JP2013507434A5 - - Google Patents
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- Publication number
- JP2013507434A5 JP2013507434A5 JP2012533716A JP2012533716A JP2013507434A5 JP 2013507434 A5 JP2013507434 A5 JP 2013507434A5 JP 2012533716 A JP2012533716 A JP 2012533716A JP 2012533716 A JP2012533716 A JP 2012533716A JP 2013507434 A5 JP2013507434 A5 JP 2013507434A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- optionally substituted
- alkyl
- represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 13
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000006719 (C6-C10) aryl (C1-C6) alkyl group Chemical group 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- -1 nitro, cyano, hydroxy, amino Chemical group 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25101609P | 2009-10-13 | 2009-10-13 | |
| US61/251,016 | 2009-10-13 | ||
| PCT/IB2010/054463 WO2011045703A2 (en) | 2009-10-13 | 2010-10-04 | C-linked hydroxamic acid derivatives useful as antibacterial agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013507434A JP2013507434A (ja) | 2013-03-04 |
| JP2013507434A5 true JP2013507434A5 (enExample) | 2013-12-12 |
| JP5671545B2 JP5671545B2 (ja) | 2015-02-18 |
Family
ID=43778193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012533716A Expired - Fee Related JP5671545B2 (ja) | 2009-10-13 | 2010-10-04 | 抗菌薬として有用なｃ結合ヒドロキサム酸誘導体 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8853258B2 (enExample) |
| EP (1) | EP2488489A2 (enExample) |
| JP (1) | JP5671545B2 (enExample) |
| CA (1) | CA2774250C (enExample) |
| WO (1) | WO2011045703A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5539864B2 (ja) | 2007-06-12 | 2014-07-02 | アカオゲン，インコーポレーテッド | 抗菌剤 |
| CA2774250C (en) * | 2009-10-13 | 2013-12-17 | Pfizer Inc. | C-linked hydroxamic acid derivatives useful as antibacterial agents |
| US8664401B2 (en) * | 2009-12-16 | 2014-03-04 | Pfizer Inc. | N-linked hydroxamic acid derivatives useful as antibacterial agents |
| US9738604B2 (en) | 2010-09-03 | 2017-08-22 | Duke University | Ethynylbenzene derivatives |
| CA2830866A1 (en) * | 2011-04-08 | 2012-10-11 | Pfizer Inc. | Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents |
| EP2847168A1 (en) | 2012-05-10 | 2015-03-18 | Achaogen, Inc. | Antibacterial agents |
| EP2725029A1 (en) | 2012-10-29 | 2014-04-30 | Laboratoire Biodim | New antibacterial compounds and biological applications thereof |
| WO2014165075A1 (en) | 2013-03-12 | 2014-10-09 | Achaogen, Inc. | Antibacterial agents |
| WO2015024010A2 (en) * | 2013-08-16 | 2015-02-19 | Duke University | Substituted hydroxamic acid compounds |
| US9908851B2 (en) | 2013-08-16 | 2018-03-06 | Duke University | 2-piperidinyl substituted N,3-dihydroxybutanamides |
| WO2015024011A2 (en) * | 2013-08-16 | 2015-02-19 | Duke University | Antibacterial compounds |
| AR097617A1 (es) * | 2013-09-13 | 2016-04-06 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos del 2h-indazol |
| JP6407288B2 (ja) * | 2013-12-19 | 2018-10-17 | イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | 抗菌性１ｈ−インダゾール及び１ｈ−インドール誘導体 |
| AR099612A1 (es) | 2014-03-04 | 2016-08-03 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona |
| US9637482B2 (en) | 2014-04-22 | 2017-05-02 | Novartis Ag | Isoxazoline hydroxamic acid derivatives as LpxC inhibitors |
| US9796686B2 (en) | 2014-05-16 | 2017-10-24 | Idorsia Pharmaceuticals Ltd | Antibacterial quinazoline-4(3H)-one derivatives |
| TW201625569A (zh) * | 2014-11-19 | 2016-07-16 | 艾克泰聯製藥有限公司 | 抗菌性苯并噻唑衍生物 |
| HRP20192009T1 (hr) * | 2014-12-16 | 2020-02-07 | Novartis Ag | Spojevi izoksazol hidroksamske kiseline kao inhibitori lpxc-a |
| AR105646A1 (es) | 2015-08-11 | 2017-10-25 | Actelion Pharmaceuticals Ltd | Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida |
| AR105889A1 (es) | 2015-09-03 | 2017-11-22 | Actelion Pharmaceuticals Ltd | Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos |
| BR112018073580A2 (pt) * | 2016-05-17 | 2019-03-19 | Idorsia Pharmaceuticals Ltd | derivados de 6-(buta-1,3-diyn-1-il) benzo [d] tiazol |
| SG11201810656WA (en) | 2016-06-14 | 2018-12-28 | Novartis Ag | Crystalline form of (r)-4-(5-(cyclopropylethynyl)isoxazol-3-yl)-n-hydroxy-2-methyl-2-(methylsulfonyl)butanamide as an antibacterial agent |
| WO2017223349A1 (en) | 2016-06-23 | 2017-12-28 | Achaogen, Inc. | Antibacterial agents |
| WO2018048882A1 (en) | 2016-09-06 | 2018-03-15 | The Research Foundation For The State University Of New York | Positron imaging tomography imaging agent composition and method for bacterial infection |
| CN110088087B (zh) * | 2016-09-28 | 2022-08-09 | 东亚St株式会社 | 四氢吡啶衍生物及其作为抗菌剂的用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EE04295B1 (et) * | 1997-02-27 | 2004-06-15 | American Cyanamid Company | N-hüdroksü-2-(alküül-, arüül- või heteroarüülsulfanüül-, -sulfinüül- või-sulfonüül-)-3-asendatud-alküülamiidid, -arüülamiidid või -heteroarüülamiididkui maatriksmetalloproteinaasi inhibiitorid |
| EP2338878A3 (en) | 2005-12-15 | 2011-11-16 | Vicuron Pharmaceuticals, Inc. | N-hydroxyamide derivatives possessing antibacterial activity |
| US7879911B2 (en) * | 2007-02-01 | 2011-02-01 | Johnson Alan T | Hydroxamic acid derivatives of phenoxy-acetic acids and analogs useful as therapeutic agents for treating anthrax poisoning |
| CA2774250C (en) * | 2009-10-13 | 2013-12-17 | Pfizer Inc. | C-linked hydroxamic acid derivatives useful as antibacterial agents |
-
2010
- 2010-10-04 CA CA2774250A patent/CA2774250C/en not_active Expired - Fee Related
- 2010-10-04 WO PCT/IB2010/054463 patent/WO2011045703A2/en not_active Ceased
- 2010-10-04 US US13/501,776 patent/US8853258B2/en not_active Expired - Fee Related
- 2010-10-04 EP EP10818065A patent/EP2488489A2/en not_active Withdrawn
- 2010-10-04 JP JP2012533716A patent/JP5671545B2/ja not_active Expired - Fee Related
-
2014
- 2014-08-27 US US14/469,657 patent/US20140364398A1/en not_active Abandoned
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