MX2009013332A - Inhibidores de ire-1 alfa. - Google Patents

Inhibidores de ire-1 alfa.

Info

Publication number
MX2009013332A
MX2009013332A MX2009013332A MX2009013332A MX2009013332A MX 2009013332 A MX2009013332 A MX 2009013332A MX 2009013332 A MX2009013332 A MX 2009013332A MX 2009013332 A MX2009013332 A MX 2009013332A MX 2009013332 A MX2009013332 A MX 2009013332A
Authority
MX
Mexico
Prior art keywords
ire
prodrugs
compounds
inhibitors
vitro
Prior art date
Application number
MX2009013332A
Other languages
English (en)
Inventor
Gary A Flynn
Qingping Zeng
John Bruce Patterson
David Gregory Lonergan
Peter V Pallai
Original Assignee
Mannkind Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mannkind Corp filed Critical Mannkind Corp
Publication of MX2009013332A publication Critical patent/MX2009013332A/es

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    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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Abstract

Se describen los compuestos que inhiben directamente la actividad de IRE-la in vitro, los profármacos y sales farmacéuticamente aceptables de los mismos. Tales compuestos y profármacos son útiles para tratar enfermedades asociadas con la respuesta de proteína desplegada, y pueden ser utilizados como agentes simples o en terapias en combinación.
MX2009013332A 2007-06-08 2008-06-09 Inhibidores de ire-1 alfa. MX2009013332A (es)

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PCT/US2008/066310 WO2008154484A1 (en) 2007-06-08 2008-06-09 Ire-1a inhibitors

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EP2155643B1 (en) 2007-06-08 2016-08-10 MannKind Corporation Ire-1a inhibitors
US20140018354A9 (en) * 2009-07-23 2014-01-16 Nathaniel Moorman Inhibitors of mtor kinase as anti-viral agents
CA2780149C (en) * 2009-11-03 2019-06-18 Mannkind Corporation Ire-1.alpha. inhibitors
MX362442B (es) * 2010-04-05 2019-01-18 Fosun Orinove Pharmatech Inc Inhibidores de enzima 1 dependiente de inositol (ire-1alfa).
TWI622573B (zh) * 2010-11-05 2018-05-01 拜耳知識產權公司 藉由亞胺氫化製備經取代ｎ－（苄基）環丙胺之方法
WO2012109238A2 (en) * 2011-02-07 2012-08-16 President And Fellows Of Harvard College Methods for increasing immune responses using agents that directly bind to and activate ire-1
WO2012138715A2 (en) 2011-04-04 2012-10-11 Georgetown University Small molecule inhibitors of xbp1 splicing
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