CN109071523A - 一种脲类化合物、其制备方法及其医药用途 - Google Patents

一种脲类化合物、其制备方法及其医药用途 Download PDF

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CN109071523A
CN109071523A CN201780026742.3A CN201780026742A CN109071523A CN 109071523 A CN109071523 A CN 109071523A CN 201780026742 A CN201780026742 A CN 201780026742A CN 109071523 A CN109071523 A CN 109071523A
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phenyl
tert
butyl
urea
benzoimidazol
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CN109071523B (zh
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司聚同
姜美锋
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Ancureall Pharmaceutical Shanghai Co Ltd
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Ancureall Pharmaceutical Shanghai Co Ltd
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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  • Veterinary Medicine (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

提供一种通式(I)所示的脲类化合物、其药学上可接受的盐，及其制备方法，以及其作为FLT3酪氨酸蛋白激酶抑制剂，特别是在预防和/或治疗癌症中的用途。

Description

PCT国内申请，说明书已公开。

Claims (23)

  1. PCT国内申请，权利要求书已公开。
CN201780026742.3A 2016-03-11 2017-03-10 一种脲类化合物、其制备方法及其医药用途 Active CN109071523B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610142049X 2016-03-11
CN201610142049.XA CN107176951A (zh) 2016-03-11 2016-03-11 一种脲类化合物、其制备方法及其医药用途
PCT/CN2017/076265 WO2017152874A1 (zh) 2016-03-11 2017-03-10 一种脲类化合物、其制备方法及其医药用途

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CN109071523A true CN109071523A (zh) 2018-12-21
CN109071523B CN109071523B (zh) 2022-05-31

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AU (1) AU2017230437B2 (zh)
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HK (1) HK1258545A1 (zh)
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WO2017152126A1 (en) 2016-03-03 2017-09-08 Cornell University Small molecule ire1-alpha inhibitors
CN107176951A (zh) 2016-03-11 2017-09-19 恩瑞生物医药科技（上海）有限公司 一种脲类化合物、其制备方法及其医药用途
WO2018161033A1 (en) * 2017-03-02 2018-09-07 Wright, Adrian Small molecule ire1-alpha inhibitors
CN110016014B (zh) * 2018-01-08 2023-02-17 中国科学院上海药物研究所 Ezh2抑制剂及其制备和抗肿瘤治疗中的应用
EP3906029A4 (en) 2018-12-31 2022-09-21 Biomea Fusion, LLC INHIBITORS OF MENIN-MLL INTERACTION
EP3906026A4 (en) 2018-12-31 2022-10-19 Biomea Fusion, LLC IRREVERSIBLE MENIN-MLL INTERACTION INHIBITORS
CN112552302B (zh) * 2019-09-26 2022-05-13 深圳市塔吉瑞生物医药有限公司 取代的芳香稠合环衍生物及其组合物及用途
WO2021104461A1 (zh) * 2019-11-29 2021-06-03 南京明德新药研发有限公司 二氮杂吲哚类衍生物及其作为Chk1抑制剂的应用
CN114341128B (zh) * 2020-07-24 2024-06-25 恩瑞生物医药科技（上海）有限公司 双功能蛋白降解靶向嵌合体类化合物及其制备方法和医药用途
AU2022331496A1 (en) 2021-08-20 2024-02-29 Biomea Fusion, Inc. Crystalline form of n-[4-[4-(4-morpholinyl)-7h-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(r)-[(1-oxo -2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide, an irreversible menin-mll inhibitor for the treatment of cancer
CN113861179A (zh) * 2021-10-22 2021-12-31 上海应用技术大学 一种新型flt3激酶抑制剂及其合成与应用

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US10647680B2 (en) 2020-05-12
JP6927994B2 (ja) 2021-09-01
JP2019507779A (ja) 2019-03-22
AU2017230437A1 (en) 2018-09-06
WO2017152874A1 (zh) 2017-09-14
CN107176951A (zh) 2017-09-19
RU2018131539A (ru) 2020-04-13
RU2018131539A3 (zh) 2020-04-13
EP3424924B1 (en) 2023-05-24
CN109071523B (zh) 2022-05-31
AU2017230437B2 (en) 2020-11-26
KR20180132664A (ko) 2018-12-12
KR102430942B1 (ko) 2022-08-08
DK3424924T3 (da) 2023-08-28
US20190047964A1 (en) 2019-02-14
BR112018016554A2 (pt) 2018-12-26
HK1258545A1 (zh) 2019-11-15
EP3424924A4 (en) 2019-08-07
RU2741596C2 (ru) 2021-01-27
EP3424924A1 (en) 2019-01-09

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