JP2003535860A5 - - Google Patents
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- Publication number
- JP2003535860A5 JP2003535860A5 JP2002501891A JP2002501891A JP2003535860A5 JP 2003535860 A5 JP2003535860 A5 JP 2003535860A5 JP 2002501891 A JP2002501891 A JP 2002501891A JP 2002501891 A JP2002501891 A JP 2002501891A JP 2003535860 A5 JP2003535860 A5 JP 2003535860A5
- Authority
- JP
- Japan
- Prior art keywords
- oxo
- oxazolidinyl
- fluorophenyl
- methylacetamide
- pyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 benzyloxy acetyl Chemical group 0.000 claims 171
- OHLUUHNLEMFGTQ-UHFFFAOYSA-N N-methylacetamide Chemical compound CNC(C)=O OHLUUHNLEMFGTQ-UHFFFAOYSA-N 0.000 claims 155
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 20
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 claims 13
- 229910052757 nitrogen Inorganic materials 0.000 claims 12
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 9
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 9
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- 239000001301 oxygen Substances 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 5
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000000350 glycoloyl group Chemical group O=C([*])C([H])([H])O[H] 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 150000000565 5-membered heterocyclic compounds Chemical class 0.000 claims 4
- 125000004938 5-pyridyl group Chemical group N1=CC=CC(=C1)* 0.000 claims 4
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 claims 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 3
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 125000001841 imino group Chemical group [H]N=* 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 239000011593 sulfur Substances 0.000 claims 3
- 125000006559 (C1-C3) alkylamino group Chemical group 0.000 claims 2
- YQCBRKFZGSRNDR-UHFFFAOYSA-M 3-trimethylstannyl-1,3-oxazolidin-2-one Chemical class C[Sn](C)(C)N1CCOC1=O YQCBRKFZGSRNDR-UHFFFAOYSA-M 0.000 claims 2
- 150000000644 6-membered heterocyclic compounds Chemical class 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 150000001540 azides Chemical class 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 229940125898 compound 5 Drugs 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002366 halogen compounds Chemical class 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 229910052763 palladium Inorganic materials 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000004953 trihalomethyl group Chemical group 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 1
- YQTCQNIPQMJNTI-UHFFFAOYSA-N 2,2-dimethylpropan-1-one Chemical group CC(C)(C)[C]=O YQTCQNIPQMJNTI-UHFFFAOYSA-N 0.000 claims 1
- FFNVQNRYTPFDDP-UHFFFAOYSA-N 2-cyanopyridine Chemical class N#CC1=CC=CC=N1 FFNVQNRYTPFDDP-UHFFFAOYSA-N 0.000 claims 1
- BGKABGGFJSTLIL-UHFFFAOYSA-N 3-(hydroxymethyl)-1,3-oxazolidin-2-one Chemical class OCN1CCOC1=O BGKABGGFJSTLIL-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims 1
- 125000003647 acryloyl group Chemical group O=C([*])C([H])=C([H])[H] 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000676 alkoxyimino group Chemical group 0.000 claims 1
- 125000004849 alkoxymethyl group Chemical group 0.000 claims 1
- 125000005036 alkoxyphenyl group Chemical group 0.000 claims 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000005277 alkyl imino group Chemical group 0.000 claims 1
- 125000005336 allyloxy group Chemical group 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 125000005587 carbonate group Chemical group 0.000 claims 1
- SKOLWUPSYHWYAM-UHFFFAOYSA-N carbonodithioic O,S-acid Chemical compound SC(S)=O SKOLWUPSYHWYAM-UHFFFAOYSA-N 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 238000005658 halogenation reaction Methods 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000004970 halomethyl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 125000005191 hydroxyalkylamino group Chemical group 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000000160 oxazolidinyl group Chemical group 0.000 claims 1
- JSGHQDAEHDRLOI-UHFFFAOYSA-N oxomalononitrile Chemical compound N#CC(=O)C#N JSGHQDAEHDRLOI-UHFFFAOYSA-N 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- HZBCXYOPFGAGJK-UHFFFAOYSA-N phenylmethoxy hydrogen carbonate Chemical group OC(=O)OOCC1=CC=CC=C1 HZBCXYOPFGAGJK-UHFFFAOYSA-N 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 claims 1
- 150000003230 pyrimidines Chemical class 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 238000005797 stannylation reaction Methods 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 125000004385 trihaloalkyl group Chemical group 0.000 claims 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020000030896A KR100674096B1 (ko) | 2000-06-05 | 2000-06-05 | 피리미딘 고리를 포함하는 신규 옥사졸리디논 유도체와그의 제조방법 |
| KR20000030895 | 2000-06-05 | ||
| KR2000/30896 | 2000-06-05 | ||
| KR2000/30895 | 2000-06-05 | ||
| KR2000/56035 | 2000-09-23 | ||
| KR1020000056035A KR100731469B1 (ko) | 2000-06-05 | 2000-09-23 | 피리딘 고리를 포함하는 옥사졸리디논 유도체 및 그의제조방법 |
| KR2001/11691 | 2001-03-07 | ||
| KR1020010011691A KR100713170B1 (ko) | 2001-03-07 | 2001-03-07 | 헤테로고리 또는 헤테로아로마틱 고리가 치환된 피리딘고리를 포함하는 옥사졸리디논 유도체 및 그의 제조방법 |
| PCT/KR2001/000821 WO2001094342A1 (en) | 2000-06-05 | 2001-05-18 | Novel oxazolidinone derivatives and a process for the preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003535860A JP2003535860A (ja) | 2003-12-02 |
| JP2003535860A5 true JP2003535860A5 (enExample) | 2005-06-02 |
Family
ID=27483456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002501891A Pending JP2003535860A (ja) | 2000-06-05 | 2001-05-18 | 新規なオキサゾリジノン誘導体及びその製造方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6689779B2 (enExample) |
| EP (1) | EP1289984A4 (enExample) |
| JP (1) | JP2003535860A (enExample) |
| CN (1) | CN1433413A (enExample) |
| AU (1) | AU5889701A (enExample) |
| BR (1) | BR0111280A (enExample) |
| CA (1) | CA2411859A1 (enExample) |
| HU (1) | HUP0301562A2 (enExample) |
| MX (1) | MXPA02012045A (enExample) |
| NZ (1) | NZ522990A (enExample) |
| WO (1) | WO2001094342A1 (enExample) |
Families Citing this family (110)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| KR100674096B1 (ko) | 2000-06-05 | 2007-01-26 | 동아제약주식회사 | 피리미딘 고리를 포함하는 신규 옥사졸리디논 유도체와그의 제조방법 |
| KR100731469B1 (ko) * | 2000-06-05 | 2007-06-21 | 동아제약주식회사 | 피리딘 고리를 포함하는 옥사졸리디논 유도체 및 그의제조방법 |
| US6861433B2 (en) * | 2000-12-15 | 2005-03-01 | Pharmacia & Upjohn Company | Oxazolidinone photoaffinity probes |
| EP1367053A4 (en) * | 2001-02-27 | 2005-08-03 | Kaneka Corp | PROCESS FOR THE PRODUCTION OF OPTICALLY ACTIVE N-ARYL-1-AMINO-2-PROPANOL DERIVATIVES |
| EP1385834B1 (en) * | 2001-04-17 | 2005-09-14 | Merck & Co., Inc. | Bicyclo[3,1,0]hexane containing oxazolidinone antibiotic and derivatives thereof |
| US7396847B2 (en) * | 2001-09-11 | 2008-07-08 | Astrazeneca Ab | Oxazolidinone and/or isoxazoline as antibacterial agents |
| FR2829766A1 (fr) * | 2001-09-14 | 2003-03-21 | Lipha | Derives d'oxamates comportant un heterocycle azote diversement substitue |
| WO2004014897A1 (en) * | 2002-08-12 | 2004-02-19 | Pharmacia & Upjohn Company Llc | N-aryl-2-oxazolidinones and their derivatives |
| KR100856745B1 (ko) | 2002-10-18 | 2008-09-04 | 동아제약주식회사 | 헤테로 고리 및 헤테로아로마틱 고리가 치환 또는 융합된피리딘을 포함하는 옥사졸리디논 유도체 및 그의 제조방법 |
| CA2507628A1 (en) * | 2002-11-28 | 2004-06-10 | Astrazeneca Ab | Oxazolidinones as antibacterial agents |
| JP2006508192A (ja) * | 2002-11-28 | 2006-03-09 | アストラゼネカ アクチボラグ | 抗細菌薬としてのオキサゾリジノンおよび／またはイソオキサゾリン誘導体 |
| GB0227701D0 (en) * | 2002-11-28 | 2003-01-08 | Astrazeneca Ab | Chemical compounds |
| GB0229522D0 (en) * | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
| GB0229526D0 (en) * | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
| GB0229521D0 (en) * | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
| GB0229518D0 (en) * | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
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| US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
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| JP2007500707A (ja) * | 2003-07-29 | 2007-01-18 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | ビアリールヘテロ環状のアミン、アミドおよび硫黄−含有化合物、並びに該化合物の製造方法および使用方法 |
| US7129259B2 (en) | 2003-12-17 | 2006-10-31 | Rib-X Pharmaceuticals, Inc. | Halogenated biaryl heterocyclic compounds and methods of making and using the same |
| KR100854211B1 (ko) * | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
| BRPI0511526A (pt) * | 2004-05-25 | 2007-12-26 | Astrazeneca Ab | composto, pró-droga, método para a produção de um efeito antibacteriano em um animal de sangue quente, uso de um composto, composição farmacêutica, e, processo para a preparação de um composto |
| CA2567929A1 (en) * | 2004-05-25 | 2005-12-08 | Astrazeneca Ab | 3- {4- (pyridin-3-yl) phenyl} -5- (1h-1, 2, 3-triazol-1-ylmethyl) -1, 3-oxazolidin-2-ones as antibacterial agents |
| EP1778653A1 (en) * | 2004-07-28 | 2007-05-02 | Rib-X Pharmaceuticals, Inc. | Biaryl heterocyclic compounds and methods of making and using the same |
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| US5130316A (en) * | 1988-07-29 | 1992-07-14 | Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazlidinyl arylbenzene derivatives useful as antibacterial agents |
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-
2001
- 2001-05-18 US US10/296,896 patent/US6689779B2/en not_active Expired - Lifetime
- 2001-05-18 HU HU0301562A patent/HUP0301562A2/hu unknown
- 2001-05-18 MX MXPA02012045A patent/MXPA02012045A/es unknown
- 2001-05-18 NZ NZ522990A patent/NZ522990A/en unknown
- 2001-05-18 EP EP01932368A patent/EP1289984A4/en not_active Withdrawn
- 2001-05-18 CN CN01810697A patent/CN1433413A/zh active Pending
- 2001-05-18 CA CA002411859A patent/CA2411859A1/en not_active Abandoned
- 2001-05-18 WO PCT/KR2001/000821 patent/WO2001094342A1/en not_active Ceased
- 2001-05-18 JP JP2002501891A patent/JP2003535860A/ja active Pending
- 2001-05-18 BR BR0111280-5A patent/BR0111280A/pt not_active IP Right Cessation
- 2001-05-18 AU AU5889701A patent/AU5889701A/xx active Pending
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