EP0956044A4 - Uses of a chemokine receptor for inhibiting hiv-1 infection - Google Patents

Uses of a chemokine receptor for inhibiting hiv-1 infection

Info

Publication number
EP0956044A4
EP0956044A4 EP97930120A EP97930120A EP0956044A4 EP 0956044 A4 EP0956044 A4 EP 0956044A4 EP 97930120 A EP97930120 A EP 97930120A EP 97930120 A EP97930120 A EP 97930120A EP 0956044 A4 EP0956044 A4 EP 0956044A4
Authority
EP
European Patent Office
Prior art keywords
infection
chemokine receptor
inhibiting hiv
hiv
inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97930120A
Other languages
German (de)
French (fr)
Other versions
EP0956044A1 (en
Inventor
Graham P Allaway
Tatjana Dragic
Virginia M Litwin
Paul J Maddon
John P Moore
Alexandra Trkola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Progenics Pharmaceuticals Inc
Aaron Diamond AIDS Research Center
Original Assignee
Progenics Pharmaceuticals Inc
Aaron Diamond AIDS Research Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Progenics Pharmaceuticals Inc, Aaron Diamond AIDS Research Center filed Critical Progenics Pharmaceuticals Inc
Publication of EP0956044A1 publication Critical patent/EP0956044A1/en
Publication of EP0956044A4 publication Critical patent/EP0956044A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
EP97930120A 1996-06-14 1997-06-13 Uses of a chemokine receptor for inhibiting hiv-1 infection Withdrawn EP0956044A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1994196P 1996-06-14 1996-06-14
US66509096A 1996-06-14 1996-06-14
US665090 1996-06-14
US19941P 1996-06-14
PCT/US1997/010619 WO1997047319A1 (en) 1996-06-14 1997-06-13 Uses of a chemokine receptor for inhibiting hiv-1 infection

Publications (2)

Publication Number Publication Date
EP0956044A1 EP0956044A1 (en) 1999-11-17
EP0956044A4 true EP0956044A4 (en) 2005-01-05

Family

ID=26692788

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97930120A Withdrawn EP0956044A4 (en) 1996-06-14 1997-06-13 Uses of a chemokine receptor for inhibiting hiv-1 infection

Country Status (5)

Country Link
EP (1) EP0956044A4 (en)
JP (1) JP4183754B2 (en)
AU (2) AU3390297A (en)
CA (1) CA2257991A1 (en)
WO (2) WO1997047318A1 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743594B1 (en) 1995-06-06 2004-06-01 Human Genome Sciences, Inc. Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5)
US6025154A (en) 1995-06-06 2000-02-15 Human Genome Sciences, Inc. Polynucleotides encoding human G-protein chemokine receptor HDGNR10
EP0847452B1 (en) 1995-06-07 2009-04-01 Progenics Pharmaceuticals, Inc. Monoclonal antibody for inhibiting hiv-1 envelope glycoprotein mediated membrane fusion
US6265184B1 (en) 1995-12-20 2001-07-24 Icos Corporation Polynucleotides encoding chemokine receptor 88C
US7118859B2 (en) 1996-01-17 2006-10-10 Progenics Pharmaceuticals, Inc. Methods for inhibiting HIV-1 infection
US7858298B1 (en) 1996-04-01 2010-12-28 Progenics Pharmaceuticals Inc. Methods of inhibiting human immunodeficiency virus type 1 (HIV-1) infection through the administration of CCR5 chemokine receptor antagonists
US6107019A (en) * 1996-06-14 2000-08-22 Progenics Pharmaceuticals, Inc. Method for preventing HIV-1 infection of CD4+ cells
WO1997045543A2 (en) 1996-05-28 1997-12-04 The Government Of The United States Of America, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health Cc chemokine receptor 5, antibodies thereto, transgenic animals
US6528625B1 (en) 1996-10-28 2003-03-04 Millennium Pharmaceuticals, Inc. Anti-CCR5 antibodies and kits comprising same
US6153431A (en) * 1997-05-30 2000-11-28 Fond Mondiale Rech & Prev Sida Human immunodeficiency virus co-receptor variants associated with resistance to virus infection
WO1999062535A2 (en) 1998-06-01 1999-12-09 University Of Maryland Biotechnology Institute Receptor ligand antagonist complexes and their use in treating or preventing receptor mediated diseases
US6312689B1 (en) 1998-07-23 2001-11-06 Millennium Pharmaceuticals, Inc. Anti-CCR2 antibodies and methods of use therefor
US6727349B1 (en) 1998-07-23 2004-04-27 Millennium Pharmaceuticals, Inc. Recombinant anti-CCR2 antibodies and methods of use therefor
US6696550B2 (en) 1998-07-23 2004-02-24 Millennium Pharmaceuticals, Inc. Humanized anti-CCR2 antibodies and methods of use therefor
WO2000029556A2 (en) * 1998-11-17 2000-05-25 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Identification of glycosphingolipids that promote hiv-1 entry into cells
EP1900376A3 (en) * 1998-12-16 2008-10-15 Progenics Pharmaceuticals, Inc. Synergistic inhibition of HIV-1 fusion and attachment, compsitions and antobodies thereto
DK1144006T3 (en) * 1998-12-16 2007-11-26 Progenics Pharm Inc Synergistic inhibition of HIV-1 fusion and binding, preparations and antibodies thereto
WO2000040964A1 (en) * 1999-01-08 2000-07-13 The Government Of The United States Of America, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health Inhibition of cd4-ccr5 interaction
JP2000229997A (en) * 1999-02-10 2000-08-22 Nissui Pharm Co Ltd Cyclic peptide and aids vaccine
JP2002538814A (en) * 1999-03-16 2002-11-19 ザ ガバメント オブ ザ ユナイテッドステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー デパートメント オブ ヘルス アンド ヒューマン サービシーズ ザ ナショナル インステ Novel chimeric proteins for prevention and treatment of HIV infection
US7115262B1 (en) 1999-03-16 2006-10-03 The United States Of America As Represented By The Department Of Health And Human Services Chimeric protein for prevention and treatment of HIV infection
WO2001016182A2 (en) * 1999-08-27 2001-03-08 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services POLYPEPTIDES THAT BIND HIV gp120 AND RELATED NUCLEIC ACIDS, ANTIBODIES, COMPOSITIONS, AND METHODS OF USE
US7304127B2 (en) 1999-08-27 2007-12-04 United States Of America As Represented By The Secretary, Department Of Health And Human Services Polypeptides that bind HIV gp120 and related nucleic acids, antibodies, compositions, and methods of use
CA2389196A1 (en) * 1999-10-28 2001-05-03 Nissui Pharmaceutical Co., Ltd. Cyclic peptides and aids vaccines
US20030049251A1 (en) * 1999-12-08 2003-03-13 Barbas Carlos F. Methods and compositions useful for inhibiting ccr5-dependent infection of cells by hiv-1
GB9930443D0 (en) * 1999-12-22 2000-02-16 King S College London Novel use of heat shock proteins
US7138119B2 (en) 2000-09-15 2006-11-21 Progenics Pharmaceuticals, Inc. Compositions and methods for inhibition of HIV-1 infection
US7175988B2 (en) 2001-02-09 2007-02-13 Human Genome Sciences, Inc. Human G-protein Chemokine Receptor (CCR5) HDGNR10
US7060273B2 (en) 2001-04-06 2006-06-13 Progenics Pharmaceuticals, Inc. Methods for inhibiting HIV-1 infection
US7393934B2 (en) 2001-12-21 2008-07-01 Human Genome Sciences, Inc. Human G-protein chemokine receptor (CCR5) HDGNR10
US7122185B2 (en) 2002-02-22 2006-10-17 Progenics Pharmaceuticals, Inc. Anti-CCR5 antibody
DK1587821T3 (en) 2002-12-19 2008-11-10 Scripps Research Inst Compositions and Methods for Stabilizing Transthyretin and Inhibiting Transthyretin Failure
WO2005105841A2 (en) 2004-03-12 2005-11-10 Human Genome Sciences, Inc. Human g-protein chemokine receptor (ccr5) hdgnr10
US20070026441A1 (en) 2005-07-22 2007-02-01 Olson William C Methods for reducing viral load in HIV-1-infected patients

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022477A1 (en) * 1993-03-26 1994-10-13 Progenics Pharmaceuticals, Inc. Hiv-1 vaccines, antibody compositions related thereto, and therapeutic and prophylactic uses thereof
WO1995016789A1 (en) * 1993-12-17 1995-06-22 Progenics Pharmaceuticals, Inc. Methods for using resonance energy transfer-based assay of hiv-1 envelope clycoprotein-mediated membrane fusion, and kits for practicing same
WO1996039437A1 (en) * 1995-06-06 1996-12-12 Human Genome Sciences, Inc. Human g-protein chemokine receptor hdgnr10
WO1996041020A1 (en) * 1995-06-07 1996-12-19 Progenics Pharmaceuticals, Inc. Fluorescence resonance energy transfer screening assay for the identification of hiv-1 envelope glycoprotein-medicated cell
WO1997032019A2 (en) * 1996-03-01 1997-09-04 Euroscreen S.A. C-c ckr-5, cc-chemikines receptor, derivatives thereof and their uses

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5126433A (en) * 1986-08-21 1992-06-30 The Trustees Of Columbia University In The City Of New York Soluble forms of the t cell surface protein cd4

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022477A1 (en) * 1993-03-26 1994-10-13 Progenics Pharmaceuticals, Inc. Hiv-1 vaccines, antibody compositions related thereto, and therapeutic and prophylactic uses thereof
WO1995016789A1 (en) * 1993-12-17 1995-06-22 Progenics Pharmaceuticals, Inc. Methods for using resonance energy transfer-based assay of hiv-1 envelope clycoprotein-mediated membrane fusion, and kits for practicing same
WO1996039437A1 (en) * 1995-06-06 1996-12-12 Human Genome Sciences, Inc. Human g-protein chemokine receptor hdgnr10
WO1996041020A1 (en) * 1995-06-07 1996-12-19 Progenics Pharmaceuticals, Inc. Fluorescence resonance energy transfer screening assay for the identification of hiv-1 envelope glycoprotein-medicated cell
WO1997032019A2 (en) * 1996-03-01 1997-09-04 Euroscreen S.A. C-c ckr-5, cc-chemikines receptor, derivatives thereof and their uses

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DRAGIC TATJANA ET AL: "Amino-terminal substitutions in the CCR5 coreceptor impair gp120 binding and human immunodeficiency virus type 1 entry", JOURNAL OF VIROLOGY, vol. 72, no. 1, January 1998 (1998-01-01), pages 279 - 285, XP002293996, ISSN: 0022-538X *
SAMSON M ET AL: "MOLECULAR CLONING AND FUNCTIONAL EXPRESSION OF A NEW HUMAN CC-CHEMOKINE RECEPTOR GENE", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 35, 19 March 1996 (1996-03-19), pages 3362 - 3367, XP002035224, ISSN: 0006-2960 *
See also references of WO9747319A1 *

Also Published As

Publication number Publication date
EP0956044A1 (en) 1999-11-17
AU735460B2 (en) 2001-07-12
AU3390297A (en) 1998-01-07
AU3402697A (en) 1998-01-07
JP4183754B2 (en) 2008-11-19
WO1997047319A1 (en) 1997-12-18
WO1997047318A1 (en) 1997-12-18
CA2257991A1 (en) 1997-12-18
JP2001503608A (en) 2001-03-21

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Legal Events

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A4 Supplementary search report drawn up and despatched

Effective date: 20041117

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STAA Information on the status of an ep patent application or granted ep patent

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