ncccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(C)cc(C)c1-n1nccn1 Chemical compound CCOc1ncccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(C)cc(C)c1-n1nccn1 LOYJVOHUKOEBNR-IBGZPJMESA-N 0.000 claims 1
• USGYMEPRBRHADY-SFHVURJKSA-N CCOc1ncccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(Cl)c(C)cc1-n1nccn1 Chemical compound CCOc1ncccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(Cl)c(C)cc1-n1nccn1 USGYMEPRBRHADY-SFHVURJKSA-N 0.000 claims 1
• UJFJDIFKGXVSMY-KRWDZBQOSA-N CCOc1ncccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(OC)c(Cl)cc1-n1nccn1 Chemical compound CCOc1ncccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(OC)c(Cl)cc1-n1nccn1 UJFJDIFKGXVSMY-KRWDZBQOSA-N 0.000 claims 1
• OXAADNBQTUMYTR-KRWDZBQOSA-N CCOc1ncccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(OC)c(F)cc1-n1nccn1 Chemical compound CCOc1ncccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(OC)c(F)cc1-n1nccn1 OXAADNBQTUMYTR-KRWDZBQOSA-N 0.000 claims 1
• GTKBGYVEQYPMTQ-IBGZPJMESA-N CCOc1ncccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(OC)ccc1-n1nccn1 Chemical compound CCOc1ncccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(OC)ccc1-n1nccn1 GTKBGYVEQYPMTQ-IBGZPJMESA-N 0.000 claims 1
• LJLAUJLSTXXHLU-SFHVURJKSA-N CCOc1ncccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cccc(F)c1-c1ccn[nH]1 Chemical compound CCOc1ncccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cccc(F)c1-c1ccn[nH]1 LJLAUJLSTXXHLU-SFHVURJKSA-N 0.000 claims 1
• PWFVKUBNBLUSME-KRWDZBQOSA-N CCOc1ncccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1nc(C)ccc1-n1nccn1 Chemical compound CCOc1ncccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1nc(C)ccc1-n1nccn1 PWFVKUBNBLUSME-KRWDZBQOSA-N 0.000 claims 1
• UZFYPNSAEROKQQ-IBGZPJMESA-N COC1=C(C=C(C=C1)C)C1=NC(=NO1)[C@H]1N(CCC1)C(=O)C1=C(C=C(C=C1)C)N1N=CC=N1 Chemical compound COC1=C(C=C(C=C1)C)C1=NC(=NO1)[C@H]1N(CCC1)C(=O)C1=C(C=C(C=C1)C)N1N=CC=N1 UZFYPNSAEROKQQ-IBGZPJMESA-N 0.000 claims 1
• IACRDAAFUXHBCC-FQEVSTJZSA-N COC1=C(C=C(C=C1)C)C1=NC(=NO1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)C)N1N=CC=N1 Chemical compound COC1=C(C=C(C=C1)C)C1=NC(=NO1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)C)N1N=CC=N1 IACRDAAFUXHBCC-FQEVSTJZSA-N 0.000 claims 1
• NQEPTESAYGYEQQ-IBGZPJMESA-N COC1=C(C=CC=C1)C1=NOC(=N1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)C)N1N=CC=N1 Chemical compound COC1=C(C=CC=C1)C1=NOC(=N1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)C)N1N=CC=N1 NQEPTESAYGYEQQ-IBGZPJMESA-N 0.000 claims 1
• OWZUKTMMAJWROI-SFHVURJKSA-N COC1=C(C=CC=C1)C=1NC(=NN1)[C@H]1N(CCC1)C(=O)C1=C(C=C(C=C1)C)N1N=CC=N1 Chemical compound COC1=C(C=CC=C1)C=1NC(=NN1)[C@H]1N(CCC1)C(=O)C1=C(C=C(C=C1)C)N1N=CC=N1 OWZUKTMMAJWROI-SFHVURJKSA-N 0.000 claims 1
• HYNROYDTRQQKQI-FQEVSTJZSA-N COC=1C(=C(C=CC1)C1=NC(=NO1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)C)N1N=CC=N1)C Chemical compound COC=1C(=C(C=CC1)C1=NC(=NO1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)C)N1N=CC=N1)C HYNROYDTRQQKQI-FQEVSTJZSA-N 0.000 claims 1
• MZISTCJNJATLBB-KRWDZBQOSA-N COC=1C(=CC(=C(C1)C(=O)N1[C@@H](CCC1)C1=NOC(=N1)C1=C(C=CC=C1)OC(F)(F)F)N1N=CC=N1)C Chemical compound COC=1C(=CC(=C(C1)C(=O)N1[C@@H](CCC1)C1=NOC(=N1)C1=C(C=CC=C1)OC(F)(F)F)N1N=CC=N1)C MZISTCJNJATLBB-KRWDZBQOSA-N 0.000 claims 1
• ZREZAWDRVGUTGE-NRFANRHFSA-N COC=1C=C(C=C(C1)C)C1=NC(=NO1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)C)N1N=CC=N1 Chemical compound COC=1C=C(C=C(C1)C)C1=NC(=NO1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)C)N1N=CC=N1 ZREZAWDRVGUTGE-NRFANRHFSA-N 0.000 claims 1
• UBKDBBIBRAMTQD-QFIPXVFZSA-N COC=1C=C(C=CC1)C1=CN=C(N1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)C)N1N=CC=N1 Chemical compound COC=1C=C(C=CC1)C1=CN=C(N1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)C)N1N=CC=N1 UBKDBBIBRAMTQD-QFIPXVFZSA-N 0.000 claims 1
• ODORFZKNSBZADC-FQEVSTJZSA-N COC=1C=C(C=CC1)C1=NOC(=N1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)C)N1N=CC=N1 Chemical compound COC=1C=C(C=CC1)C1=NOC(=N1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)C)N1N=CC=N1 ODORFZKNSBZADC-FQEVSTJZSA-N 0.000 claims 1
• UETJNGPHNQZUIC-FQEVSTJZSA-N COC=1C=CC(=C(C1)C1=NC(=NO1)[C@H]1N(CCC1)C(=O)C1=C(C=C(C=C1)C)N1N=CC=N1)C Chemical compound COC=1C=CC(=C(C1)C1=NC(=NO1)[C@H]1N(CCC1)C(=O)C1=C(C=C(C=C1)C)N1N=CC=N1)C UETJNGPHNQZUIC-FQEVSTJZSA-N 0.000 claims 1
• NYYKCZLMJCQVJQ-NRFANRHFSA-N COC=1C=CC(=C(C1)C1=NC(=NO1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)C)N1N=CC=N1)C Chemical compound COC=1C=CC(=C(C1)C1=NC(=NO1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)C)N1N=CC=N1)C NYYKCZLMJCQVJQ-NRFANRHFSA-N 0.000 claims 1
• YRVOVIRWOCPRBZ-NRFANRHFSA-N COCc1ccccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(C)ccc1-n1nccn1 Chemical compound COCc1ccccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(C)ccc1-n1nccn1 YRVOVIRWOCPRBZ-NRFANRHFSA-N 0.000 claims 1
• MNDDUDYFBNUSMN-SFHVURJKSA-N COc1c(Cl)cccc1-c1nc(no1)[C@@H]1CCCN1C(=O)c1cc(Cl)ccc1-n1nccn1 Chemical compound COc1c(Cl)cccc1-c1nc(no1)[C@@H]1CCCN1C(=O)c1cc(Cl)ccc1-n1nccn1 MNDDUDYFBNUSMN-SFHVURJKSA-N 0.000 claims 1
• NVXVUURIOYXZOO-NRFANRHFSA-N COc1c(F)cccc1-c1cc(on1)[C@@H]1CCCN1C(=O)c1cc(C)ccc1-n1nccn1 Chemical compound COc1c(F)cccc1-c1cc(on1)[C@@H]1CCCN1C(=O)c1cc(C)ccc1-n1nccn1 NVXVUURIOYXZOO-NRFANRHFSA-N 0.000 claims 1
• RLTWWZBLCRMJMS-SFHVURJKSA-N COc1c(F)cccc1-c1nc(no1)[C@@H]1CCCN1C(=O)c1ccccc1-n1nccn1 Chemical compound COc1c(F)cccc1-c1nc(no1)[C@@H]1CCCN1C(=O)c1ccccc1-n1nccn1 RLTWWZBLCRMJMS-SFHVURJKSA-N 0.000 claims 1
• ZOJKXWFXEAGBLO-SFHVURJKSA-N COc1c(F)cccc1-c1nnc([nH]1)[C@@H]1CCCN1C(=O)c1cc(Cl)c(C)cc1-n1nccn1 Chemical compound COc1c(F)cccc1-c1nnc([nH]1)[C@@H]1CCCN1C(=O)c1cc(Cl)c(C)cc1-n1nccn1 ZOJKXWFXEAGBLO-SFHVURJKSA-N 0.000 claims 1
• WTMWAONOZHUUEE-KRWDZBQOSA-N COc1c(F)cccc1-c1nnc([nH]1)[C@@H]1CCCN1C(=O)c1ccc(Cl)cc1-n1nccn1 Chemical compound COc1c(F)cccc1-c1nnc([nH]1)[C@@H]1CCCN1C(=O)c1ccc(Cl)cc1-n1nccn1 WTMWAONOZHUUEE-KRWDZBQOSA-N 0.000 claims 1
• DXEUYBMFYQTSPN-IBGZPJMESA-N COc1c(F)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(C)cc(C)c1-n1nccn1 Chemical compound COc1c(F)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(C)cc(C)c1-n1nccn1 DXEUYBMFYQTSPN-IBGZPJMESA-N 0.000 claims 1
• QYHPIHQZYLRNIG-KRWDZBQOSA-N COc1c(F)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1ccc(Cl)cc1-n1nccn1 Chemical compound COc1c(F)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1ccc(Cl)cc1-n1nccn1 QYHPIHQZYLRNIG-KRWDZBQOSA-N 0.000 claims 1
• FETULTQYTLUDQW-KRWDZBQOSA-N COc1c(F)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1ccc(cc1-n1nccn1)C(F)(F)F Chemical compound COc1c(F)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1ccc(cc1-n1nccn1)C(F)(F)F FETULTQYTLUDQW-KRWDZBQOSA-N 0.000 claims 1
• XPCGYJYMBRVUIM-SFHVURJKSA-N COc1c(F)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1ccccc1-n1nccn1 Chemical compound COc1c(F)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1ccccc1-n1nccn1 XPCGYJYMBRVUIM-SFHVURJKSA-N 0.000 claims 1
• JJYKGAQEFYNQGC-NRFANRHFSA-N COc1cc(C(=O)N2CCC[C@H]2c2cc(on2)-c2cccc(Cl)c2C)c(cc1C)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2cc(on2)-c2cccc(Cl)c2C)c(cc1C)-n1nccn1 JJYKGAQEFYNQGC-NRFANRHFSA-N 0.000 claims 1
• FEPSIKBJFYIGIT-IBGZPJMESA-N COc1cc(C(=O)N2CCC[C@H]2c2cc(on2)-c2ccccc2OC(F)(F)F)c(cc1C)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2cc(on2)-c2ccccc2OC(F)(F)F)c(cc1C)-n1nccn1 FEPSIKBJFYIGIT-IBGZPJMESA-N 0.000 claims 1
• NUSZUJKDTVBPKK-SFHVURJKSA-N COc1cc(C(=O)N2CCC[C@H]2c2cc(on2)-c2ccccc2OC(F)(F)F)c(cc1Cl)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2cc(on2)-c2ccccc2OC(F)(F)F)c(cc1Cl)-n1nccn1 NUSZUJKDTVBPKK-SFHVURJKSA-N 0.000 claims 1
• XBUJZBOQNZNSMC-NRFANRHFSA-N COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(Cl)c2C)c(cc1C)-c1ncccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(Cl)c2C)c(cc1C)-c1ncccn1 XBUJZBOQNZNSMC-NRFANRHFSA-N 0.000 claims 1
• LCFMWSWABLJLMB-FQEVSTJZSA-N COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(Cl)c2C)c(cc1C)-n1cccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(Cl)c2C)c(cc1C)-n1cccn1 LCFMWSWABLJLMB-FQEVSTJZSA-N 0.000 claims 1
• SGNPVWBMWUNMDF-SFHVURJKSA-N COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(Cl)c2C)c(cc1Cl)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(Cl)c2C)c(cc1Cl)-n1nccn1 SGNPVWBMWUNMDF-SFHVURJKSA-N 0.000 claims 1
• GOSHEXFXRFZAPB-SFHVURJKSA-N COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(Cl)c2C)c(cc1F)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(Cl)c2C)c(cc1F)-n1nccn1 GOSHEXFXRFZAPB-SFHVURJKSA-N 0.000 claims 1
• FGJVFGAGGIQTLO-SFHVURJKSA-N COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(Cl)c2C)c(cc1OC)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(Cl)c2C)c(cc1OC)-n1nccn1 FGJVFGAGGIQTLO-SFHVURJKSA-N 0.000 claims 1
• SLPBBNNNUASMRF-IBGZPJMESA-N COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(F)c2C)c(cc1C)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(F)c2C)c(cc1C)-n1nccn1 SLPBBNNNUASMRF-IBGZPJMESA-N 0.000 claims 1
• DEUNGEPMJAXTRL-SFHVURJKSA-N COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(F)c2C)c(cc1Cl)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(F)c2C)c(cc1Cl)-n1nccn1 DEUNGEPMJAXTRL-SFHVURJKSA-N 0.000 claims 1
• RTGIDLKDGHUJGH-FQEVSTJZSA-N COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(F)c2OC)c(cc1C)-c1ncccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(F)c2OC)c(cc1C)-c1ncccn1 RTGIDLKDGHUJGH-FQEVSTJZSA-N 0.000 claims 1
• CIYPBPJMLYOKQS-KRWDZBQOSA-N COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(F)c2OC)c(cc1Cl)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(F)c2OC)c(cc1Cl)-n1nccn1 CIYPBPJMLYOKQS-KRWDZBQOSA-N 0.000 claims 1
• KLCQUHRBSBBNPE-KRWDZBQOSA-N COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(F)c2OC)c(cc1F)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(F)c2OC)c(cc1F)-n1nccn1 KLCQUHRBSBBNPE-KRWDZBQOSA-N 0.000 claims 1
• HAUFXBYQCBBPLG-KRWDZBQOSA-N COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(F)c2OC)c(cc1OC)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(F)c2OC)c(cc1OC)-n1nccn1 HAUFXBYQCBBPLG-KRWDZBQOSA-N 0.000 claims 1
• MMYJITCJETUVAA-SFHVURJKSA-N COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2ccccc2C(F)(F)F)c(cc1C)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2ccccc2C(F)(F)F)c(cc1C)-n1nccn1 MMYJITCJETUVAA-SFHVURJKSA-N 0.000 claims 1
• XNOXJRMDPXDIPI-SFHVURJKSA-N COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2ccccc2Cl)c(cc1C)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2ccccc2Cl)c(cc1C)-n1nccn1 XNOXJRMDPXDIPI-SFHVURJKSA-N 0.000 claims 1
• WDDLEGYJQLYTLS-SFHVURJKSA-N COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2ccccc2OC(F)(F)F)c(cc1C)-n1cccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2ccccc2OC(F)(F)F)c(cc1C)-n1cccn1 WDDLEGYJQLYTLS-SFHVURJKSA-N 0.000 claims 1
• FJNOZYLBMXDFMS-INIZCTEOSA-N COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2ccccc2OC(F)(F)F)c(cc1Cl)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2ccccc2OC(F)(F)F)c(cc1Cl)-n1nccn1 FJNOZYLBMXDFMS-INIZCTEOSA-N 0.000 claims 1
• PUJXIDCJYRYWTP-SFHVURJKSA-N COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2ccccc2OC)c(cc1C)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2ccccc2OC)c(cc1C)-n1nccn1 PUJXIDCJYRYWTP-SFHVURJKSA-N 0.000 claims 1
• PEKATTSYWBWHSV-SFHVURJKSA-N COc1cc(C(=O)N2CCC[C@H]2c2nnc([nH]2)-c2cccc(Cl)c2OC)c(cc1C)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2nnc([nH]2)-c2cccc(Cl)c2OC)c(cc1C)-n1nccn1 PEKATTSYWBWHSV-SFHVURJKSA-N 0.000 claims 1
• QUQQYPYIPBBWEY-KRWDZBQOSA-N COc1cc(C(=O)N2CCC[C@H]2c2nnc([nH]2)-c2cccc(Cl)c2OC)c(cc1Cl)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2nnc([nH]2)-c2cccc(Cl)c2OC)c(cc1Cl)-n1nccn1 QUQQYPYIPBBWEY-KRWDZBQOSA-N 0.000 claims 1
• CJXLJKJEJSIZHV-KRWDZBQOSA-N COc1cc(C(=O)N2CCC[C@H]2c2nnc([nH]2)-c2cccc(F)c2OC)c(cc1Cl)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2nnc([nH]2)-c2cccc(F)c2OC)c(cc1Cl)-n1nccn1 CJXLJKJEJSIZHV-KRWDZBQOSA-N 0.000 claims 1
• JOZFZVGLUUAMKM-KRWDZBQOSA-N COc1cc(C(=O)N2CCC[C@H]2c2nnc([nH]2)-c2ccccc2OC(F)(F)F)c(cc1C)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2nnc([nH]2)-c2ccccc2OC(F)(F)F)c(cc1C)-n1nccn1 JOZFZVGLUUAMKM-KRWDZBQOSA-N 0.000 claims 1
• ITWIBXFRJRYAIY-INIZCTEOSA-N COc1cc(C(=O)N2CCC[C@H]2c2nnc([nH]2)-c2ccccc2OC(F)(F)F)c(cc1Cl)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2nnc([nH]2)-c2ccccc2OC(F)(F)F)c(cc1Cl)-n1nccn1 ITWIBXFRJRYAIY-INIZCTEOSA-N 0.000 claims 1
• YACRFROESHCZFU-SFHVURJKSA-N COc1cc(C(=O)N2CCC[C@H]2c2nnc([nH]2)-c2ccccc2OC)c(cc1C)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2nnc([nH]2)-c2ccccc2OC)c(cc1C)-n1nccn1 YACRFROESHCZFU-SFHVURJKSA-N 0.000 claims 1
• RSXKWQLWTISAIG-KRWDZBQOSA-N COc1cc(C(=O)N2CCC[C@H]2c2nnc([nH]2)-c2ccccc2OC)c(cc1Cl)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2nnc([nH]2)-c2ccccc2OC)c(cc1Cl)-n1nccn1 RSXKWQLWTISAIG-KRWDZBQOSA-N 0.000 claims 1
• IVMDLDGIDMROLZ-IBGZPJMESA-N COc1cc(C(=O)N2CCC[C@H]2c2nnc(o2)-c2cccc(Cl)c2C)c(cc1C)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2nnc(o2)-c2cccc(Cl)c2C)c(cc1C)-n1nccn1 IVMDLDGIDMROLZ-IBGZPJMESA-N 0.000 claims 1
• HYRKSIIFYOQSTD-SFHVURJKSA-N COc1cc(C(=O)N2CCC[C@H]2c2nnc(o2)-c2cccc(Cl)c2C)c(cc1Cl)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2nnc(o2)-c2cccc(Cl)c2C)c(cc1Cl)-n1nccn1 HYRKSIIFYOQSTD-SFHVURJKSA-N 0.000 claims 1
• SGSJJQIHTRVECV-IBGZPJMESA-N COc1cc(C(=O)N2CCC[C@H]2c2noc(n2)-c2cc(C)ccc2OC)c(cc1C)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2noc(n2)-c2cc(C)ccc2OC)c(cc1C)-n1nccn1 SGSJJQIHTRVECV-IBGZPJMESA-N 0.000 claims 1
• GNFWZOLSZWTYRR-IBGZPJMESA-N COc1cc(C(=O)N2CCC[C@H]2c2noc(n2)-c2cccc(Cl)c2C)c(cc1C)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2noc(n2)-c2cccc(Cl)c2C)c(cc1C)-n1nccn1 GNFWZOLSZWTYRR-IBGZPJMESA-N 0.000 claims 1
• CKQSGZJWVRFHLL-SFHVURJKSA-N COc1cc(C(=O)N2CCC[C@H]2c2noc(n2)-c2cccc(Cl)c2C)c(cc1Cl)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2noc(n2)-c2cccc(Cl)c2C)c(cc1Cl)-n1nccn1 CKQSGZJWVRFHLL-SFHVURJKSA-N 0.000 claims 1
• RRGQDAPENZQDHE-SFHVURJKSA-N COc1cc(C(=O)N2CCC[C@H]2c2noc(n2)-c2cccc(F)c2OC)c(cc1C)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2noc(n2)-c2cccc(F)c2OC)c(cc1C)-n1nccn1 RRGQDAPENZQDHE-SFHVURJKSA-N 0.000 claims 1
• TVOPOIUNCIFOAI-KRWDZBQOSA-N COc1cc(C(=O)N2CCC[C@H]2c2noc(n2)-c2cccc(F)c2OC)c(cc1Cl)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2noc(n2)-c2cccc(F)c2OC)c(cc1Cl)-n1nccn1 TVOPOIUNCIFOAI-KRWDZBQOSA-N 0.000 claims 1
• WAKHHOMDKVZUIA-IBGZPJMESA-N COc1cc(C(=O)N2CCC[C@H]2c2noc(n2)-c2cccc(OC)c2C)c(cc1C)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2noc(n2)-c2cccc(OC)c2C)c(cc1C)-n1nccn1 WAKHHOMDKVZUIA-IBGZPJMESA-N 0.000 claims 1
• BJPSPFZAURHPMP-SFHVURJKSA-N COc1cc(C(=O)N2CCC[C@H]2c2noc(n2)-c2cccc(OC)c2C)c(cc1Cl)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2noc(n2)-c2cccc(OC)c2C)c(cc1Cl)-n1nccn1 BJPSPFZAURHPMP-SFHVURJKSA-N 0.000 claims 1
• RCGXSJKXQQBROC-INIZCTEOSA-N COc1cc(C(=O)N2CCC[C@H]2c2noc(n2)-c2ccccc2OC(F)(F)F)c(cc1Cl)-n1nccn1 Chemical compound COc1cc(C(=O)N2CCC[C@H]2c2noc(n2)-c2ccccc2OC(F)(F)F)c(cc1Cl)-n1nccn1 RCGXSJKXQQBROC-INIZCTEOSA-N 0.000 claims 1
• NVJRIZJWOJFZRM-FQEVSTJZSA-N COc1cc(C)cc(c1)-c1nc(no1)[C@@H]1CCCN1C(=O)c1cc(Cl)ccc1-n1nccn1 Chemical compound COc1cc(C)cc(c1)-c1nc(no1)[C@@H]1CCCN1C(=O)c1cc(Cl)ccc1-n1nccn1 NVJRIZJWOJFZRM-FQEVSTJZSA-N 0.000 claims 1
• XZFQMZJMIJHWDC-IBGZPJMESA-N COc1ccc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(Cl)c2C)c(c1)-n1nccn1 Chemical compound COc1ccc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(Cl)c2C)c(c1)-n1nccn1 XZFQMZJMIJHWDC-IBGZPJMESA-N 0.000 claims 1
• RVRXQRGZGPRNHO-FQEVSTJZSA-N COc1ccc(C)c(c1)-c1nc(no1)[C@@H]1CCCN1C(=O)c1cc(OC)c(C)cc1-n1nccn1 Chemical compound COc1ccc(C)c(c1)-c1nc(no1)[C@@H]1CCCN1C(=O)c1cc(OC)c(C)cc1-n1nccn1 RVRXQRGZGPRNHO-FQEVSTJZSA-N 0.000 claims 1
• NJUZPIMKSDPESQ-HNNXBMFYSA-N COc1ccc(c(C(=O)N2CCC[C@H]2c2nc(no2)-c2ccccc2OC(F)(F)F)c1F)-n1nccn1 Chemical compound COc1ccc(c(C(=O)N2CCC[C@H]2c2nc(no2)-c2ccccc2OC(F)(F)F)c1F)-n1nccn1 NJUZPIMKSDPESQ-HNNXBMFYSA-N 0.000 claims 1
• LKEXOZJOQISQCI-NRFANRHFSA-N COc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(Cl)c1C)-n1cccn1 Chemical compound COc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(Cl)c1C)-n1cccn1 LKEXOZJOQISQCI-NRFANRHFSA-N 0.000 claims 1
• MZYVEKPEYBFDIX-FQEVSTJZSA-N COc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(Cl)c1C)-n1nccn1 Chemical compound COc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(Cl)c1C)-n1nccn1 MZYVEKPEYBFDIX-FQEVSTJZSA-N 0.000 claims 1
• PTCUMGQXAABERF-FQEVSTJZSA-N COc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(F)c1C)-n1nccn1 Chemical compound COc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(F)c1C)-n1nccn1 PTCUMGQXAABERF-FQEVSTJZSA-N 0.000 claims 1
• WYRXYORDVZVURM-IBGZPJMESA-N COc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(F)c1OC)-n1nccn1 Chemical compound COc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(F)c1OC)-n1nccn1 WYRXYORDVZVURM-IBGZPJMESA-N 0.000 claims 1
• WFRSYFPLJNYJBR-IBGZPJMESA-N COc1cccc(-c2noc(n2)[C@@H]2CCCN2C(=O)c2cc(C)ccc2-n2nccn2)c1OC Chemical compound COc1cccc(-c2noc(n2)[C@@H]2CCCN2C(=O)c2cc(C)ccc2-n2nccn2)c1OC WFRSYFPLJNYJBR-IBGZPJMESA-N 0.000 claims 1
• OPODZHORDYECHR-IBGZPJMESA-N COc1ccccc1-c1nnc([nH]1)[C@@H]1CCCN1C(=O)c1cc(C)ccc1-n1nccn1 Chemical compound COc1ccccc1-c1nnc([nH]1)[C@@H]1CCCN1C(=O)c1cc(C)ccc1-n1nccn1 OPODZHORDYECHR-IBGZPJMESA-N 0.000 claims 1
• HFHGPXBQPZWTMC-SFHVURJKSA-N COc1ccccc1-c1nnc([nH]1)[C@@H]1CCCN1C(=O)c1cc(Cl)c(C)cc1-n1nccn1 Chemical compound COc1ccccc1-c1nnc([nH]1)[C@@H]1CCCN1C(=O)c1cc(Cl)c(C)cc1-n1nccn1 HFHGPXBQPZWTMC-SFHVURJKSA-N 0.000 claims 1
• IRCNQCYCHFKASB-KRWDZBQOSA-N COc1ccccc1-c1nnc([nH]1)[C@@H]1CCCN1C(=O)c1ccc(Cl)cc1-n1nccn1 Chemical compound COc1ccccc1-c1nnc([nH]1)[C@@H]1CCCN1C(=O)c1ccc(Cl)cc1-n1nccn1 IRCNQCYCHFKASB-KRWDZBQOSA-N 0.000 claims 1
• MHTCZZUOEDKSAU-FQEVSTJZSA-N COc1ncccc1-c1cc(on1)[C@@H]1CCCN1C(=O)c1cc(C)ccc1-n1nccn1 Chemical compound COc1ncccc1-c1cc(on1)[C@@H]1CCCN1C(=O)c1cc(C)ccc1-n1nccn1 MHTCZZUOEDKSAU-FQEVSTJZSA-N 0.000 claims 1
• AQBKLPMTBJFAPO-QFIPXVFZSA-N C[C@]1(CCCN1C(=O)c1ccc(Cl)cc1-n1nccn1)c1nnc([nH]1)-c1ccccc1OC(F)(F)F Chemical compound C[C@]1(CCCN1C(=O)c1ccc(Cl)cc1-n1nccn1)c1nnc([nH]1)-c1ccccc1OC(F)(F)F AQBKLPMTBJFAPO-QFIPXVFZSA-N 0.000 claims 1
• CCSIHNMFYZGXOF-FQEVSTJZSA-N Cc1c(Cl)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(F)ccc1-c1ccn[nH]1 Chemical compound Cc1c(Cl)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(F)ccc1-c1ccn[nH]1 CCSIHNMFYZGXOF-FQEVSTJZSA-N 0.000 claims 1
• LOCJXCDSAXLNDA-IBGZPJMESA-N Cc1c(Cl)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cccc(F)c1-c1ccn[nH]1 Chemical compound Cc1c(Cl)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cccc(F)c1-c1ccn[nH]1 LOCJXCDSAXLNDA-IBGZPJMESA-N 0.000 claims 1
• OGPTYJIINPGXJR-QHCPKHFHSA-N Cc1c(Cl)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1ccccc1-c1ccccc1 Chemical compound Cc1c(Cl)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1ccccc1-c1ccccc1 OGPTYJIINPGXJR-QHCPKHFHSA-N 0.000 claims 1
• DXUJRFSLVWXJAM-IBGZPJMESA-N Cc1c(Cl)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1ccccc1-c1ncco1 Chemical compound Cc1c(Cl)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1ccccc1-c1ncco1 DXUJRFSLVWXJAM-IBGZPJMESA-N 0.000 claims 1
• NWIQYFNGCHIJSD-IBGZPJMESA-N Cc1c(F)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(F)ccc1-n1nccn1 Chemical compound Cc1c(F)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cc(F)ccc1-n1nccn1 NWIQYFNGCHIJSD-IBGZPJMESA-N 0.000 claims 1
• UZAWEHKKXGQPBY-SFHVURJKSA-N Cc1c(F)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1ccc(Cl)cc1-n1nccn1 Chemical compound Cc1c(F)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1ccc(Cl)cc1-n1nccn1 UZAWEHKKXGQPBY-SFHVURJKSA-N 0.000 claims 1
• AXVKMHHQSPETDL-IBGZPJMESA-N Cc1c(F)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cccc(F)c1-c1ccn[nH]1 Chemical compound Cc1c(F)cccc1-c1noc(n1)[C@@H]1CCCN1C(=O)c1cccc(F)c1-c1ccn[nH]1 AXVKMHHQSPETDL-IBGZPJMESA-N 0.000 claims 1
• YMCIMSDKANXDNQ-NRFANRHFSA-N Cc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(Cl)c2C)c(cc1C)-n1cccn1 Chemical compound Cc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(Cl)c2C)c(cc1C)-n1cccn1 YMCIMSDKANXDNQ-NRFANRHFSA-N 0.000 claims 1
• AKMDANQXWMVNEY-FQEVSTJZSA-N Cc1cc(C(=O)N2CCC[C@H]2c2noc(n2)-c2cccc(F)c2C)c(cc1C)-n1nccn1 Chemical compound Cc1cc(C(=O)N2CCC[C@H]2c2noc(n2)-c2cccc(F)c2C)c(cc1C)-n1nccn1 AKMDANQXWMVNEY-FQEVSTJZSA-N 0.000 claims 1
• BAJYHTHIBJYXEG-FQEVSTJZSA-N Cc1cc(C)c(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(Cl)c1C)-n1nccn1 Chemical compound Cc1cc(C)c(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(Cl)c1C)-n1nccn1 BAJYHTHIBJYXEG-FQEVSTJZSA-N 0.000 claims 1
• SXKBBAYXXRENQD-SFHVURJKSA-N Cc1cc(C)c(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1ccccc1OC(F)(F)F)-n1nccn1 Chemical compound Cc1cc(C)c(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1ccccc1OC(F)(F)F)-n1nccn1 SXKBBAYXXRENQD-SFHVURJKSA-N 0.000 claims 1
• RSXSJNWYISSNHS-QHCPKHFHSA-N Cc1cc(c(cc1Cl)C(=O)N1CCC[C@@]1(C)c1nnc([nH]1)-c1ccccc1OC(F)(F)F)-n1nccn1 Chemical compound Cc1cc(c(cc1Cl)C(=O)N1CCC[C@@]1(C)c1nnc([nH]1)-c1ccccc1OC(F)(F)F)-n1nccn1 RSXSJNWYISSNHS-QHCPKHFHSA-N 0.000 claims 1
• LBNDFXDQHYIPKB-IBGZPJMESA-N Cc1cc(c(cc1Cl)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(Cl)c1C)-n1nccn1 Chemical compound Cc1cc(c(cc1Cl)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(Cl)c1C)-n1nccn1 LBNDFXDQHYIPKB-IBGZPJMESA-N 0.000 claims 1
• ARQJMHUEYJWKJG-KRWDZBQOSA-N Cc1cc(c(cc1Cl)C(=O)N1CCC[C@H]1c1nc(no1)-c1ccccc1OC(F)(F)F)-n1nccn1 Chemical compound Cc1cc(c(cc1Cl)C(=O)N1CCC[C@H]1c1nc(no1)-c1ccccc1OC(F)(F)F)-n1nccn1 ARQJMHUEYJWKJG-KRWDZBQOSA-N 0.000 claims 1
• FTJXPOYMWDMSQX-KRWDZBQOSA-N Cc1cc(c(cc1Cl)C(=O)N1CCC[C@H]1c1nnc([nH]1)-c1ccccc1OC(F)(F)F)-n1nccn1 Chemical compound Cc1cc(c(cc1Cl)C(=O)N1CCC[C@H]1c1nnc([nH]1)-c1ccccc1OC(F)(F)F)-n1nccn1 FTJXPOYMWDMSQX-KRWDZBQOSA-N 0.000 claims 1
• OMDRHDUQTSXHKY-KRWDZBQOSA-N Cc1cc(c(cc1Cl)C(=O)N1CCC[C@H]1c1noc(n1)-c1ccccc1OC(F)(F)F)-n1nccn1 Chemical compound Cc1cc(c(cc1Cl)C(=O)N1CCC[C@H]1c1noc(n1)-c1ccccc1OC(F)(F)F)-n1nccn1 OMDRHDUQTSXHKY-KRWDZBQOSA-N 0.000 claims 1
• HUBYIXDVGHMDRD-MHZLTWQESA-N Cc1ccc(-c2ccccc2)c(c1)C(=O)N1CCC[C@@]1(C)c1nnc([nH]1)-c1ccccc1OC(F)(F)F Chemical compound Cc1ccc(-c2ccccc2)c(c1)C(=O)N1CCC[C@@]1(C)c1nnc([nH]1)-c1ccccc1OC(F)(F)F HUBYIXDVGHMDRD-MHZLTWQESA-N 0.000 claims 1
• XMRRXJMXOZZRAE-QHCPKHFHSA-N Cc1ccc(-c2ccccn2)c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(Cl)c1C Chemical compound Cc1ccc(-c2ccccn2)c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(Cl)c1C XMRRXJMXOZZRAE-QHCPKHFHSA-N 0.000 claims 1
• YFGHKUFHITWOKA-NRFANRHFSA-N Cc1ccc(-c2ccccn2)c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1ccccc1OC(F)F Chemical compound Cc1ccc(-c2ccccn2)c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1ccccc1OC(F)F YFGHKUFHITWOKA-NRFANRHFSA-N 0.000 claims 1
• KWACSOLYZAQQDE-NRFANRHFSA-N Cc1ccc(-c2ncccn2)c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(Cl)c1C Chemical compound Cc1ccc(-c2ncccn2)c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(Cl)c1C KWACSOLYZAQQDE-NRFANRHFSA-N 0.000 claims 1
• YFYGRKNEQLTPLB-NRFANRHFSA-N Cc1ccc(-c2noc(n2)[C@@H]2CCCN2C(=O)c2cc(C)ccc2-n2nccn2)c(C)c1 Chemical compound Cc1ccc(-c2noc(n2)[C@@H]2CCCN2C(=O)c2cc(C)ccc2-n2nccn2)c(C)c1 YFYGRKNEQLTPLB-NRFANRHFSA-N 0.000 claims 1
• LDBFMBPUWQRKER-MHZLTWQESA-N Cc1ccc(C(=O)N2CCC[C@@]2(C)c2nnc([nH]2)-c2ccccc2OC(F)(F)F)c(c1)-c1ccccc1 Chemical compound Cc1ccc(C(=O)N2CCC[C@@]2(C)c2nnc([nH]2)-c2ccccc2OC(F)(F)F)c(c1)-c1ccccc1 LDBFMBPUWQRKER-MHZLTWQESA-N 0.000 claims 1
• OIWYQRRPKCUGOL-FQEVSTJZSA-N Cc1ccc(C(=O)N2CCC[C@H]2c2noc(n2)-c2cccc(C)c2C)c(c1)-n1nccn1 Chemical compound Cc1ccc(C(=O)N2CCC[C@H]2c2noc(n2)-c2cccc(C)c2C)c(c1)-n1nccn1 OIWYQRRPKCUGOL-FQEVSTJZSA-N 0.000 claims 1
• CXZXWKINGRPWER-IBGZPJMESA-N Cc1ccc(C(=O)N2CCC[C@H]2c2noc(n2)-c2cccc(F)c2C)c(c1)-n1nccn1 Chemical compound Cc1ccc(C(=O)N2CCC[C@H]2c2noc(n2)-c2cccc(F)c2C)c(c1)-n1nccn1 CXZXWKINGRPWER-IBGZPJMESA-N 0.000 claims 1
• PIHWDDCXPKYNRC-NRFANRHFSA-N Cc1ccc(C)c(c1)-c1nc(no1)[C@@H]1CCCN1C(=O)c1cc(C)c(C)cc1-n1nccn1 Chemical compound Cc1ccc(C)c(c1)-c1nc(no1)[C@@H]1CCCN1C(=O)c1cc(C)c(C)cc1-n1nccn1 PIHWDDCXPKYNRC-NRFANRHFSA-N 0.000 claims 1
• JHNHHPVZHOFWGP-FQEVSTJZSA-N Cc1ccc(C)c(c1)-c1nc(no1)[C@@H]1CCCN1C(=O)c1ccc(C)cc1-n1nccn1 Chemical compound Cc1ccc(C)c(c1)-c1nc(no1)[C@@H]1CCCN1C(=O)c1ccc(C)cc1-n1nccn1 JHNHHPVZHOFWGP-FQEVSTJZSA-N 0.000 claims 1
• KINPBHSOFYDWIG-SFHVURJKSA-N Cc1ccc(c(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(Cl)c2C)c1F)-n1nccn1 Chemical compound Cc1ccc(c(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(Cl)c2C)c1F)-n1nccn1 KINPBHSOFYDWIG-SFHVURJKSA-N 0.000 claims 1
• ARHATBKAZZLECO-QHCPKHFHSA-N Cc1ccc(c(c1)C(=O)N1CCC[C@@]1(C)c1nnc([nH]1)-c1ccccc1OC(F)(F)F)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@@]1(C)c1nnc([nH]1)-c1ccccc1OC(F)(F)F)-n1nccn1 ARHATBKAZZLECO-QHCPKHFHSA-N 0.000 claims 1
• MSIMSLNPAMFICZ-QHCPKHFHSA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1cc(no1)-c1cc(C)cc(C)c1)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1cc(no1)-c1cc(C)cc(C)c1)-n1nccn1 MSIMSLNPAMFICZ-QHCPKHFHSA-N 0.000 claims 1
• LXBCMXPABDHUIZ-QHCPKHFHSA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1cc(no1)-c1cccc(C)c1C)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1cc(no1)-c1cccc(C)c1C)-n1nccn1 LXBCMXPABDHUIZ-QHCPKHFHSA-N 0.000 claims 1
• LTFGTTHIBQURPD-QFIPXVFZSA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1cc(no1)-c1cccc(Cl)c1C)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1cc(no1)-c1cccc(Cl)c1C)-n1nccn1 LTFGTTHIBQURPD-QFIPXVFZSA-N 0.000 claims 1
• WHFQIPFBRFYCKU-NRFANRHFSA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1cc(on1)-c1ccccc1)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1cc(on1)-c1ccccc1)-n1nccn1 WHFQIPFBRFYCKU-NRFANRHFSA-N 0.000 claims 1
• FABVICYLPLKVAI-FQEVSTJZSA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1cc(on1)-c1ccccc1OC(F)(F)F)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1cc(on1)-c1ccccc1OC(F)(F)F)-n1nccn1 FABVICYLPLKVAI-FQEVSTJZSA-N 0.000 claims 1
• KTAATWIYCNEXBN-FQEVSTJZSA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(co1)-c1ccccc1OC(F)(F)F)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(co1)-c1ccccc1OC(F)(F)F)-n1nccn1 KTAATWIYCNEXBN-FQEVSTJZSA-N 0.000 claims 1
• HORXSENWOLHVDG-IBGZPJMESA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1c(C)cccc1F)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1c(C)cccc1F)-n1nccn1 HORXSENWOLHVDG-IBGZPJMESA-N 0.000 claims 1
• FRNQNWNTFIWAKP-NRFANRHFSA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cc(C)cc(C)c1)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cc(C)cc(C)c1)-n1nccn1 FRNQNWNTFIWAKP-NRFANRHFSA-N 0.000 claims 1
• LDDNOOJOLFTAOG-NRFANRHFSA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1ccc(C)c(C)c1)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1ccc(C)c(C)c1)-n1nccn1 LDDNOOJOLFTAOG-NRFANRHFSA-N 0.000 claims 1
• VTEVWDZJGRFWAY-NRFANRHFSA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(C)c1C)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(C)c1C)-n1nccn1 VTEVWDZJGRFWAY-NRFANRHFSA-N 0.000 claims 1
• HMSHNWRVNFMPDS-IBGZPJMESA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(C)c1Cl)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(C)c1Cl)-n1nccn1 HMSHNWRVNFMPDS-IBGZPJMESA-N 0.000 claims 1
• RNJSXDPVIKEQDS-IBGZPJMESA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(Cl)c1)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(Cl)c1)-n1nccn1 RNJSXDPVIKEQDS-IBGZPJMESA-N 0.000 claims 1
• COTMFCFRNPCBHW-NRFANRHFSA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(Cl)c1C)-n1cccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(Cl)c1C)-n1cccn1 COTMFCFRNPCBHW-NRFANRHFSA-N 0.000 claims 1
• JKXYYYNZENVKEZ-FQEVSTJZSA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(F)c1C)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(F)c1C)-n1nccn1 JKXYYYNZENVKEZ-FQEVSTJZSA-N 0.000 claims 1
• BYYZAURIVFCTLA-IBGZPJMESA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(OC(F)F)c1)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(OC(F)F)c1)-n1nccn1 BYYZAURIVFCTLA-IBGZPJMESA-N 0.000 claims 1
• QCTSLXOYSVLZGK-FQEVSTJZSA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(c1C)C(F)(F)F)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc(c1C)C(F)(F)F)-n1nccn1 QCTSLXOYSVLZGK-FQEVSTJZSA-N 0.000 claims 1
• UYYARKFPQXKYMD-NRFANRHFSA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc2ccn(C)c12)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc2ccn(C)c12)-n1nccn1 UYYARKFPQXKYMD-NRFANRHFSA-N 0.000 claims 1
• GUTYDJGKTMGHRF-QFIPXVFZSA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc2n(C)ccc12)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccc2n(C)ccc12)-n1nccn1 GUTYDJGKTMGHRF-QFIPXVFZSA-N 0.000 claims 1
• CKYYOWDVDOICHK-IBGZPJMESA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1ccccc1)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1ccccc1)-n1nccn1 CKYYOWDVDOICHK-IBGZPJMESA-N 0.000 claims 1
• JLEZJDNALDAHLQ-FQEVSTJZSA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1ccccc1C)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1ccccc1C)-n1nccn1 JLEZJDNALDAHLQ-FQEVSTJZSA-N 0.000 claims 1
• AMECXQVHMZKCLX-IBGZPJMESA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1ccccc1Cl)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1ccccc1Cl)-n1nccn1 AMECXQVHMZKCLX-IBGZPJMESA-N 0.000 claims 1
• NZXVXTQNTGPZSS-SFHVURJKSA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1ccccc1OC(F)F)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1ccccc1OC(F)F)-n1nccn1 NZXVXTQNTGPZSS-SFHVURJKSA-N 0.000 claims 1
• XNLSATLYUDTNKN-IBGZPJMESA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccnc1C)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccnc1C)-n1nccn1 XNLSATLYUDTNKN-IBGZPJMESA-N 0.000 claims 1
• VJYJPTZOKUNTGS-KRWDZBQOSA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccnc1Cl)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccnc1Cl)-n1nccn1 VJYJPTZOKUNTGS-KRWDZBQOSA-N 0.000 claims 1
• NFUAMNKNBVJOHM-KRWDZBQOSA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccnc1OC(F)F)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccnc1OC(F)F)-n1nccn1 NFUAMNKNBVJOHM-KRWDZBQOSA-N 0.000 claims 1
• PDVSZNGWSRAFQD-NRFANRHFSA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccnc1OC1CCC1)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1nc(no1)-c1cccnc1OC1CCC1)-n1nccn1 PDVSZNGWSRAFQD-NRFANRHFSA-N 0.000 claims 1
• DPJNNAKPGUYLIP-FQEVSTJZSA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1ncn(n1)-c1ccccc1)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1ncn(n1)-c1ccccc1)-n1nccn1 DPJNNAKPGUYLIP-FQEVSTJZSA-N 0.000 claims 1
• HXLWTZGQBQSCHZ-NRFANRHFSA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1noc(n1)-c1cc(C)ccc1C)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1noc(n1)-c1cc(C)ccc1C)-n1nccn1 HXLWTZGQBQSCHZ-NRFANRHFSA-N 0.000 claims 1
• LYGHSSIGYGGLMZ-NRFANRHFSA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1noc(n1)-c1cccc(C)c1C)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1noc(n1)-c1cccc(C)c1C)-n1nccn1 LYGHSSIGYGGLMZ-NRFANRHFSA-N 0.000 claims 1
• KTQDXFVMBAMYRT-FQEVSTJZSA-N Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1noc(n1)-c1cccc(F)c1C)-n1nccn1 Chemical compound Cc1ccc(c(c1)C(=O)N1CCC[C@H]1c1noc(n1)-c1cccc(F)c1C)-n1nccn1 KTQDXFVMBAMYRT-FQEVSTJZSA-N 0.000 claims 1
• CQXDHNQICUYCME-KRWDZBQOSA-N Cc1nc(C(=O)N2CCC[C@H]2c2nnc(o2)-c2ccccc2OC(F)(F)F)c(s1)-c1cccc(F)c1 Chemical compound Cc1nc(C(=O)N2CCC[C@H]2c2nnc(o2)-c2ccccc2OC(F)(F)F)c(s1)-c1cccc(F)c1 CQXDHNQICUYCME-KRWDZBQOSA-N 0.000 claims 1
• MLVMGAOQNWHRLW-IBGZPJMESA-N ClC1=C(C=CC=C1)C1=NOC(=N1)[C@H]1N(CCC1)C(=O)C1=C(C=C(C(=C1)C)C)N1N=CC=N1 Chemical compound ClC1=C(C=CC=C1)C1=NOC(=N1)[C@H]1N(CCC1)C(=O)C1=C(C=C(C(=C1)C)C)N1N=CC=N1 MLVMGAOQNWHRLW-IBGZPJMESA-N 0.000 claims 1
• CIXFDKCSGHGGNM-KRWDZBQOSA-N ClC1=CC(=C(C=C1)C(=O)N1[C@@H](CCC1)C1=NC(=NO1)C=1C(=NC=CC1)OCC)N1N=CC=N1 Chemical compound ClC1=CC(=C(C=C1)C(=O)N1[C@@H](CCC1)C1=NC(=NO1)C=1C(=NC=CC1)OCC)N1N=CC=N1 CIXFDKCSGHGGNM-KRWDZBQOSA-N 0.000 claims 1
• XEWMCRKQHIEWNY-KRWDZBQOSA-N ClC1=CC(=C(C=C1)C(=O)N1[C@@H](CCC1)C1=NN=C(N1)C=1C(=NC=CC1)OCC)N1N=CC=N1 Chemical compound ClC1=CC(=C(C=C1)C(=O)N1[C@@H](CCC1)C1=NN=C(N1)C=1C(=NC=CC1)OCC)N1N=CC=N1 XEWMCRKQHIEWNY-KRWDZBQOSA-N 0.000 claims 1
• RMSUYCUIZRSRCK-IBGZPJMESA-N ClC1=CC(=C(C=C1)C(=O)N1[C@@H](CCC1)C1=NOC(=N1)C1=C(C(=CC=C1)C)C)N1N=CC=N1 Chemical compound ClC1=CC(=C(C=C1)C(=O)N1[C@@H](CCC1)C1=NOC(=N1)C1=C(C(=CC=C1)C)C)N1N=CC=N1 RMSUYCUIZRSRCK-IBGZPJMESA-N 0.000 claims 1
• HEWRQKPGVCKCIB-SFHVURJKSA-N ClC1=CC(=C(C=C1)C(=O)N1[C@@H](CCC1)C1=NOC(=N1)C1=C(C(=CC=C1)F)C)N1N=CC=N1 Chemical compound ClC1=CC(=C(C=C1)C(=O)N1[C@@H](CCC1)C1=NOC(=N1)C1=C(C(=CC=C1)F)C)N1N=CC=N1 HEWRQKPGVCKCIB-SFHVURJKSA-N 0.000 claims 1
• JFKPHXAMVDYFHM-IBGZPJMESA-N ClC1=CC(=C(C=C1)C(=O)N1[C@@H](CCC1)C1=NOC(=N1)C1=C(C=CC(=C1)C)C)N1N=CC=N1 Chemical compound ClC1=CC(=C(C=C1)C(=O)N1[C@@H](CCC1)C1=NOC(=N1)C1=C(C=CC(=C1)C)C)N1N=CC=N1 JFKPHXAMVDYFHM-IBGZPJMESA-N 0.000 claims 1
• BDKZCWUCGJUALO-SFHVURJKSA-N ClC1=CC(=C(C=C1)C(=O)N1[C@@H](CCC1)C1=NOC(=N1)C1=C(C=CC(=C1)C)OC)N1N=CC=N1 Chemical compound ClC1=CC(=C(C=C1)C(=O)N1[C@@H](CCC1)C1=NOC(=N1)C1=C(C=CC(=C1)C)OC)N1N=CC=N1 BDKZCWUCGJUALO-SFHVURJKSA-N 0.000 claims 1
• KOAIPQZPHNCZCQ-IBGZPJMESA-N ClC1=CC(=C(C=C1)C(=O)N1[C@@H](CCC1)C1=NOC(=N1)C1=C(C=CC(=C1)OC)C)N1N=CC=N1 Chemical compound ClC1=CC(=C(C=C1)C(=O)N1[C@@H](CCC1)C1=NOC(=N1)C1=C(C=CC(=C1)OC)C)N1N=CC=N1 KOAIPQZPHNCZCQ-IBGZPJMESA-N 0.000 claims 1
• CDOIUTYZVCLBBB-IBGZPJMESA-N ClC1=CC(=C(C=C1)C(=O)N1[C@@H](CCC1)C1=NOC(=N1)C1=CC(=CC(=C1)C)OC)N1N=CC=N1 Chemical compound ClC1=CC(=C(C=C1)C(=O)N1[C@@H](CCC1)C1=NOC(=N1)C1=CC(=CC(=C1)C)OC)N1N=CC=N1 CDOIUTYZVCLBBB-IBGZPJMESA-N 0.000 claims 1
• XALXDCYASGVZAD-KRWDZBQOSA-N ClC1=CC(=C(C=C1)C(=O)N1[C@@H](CCC1)C1=NOC(=N1)C=1C(=NC=CC1)OCC)N1N=CC=N1 Chemical compound ClC1=CC(=C(C=C1)C(=O)N1[C@@H](CCC1)C1=NOC(=N1)C=1C(=NC=CC1)OCC)N1N=CC=N1 XALXDCYASGVZAD-KRWDZBQOSA-N 0.000 claims 1
• WLBCPTKNCBIYOL-KRWDZBQOSA-N ClC1=CC(=C(C=C1OC)C(=O)N1[C@@H](CCC1)C1=NOC(=N1)C=1C(=NC=CC1)OCC)N1N=CC=N1 Chemical compound ClC1=CC(=C(C=C1OC)C(=O)N1[C@@H](CCC1)C1=NOC(=N1)C=1C(=NC=CC1)OCC)N1N=CC=N1 WLBCPTKNCBIYOL-KRWDZBQOSA-N 0.000 claims 1
• SIFXMAVPETUVES-QFIPXVFZSA-N ClC=1C(=C(C=CC1)C1=CC(=NO1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)C)N1N=CC=N1)C Chemical compound ClC=1C(=C(C=CC1)C1=CC(=NO1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)C)N1N=CC=N1)C SIFXMAVPETUVES-QFIPXVFZSA-N 0.000 claims 1
• GSZLOBRWCYPYOC-FQEVSTJZSA-N ClC=1C(=C(C=CC1)C1=NC(=NO1)[C@H]1N(CCC1)C(=O)C1=C(C=C(C(=C1)C)C)N1N=CC=N1)C Chemical compound ClC=1C(=C(C=CC1)C1=NC(=NO1)[C@H]1N(CCC1)C(=O)C1=C(C=C(C(=C1)C)C)N1N=CC=N1)C GSZLOBRWCYPYOC-FQEVSTJZSA-N 0.000 claims 1
• ODDWFVQXCLKZAD-SFHVURJKSA-N ClC=1C(=C(C=CC1)C1=NC(=NO1)[C@H]1N(CCC1)C(=O)C1=C(C=C(C(=C1)OC)F)N1N=CC=N1)C Chemical compound ClC=1C(=C(C=CC1)C1=NC(=NO1)[C@H]1N(CCC1)C(=O)C1=C(C=C(C(=C1)OC)F)N1N=CC=N1)C ODDWFVQXCLKZAD-SFHVURJKSA-N 0.000 claims 1
• HHLSEUYVEXYXSK-FQEVSTJZSA-N ClC=1C(=C(C=CC1)C1=NN=C(O1)[C@H]1N(CCC1)C(=O)C1=C(C=C(C(=C1)C)C)N1N=CC=N1)C Chemical compound ClC=1C(=C(C=CC1)C1=NN=C(O1)[C@H]1N(CCC1)C(=O)C1=C(C=C(C(=C1)C)C)N1N=CC=N1)C HHLSEUYVEXYXSK-FQEVSTJZSA-N 0.000 claims 1
• VWZLKTHNERNQKO-FQEVSTJZSA-N ClC=1C(=C(C=CC1)C1=NN=C(O1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)C)N1N=CC=N1)C Chemical compound ClC=1C(=C(C=CC1)C1=NN=C(O1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)C)N1N=CC=N1)C VWZLKTHNERNQKO-FQEVSTJZSA-N 0.000 claims 1
• FMWKBJSUYHPPBB-IBGZPJMESA-N ClC=1C(=C(C=CC1)C1=NOC(=N1)[C@H]1N(CCC1)C(=O)C1=C(C=C(C=C1)C)N1N=CC=N1)C Chemical compound ClC=1C(=C(C=CC1)C1=NOC(=N1)[C@H]1N(CCC1)C(=O)C1=C(C=C(C=C1)C)N1N=CC=N1)C FMWKBJSUYHPPBB-IBGZPJMESA-N 0.000 claims 1
• XKSXDMMDHQSNPE-IBGZPJMESA-N ClC=1C(=C(C=CC1)C1=NOC(=N1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)Cl)N1N=CC=N1)C Chemical compound ClC=1C(=C(C=CC1)C1=NOC(=N1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)Cl)N1N=CC=N1)C XKSXDMMDHQSNPE-IBGZPJMESA-N 0.000 claims 1
• BTEPZYPEINXPCH-IBGZPJMESA-N ClC=1C(=C(C=CC1)C1=NOC(=N1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)F)N1N=CC=N1)C Chemical compound ClC=1C(=C(C=CC1)C1=NOC(=N1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)F)N1N=CC=N1)C BTEPZYPEINXPCH-IBGZPJMESA-N 0.000 claims 1
• WGNVKGARGFBADT-IBGZPJMESA-N ClC=1C(=C(C=CC1)C1=NOC(=N1)[C@H]1N(CCC1)C(=O)C1=C(C=CC=C1)N1N=CC=N1)C Chemical compound ClC=1C(=C(C=CC1)C1=NOC(=N1)[C@H]1N(CCC1)C(=O)C1=C(C=CC=C1)N1N=CC=N1)C WGNVKGARGFBADT-IBGZPJMESA-N 0.000 claims 1
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• HOEQPSNBDXUTKR-FQEVSTJZSA-N O1CCC2=C1C(=CC=C2)C2=NC(=NO2)[C@H]2N(CCC2)C(=O)C2=C(C=CC(=C2)C)N2N=CC=N2 Chemical compound O1CCC2=C1C(=CC=C2)C2=NC(=NO2)[C@H]2N(CCC2)C(=O)C2=C(C=CC(=C2)C)N2N=CC=N2 HOEQPSNBDXUTKR-FQEVSTJZSA-N 0.000 claims 1
• 102000002512 Orexin Human genes 0.000 claims 1
• INHPFTDEDVOXBF-NRFANRHFSA-N [(2S)-2-[3-(1H-indol-3-yl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound N1C=C(C2=CC=CC=C12)C1=NOC(=N1)[C@H]1N(CCC1)C(=O)C1=C(C=CC(=C1)C)N1N=CC=N1 INHPFTDEDVOXBF-NRFANRHFSA-N 0.000 claims 1
• ZITUKKHGVQJWGU-QFIPXVFZSA-N [(2s)-2-[3-(1-methylindol-3-yl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound N1([C@@H](CCC1)C=1ON=C(N=1)C=1C2=CC=CC=C2N(C)C=1)C(=O)C1=CC(C)=CC=C1N1N=CC=N1 ZITUKKHGVQJWGU-QFIPXVFZSA-N 0.000 claims 1
• YVTHIABVFFJHMP-FQEVSTJZSA-N [(2s)-2-[3-(1-methylpyrrolo[2,3-b]pyridin-3-yl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound N1([C@@H](CCC1)C=1ON=C(N=1)C=1C2=CC=CN=C2N(C)C=1)C(=O)C1=CC(C)=CC=C1N1N=CC=N1 YVTHIABVFFJHMP-FQEVSTJZSA-N 0.000 claims 1
• JSJSRBOREVOTHH-FQEVSTJZSA-N [(2s)-2-[3-(1h-indol-7-yl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound N1([C@@H](CCC1)C=1ON=C(N=1)C=1C=2NC=CC=2C=CC=1)C(=O)C1=CC(C)=CC=C1N1N=CC=N1 JSJSRBOREVOTHH-FQEVSTJZSA-N 0.000 claims 1
• YPFANHJCIUGNFX-IBGZPJMESA-N [(2s)-2-[3-(2,3-dihydro-1,4-benzodioxin-5-yl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound N1([C@@H](CCC1)C=1ON=C(N=1)C=1C=2OCCOC=2C=CC=1)C(=O)C1=CC(C)=CC=C1N1N=CC=N1 YPFANHJCIUGNFX-IBGZPJMESA-N 0.000 claims 1
• KLYDQFHKQVGPQO-QFIPXVFZSA-N [(2s)-2-[3-(2-cyclopropylphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound N=1OC([C@@H]2CCCN2C(=O)C=2C(=CC=C(C=2)C)N2N=CC=N2)=NC=1C1=CC=CC=C1C1CC1 KLYDQFHKQVGPQO-QFIPXVFZSA-N 0.000 claims 1
• ALBXNFSZYZOJKH-FQEVSTJZSA-N [(2s)-2-[3-(2-ethoxy-3-fluorophenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound CCOC1=C(F)C=CC=C1C1=NOC([C@H]2N(CCC2)C(=O)C=2C(=CC=C(C)C=2)N2N=CC=N2)=N1 ALBXNFSZYZOJKH-FQEVSTJZSA-N 0.000 claims 1
• OVALEAYBEXPOBZ-IBGZPJMESA-N [(2s)-2-[3-(2-ethoxyphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-[4-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound CCOC1=CC=CC=C1C1=NOC([C@H]2N(CCC2)C(=O)C=2C(=CC(C)=CC=2)N2N=CC=N2)=N1 OVALEAYBEXPOBZ-IBGZPJMESA-N 0.000 claims 1
• AEQCSYKEJXBYLJ-FQEVSTJZSA-N [(2s)-2-[3-(2-ethoxyphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-[5-methoxy-2-(triazol-2-yl)phenyl]methanone Chemical compound CCOC1=CC=CC=C1C1=NOC([C@H]2N(CCC2)C(=O)C=2C(=CC=C(OC)C=2)N2N=CC=N2)=N1 AEQCSYKEJXBYLJ-FQEVSTJZSA-N 0.000 claims 1
• LDRMAURZTZUDBO-IBGZPJMESA-N [(2s)-2-[3-(2-ethoxyphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-[5-methoxy-4-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound CCOC1=CC=CC=C1C1=NOC([C@H]2N(CCC2)C(=O)C=2C(=CC(C)=C(OC)C=2)N2N=CC=N2)=N1 LDRMAURZTZUDBO-IBGZPJMESA-N 0.000 claims 1
• MOOJFCAHSQXGTF-FQEVSTJZSA-N [(2s)-2-[3-(2-ethoxyphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound CCOC1=CC=CC=C1C1=NOC([C@H]2N(CCC2)C(=O)C=2C(=CC=C(C)C=2)N2N=CC=N2)=N1 MOOJFCAHSQXGTF-FQEVSTJZSA-N 0.000 claims 1
• KIQOCRUHKZKGSM-FQEVSTJZSA-N [(2s)-2-[3-(2-ethoxyphenyl)-1h-1,2,4-triazol-5-yl]pyrrolidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound CCOC1=CC=CC=C1C1=NNC([C@H]2N(CCC2)C(=O)C=2C(=CC=C(C)C=2)N2N=CC=N2)=N1 KIQOCRUHKZKGSM-FQEVSTJZSA-N 0.000 claims 1
• MWMQFJWXGDHJEA-QFIPXVFZSA-N [(2s)-2-[3-(2-ethoxypyridin-3-yl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-(5-methyl-2-pyridin-2-ylphenyl)methanone Chemical compound CCOC1=NC=CC=C1C1=NOC([C@H]2N(CCC2)C(=O)C=2C(=CC=C(C)C=2)C=2N=CC=CC=2)=N1 MWMQFJWXGDHJEA-QFIPXVFZSA-N 0.000 claims 1
• OICXNPWYVQDQDJ-SFHVURJKSA-N [(2s)-2-[3-(2-ethoxypyridin-3-yl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-[5-methoxy-4-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound CCOC1=NC=CC=C1C1=NOC([C@H]2N(CCC2)C(=O)C=2C(=CC(C)=C(OC)C=2)N2N=CC=N2)=N1 OICXNPWYVQDQDJ-SFHVURJKSA-N 0.000 claims 1
• XDTWUYIFUWJHJO-IBGZPJMESA-N [(2s)-2-[3-(2-ethoxypyridin-3-yl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-[5-methyl-2-(1,3-oxazol-2-yl)phenyl]methanone Chemical compound CCOC1=NC=CC=C1C1=NOC([C@H]2N(CCC2)C(=O)C=2C(=CC=C(C)C=2)C=2OC=CN=2)=N1 XDTWUYIFUWJHJO-IBGZPJMESA-N 0.000 claims 1
• HNDFUSHHJCZIBK-IBGZPJMESA-N [(2s)-2-[3-(2-ethoxypyridin-3-yl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound CCOC1=NC=CC=C1C1=NOC([C@H]2N(CCC2)C(=O)C=2C(=CC=C(C)C=2)N2N=CC=N2)=N1 HNDFUSHHJCZIBK-IBGZPJMESA-N 0.000 claims 1
• JOJYKUAAFKCDAP-NRFANRHFSA-N [(2s)-2-[3-(2-ethylphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound CCC1=CC=CC=C1C1=NOC([C@H]2N(CCC2)C(=O)C=2C(=CC=C(C)C=2)N2N=CC=N2)=N1 JOJYKUAAFKCDAP-NRFANRHFSA-N 0.000 claims 1
• DYOCRWOKDQEUMZ-DEOSSOPVSA-N [(2s)-2-[3-(3-chloro-2-methylphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-(5-methoxy-2-phenylphenyl)methanone Chemical compound N1([C@@H](CCC1)C=1ON=C(N=1)C=1C(=C(Cl)C=CC=1)C)C(=O)C1=CC(OC)=CC=C1C1=CC=CC=C1 DYOCRWOKDQEUMZ-DEOSSOPVSA-N 0.000 claims 1
• AOTBDTKVDOOBKK-DEOSSOPVSA-N [(2s)-2-[3-(3-chloro-2-methylphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-(5-methyl-2-phenylphenyl)methanone Chemical compound N1([C@@H](CCC1)C=1ON=C(N=1)C=1C(=C(Cl)C=CC=1)C)C(=O)C1=CC(C)=CC=C1C1=CC=CC=C1 AOTBDTKVDOOBKK-DEOSSOPVSA-N 0.000 claims 1
• BYRMZJPZYRHYMU-FQEVSTJZSA-N [(2s)-2-[3-(3-chloro-2-methylphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-[4,5-dimethyl-2-(triazol-2-yl)phenyl]methanone Chemical compound N=1OC([C@@H]2CCCN2C(=O)C=2C=C(C(=CC=2N2N=CC=N2)C)C)=NC=1C1=CC=CC(Cl)=C1C BYRMZJPZYRHYMU-FQEVSTJZSA-N 0.000 claims 1
• OQKNBRCSHWHRMT-IBGZPJMESA-N [(2s)-2-[3-(3-chloro-2-methylphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-[5-methoxy-4-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound N=1OC([C@@H]2CCCN2C(=O)C=2C=C(C(=CC=2N2N=CC=N2)C)OC)=NC=1C1=CC=CC(Cl)=C1C OQKNBRCSHWHRMT-IBGZPJMESA-N 0.000 claims 1
• RGPJTJSFVNOMPE-FQEVSTJZSA-N [(2s)-2-[3-(3-chloro-2-methylphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-[5-methyl-2-(1,3-oxazol-2-yl)phenyl]methanone Chemical compound N1([C@@H](CCC1)C=1ON=C(N=1)C=1C(=C(Cl)C=CC=1)C)C(=O)C1=CC(C)=CC=C1C1=NC=CO1 RGPJTJSFVNOMPE-FQEVSTJZSA-N 0.000 claims 1
• NGQAYYCFKZGBNI-FQEVSTJZSA-N [(2s)-2-[3-(3-chloro-2-methylphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound N=1OC([C@@H]2CCCN2C(=O)C=2C(=CC=C(C=2)C)N2N=CC=N2)=NC=1C1=CC=CC(Cl)=C1C NGQAYYCFKZGBNI-FQEVSTJZSA-N 0.000 claims 1
• LIQZDMACERNNNO-SFHVURJKSA-N [(2s)-2-[3-(3-fluoro-2-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-[5-methoxy-4-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound N=1OC([C@@H]2CCCN2C(=O)C=2C=C(C(=CC=2N2N=CC=N2)C)OC)=NC=1C1=CC=CC(F)=C1OC LIQZDMACERNNNO-SFHVURJKSA-N 0.000 claims 1
• GHZBHHGLXHLLGK-IBGZPJMESA-N [(2s)-2-[3-(3-fluoro-2-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound COC1=C(F)C=CC=C1C1=NOC([C@H]2N(CCC2)C(=O)C=2C(=CC=C(C)C=2)N2N=CC=N2)=N1 GHZBHHGLXHLLGK-IBGZPJMESA-N 0.000 claims 1
• PHECLAFBTXLENM-IBGZPJMESA-N [(2s)-2-[3-(3-fluoro-2-methoxyphenyl)-1h-1,2,4-triazol-5-yl]pyrrolidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound COC1=C(F)C=CC=C1C1=NNC([C@H]2N(CCC2)C(=O)C=2C(=CC=C(C)C=2)N2N=CC=N2)=N1 PHECLAFBTXLENM-IBGZPJMESA-N 0.000 claims 1
• FHKLCVQERNPNFB-SFHVURJKSA-N [(2s)-2-[3-[2-(difluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-[4,5-dimethyl-2-(triazol-2-yl)phenyl]methanone Chemical compound N=1OC([C@@H]2CCCN2C(=O)C=2C=C(C(=CC=2N2N=CC=N2)C)C)=NC=1C1=CC=CC=C1OC(F)F FHKLCVQERNPNFB-SFHVURJKSA-N 0.000 claims 1
• DXCJSSMKWSUPJG-KRWDZBQOSA-N [(2s)-2-[3-[2-(difluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]-[5-methoxy-4-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound N=1OC([C@@H]2CCCN2C(=O)C=2C=C(C(=CC=2N2N=CC=N2)C)OC)=NC=1C1=CC=CC=C1OC(F)F DXCJSSMKWSUPJG-KRWDZBQOSA-N 0.000 claims 1
• UOSSAVXHFVDLHG-FQEVSTJZSA-N [(2s)-2-[5-(2,3-dimethylphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]-[5-methoxy-4-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound N=1C([C@@H]2CCCN2C(=O)C=2C=C(C(=CC=2N2N=CC=N2)C)OC)=NOC=1C1=CC=CC(C)=C1C UOSSAVXHFVDLHG-FQEVSTJZSA-N 0.000 claims 1
• WYKNCJASXYZRBP-FQEVSTJZSA-N [(2s)-2-[5-(2,5-dimethylphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]-[5-methoxy-4-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound N=1C([C@@H]2CCCN2C(=O)C=2C=C(C(=CC=2N2N=CC=N2)C)OC)=NOC=1C1=CC(C)=CC=C1C WYKNCJASXYZRBP-FQEVSTJZSA-N 0.000 claims 1
• WAEXOHCHFPXJKG-IBGZPJMESA-N [(2s)-2-[5-(2-ethoxy-3-fluorophenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]-[4-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound CCOC1=C(F)C=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC(C)=CC=2)N2N=CC=N2)=NO1 WAEXOHCHFPXJKG-IBGZPJMESA-N 0.000 claims 1
• FCJMMEVNQNVXGE-FQEVSTJZSA-N [(2s)-2-[5-(2-ethoxy-3-fluorophenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]-[5-methoxy-2-(triazol-2-yl)phenyl]methanone Chemical compound CCOC1=C(F)C=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC=C(OC)C=2)N2N=CC=N2)=NO1 FCJMMEVNQNVXGE-FQEVSTJZSA-N 0.000 claims 1
• SDAUGRXYUNFKEF-FQEVSTJZSA-N [(2s)-2-[5-(2-ethoxy-3-fluorophenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound CCOC1=C(F)C=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC=C(C)C=2)N2N=CC=N2)=NO1 SDAUGRXYUNFKEF-FQEVSTJZSA-N 0.000 claims 1
• NCMHZVAFPWWMGJ-IBGZPJMESA-N [(2s)-2-[5-(2-ethoxyphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]-[5-methoxy-4-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound CCOC1=CC=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC(C)=C(OC)C=2)N2N=CC=N2)=NO1 NCMHZVAFPWWMGJ-IBGZPJMESA-N 0.000 claims 1
• MAOUWQSDIAWQEC-FQEVSTJZSA-N [(2s)-2-[5-(2-ethoxyphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound CCOC1=CC=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC=C(C)C=2)N2N=CC=N2)=NO1 MAOUWQSDIAWQEC-FQEVSTJZSA-N 0.000 claims 1
• HCOCPXCAVLDJOP-SFHVURJKSA-N [(2s)-2-[5-(2-ethoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]-[4-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound CCOC1=NC=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC(C)=CC=2)N2N=CC=N2)=NO1 HCOCPXCAVLDJOP-SFHVURJKSA-N 0.000 claims 1
• QZJBWKPFJDTYKJ-SFHVURJKSA-N [(2s)-2-[5-(2-ethoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]-[5-methoxy-4-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound CCOC1=NC=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC(C)=C(OC)C=2)N2N=CC=N2)=NO1 QZJBWKPFJDTYKJ-SFHVURJKSA-N 0.000 claims 1
• YXGWHKJTXBZROR-IBGZPJMESA-N [(2s)-2-[5-(2-ethoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound CCOC1=NC=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC=C(C)C=2)N2N=CC=N2)=NO1 YXGWHKJTXBZROR-IBGZPJMESA-N 0.000 claims 1
• PTYRUMWEJWQKEX-FQEVSTJZSA-N [(2s)-2-[5-(2-ethylphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]-[4-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound CCC1=CC=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC(C)=CC=2)N2N=CC=N2)=NO1 PTYRUMWEJWQKEX-FQEVSTJZSA-N 0.000 claims 1
• DHYDDYGJWVOABE-FQEVSTJZSA-N [(2s)-2-[5-(2-ethylphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]-[5-methoxy-4-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound CCC1=CC=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC(C)=C(OC)C=2)N2N=CC=N2)=NO1 DHYDDYGJWVOABE-FQEVSTJZSA-N 0.000 claims 1
• LOMMSPUQTUQVKU-NRFANRHFSA-N [(2s)-2-[5-(2-ethylphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound CCC1=CC=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC=C(C)C=2)N2N=CC=N2)=NO1 LOMMSPUQTUQVKU-NRFANRHFSA-N 0.000 claims 1
• RHUPJZFHSQTXAK-IBGZPJMESA-N [(2s)-2-[5-(3-chloro-2-methoxyphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]-[4,5-dimethyl-2-(triazol-2-yl)phenyl]methanone Chemical compound COC1=C(Cl)C=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC(C)=C(C)C=2)N2N=CC=N2)=NO1 RHUPJZFHSQTXAK-IBGZPJMESA-N 0.000 claims 1
• CGZZINUKGZISIW-KRWDZBQOSA-N [(2s)-2-[5-(3-chloro-2-methoxyphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]-[4-chloro-2-(triazol-2-yl)phenyl]methanone Chemical compound COC1=C(Cl)C=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC(Cl)=CC=2)N2N=CC=N2)=NO1 CGZZINUKGZISIW-KRWDZBQOSA-N 0.000 claims 1
• XVMBACKIQPNUGC-KRWDZBQOSA-N [(2s)-2-[5-(3-chloro-2-methoxyphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]-[4-chloro-5-methoxy-2-(triazol-2-yl)phenyl]methanone Chemical compound N=1C([C@@H]2CCCN2C(=O)C=2C=C(C(=CC=2N2N=CC=N2)Cl)OC)=NOC=1C1=CC=CC(Cl)=C1OC XVMBACKIQPNUGC-KRWDZBQOSA-N 0.000 claims 1
• KYTNZCGPNOLKFR-SFHVURJKSA-N [(2s)-2-[5-(3-chloro-2-methoxyphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]-[4-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound COC1=C(Cl)C=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC(C)=CC=2)N2N=CC=N2)=NO1 KYTNZCGPNOLKFR-SFHVURJKSA-N 0.000 claims 1
• KGKGDIZMVSOFOL-SFHVURJKSA-N [(2s)-2-[5-(3-chloro-2-methoxyphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]-[5-methoxy-4-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound N=1C([C@@H]2CCCN2C(=O)C=2C=C(C(=CC=2N2N=CC=N2)C)OC)=NOC=1C1=CC=CC(Cl)=C1OC KGKGDIZMVSOFOL-SFHVURJKSA-N 0.000 claims 1
• ZDNRNMMSPMXUID-IBGZPJMESA-N [(2s)-2-[5-(3-chloro-2-methoxyphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound COC1=C(Cl)C=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC=C(C)C=2)N2N=CC=N2)=NO1 ZDNRNMMSPMXUID-IBGZPJMESA-N 0.000 claims 1
• VKXRYIXAFXMKJX-IBGZPJMESA-N [(2s)-2-[5-(3-chloro-2-methylphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]-[5-chloro-4-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound N=1C([C@@H]2CCCN2C(=O)C2=C(C=C(C(=C2)Cl)C)N2N=CC=N2)=NOC=1C1=CC=CC(Cl)=C1C VKXRYIXAFXMKJX-IBGZPJMESA-N 0.000 claims 1
• TYCFKFVBDFJNLG-FQEVSTJZSA-N [(2s)-2-[5-(3-chloro-2-methylphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound N=1C([C@@H]2CCCN2C(=O)C=2C(=CC=C(C=2)C)N2N=CC=N2)=NOC=1C1=CC=CC(Cl)=C1C TYCFKFVBDFJNLG-FQEVSTJZSA-N 0.000 claims 1
• YGMFAGAXNKHGHK-SFHVURJKSA-N [(2s)-2-[5-(3-fluoro-2-methoxyphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]-[4-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound COC1=C(F)C=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC(C)=CC=2)N2N=CC=N2)=NO1 YGMFAGAXNKHGHK-SFHVURJKSA-N 0.000 claims 1
• RMNHSADRXFGNFC-IBGZPJMESA-N [(2s)-2-[5-(3-fluoro-2-methoxyphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]-[5-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound COC1=C(F)C=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC=C(C)C=2)N2N=CC=N2)=NO1 RMNHSADRXFGNFC-IBGZPJMESA-N 0.000 claims 1
• ITUQWEVHCQGQNX-FQEVSTJZSA-N [(2s)-2-[5-(3-methoxy-5-methylphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]-[5-methoxy-4-methyl-2-(triazol-2-yl)phenyl]methanone Chemical compound COC1=CC(C)=CC(C=2ON=C(N=2)[C@H]2N(CCC2)C(=O)C=2C(=CC(C)=C(OC)C=2)N2N=CC=N2)=C1 ITUQWEVHCQGQNX-FQEVSTJZSA-N 0.000 claims 1
• VDDCPARAGTYUEF-KRWDZBQOSA-N [3-fluoro-2-(1h-pyrazol-5-yl)phenyl]-[(2s)-2-[3-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]methanone Chemical compound N=1OC([C@@H]2CCCN2C(=O)C=2C=CC=C(C=2C=2NN=CC=2)F)=NC=1C1=CC=CC=C1OC(F)(F)F VDDCPARAGTYUEF-KRWDZBQOSA-N 0.000 claims 1
• BXNCXMMOWAUHNN-FQEVSTJZSA-N [4,5-dimethyl-2-(triazol-2-yl)phenyl]-[(2s)-2-[3-(2-ethoxyphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]methanone Chemical compound CCOC1=CC=CC=C1C1=NOC([C@H]2N(CCC2)C(=O)C=2C(=CC(C)=C(C)C=2)N2N=CC=N2)=N1 BXNCXMMOWAUHNN-FQEVSTJZSA-N 0.000 claims 1
• BOQVDFTVLWLBKS-IBGZPJMESA-N [4,5-dimethyl-2-(triazol-2-yl)phenyl]-[(2s)-2-[3-(2-ethoxypyridin-3-yl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]methanone Chemical compound CCOC1=NC=CC=C1C1=NOC([C@H]2N(CCC2)C(=O)C=2C(=CC(C)=C(C)C=2)N2N=CC=N2)=N1 BOQVDFTVLWLBKS-IBGZPJMESA-N 0.000 claims 1
• AOZWQYYEGGLQBY-IBGZPJMESA-N [4,5-dimethyl-2-(triazol-2-yl)phenyl]-[(2s)-2-[3-(2-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]methanone Chemical compound COC1=CC=CC=C1C1=NOC([C@H]2N(CCC2)C(=O)C=2C(=CC(C)=C(C)C=2)N2N=CC=N2)=N1 AOZWQYYEGGLQBY-IBGZPJMESA-N 0.000 claims 1
• ATARZXBFRHLHQO-IBGZPJMESA-N [4,5-dimethyl-2-(triazol-2-yl)phenyl]-[(2s)-2-[3-(3-fluoro-2-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]methanone Chemical compound COC1=C(F)C=CC=C1C1=NOC([C@H]2N(CCC2)C(=O)C=2C(=CC(C)=C(C)C=2)N2N=CC=N2)=N1 ATARZXBFRHLHQO-IBGZPJMESA-N 0.000 claims 1
• XFRQAEZGKBUEPA-FQEVSTJZSA-N [4,5-dimethyl-2-(triazol-2-yl)phenyl]-[(2s)-2-[3-(3-fluoro-2-methylphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]methanone Chemical compound N=1OC([C@@H]2CCCN2C(=O)C=2C=C(C(=CC=2N2N=CC=N2)C)C)=NC=1C1=CC=CC(F)=C1C XFRQAEZGKBUEPA-FQEVSTJZSA-N 0.000 claims 1
• ZOYRDRBQOSBGOX-SFHVURJKSA-N [4,5-dimethyl-2-(triazol-2-yl)phenyl]-[(2s)-2-[3-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]methanone Chemical compound N=1OC([C@@H]2CCCN2C(=O)C=2C=C(C(=CC=2N2N=CC=N2)C)C)=NC=1C1=CC=CC=C1OC(F)(F)F ZOYRDRBQOSBGOX-SFHVURJKSA-N 0.000 claims 1
• ALLRFJYWSLYPOG-FQEVSTJZSA-N [4,5-dimethyl-2-(triazol-2-yl)phenyl]-[(2s)-2-[5-(2-ethoxy-3-fluorophenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]methanone Chemical compound CCOC1=C(F)C=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC(C)=C(C)C=2)N2N=CC=N2)=NO1 ALLRFJYWSLYPOG-FQEVSTJZSA-N 0.000 claims 1
• SXDFZCLHFGCOFB-IBGZPJMESA-N [4,5-dimethyl-2-(triazol-2-yl)phenyl]-[(2s)-2-[5-(2-ethoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]methanone Chemical compound CCOC1=NC=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC(C)=C(C)C=2)N2N=CC=N2)=NO1 SXDFZCLHFGCOFB-IBGZPJMESA-N 0.000 claims 1
• WFKJFMTZYPXCJR-NRFANRHFSA-N [4,5-dimethyl-2-(triazol-2-yl)phenyl]-[(2s)-2-[5-(2-ethylphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]methanone Chemical compound CCC1=CC=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC(C)=C(C)C=2)N2N=CC=N2)=NO1 WFKJFMTZYPXCJR-NRFANRHFSA-N 0.000 claims 1
• JWAFZGHEIPYAAF-NRFANRHFSA-N [4,5-dimethyl-2-(triazol-2-yl)phenyl]-[(2s)-2-[5-(3-methoxy-5-methylphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]methanone Chemical compound COC1=CC(C)=CC(C=2ON=C(N=2)[C@H]2N(CCC2)C(=O)C=2C(=CC(C)=C(C)C=2)N2N=CC=N2)=C1 JWAFZGHEIPYAAF-NRFANRHFSA-N 0.000 claims 1
• UEQIXEFMENPZOI-NRFANRHFSA-N [4,5-dimethyl-2-(triazol-2-yl)phenyl]-[(2s)-2-[5-(5-methoxy-2-methylphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]methanone Chemical compound COC1=CC=C(C)C(C=2ON=C(N=2)[C@H]2N(CCC2)C(=O)C=2C(=CC(C)=C(C)C=2)N2N=CC=N2)=C1 UEQIXEFMENPZOI-NRFANRHFSA-N 0.000 claims 1
• OESAAULEOZNLQH-SFHVURJKSA-N [4,5-dimethyl-2-(triazol-2-yl)phenyl]-[(2s)-2-[5-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]methanone Chemical compound N=1C([C@@H]2CCCN2C(=O)C=2C=C(C(=CC=2N2N=CC=N2)C)C)=NOC=1C1=CC=CC=C1OC(F)(F)F OESAAULEOZNLQH-SFHVURJKSA-N 0.000 claims 1
• CMBMBKUVYWOSMU-SFHVURJKSA-N [4-chloro-2-(triazol-2-yl)phenyl]-[(2s)-2-[5-(2-ethoxy-3-fluorophenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]methanone Chemical compound CCOC1=C(F)C=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC(Cl)=CC=2)N2N=CC=N2)=NO1 CMBMBKUVYWOSMU-SFHVURJKSA-N 0.000 claims 1
• KNKZHYJZNLJPTJ-IBGZPJMESA-N [4-chloro-2-(triazol-2-yl)phenyl]-[(2s)-2-[5-(2-ethylphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]methanone Chemical compound CCC1=CC=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC(Cl)=CC=2)N2N=CC=N2)=NO1 KNKZHYJZNLJPTJ-IBGZPJMESA-N 0.000 claims 1
• VKQDVMGJZIQRCE-KRWDZBQOSA-N [4-chloro-2-(triazol-2-yl)phenyl]-[(2s)-2-[5-(3-fluoro-2-methoxyphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]methanone Chemical compound COC1=C(F)C=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC(Cl)=CC=2)N2N=CC=N2)=NO1 VKQDVMGJZIQRCE-KRWDZBQOSA-N 0.000 claims 1
• FRYUNBZKBYREKE-INIZCTEOSA-N [4-chloro-2-(triazol-2-yl)phenyl]-[(2s)-2-[5-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]methanone Chemical compound FC(F)(F)OC1=CC=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC(Cl)=CC=2)N2N=CC=N2)=NO1 FRYUNBZKBYREKE-INIZCTEOSA-N 0.000 claims 1
• UPCSQQLORDJECH-IBGZPJMESA-N [4-chloro-5-methoxy-2-(triazol-2-yl)phenyl]-[(2s)-2-[5-(2,3-dimethylphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]methanone Chemical compound N=1C([C@@H]2CCCN2C(=O)C=2C=C(C(=CC=2N2N=CC=N2)Cl)OC)=NOC=1C1=CC=CC(C)=C1C UPCSQQLORDJECH-IBGZPJMESA-N 0.000 claims 1
• IDVJAKOPKJBANF-IBGZPJMESA-N [4-chloro-5-methoxy-2-(triazol-2-yl)phenyl]-[(2s)-2-[5-(2,5-dimethylphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]methanone Chemical compound N=1C([C@@H]2CCCN2C(=O)C=2C=C(C(=CC=2N2N=CC=N2)Cl)OC)=NOC=1C1=CC(C)=CC=C1C IDVJAKOPKJBANF-IBGZPJMESA-N 0.000 claims 1
• FEQYQBGREABPNL-IBGZPJMESA-N [4-chloro-5-methoxy-2-(triazol-2-yl)phenyl]-[(2s)-2-[5-(2-ethylphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]methanone Chemical compound CCC1=CC=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC(Cl)=C(OC)C=2)N2N=CC=N2)=NO1 FEQYQBGREABPNL-IBGZPJMESA-N 0.000 claims 1
• OODNYHMRLDGQLL-SFHVURJKSA-N [4-chloro-5-methoxy-2-(triazol-2-yl)phenyl]-[(2s)-2-[5-(2-methoxy-5-methylphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]methanone Chemical compound N=1C([C@@H]2CCCN2C(=O)C=2C=C(C(=CC=2N2N=CC=N2)Cl)OC)=NOC=1C1=CC(C)=CC=C1OC OODNYHMRLDGQLL-SFHVURJKSA-N 0.000 claims 1
• IPMQEASFHAYFRE-IBGZPJMESA-N [4-chloro-5-methoxy-2-(triazol-2-yl)phenyl]-[(2s)-2-[5-(3-methoxy-5-methylphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]methanone Chemical compound COC1=CC(C)=CC(C=2ON=C(N=2)[C@H]2N(CCC2)C(=O)C=2C(=CC(Cl)=C(OC)C=2)N2N=CC=N2)=C1 IPMQEASFHAYFRE-IBGZPJMESA-N 0.000 claims 1
• REPVSWJXPJSSQI-KRWDZBQOSA-N [4-methyl-2-(triazol-2-yl)phenyl]-[(2s)-2-[3-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]methanone Chemical compound N=1OC([C@@H]2CCCN2C(=O)C2=CC=C(C=C2N2N=CC=N2)C)=NC=1C1=CC=CC=C1OC(F)(F)F REPVSWJXPJSSQI-KRWDZBQOSA-N 0.000 claims 1
• WSRFZKRDPZBUHO-KRWDZBQOSA-N [4-methyl-2-(triazol-2-yl)phenyl]-[(2s)-2-[5-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]methanone Chemical compound N=1C([C@@H]2CCCN2C(=O)C2=CC=C(C=C2N2N=CC=N2)C)=NOC=1C1=CC=CC=C1OC(F)(F)F WSRFZKRDPZBUHO-KRWDZBQOSA-N 0.000 claims 1
• CHNRUHKJLUIOKH-IBGZPJMESA-N [5-chloro-2-(triazol-2-yl)phenyl]-[(2s)-2-[3-(2-ethoxyphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]methanone Chemical compound CCOC1=CC=CC=C1C1=NOC([C@H]2N(CCC2)C(=O)C=2C(=CC=C(Cl)C=2)N2N=CC=N2)=N1 CHNRUHKJLUIOKH-IBGZPJMESA-N 0.000 claims 1
• YOYXDJZKPVMUAZ-SFHVURJKSA-N [5-chloro-2-(triazol-2-yl)phenyl]-[(2s)-2-[3-(2-ethoxypyridin-3-yl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]methanone Chemical compound CCOC1=NC=CC=C1C1=NOC([C@H]2N(CCC2)C(=O)C=2C(=CC=C(Cl)C=2)N2N=CC=N2)=N1 YOYXDJZKPVMUAZ-SFHVURJKSA-N 0.000 claims 1
• HSINAKNHTYNXPR-KRWDZBQOSA-N [5-chloro-2-(triazol-2-yl)phenyl]-[(2s)-2-[3-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]methanone Chemical compound FC(F)(F)OC1=CC=CC=C1C1=NOC([C@H]2N(CCC2)C(=O)C=2C(=CC=C(Cl)C=2)N2N=CC=N2)=N1 HSINAKNHTYNXPR-KRWDZBQOSA-N 0.000 claims 1
• GHVMBSHTEQHUHQ-SFHVURJKSA-N [5-chloro-2-(triazol-2-yl)phenyl]-[(2s)-2-[5-(2-ethoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]methanone Chemical compound CCOC1=NC=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC=C(Cl)C=2)N2N=CC=N2)=NO1 GHVMBSHTEQHUHQ-SFHVURJKSA-N 0.000 claims 1
• RKKXHCSZASMNJB-FQEVSTJZSA-N [5-chloro-2-(triazol-2-yl)phenyl]-[(2s)-2-[5-(2-ethylphenyl)-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]methanone Chemical compound CCC1=CC=CC=C1C1=NC([C@H]2N(CCC2)C(=O)C=2C(=CC=C(Cl)C=2)N2N=CC=N2)=NO1 RKKXHCSZASMNJB-FQEVSTJZSA-N 0.000 claims 1
• AXFHTSCHDWECSS-SFHVURJKSA-N [5-methoxy-2-(triazol-2-yl)phenyl]-[(2s)-2-[3-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]methanone Chemical compound N=1OC([C@@H]2CCCN2C(=O)C=2C(=CC=C(C=2)OC)N2N=CC=N2)=NC=1C1=CC=CC=C1OC(F)(F)F AXFHTSCHDWECSS-SFHVURJKSA-N 0.000 claims 1
• OKUWLYOXCJVLDR-KRWDZBQOSA-N [5-methoxy-4-methyl-2-(triazol-2-yl)phenyl]-[(2s)-2-[3-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]methanone Chemical compound N=1OC([C@@H]2CCCN2C(=O)C=2C=C(C(=CC=2N2N=CC=N2)C)OC)=NC=1C1=CC=CC=C1OC(F)(F)F OKUWLYOXCJVLDR-KRWDZBQOSA-N 0.000 claims 1
• DUMKORAJXQRADB-SFHVURJKSA-N [5-methyl-2-(1,3-oxazol-2-yl)phenyl]-[(2s)-2-[3-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]methanone Chemical compound N1([C@@H](CCC1)C=1ON=C(N=1)C=1C(=CC=CC=1)OC(F)(F)F)C(=O)C1=CC(C)=CC=C1C1=NC=CO1 DUMKORAJXQRADB-SFHVURJKSA-N 0.000 claims 1
• GKOVSCFLLBBOMY-FQEVSTJZSA-N [5-methyl-2-(triazol-2-yl)phenyl]-[(2s)-2-[3-(2-propan-2-yloxypyridin-3-yl)-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]methanone Chemical compound CC(C)OC1=NC=CC=C1C1=NOC([C@H]2N(CCC2)C(=O)C=2C(=CC=C(C)C=2)N2N=CC=N2)=N1 GKOVSCFLLBBOMY-FQEVSTJZSA-N 0.000 claims 1
• MISGPPIHLOOXSD-SFHVURJKSA-N [5-methyl-2-(triazol-2-yl)phenyl]-[(2s)-2-[3-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]pyrrolidin-1-yl]methanone Chemical compound N=1OC([C@@H]2CCCN2C(=O)C=2C(=CC=C(C=2)C)N2N=CC=N2)=NC=1C1=CC=CC=C1OC(F)(F)F MISGPPIHLOOXSD-SFHVURJKSA-N 0.000 claims 1
• WTIYRLUBVOWDQN-SFHVURJKSA-N [5-methyl-2-(triazol-2-yl)phenyl]-[(2s)-2-[5-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-3-yl]pyrrolidin-1-yl]methanone Chemical compound N=1C([C@@H]2CCCN2C(=O)C=2C(=CC=C(C=2)C)N2N=CC=N2)=NOC=1C1=CC=CC=C1OC(F)(F)F WTIYRLUBVOWDQN-SFHVURJKSA-N 0.000 claims 1
• 125000003118 aryl group Chemical group 0.000 claims 1
• 208000010877 cognitive disease Diseases 0.000 claims 1
• 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
• 230000004064 dysfunction Effects 0.000 claims 1
• 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 1
• ZLTPDFXIESTBQG-UHFFFAOYSA-N isothiazole Chemical compound C=1C=NSC=1 ZLTPDFXIESTBQG-UHFFFAOYSA-N 0.000 claims 1
• 125000004498 isoxazol-4-yl group Chemical group O1N=CC(=C1)* 0.000 claims 1
• 230000004630 mental health Effects 0.000 claims 1
• 230000036651 mood Effects 0.000 claims 1
• 108060005714 orexin Proteins 0.000 claims 1
• 125000001715 oxadiazolyl group Chemical group 0.000 claims 1
• 125000002971 oxazolyl group Chemical group 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 230000000069 prophylactic effect Effects 0.000 claims 1
• 125000003373 pyrazinyl group Chemical group 0.000 claims 1
• 125000004076 pyridyl group Chemical group 0.000 claims 1
• 125000006085 pyrrolopyridyl group Chemical group 0.000 claims 1
• VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 claims 1
• 0 Cc(cc(c(*)c1)OC)c1NN=CC=N Chemical compound Cc(cc(c(*)c1)OC)c1NN=CC=N 0.000 description 6
• DMKJDFYHZNBLIS-QTIHDTJGSA-N CC/C(/C(O[IH]/N=C/C)=N)=C\N(C)CC#C Chemical compound CC/C(/C(O[IH]/N=C/C)=N)=C\N(C)CC#C DMKJDFYHZNBLIS-QTIHDTJGSA-N 0.000 description 1
• OSDCDYTYPRUGKJ-UHFFFAOYSA-N Cc(c(C)c1)cc(C)c1-[n]1nccn1 Chemical compound Cc(c(C)c1)cc(C)c1-[n]1nccn1 OSDCDYTYPRUGKJ-UHFFFAOYSA-N 0.000 description 1
• ZCZOPWNVSAQEBN-KVLDKXKJSA-N Cc(cc(c(C)c1)OC)c1N/N=C\C=N Chemical compound Cc(cc(c(C)c1)OC)c1N/N=C\C=N ZCZOPWNVSAQEBN-KVLDKXKJSA-N 0.000 description 1
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