BRPI0512910A - composto, uso do mesmo, método para elevar hdl-c em um paciente em necessidade de tratamento, e, composição farmacêutica - Google Patents
composto, uso do mesmo, método para elevar hdl-c em um paciente em necessidade de tratamento, e, composição farmacêuticaInfo
- Publication number
- BRPI0512910A BRPI0512910A BRPI0512910-9A BRPI0512910A BRPI0512910A BR PI0512910 A BRPI0512910 A BR PI0512910A BR PI0512910 A BRPI0512910 A BR PI0512910A BR PI0512910 A BRPI0512910 A BR PI0512910A
- Authority
- BR
- Brazil
- Prior art keywords
- heterocyclic
- compound
- pharmaceutical composition
- same
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 108010023302 HDL Cholesterol Proteins 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 108010028554 LDL Cholesterol Proteins 0.000 abstract 1
- 238000008214 LDL Cholesterol Methods 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 239000003354 cholesterol ester transfer protein inhibitor Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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- A61K31/4164—1,3-Diazoles
- A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
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- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
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- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D233/32—One oxygen atom
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Abstract
COMPOSTO, USO DO MESMO, MéTODO PARA ELEVAR HDL-C EM UM PACIENTE EM NECESSIDADE DE TRATAMENTO, E, COMPOSIçãO FARMACêUTICA Compostos tendo as estruturas de fórmula I, incluindo sais farmaceuticamente aceitáveis dos compostos, são inibidores de CETP, e são utilizáveis para relevar HDL- colesterol, reduzir LDL - colesterol, e para tratar ou prevenir aterosclerose. Nos compostos de fórmula I, B ou R¬2¬ é um grupo fenila que tem um substituinte orto arila, heterocíclico, benzo heterocíclico ou benzocicloalquila, e uma outra posição no anel de 5 membros tem um substituinte aromático, heterocíclico, cicloalquila, benzo-heterocíclico ou benzocicloalquila conectado diretamente ao anel ou fixado ao anel através de um -CH~2~-.
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BRPI0512910-9A BRPI0512910A (pt) | 2004-07-02 | 2005-07-01 | composto, uso do mesmo, método para elevar hdl-c em um paciente em necessidade de tratamento, e, composição farmacêutica |
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EP (2) | EP2415759A1 (pt) |
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AR (2) | AR049956A1 (pt) |
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BR (1) | BRPI0512910A (pt) |
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CY (1) | CY1117930T1 (pt) |
DK (1) | DK1765793T3 (pt) |
DO (1) | DOP2005000123A (pt) |
EA (1) | EA011130B1 (pt) |
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Families Citing this family (118)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7270971B2 (en) * | 2003-10-16 | 2007-09-18 | Merck & Co., Inc. | Fluorescence assay for measuring the rate of cholesterol ester transfer |
DOP2005000123A (es) * | 2004-07-02 | 2011-07-15 | Merck Sharp & Dohme | Inhibidores de cetp |
AU2006265975B2 (en) * | 2005-07-01 | 2011-12-15 | Merck Sharp & Dohme Corp. | Process for synthesizing a CETP inhibitor |
US8486983B2 (en) | 2005-12-05 | 2013-07-16 | Merck Sharp & Dohme Corp. | Self-emulsifying formulations of CETP inhibitors |
TW200732313A (en) * | 2005-12-15 | 2007-09-01 | Astrazeneca Ab | Oxazolidinone compounds and their use as metabotropic glutamate receptor potentiators |
US7781426B2 (en) * | 2005-12-30 | 2010-08-24 | Merck Sharp & Dohme Corp. | CETP inhibitors |
EP1973546B1 (en) * | 2005-12-30 | 2012-06-13 | Merck Sharp & Dohme Corp. | Cholesteryl ester transfer protein inhibitors |
RU2513107C2 (ru) * | 2005-12-30 | 2014-04-20 | Мерк Шарп И Доум Корп. | Ингибиторы сетр |
WO2007081569A2 (en) * | 2005-12-30 | 2007-07-19 | Merck & Co., Inc. | Cetp inhibitors |
EP1983966B1 (en) | 2006-02-09 | 2013-06-26 | Merck Sharp & Dohme Corp. | Polymer formulations of cetp inhibitors |
US7919506B2 (en) | 2006-03-10 | 2011-04-05 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
US8383660B2 (en) | 2006-03-10 | 2013-02-26 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
WO2007136672A2 (en) * | 2006-05-19 | 2007-11-29 | Merck & Co., Inc. | Synthesis of a biaryl synthetic intermediate |
WO2008082567A1 (en) * | 2006-12-29 | 2008-07-10 | Merck & Co., Inc. | Process for synthesizing a cetp inhibitor |
NZ578296A (en) | 2007-01-26 | 2012-07-27 | Kaneq Pharma Inc | Fused aromatic ptp-1b inhibitors |
CA2678577A1 (en) | 2007-02-26 | 2008-09-04 | Vitae Pharmaceuticals, Inc. | Cyclic urea and carbamate inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
CA2681628C (en) | 2007-03-16 | 2016-10-18 | Concert Pharmaceuticals, Inc. | Inhibitors of cholesterol ester transfer protein |
JP2010526807A (ja) | 2007-05-07 | 2010-08-05 | メルク・シャープ・エンド・ドーム・コーポレイション | 抗糖尿病活性を有する縮合芳香族化合物を用いた治療法 |
EP2520561B1 (en) | 2007-06-08 | 2016-02-10 | MannKind Corporation | IRE-1A Inhibitors |
AU2008266954A1 (en) * | 2007-06-20 | 2008-12-24 | Merck Sharp & Dohme Corp. | CETP inhibitors derived from benzoxazole arylamides |
EP2170059B1 (en) * | 2007-06-20 | 2014-11-19 | Merck Sharp & Dohme Corp. | Cetp inhibitors derived from benzoxazole arylamides |
EP2166847B1 (en) * | 2007-06-20 | 2014-11-19 | Merck Sharp & Dohme Corp. | Cetp inhibitors derived from benzoxazole arylamides |
KR101171480B1 (ko) | 2007-07-02 | 2012-08-07 | 에프. 호프만-라 로슈 아게 | Ccr-2 수용체 길항제로서의 이미다졸 유도체 |
AR067673A1 (es) * | 2007-07-26 | 2009-10-21 | Vitae Pharmaceuticals Inc | Derivados de 1,3 oxazinan - 2 - ona como inhibidores ciclicos de la 11 beta -hidroxiesteroide deshidrogenasa 1. composiciones farmaceuticas. |
AR069207A1 (es) * | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
US8440658B2 (en) | 2007-12-11 | 2013-05-14 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
TW200934490A (en) * | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
WO2009094169A1 (en) * | 2008-01-24 | 2009-07-30 | Vitae Pharmaceuticals, Inc. | Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
KR101235961B1 (ko) | 2008-02-01 | 2013-02-21 | 판미라 파마슈티칼스, 엘엘씨 | 프로스타글란딘 d2 수용체의 n,n-이치환 아미노알킬비페닐 길항제 |
US20110098352A1 (en) * | 2008-02-01 | 2011-04-28 | Amira Pharmaceuticals, Inc. | N,n-disubstituted aminoalkylbiphenyl antagonists of prostaglandin d2 receptors |
JP5734666B2 (ja) * | 2008-02-11 | 2015-06-17 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の1,3−オキサアゼパン−2−オン及び1,3−ジアゼパン−2−オン阻害剤 |
US8242145B2 (en) | 2008-02-14 | 2012-08-14 | Panmira Pharmaceuticals, Llc | Cyclic diaryl ether compounds as antagonists of prostaglandin D2 receptors |
JP5730021B2 (ja) * | 2008-02-15 | 2015-06-03 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の阻害剤としてのシクロアルキルラクタム誘導体 |
JP2011513242A (ja) * | 2008-02-25 | 2011-04-28 | アミラ ファーマシューティカルズ,インク. | プロスタグランジンd2受容体アンタゴニスト |
CA2718264A1 (en) * | 2008-03-18 | 2009-09-24 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
WO2009145989A2 (en) | 2008-04-02 | 2009-12-03 | Amira Pharmaceuticals, Inc. | Aminoalkylphenyl antagonists of prostaglandin d2 receptors |
ES2421537T3 (es) | 2008-05-01 | 2013-09-03 | Vitae Pharmaceuticals Inc | Inhibidores cíclicos de la 11beta-hidroxiesteroide deshidrogenasa 1 |
CA2723034A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
US8569292B2 (en) | 2008-05-01 | 2013-10-29 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
US8063088B2 (en) * | 2008-06-11 | 2011-11-22 | Hoffmann-La Roche Inc. | Imidazolidine derivatives |
PL2324018T3 (pl) | 2008-07-25 | 2014-02-28 | Boehringer Ingelheim Int | Cykliczne inhibitory dehydrogenazy 11 beta-hydroksysteroidowej typu 1 |
JP5390610B2 (ja) | 2008-07-25 | 2014-01-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 11β−ヒドロキシステロイドデヒドロゲナーゼ1型の阻害剤の合成 |
US8846668B2 (en) | 2008-07-25 | 2014-09-30 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
GB2463788B (en) | 2008-09-29 | 2010-12-15 | Amira Pharmaceuticals Inc | Heteroaryl antagonists of prostaglandin D2 receptors |
DE102008049675A1 (de) | 2008-09-30 | 2010-04-01 | Markus Dr. Heinrich | Verfahren zur Herstellung von 3-Aminobiphenylen |
EP2348859B1 (en) * | 2008-10-01 | 2013-12-04 | Merck Sharp & Dohme Corp. | Prodrugs of oxazolidinone cetp inhibitors |
US8378107B2 (en) | 2008-10-01 | 2013-02-19 | Panmira Pharmaceuticals, Llc | Heteroaryl antagonists of prostaglandin D2 receptors |
WO2010042652A2 (en) | 2008-10-08 | 2010-04-15 | Amira Pharmaceuticals, Inc. | Heteroalkyl biphenyl antagonists of prostaglandin d2 receptors |
CN102264228A (zh) | 2008-10-22 | 2011-11-30 | 默沙东公司 | 用于抗糖尿病药的新的环状苯并咪唑衍生物 |
US8329914B2 (en) | 2008-10-31 | 2012-12-11 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
US8383654B2 (en) | 2008-11-17 | 2013-02-26 | Panmira Pharmaceuticals, Llc | Heterocyclic antagonists of prostaglandin D2 receptors |
TW201028414A (en) | 2009-01-16 | 2010-08-01 | Merck Sharp & Dohme | Oxadiazole beta carboline derivatives as antidiabetic compounds |
US20110312995A1 (en) | 2009-01-23 | 2011-12-22 | Schering Corporation | Bridged and fused heterocyclic antidiabetic compounds |
US20110312967A1 (en) | 2009-01-23 | 2011-12-22 | Schering Corporation | Bridged and fused antidiabetic compounds |
CA2744946A1 (en) | 2009-02-04 | 2010-08-12 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
WO2010091176A1 (en) | 2009-02-05 | 2010-08-12 | Schering Corporation | Phthalazine-containing antidiabetic compounds |
US8680093B2 (en) | 2009-04-30 | 2014-03-25 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
US8927539B2 (en) | 2009-06-11 | 2015-01-06 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure |
JP5749263B2 (ja) | 2009-07-01 | 2015-07-15 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状インヒビター |
KR20120047273A (ko) | 2009-08-05 | 2012-05-11 | 판미라 파마슈티칼스, 엘엘씨 | Dp2 길항제 및 이의 용도 |
JP2011057661A (ja) | 2009-08-14 | 2011-03-24 | Bayer Cropscience Ag | 殺虫性カルボキサミド類 |
JP5750449B2 (ja) | 2009-11-05 | 2015-07-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規キラルリンリガンド |
KR20120125468A (ko) | 2010-01-15 | 2012-11-15 | 머크 샤프 앤드 돔 코포레이션 | 항당뇨 화합물로서 옥사디아졸 베타 카르볼린 유도체 |
WO2011106273A1 (en) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
US8648192B2 (en) | 2010-05-26 | 2014-02-11 | Boehringer Ingelheim International Gmbh | 2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives |
EP2397473A1 (en) | 2010-06-14 | 2011-12-21 | LEK Pharmaceuticals d.d. | A stable highly crystalline anacetrapib |
US8933072B2 (en) | 2010-06-16 | 2015-01-13 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
JP5813106B2 (ja) | 2010-06-25 | 2015-11-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 代謝障害の処置のための11−β−HSD1のインヒビターとしてのアザスピロヘキサノン |
JPWO2012046681A1 (ja) | 2010-10-04 | 2014-02-24 | 興和株式会社 | 脂質代謝関連mRNAの発現抑制剤 |
EP2632269B1 (en) * | 2010-10-29 | 2017-03-15 | Merck Sharp & Dohme Corp. | Cyclic amine substituted oxazolidinones as cetp inhibitors |
AU2011325286B2 (en) | 2010-11-02 | 2015-04-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations for the treatment of metabolic disorders |
EP2468735A1 (en) | 2010-12-23 | 2012-06-27 | LEK Pharmaceuticals d.d. | Synthesis of intermediates for preparing anacetrapib and derivates thereof |
EP2468736A1 (en) | 2010-12-23 | 2012-06-27 | LEK Pharmaceuticals d.d. | Synthesis of intermediates for preparing anacetrapib and derivates thereof |
WO2012101142A1 (en) | 2011-01-26 | 2012-08-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for assessing a subject's risk of having a cardiovascular disease. |
CA2826649C (en) | 2011-02-25 | 2016-07-26 | Merck Sharp & Dohme Corp. | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
MX342104B (es) | 2011-04-12 | 2016-09-13 | Chong Kun Dang Pharmaceutical Corp | Derivados de cicloalquenil arilo para inhibidor de cetp. |
CN103813789A (zh) * | 2011-07-07 | 2014-05-21 | 持田制药株式会社 | 含有高纯度epa的抗肥胖药 |
TWI627167B (zh) | 2011-07-08 | 2018-06-21 | 諾華公司 | 用於高三酸甘油酯個體治療動脈粥狀硬化之方法 |
JO3210B1 (ar) | 2011-10-28 | 2018-03-08 | Merck Sharp & Dohme | مثبط منصهر لبروتين نقل الكوليسترليستير اوكسازوليدينون ثمائي الحلقة |
EP2773210A4 (en) * | 2011-10-31 | 2015-07-22 | Merck Sharp & Dohme | PROCESS FOR A CETP HEMMER |
WO2013064188A1 (en) | 2011-11-03 | 2013-05-10 | Lek Pharmaceuticals D.D. | A stable highly crystalline anacetrapib |
US20140303198A1 (en) | 2011-11-29 | 2014-10-09 | Kowa Company, Ltd. | Agent for inhibiting expression of npc1l1 and/or lipg mrna and agent for preventing and/or treating obesity |
RU2604132C2 (ru) * | 2011-11-30 | 2016-12-10 | Дэунг Фармасьютикл Ко., Лтд. | Фармацевтическая композиция для профилактики или лечения гипертриглицеридемии или вызванных гипертриглицеридемией заболеваний |
WO2013091696A1 (en) | 2011-12-21 | 2013-06-27 | Lek Pharmaceuticals D.D. | Synthesis of intermediates for preparing anacetrapib and derivatives thereof |
US9353101B2 (en) | 2012-05-02 | 2016-05-31 | Merck Sharp & Dohme Corp. | Cyclic amine substituted heterocyclic CETP inhibitors |
MX347400B (es) | 2012-06-29 | 2017-04-18 | Univ Nac Autónoma De México | Vacuna de aplicacion nasal contra el desarrollo de la enfermedad aterosclerotica y el higado graso. |
WO2014012428A1 (zh) * | 2012-07-19 | 2014-01-23 | 上海恒瑞医药有限公司 | 噁唑烷酮类衍生物、其制备方法及其在医药上的应用 |
US9382243B2 (en) | 2012-08-22 | 2016-07-05 | Merck Sharp & Dohme Corp. | Azabenzimidazole tetrahydropyran derivatives |
EP2934518B1 (en) | 2012-12-19 | 2020-02-19 | Merck Sharp & Dohme Corp. | Spirocyclic cetp inhibitors |
EP2934519B1 (en) | 2012-12-20 | 2021-05-12 | Merck Sharp & Dohme Corp. | Therapeutic thiazolidinone compounds |
WO2014111953A1 (en) * | 2013-01-17 | 2014-07-24 | Glenmark Pharmaceuticals Limited; Glenmark Generics Limited | Process for preparation of anacetrapib and intermediates thereof |
MX2015009851A (es) | 2013-01-31 | 2015-10-14 | Chong Kun Dang Pharm Corp | Compuestos derivados de ciclohexeno sustituidos con biarilos o biarilos heterociclicos como inhibidores de cetp. |
US9650375B2 (en) | 2013-03-14 | 2017-05-16 | Merck Sharp & Dohme Corp. | Indole derivatives useful as anti-diabetic agents |
WO2015017302A2 (en) | 2013-07-30 | 2015-02-05 | Merck Sharp & Dohme Corp. | Bicyclic ureas and thiadiazolidine-1,1-dioxides as cetp inhibitors |
EP3054945B1 (en) | 2013-10-10 | 2018-08-15 | Merck Sharp & Dohme Corp. | 3,3'-disubstituted indolines as inhibitors of cholesterol ester transfer protein |
CN105814064A (zh) | 2013-12-17 | 2016-07-27 | 默沙东公司 | 作为胆固醇酯转运蛋白的抑制剂的稠合双环异噁唑啉类 |
CN104955816B (zh) * | 2014-01-14 | 2016-08-31 | 杭州普晒医药科技有限公司 | 一种安塞曲匹的晶型及其制备方法、其药物组合物和用途 |
CN103923030B (zh) * | 2014-03-27 | 2015-07-22 | 汕头经济特区鮀滨制药厂 | 一种安塞曲匹的关键中间体的合成方法 |
CN103923031A (zh) * | 2014-04-01 | 2014-07-16 | 汕头经济特区鮀滨制药厂 | 一种安塞曲匹的中间体的合成方法 |
US10011572B2 (en) | 2014-07-29 | 2018-07-03 | Merck Sharp & Dohme Corp. | Monocyclic isoxazolines as inhibitors of cholesterol ester transfer protein |
MX2017000582A (es) | 2014-07-30 | 2017-04-27 | Hoffmann La Roche | Marcadores geneticos para predecir la reactividad a terapia con agente que eleva la lipoproteina de alta densidad (hdl) o que imita la lipoproteina de alta densidad (hdl). |
CN104230835B (zh) * | 2014-09-01 | 2017-01-25 | 福建师范大学 | 一种合成n‑苯乙烯基恶唑烷‑2‑酮衍生物的方法 |
WO2016067194A1 (en) * | 2014-10-27 | 2016-05-06 | Sun Pharmaceutical Industries Limited | Process for the preparation of anacetrapib and an intermediate thereof |
CN106032362B (zh) * | 2015-03-10 | 2018-06-19 | 湖南千金湘江药业股份有限公司 | 安塞曲匹的制备方法 |
JP2019519582A (ja) | 2016-06-29 | 2019-07-11 | オリオン コーポレーション | ベンゾジオキサン誘導体およびその医薬用途 |
WO2018016743A1 (ko) * | 2016-07-19 | 2018-01-25 | 재단법인 대구경북첨단의료산업진흥재단 | Cetp 억제제로서의 옥사졸리딘온 유도체 화합물 |
WO2018033866A1 (en) * | 2016-08-17 | 2018-02-22 | Novartis Ag | New processes and intermediates for nep inhibitor synthesis |
CN106496154A (zh) * | 2016-10-18 | 2017-03-15 | 湖南德魅信息技术有限公司 | 安塞曲匹的制备方法 |
CN106496211A (zh) * | 2016-10-18 | 2017-03-15 | 湖南德魅信息技术有限公司 | 二氟甲基取代的噁唑烷酮化合物及其用途 |
CN106749075A (zh) * | 2016-11-24 | 2017-05-31 | 山东新华制药股份有限公司 | 阿那曲波的恶唑烷酮中间体的晶型及其制备方法 |
US20190070178A1 (en) | 2017-08-29 | 2019-03-07 | Dalcor Pharma Uk Ltd., Stockport Zug Branch | Methods for treating or preventing cardiovascular disorders and lowering risk of cardiovascular events |
JOP20180092A1 (ar) | 2017-10-13 | 2019-04-13 | Gilead Sciences Inc | مثبطات hiv بروتياز |
BR112021002387A2 (pt) | 2018-08-09 | 2021-05-11 | Dalcor Pharma Uk Ltd., Leatherhead, Zug Branch | métodos para retardo de ocorrência de diabetes tipo 2 de início recente e para redução da progressão e tratamento de diabetes tipo 2 |
WO2020178443A1 (en) | 2019-03-07 | 2020-09-10 | Dalcor Pharma Uk Ltd., Leatherhead, Zug Branch | Methods for treating or preventing heart failure and reducing risk of heart failure |
TW202104210A (zh) | 2019-04-17 | 2021-02-01 | 美商基利科學股份有限公司 | Hiv蛋白酶抑制劑 |
CN114423771A (zh) | 2019-07-19 | 2022-04-29 | 生物合成股份公司 | 制备烟酰胺呋喃核糖苷盐的方法、烟酰胺呋喃核糖苷盐本身及其用途 |
WO2022075645A1 (ko) * | 2020-10-08 | 2022-04-14 | 재단법인 대구경북첨단의료산업진흥재단 | Pcsk9 억제제로서 아미노알콜 유도체 및 이를 함유하는 고콜레스테롤 혈증의 예방 또는 치료용 약학적 조성물 |
EP4362933A1 (en) * | 2021-06-30 | 2024-05-08 | Apellis Pharmaceuticals, Inc. | Complement inhibition |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179442A (en) * | 1975-08-29 | 1979-12-18 | York Hartleben | 4-(Alpha-hydroxy-isopropyl)-5-phenyl-oxazolidin-2-one |
DE2655369A1 (de) * | 1976-12-03 | 1978-06-08 | Schering Ag | 5-(subst. phenyl)-oxazolidinone und deren schwefelanaloga sowie verfahren zu deren herstellung |
US4851423A (en) | 1986-12-10 | 1989-07-25 | Schering Corporation | Pharmaceutically active compounds |
US4968707A (en) * | 1987-06-10 | 1990-11-06 | Pfizer Inc. | Oxazolidin-2-one derivatives as hypoglycemic agents |
HU220601B1 (hu) * | 1992-04-30 | 2002-03-28 | Taiho Pharmaceutical Co. Ltd. | Fenoxi-alkil-oxazolidin-származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények |
WO1995010508A1 (fr) * | 1993-10-15 | 1995-04-20 | Shionogi & Co., Ltd. | Derive d'oxazolinone presentant une activite inhibitrice de la phospholipase a2 intracellulaire |
US5482971A (en) * | 1993-10-01 | 1996-01-09 | American Cyanamid Company | Beta3 -adrenergic agents and their use in pharmaceutical compositions |
EP0758233B1 (en) * | 1994-04-21 | 2003-12-03 | Schering Aktiengesellschaft | Pde iv inhibitors for treating multiple sclerosis |
FR2729954B1 (fr) * | 1995-01-30 | 1997-08-01 | Sanofi Sa | Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant |
JPH11500110A (ja) * | 1995-02-10 | 1999-01-06 | シエーリング アクチエンゲゼルシヤフト | Tnf−抑制用製剤 |
KR19990014856A (ko) * | 1995-05-17 | 1999-02-25 | 미디암 디, 메코너헤이 | 살진균성 시클릭 아미드 |
US5612363A (en) | 1995-06-02 | 1997-03-18 | Berlex Laboratories, Inc. | N,N-di(aryl) cyclic urea derivatives as anti-coagulants |
EP0836384A1 (en) | 1995-06-20 | 1998-04-22 | E.I. Du Pont De Nemours And Company | Arthropodicidal and fungicidal cyclic amides |
US5846990A (en) * | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
US6310095B1 (en) * | 1995-11-06 | 2001-10-30 | University Of Pittsburgh | Inhibitors of protein isoprenyl transferases |
WO1997028149A1 (en) | 1996-02-02 | 1997-08-07 | Merck & Co., Inc. | Method for raising hdl cholesterol levels |
DE19647380A1 (de) * | 1996-11-15 | 1998-05-20 | Hoechst Ag | 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
WO1998023155A1 (en) | 1996-11-26 | 1998-06-04 | E.I. Du Pont De Nemours And Company | Arthropodicidal and fungicidal cyclic amides |
DE19704243A1 (de) * | 1997-02-05 | 1998-08-06 | Bayer Ag | Neue 2-Amino-substituierte Pyridine |
KR20000075893A (ko) * | 1997-03-03 | 2000-12-26 | 데이비드 이. 프랭크하우저 | 염증성 질환의 치료에 유용한 소분자 화합물 |
JP2002518985A (ja) | 1997-05-07 | 2002-06-25 | ユニバーシティー・オブ・ピッツバーグ | タンパク質イソプレニルトランスフェラーゼの阻害剤 |
DE19741400A1 (de) | 1997-09-19 | 1999-03-25 | Bayer Ag | Benzyl-biphenyle |
AU764184B2 (en) | 1998-01-23 | 2003-08-14 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
DE19816880A1 (de) * | 1998-04-17 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue Diphenyl-substituierte 5-Ring-Heterocyclen, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
GT199900147A (es) | 1998-09-17 | 1999-09-06 | 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas. | |
WO2001019788A2 (en) | 1999-09-17 | 2001-03-22 | Cor Therapeutics, Inc. | BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa |
HN2000000203A (es) * | 1999-11-30 | 2001-06-13 | Pfizer Prod Inc | Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas. |
US6462063B1 (en) | 2000-02-04 | 2002-10-08 | Fibrogen, Inc. | C-proteinase inhibitors |
AU4456601A (en) | 2000-03-28 | 2001-10-08 | Nippon Soda Co., Ltd. | Oxa(thia)zolidine derivative and anti-inflammatory drug |
RS50864B (sr) * | 2000-12-21 | 2010-08-31 | Sanofi-Aventis Deutschland Gmbh. | Novi 1,2-difenil-azetidinoni, postupak za njihovu proizvodnju, lekovi koji sadrže ova jedinjenja i njihova primena za lečenje poremećaja u metabolizmu lipida |
KR20040044886A (ko) | 2001-09-11 | 2004-05-31 | 아스트라제네카 아베 | 항균제로서의 옥사졸리디논 및(또는) 이속사졸린 |
IL161317A0 (en) | 2001-10-16 | 2004-09-27 | Memory Pharm Corp | 4-(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes |
AR043050A1 (es) * | 2002-09-26 | 2005-07-13 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos |
KR100857759B1 (ko) | 2003-03-17 | 2008-09-09 | 니뽄 다바코 산교 가부시키가이샤 | Cetp 억제제의 약제학적 조성물 |
UA90269C2 (ru) | 2004-04-02 | 2010-04-26 | Мицубиси Танабе Фарма Корпорейшн | Тетрагидрохинолиновые производные и способ их получения |
DOP2005000123A (es) * | 2004-07-02 | 2011-07-15 | Merck Sharp & Dohme | Inhibidores de cetp |
WO2006103527A1 (en) | 2005-03-31 | 2006-10-05 | Council Of Scientific And Industrial Research | Aromatic substituted pentadienoic acid amide for combination with anti-infective drugs |
RU2513107C2 (ru) | 2005-12-30 | 2014-04-20 | Мерк Шарп И Доум Корп. | Ингибиторы сетр |
US7781426B2 (en) * | 2005-12-30 | 2010-08-24 | Merck Sharp & Dohme Corp. | CETP inhibitors |
WO2007081569A2 (en) * | 2005-12-30 | 2007-07-19 | Merck & Co., Inc. | Cetp inhibitors |
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