AR052156A1 - Fenil-metanonas bi- y triciclicas sustituidas para el tratamiento de trastornos neurologicos y neuropsiquiatricos - Google Patents

Fenil-metanonas bi- y triciclicas sustituidas para el tratamiento de trastornos neurologicos y neuropsiquiatricos

Info

Publication number
AR052156A1
AR052156A1 ARP050105207A ARP050105207A AR052156A1 AR 052156 A1 AR052156 A1 AR 052156A1 AR P050105207 A ARP050105207 A AR P050105207A AR P050105207 A ARP050105207 A AR P050105207A AR 052156 A1 AR052156 A1 AR 052156A1
Authority
AR
Argentina
Prior art keywords
lower alkyl
halogen
substituted
neurological
treatment
Prior art date
Application number
ARP050105207A
Other languages
English (en)
Inventor
Synese Jolidon
Robert Narquizian
Roger David Norcross
Emmanuel Pinard
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR052156A1 publication Critical patent/AR052156A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

La presente se refiere a compuesto de la formula general (1), en la que la formula (2) es un grupo de formulas (3) a (8), R1 es un heterociclo no aromático o es OR' o N(R'')2; R' es alquilo inferior, alquilo inferior sustituido por halogeno o es - (CH2)n-cicloalquilo; R'' es alquilo inferior; R2 es NO2, CN o SO2R''; R3 es hidrogeno, halogeno, alquilo inferior, alcoxi inferior o alquilo inferior sustituido por halogeno; R4 es hidrogeno, alquilo inferior, fenilo sustituido por halogeno o CF3 o es un heterociclo aromático de cinco o seis eslabones; R5/R6 son hidrogeno, halogeno, alquilo inferior, alcoxi inferior o son alquilo inferior o alcoxi inferior sustituido por halogeno; R7 es hidrogeno o alquilo inferior; n es 0, 1 o 2; y sus sales de adicion de ácido farmacéuticamente activas para el tratamiento de trastornos neurologicos y neuropsiquiátricos.
ARP050105207A 2004-12-15 2005-12-13 Fenil-metanonas bi- y triciclicas sustituidas para el tratamiento de trastornos neurologicos y neuropsiquiatricos AR052156A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04106597 2004-12-15

Publications (1)

Publication Number Publication Date
AR052156A1 true AR052156A1 (es) 2007-03-07

Family

ID=35841863

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050105207A AR052156A1 (es) 2004-12-15 2005-12-13 Fenil-metanonas bi- y triciclicas sustituidas para el tratamiento de trastornos neurologicos y neuropsiquiatricos

Country Status (20)

Country Link
US (1) US7375226B2 (es)
EP (1) EP1828200B1 (es)
JP (1) JP4709849B2 (es)
KR (1) KR100883003B1 (es)
CN (1) CN100586951C (es)
AR (1) AR052156A1 (es)
AT (1) ATE457989T1 (es)
AU (1) AU2005315914B2 (es)
BR (1) BRPI0519054A2 (es)
CA (1) CA2590316A1 (es)
DE (1) DE602005019465D1 (es)
ES (1) ES2338139T3 (es)
IL (1) IL183592A0 (es)
MX (1) MX2007006896A (es)
NO (1) NO20072833L (es)
NZ (1) NZ555476A (es)
RU (1) RU2007121768A (es)
TW (1) TWI299041B (es)
WO (1) WO2006063709A1 (es)
ZA (1) ZA200705044B (es)

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US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
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Also Published As

Publication number Publication date
US20060128713A1 (en) 2006-06-15
DE602005019465D1 (de) 2010-04-01
EP1828200B1 (en) 2010-02-17
WO2006063709A1 (en) 2006-06-22
AU2005315914B2 (en) 2011-03-03
CA2590316A1 (en) 2006-06-22
KR20070086196A (ko) 2007-08-27
ES2338139T3 (es) 2010-05-04
BRPI0519054A2 (pt) 2008-12-23
AU2005315914A1 (en) 2006-06-22
US7375226B2 (en) 2008-05-20
EP1828200A1 (en) 2007-09-05
ATE457989T1 (de) 2010-03-15
RU2007121768A (ru) 2009-01-27
TW200634017A (en) 2006-10-01
MX2007006896A (es) 2007-06-26
JP2008523126A (ja) 2008-07-03
CN101076532A (zh) 2007-11-21
TWI299041B (en) 2008-07-21
NZ555476A (en) 2009-09-25
KR100883003B1 (ko) 2009-02-12
CN100586951C (zh) 2010-02-03
IL183592A0 (en) 2007-09-20
NO20072833L (no) 2007-07-17
JP4709849B2 (ja) 2011-06-29
ZA200705044B (en) 2008-09-25

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