JP2011137006A5 - - Google Patents

Download PDF

Info

Publication number
JP2011137006A5
JP2011137006A5 JP2011015653A JP2011015653A JP2011137006A5 JP 2011137006 A5 JP2011137006 A5 JP 2011137006A5 JP 2011015653 A JP2011015653 A JP 2011015653A JP 2011015653 A JP2011015653 A JP 2011015653A JP 2011137006 A5 JP2011137006 A5 JP 2011137006A5
Authority
JP
Japan
Prior art keywords
alkyl
substituted
group
double bonds
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011015653A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011137006A (ja
JP5543932B2 (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2011137006A publication Critical patent/JP2011137006A/ja
Publication of JP2011137006A5 publication Critical patent/JP2011137006A5/ja
Application granted granted Critical
Publication of JP5543932B2 publication Critical patent/JP5543932B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2011015653A 2004-07-02 2011-01-27 Cetp阻害薬 Expired - Fee Related JP5543932B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58527404P 2004-07-02 2004-07-02
US60/585,274 2004-07-02
US64610305P 2005-01-21 2005-01-21
US60/646,103 2005-01-21

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2007519533A Division JP4695139B2 (ja) 2004-07-02 2005-07-01 Cetp阻害薬

Publications (3)

Publication Number Publication Date
JP2011137006A JP2011137006A (ja) 2011-07-14
JP2011137006A5 true JP2011137006A5 (enExample) 2012-04-12
JP5543932B2 JP5543932B2 (ja) 2014-07-09

Family

ID=35045145

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2007519533A Expired - Fee Related JP4695139B2 (ja) 2004-07-02 2005-07-01 Cetp阻害薬
JP2010031195A Expired - Fee Related JP4491062B1 (ja) 2004-07-02 2010-02-16 Cetp阻害薬
JP2011015653A Expired - Fee Related JP5543932B2 (ja) 2004-07-02 2011-01-27 Cetp阻害薬

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP2007519533A Expired - Fee Related JP4695139B2 (ja) 2004-07-02 2005-07-01 Cetp阻害薬
JP2010031195A Expired - Fee Related JP4491062B1 (ja) 2004-07-02 2010-02-16 Cetp阻害薬

Country Status (37)

Country Link
US (5) US7652049B2 (enExample)
EP (2) EP2415759A1 (enExample)
JP (3) JP4695139B2 (enExample)
KR (1) KR101204336B1 (enExample)
CN (4) CN102304096B (enExample)
AR (2) AR049956A1 (enExample)
AU (1) AU2005270058B2 (enExample)
BR (1) BRPI0512910A (enExample)
CA (1) CA2570717C (enExample)
CR (1) CR8808A (enExample)
CY (1) CY1117930T1 (enExample)
DK (1) DK1765793T3 (enExample)
DO (1) DOP2005000123A (enExample)
EA (1) EA011130B1 (enExample)
EC (1) ECSP067124A (enExample)
EG (1) EG27138A (enExample)
ES (1) ES2393721T3 (enExample)
GE (1) GEP20094694B (enExample)
GT (1) GT200500175A (enExample)
HR (1) HRP20120993T1 (enExample)
IL (2) IL180432A (enExample)
JO (1) JO2994B1 (enExample)
MA (1) MA28780B1 (enExample)
MX (1) MX2007000035A (enExample)
MY (1) MY167430A (enExample)
NI (1) NI200600322A (enExample)
NO (1) NO339808B1 (enExample)
NZ (1) NZ552061A (enExample)
PA (1) PA8638101A1 (enExample)
PE (1) PE20060525A1 (enExample)
PL (1) PL1765793T3 (enExample)
PT (1) PT1765793E (enExample)
RS (1) RS52563B (enExample)
SI (1) SI1765793T1 (enExample)
SV (1) SV2007002160A (enExample)
TW (1) TWI299991B (enExample)
WO (2) WO2006014413A1 (enExample)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7270971B2 (en) * 2003-10-16 2007-09-18 Merck & Co., Inc. Fluorescence assay for measuring the rate of cholesterol ester transfer
DOP2005000123A (es) 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
CA2612142A1 (en) * 2005-07-01 2007-01-11 Merck & Co., Inc. Process for synthesizing a cetp inhibitor
EP1965764B1 (en) * 2005-12-05 2011-07-13 Merck Sharp & Dohme Corp. Self-emulsifying formulations of cetp inhibitors
TW200732313A (en) * 2005-12-15 2007-09-01 Astrazeneca Ab Oxazolidinone compounds and their use as metabotropic glutamate receptor potentiators
AU2006332681B2 (en) * 2005-12-30 2011-04-07 Merck Sharp & Dohme Corp. 1, 3-oxazolidin-2-one derivatives useful as CETP inhibitors
AU2006335110B2 (en) * 2005-12-30 2011-04-14 Merck Sharp & Dohme Corp. CETP inhibitors
AU2006335108B2 (en) * 2005-12-30 2011-04-07 Merck Sharp & Dohme Corp. CETP inhibitors
WO2007081570A2 (en) * 2005-12-30 2007-07-19 Merck & Co., Inc. Cholesteryl ester transfer protein inhibitors
EP1983966B1 (en) * 2006-02-09 2013-06-26 Merck Sharp & Dohme Corp. Polymer formulations of cetp inhibitors
US8383660B2 (en) * 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives
US7919506B2 (en) * 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
WO2007136672A2 (en) * 2006-05-19 2007-11-29 Merck & Co., Inc. Synthesis of a biaryl synthetic intermediate
WO2008082567A1 (en) * 2006-12-29 2008-07-10 Merck & Co., Inc. Process for synthesizing a cetp inhibitor
RU2462469C2 (ru) 2007-01-26 2012-09-27 Канек Фарма Инк. Конденсированные ароматические дифторметанфосфонаты в качестве ингибиторов протеинтирозинфосфатазы ib (ptp-1b)
WO2008115442A1 (en) 2007-03-16 2008-09-25 Concert Pharmceuticals, Inc. Inhibitors of cholesterol ester transfer protein
AU2008248186B2 (en) 2007-05-07 2014-02-06 Merck Sharp & Dohme Corp. Method of treatment using fused aromatic compounds having anti-diabetic activity
EP2520561B1 (en) 2007-06-08 2016-02-10 MannKind Corporation IRE-1A Inhibitors
US8445480B2 (en) * 2007-06-20 2013-05-21 Merck Sharp & Dohme Corp. CETP inhibitors derived from benzoxazole arylamides
AU2008266956A1 (en) * 2007-06-20 2008-12-24 Merck Sharp & Dohme Corp. CETP inhibitors derived from benzoxazole arylamides
AU2008266957A1 (en) * 2007-06-20 2008-12-24 Merck Sharp & Dohme Corp. CETP inhibitors derived from benzoxazole arylamides
EP2173735B1 (en) 2007-07-02 2012-01-11 F. Hoffmann-La Roche AG Imidazole derivatives as ccr2 receptor antagonists
US8575156B2 (en) * 2007-07-26 2013-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
WO2009075835A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceutical, Inc CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
JP5490020B2 (ja) * 2008-01-24 2014-05-14 ヴァイティー ファーマシューティカルズ,インコーポレイテッド 11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状カルバゼート及びセミカルバジドインヒビター
BRPI0907364A2 (pt) 2008-02-01 2015-07-14 Amira Pharmaceuticals Inc Antagonistas aminoalquilbifenil n,n-disubstituídos de receptores d2 de prostaglandina
UA98839C2 (en) * 2008-02-01 2012-06-25 Панмира Фармасьютикалз, Ллк. N,n-disubstituted aminoalkylbiphenyl antagonists of prostaglandin d2 receptors
EP2252598A2 (en) * 2008-02-11 2010-11-24 Vitae Pharmaceuticals, Inc. 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2009102893A2 (en) 2008-02-14 2009-08-20 Amira Pharmaceuticals, Inc. CYCLIC DIARYL ETHER COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 receptors
US8598160B2 (en) * 2008-02-15 2013-12-03 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
WO2009108720A2 (en) 2008-02-25 2009-09-03 Amira Pharmaceuticals, Inc. Antagonists of prostaglandin d2 receptors
CA2718264A1 (en) * 2008-03-18 2009-09-24 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
WO2009145989A2 (en) 2008-04-02 2009-12-03 Amira Pharmaceuticals, Inc. Aminoalkylphenyl antagonists of prostaglandin d2 receptors
NZ588954A (en) 2008-05-01 2012-08-31 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2009134387A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
TW201004945A (en) 2008-05-01 2010-02-01 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8063088B2 (en) 2008-06-11 2011-11-22 Hoffmann-La Roche Inc. Imidazolidine derivatives
TW201016691A (en) 2008-07-25 2010-05-01 Boehringer Ingelheim Int Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CN104327062A (zh) 2008-07-25 2015-02-04 贝林格尔·英格海姆国际有限公司 11β-羟基类固醇脱氢酶1的环状抑制剂
CA2729993A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
GB2463788B (en) 2008-09-29 2010-12-15 Amira Pharmaceuticals Inc Heteroaryl antagonists of prostaglandin D2 receptors
DE102008049675A1 (de) 2008-09-30 2010-04-01 Markus Dr. Heinrich Verfahren zur Herstellung von 3-Aminobiphenylen
EP2348859B1 (en) * 2008-10-01 2013-12-04 Merck Sharp & Dohme Corp. Prodrugs of oxazolidinone cetp inhibitors
US8378107B2 (en) 2008-10-01 2013-02-19 Panmira Pharmaceuticals, Llc Heteroaryl antagonists of prostaglandin D2 receptors
WO2010042652A2 (en) 2008-10-08 2010-04-15 Amira Pharmaceuticals, Inc. Heteroalkyl biphenyl antagonists of prostaglandin d2 receptors
US8410284B2 (en) 2008-10-22 2013-04-02 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
CA2741672A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
WO2010057118A2 (en) 2008-11-17 2010-05-20 Amira Pharmaceuticals, Inc. Heterocyclic antagonists of prostaglandin d2 receptors
TW201028414A (en) 2009-01-16 2010-08-01 Merck Sharp & Dohme Oxadiazole beta carboline derivatives as antidiabetic compounds
CA2749891A1 (en) 2009-01-23 2010-07-29 Hubert B. Josien Bridged and fused antidiabetic compounds
WO2010085525A1 (en) 2009-01-23 2010-07-29 Schering Corporation Bridged and fused heterocyclic antidiabetic compounds
EP2393807B1 (en) 2009-02-04 2013-08-14 Boehringer Ingelheim International GmbH Cyclic inhibitors of 11 -hydroxysteroid dehydrogenase 1
WO2010091176A1 (en) 2009-02-05 2010-08-12 Schering Corporation Phthalazine-containing antidiabetic compounds
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
WO2011011123A1 (en) 2009-06-11 2011-01-27 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
EP2448928B1 (en) 2009-07-01 2014-08-13 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2462110A4 (en) 2009-08-05 2013-04-03 Panmira Pharmaceuticals Llc DP2 ANTAGONIST AND USES THEREOF
JP2011057661A (ja) 2009-08-14 2011-03-24 Bayer Cropscience Ag 殺虫性カルボキサミド類
EP2496589B1 (en) 2009-11-05 2014-03-05 Boehringer Ingelheim International GmbH Novel chiral phosphorus ligands
WO2011088025A1 (en) 2010-01-15 2011-07-21 Merck Sharp & Dohme Corp. Oxadiazole beta carboline derivatives as antidiabetic compounds
AU2011218830B2 (en) 2010-02-25 2014-07-24 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
WO2011149822A1 (en) 2010-05-26 2011-12-01 Boehringer Ingelheim International Gmbh 2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives
EP2397473A1 (en) 2010-06-14 2011-12-21 LEK Pharmaceuticals d.d. A stable highly crystalline anacetrapib
JP5860042B2 (ja) 2010-06-16 2016-02-16 ヴァイティー ファーマシューティカルズ,インコーポレイテッド 置換5、6及び7員複素環、そのような化合物を含有する医薬及びそれらの使用
EP2585444B1 (en) 2010-06-25 2014-10-22 Boehringer Ingelheim International GmbH Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
US20130225618A1 (en) 2010-10-04 2013-08-29 Kowa Co., Ltd. Agent for inhibiting expression of lipid metabolism related mrna
JP5852662B2 (ja) * 2010-10-29 2016-02-03 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. 環状アミン置換されたオキサゾリジノン系cetp阻害薬
EA201300522A1 (ru) 2010-11-02 2013-11-29 Бёрингер Ингельхайм Интернациональ Гмбх Фармацевтические комбинации для лечения метаболических нарушений
EP2468735A1 (en) 2010-12-23 2012-06-27 LEK Pharmaceuticals d.d. Synthesis of intermediates for preparing anacetrapib and derivates thereof
EP2468736A1 (en) 2010-12-23 2012-06-27 LEK Pharmaceuticals d.d. Synthesis of intermediates for preparing anacetrapib and derivates thereof
EP2668507B1 (en) 2011-01-26 2017-08-23 INSERM - Institut National de la Santé et de la Recherche Médicale Method for assessing a subject's risk of having a cardiovascular disease.
CA2826649C (en) 2011-02-25 2016-07-26 Merck Sharp & Dohme Corp. Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
AU2012243583B2 (en) 2011-04-12 2015-10-22 Chong Kun Dang Pharmaceutical Corp. Cycloalkenyl aryl derivatives for CETP inhibitor
CA2840985A1 (en) 2011-07-07 2013-01-10 Mochida Phamaceutical Co., Ltd. Anti-obesity agent comprising high-purity epa
PL2729142T3 (pl) 2011-07-08 2018-10-31 Novartis Ag Sposób leczenia miażdżycy tętnic u osobników z wysokim poziomem triglicerydów
JO3210B1 (ar) 2011-10-28 2018-03-08 Merck Sharp & Dohme مثبط منصهر لبروتين نقل الكوليسترليستير اوكسازوليدينون ثمائي الحلقة
EP2773210A4 (en) * 2011-10-31 2015-07-22 Merck Sharp & Dohme Process for a cetp inhibitor
WO2013064188A1 (en) 2011-11-03 2013-05-10 Lek Pharmaceuticals D.D. A stable highly crystalline anacetrapib
JPWO2013080999A1 (ja) 2011-11-29 2015-04-27 興和株式会社 NPC1L1及び/又はLIPGmRNAの発現抑制剤並びに肥満症の予防及び/又は治療剤
JP6108631B2 (ja) * 2011-11-30 2017-04-05 デウン ファーマシューティカル カンパニー リミテッド 高脂血症を予防または治療するための医薬組成物
WO2013091696A1 (en) 2011-12-21 2013-06-27 Lek Pharmaceuticals D.D. Synthesis of intermediates for preparing anacetrapib and derivatives thereof
US9353101B2 (en) 2012-05-02 2016-05-31 Merck Sharp & Dohme Corp. Cyclic amine substituted heterocyclic CETP inhibitors
MX347400B (es) 2012-06-29 2017-04-18 Univ Nac Autónoma De México Vacuna de aplicacion nasal contra el desarrollo de la enfermedad aterosclerotica y el higado graso.
WO2014012428A1 (zh) * 2012-07-19 2014-01-23 上海恒瑞医药有限公司 噁唑烷酮类衍生物、其制备方法及其在医药上的应用
WO2014031465A1 (en) 2012-08-22 2014-02-27 Merck Sharp & Dohme Corp. Novel azabenzimidazole tetrahydropyran derivatives
EP2934518B1 (en) 2012-12-19 2020-02-19 Merck Sharp & Dohme Corp. Spirocyclic cetp inhibitors
US9376408B2 (en) 2012-12-20 2016-06-28 Merck Sharp & Dohme Corp. Therapeutic thiazolidinone compounds
WO2014111953A1 (en) * 2013-01-17 2014-07-24 Glenmark Pharmaceuticals Limited; Glenmark Generics Limited Process for preparation of anacetrapib and intermediates thereof
CN105143193B (zh) 2013-01-31 2017-12-15 株式会社钟根堂 作为cetp抑制剂的联芳基或杂环联芳基取代的环己烯衍生化合物
EP2970119B1 (en) 2013-03-14 2021-11-03 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
US9981970B2 (en) 2013-07-30 2018-05-29 Merck Sharp & Dohme Corp. Bicyclic ureas and thiadiazolidine-1, 1-dioxides as CETP inhibitors
EP3054945B1 (en) 2013-10-10 2018-08-15 Merck Sharp & Dohme Corp. 3,3'-disubstituted indolines as inhibitors of cholesterol ester transfer protein
CN105814064A (zh) 2013-12-17 2016-07-27 默沙东公司 作为胆固醇酯转运蛋白的抑制剂的稠合双环异噁唑啉类
CN104955816B (zh) * 2014-01-14 2016-08-31 杭州普晒医药科技有限公司 一种安塞曲匹的晶型及其制备方法、其药物组合物和用途
CN103923030B (zh) * 2014-03-27 2015-07-22 汕头经济特区鮀滨制药厂 一种安塞曲匹的关键中间体的合成方法
CN103923031A (zh) * 2014-04-01 2014-07-16 汕头经济特区鮀滨制药厂 一种安塞曲匹的中间体的合成方法
EP3174537B1 (en) 2014-07-29 2021-06-23 Merck Sharp & Dohme Corp. Monocyclic isoxazolines as inhibitors of cholesterol ester transfer protein
JP6854752B2 (ja) 2014-07-30 2021-04-07 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Hdl上昇剤又はhdl模倣剤を用いた治療に対する応答性を予測するための遺伝マーカー
CN104230835B (zh) * 2014-09-01 2017-01-25 福建师范大学 一种合成n‑苯乙烯基恶唑烷‑2‑酮衍生物的方法
WO2016067194A1 (en) * 2014-10-27 2016-05-06 Sun Pharmaceutical Industries Limited Process for the preparation of anacetrapib and an intermediate thereof
CN106032362B (zh) * 2015-03-10 2018-06-19 湖南千金湘江药业股份有限公司 安塞曲匹的制备方法
KR20190020343A (ko) 2016-06-29 2019-02-28 오리온 코포레이션 벤조디옥산 유도체 및 이의 약제학적 용도
KR101902002B1 (ko) * 2016-07-19 2018-09-27 재단법인 대구경북첨단의료산업진흥재단 Cetp 억제제로서의 옥사졸리딘온 유도체 화합물
EP3500549B1 (en) * 2016-08-17 2020-12-16 Novartis AG New processes and intermediates for nep inhibitor synthesis
CN106496211A (zh) * 2016-10-18 2017-03-15 湖南德魅信息技术有限公司 二氟甲基取代的噁唑烷酮化合物及其用途
CN106496154A (zh) * 2016-10-18 2017-03-15 湖南德魅信息技术有限公司 安塞曲匹的制备方法
CN106749075A (zh) * 2016-11-24 2017-05-31 山东新华制药股份有限公司 阿那曲波的恶唑烷酮中间体的晶型及其制备方法
WO2019043018A1 (en) 2017-08-29 2019-03-07 Dalcor Pharma Uk Ltd., Stockport Zug Branch METHODS OF TREATING OR PREVENTING CARDIOVASCULAR DISORDERS AND REDUCING THE RISK OF CARDIOVASCULAR EVENTS
JOP20180092A1 (ar) 2017-10-13 2019-04-13 Gilead Sciences Inc مثبطات hiv بروتياز
JP2021534236A (ja) 2018-08-09 2021-12-09 ダルコア ファーマ ユーケー リミテッド,レザーヘッド,ツーク ブランチ 新規発症2型糖尿病の発生遅延並びに2型糖尿病の進行緩徐化及び治療の方法
CA3126323A1 (en) 2019-03-07 2020-09-10 Jean-Claude Tardif Methods for treating or preventing heart failure and reducing risk of heart failure
TW202104210A (zh) 2019-04-17 2021-02-01 美商基利科學股份有限公司 Hiv蛋白酶抑制劑
CN119684381A (zh) 2019-07-19 2025-03-25 生物合成股份公司 烟酰胺呋喃核糖苷盐的结晶形式以及包含其的营养补充剂和药物组合物
EP4146205A4 (en) 2020-05-05 2024-05-29 Nuvalent, Inc. HETEROAROMATIC MACROCYCLIC ETHERS AS CHEMOTHERAPEUTIC AGENTS
MX2022013657A (es) 2020-05-05 2023-02-01 Nuvalent Inc Quimioterápicos de éter macrocíclico heteroaromático.
KR102651062B1 (ko) * 2020-10-08 2024-03-25 재단법인 대구경북첨단의료산업진흥재단 Pcsk9 억제제로서 아미노알콜 유도체 및 이를 함유하는 고콜레스테롤 혈증의 예방 또는 치료용 약학적 조성물
EP4362933A4 (en) * 2021-06-30 2025-06-04 Apellis Pharmaceuticals, Inc. COMPLEMENT INHIBITION
CA3231813A1 (en) 2021-10-01 2023-04-06 Sibao CHEN Solid forms, pharmaceutical compositions and preparation of heteroaromatic macrocyclic ether compounds
WO2025093129A1 (en) 2023-11-01 2025-05-08 Newamsterdam Pharma B.V. Treatment and prevention of age-related macular degeneration using a cetp inhibitor

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179442A (en) 1975-08-29 1979-12-18 York Hartleben 4-(Alpha-hydroxy-isopropyl)-5-phenyl-oxazolidin-2-one
DE2655369A1 (de) 1976-12-03 1978-06-08 Schering Ag 5-(subst. phenyl)-oxazolidinone und deren schwefelanaloga sowie verfahren zu deren herstellung
US4851423A (en) 1986-12-10 1989-07-25 Schering Corporation Pharmaceutically active compounds
WO1988009661A1 (en) 1987-06-10 1988-12-15 Pfizer Inc. Oxazolidin-2-one derivatives as hypoglycemic agents
ATE194981T1 (de) * 1992-04-30 2000-08-15 Taiho Pharmaceutical Co Ltd Oxazolidinderivat und sein pharmazeutisch verträgliches salz
US5482971A (en) * 1993-10-01 1996-01-09 American Cyanamid Company Beta3 -adrenergic agents and their use in pharmaceutical compositions
AU684316B2 (en) 1993-10-15 1997-12-11 Shionogi & Co., Ltd. Oxazolinone derivative having intracellular phospholipase A2 inhibitor activity
CA2188269A1 (en) * 1994-04-21 1995-11-02 Schering Aktiengesellschaft Pde iv inhibitors for treating multiple sclerosis
FR2729954B1 (fr) * 1995-01-30 1997-08-01 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
CN1173818A (zh) * 1995-02-10 1998-02-18 舍林股份公司 用于tnf抑制的药物制剂
BR9608756A (pt) * 1995-05-17 1999-07-06 Du Pont Composto composição fungicida e método para controle de doenças de plantas
US5612363A (en) 1995-06-02 1997-03-18 Berlex Laboratories, Inc. N,N-di(aryl) cyclic urea derivatives as anti-coagulants
HUP9901228A3 (en) 1995-06-20 2001-11-28 Du Pont Cyclic amides, their intermediates, arthropodicide and fungicide compositions containing theses compounds as active ingredients and use thereof
US5846990A (en) 1995-07-24 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
US6310095B1 (en) 1995-11-06 2001-10-30 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
WO1997028149A1 (en) 1996-02-02 1997-08-07 Merck & Co., Inc. Method for raising hdl cholesterol levels
DE19647380A1 (de) 1996-11-15 1998-05-20 Hoechst Ag 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
WO1998023155A1 (en) 1996-11-26 1998-06-04 E.I. Du Pont De Nemours And Company Arthropodicidal and fungicidal cyclic amides
DE19704243A1 (de) * 1997-02-05 1998-08-06 Bayer Ag Neue 2-Amino-substituierte Pyridine
EP0966447B1 (en) * 1997-03-03 2003-03-05 Boehringer Ingelheim Pharmaceuticals Inc. Small molecules useful in the treatment of inflammatory disease
WO1998050030A1 (en) 1997-05-07 1998-11-12 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
DE19741400A1 (de) * 1997-09-19 1999-03-25 Bayer Ag Benzyl-biphenyle
US6239152B1 (en) 1998-01-23 2001-05-29 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
IT1300055B1 (it) * 1998-04-17 2000-04-05 Boehringer Ingelheim Italia Eterocicli con anello a 5 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmici
GT199900147A (es) 1998-09-17 1999-09-06 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas.
ES2316383T3 (es) 1999-09-17 2009-04-16 Millennium Pharmaceuticals, Inc. Benzamidas e inhibidores relacionados del factor xa.
HN2000000203A (es) * 1999-11-30 2001-06-13 Pfizer Prod Inc Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.
US6462063B1 (en) 2000-02-04 2002-10-08 Fibrogen, Inc. C-proteinase inhibitors
WO2001072723A1 (en) 2000-03-28 2001-10-04 Nippon Soda Co.,Ltd. Oxa(thia)zolidine derivative and anti-inflammatory drug
AU1609702A (en) * 2000-12-21 2002-07-01 Aventis Pharma Gmbh Novel 1,2-diphenzylazetidinones, method for producing the same, medicaments containing said compounds, and the use thereof for treating disorders of the lipid metabolism
CA2459766A1 (en) 2001-09-11 2003-03-20 Astrazeneca Ab Oxazolidinone and/or isoxazoline as antibacterial agents
BR0213660A (pt) * 2001-10-16 2004-08-24 Memory Pharm Corp Composto, composição farmacêutica e método para tratar pacientes
TW200420573A (en) 2002-09-26 2004-10-16 Rib X Pharmaceuticals Inc Bifunctional heterocyclic compounds and methods of making and using same
PL1603553T3 (pl) 2003-03-17 2012-04-30 Japan Tobacco Inc Kompozycje farmaceutyczne inhibitorów CETP
UA90269C2 (ru) 2004-04-02 2010-04-26 Мицубиси Танабе Фарма Корпорейшн Тетрагидрохинолиновые производные и способ их получения
DOP2005000123A (es) * 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
KR101353030B1 (ko) 2005-03-31 2014-01-17 카운슬 오브 사이언티픽 앤드 인더스트리얼 리서치 항-감염성 약물과의 배합을 위한 방향족 치환된 펜타디엔산아미드
AU2006332681B2 (en) * 2005-12-30 2011-04-07 Merck Sharp & Dohme Corp. 1, 3-oxazolidin-2-one derivatives useful as CETP inhibitors
AU2006335108B2 (en) 2005-12-30 2011-04-07 Merck Sharp & Dohme Corp. CETP inhibitors
AU2006335110B2 (en) 2005-12-30 2011-04-14 Merck Sharp & Dohme Corp. CETP inhibitors

Similar Documents

Publication Publication Date Title
JP2011137006A5 (enExample)
RU2477723C2 (ru) Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе
JP2016506958A5 (enExample)
JP2013542218A5 (enExample)
AR088000A1 (es) Derivados de pirazolquinolinona, su preparacion y su uso terapeutico
JP2012522729A5 (enExample)
JP2009529540A5 (enExample)
JP2015535277A5 (enExample)
JP2008505120A5 (enExample)
JP2013544860A5 (enExample)
JP2014521688A5 (enExample)
JP2014520898A5 (enExample)
JP2013510120A5 (enExample)
JP2013545785A5 (enExample)
JP2017538722A5 (enExample)
EA200602058A1 (ru) Производные адамантилпирролидин-2-она в качестве ингибиторов 11-бета-гидроксистероид-дегидрогеназы
JP2012515776A5 (enExample)
JP2016528273A5 (enExample)
JP2011516591A5 (enExample)
MX2013004407A (es) Derivado de piridina y agente medicinal.
JP2008525417A5 (enExample)
JP2010525023A5 (enExample)
JP2016531126A5 (enExample)
JP2009535358A5 (enExample)
JP2012520247A5 (enExample)