JP2011522789A5 - - Google Patents
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- Publication number
- JP2011522789A5 JP2011522789A5 JP2011507540A JP2011507540A JP2011522789A5 JP 2011522789 A5 JP2011522789 A5 JP 2011522789A5 JP 2011507540 A JP2011507540 A JP 2011507540A JP 2011507540 A JP2011507540 A JP 2011507540A JP 2011522789 A5 JP2011522789 A5 JP 2011522789A5
- Authority
- JP
- Japan
- Prior art keywords
- aryl
- heteroaryl
- alkyl
- alkynyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 37
- 125000003118 aryl group Chemical group 0.000 claims 29
- 125000001072 heteroaryl group Chemical group 0.000 claims 27
- 125000000217 alkyl group Chemical group 0.000 claims 26
- 125000000304 alkynyl group Chemical group 0.000 claims 23
- 125000003342 alkenyl group Chemical group 0.000 claims 19
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 16
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims 14
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 11
- 125000005843 halogen group Chemical group 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000004442 acylamino group Chemical group 0.000 claims 3
- 125000000732 arylene group Chemical group 0.000 claims 3
- 125000004104 aryloxy group Chemical group 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 125000005549 heteroarylene group Chemical group 0.000 claims 3
- -1 nitro, cyano, amino, hydroxy Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 2
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4906308P | 2008-04-30 | 2008-04-30 | |
| US61/049,063 | 2008-04-30 | ||
| PCT/US2009/041382 WO2009134658A2 (en) | 2008-04-30 | 2009-04-22 | Fused bicyclic pyrimidine compounds as aurora kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011522789A JP2011522789A (ja) | 2011-08-04 |
| JP2011522789A5 true JP2011522789A5 (enExample) | 2012-06-14 |
| JP5502072B2 JP5502072B2 (ja) | 2014-05-28 |
Family
ID=41255689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011507540A Active JP5502072B2 (ja) | 2008-04-30 | 2009-04-22 | オーロラキナーゼ阻害剤としての縮合二環式ピリミジン化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8138194B2 (enExample) |
| EP (1) | EP2276346B1 (enExample) |
| JP (1) | JP5502072B2 (enExample) |
| KR (1) | KR101667822B1 (enExample) |
| CN (1) | CN102014627B (enExample) |
| AU (1) | AU2009241469B2 (enExample) |
| CA (1) | CA2722220C (enExample) |
| DK (1) | DK2276346T3 (enExample) |
| ES (1) | ES2616255T3 (enExample) |
| PL (1) | PL2276346T3 (enExample) |
| TW (1) | TWI363627B (enExample) |
| WO (1) | WO2009134658A2 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013515740A (ja) * | 2009-12-23 | 2013-05-09 | バイオクライスト ファーマシューティカルズ， インコーポレイテッド | Ｊａｎｕｓキナーゼインヒビターとしての複素環式化合物 |
| WO2011082273A2 (en) | 2009-12-30 | 2011-07-07 | Arqule, Inc. | Substituted pyrrolo-aminopyrimidine compounds |
| TW201307347A (zh) | 2010-11-01 | 2013-02-16 | Arqule Inc | 經取代苯並－咪唑並－吡啶並－二氮呯化合物 |
| BR112014024251A8 (pt) * | 2012-03-30 | 2018-01-23 | Rhizen Pharmaceuticals S A | novos compostos piridina 3,5-dissubstituída-3h-imidazo [4,5-b] e piridina 3,5-dissubstituída -3h-[1,2,3]triazolo[4,5-b] como moduladores de quinases de proteína c-met |
| JP6235001B2 (ja) | 2012-05-21 | 2017-11-22 | バイエル・ファルマ・アクティエンゲゼルシャフト | 置換ベンゾチエノピリミジン |
| CA2873971A1 (en) | 2012-05-21 | 2013-11-28 | Bayer Pharma Aktiengesellschaft | Substituted pyrrolopyrimidines |
| CN104507950B (zh) | 2012-05-21 | 2017-03-22 | 拜耳医药股份有限公司 | 噻吩并嘧啶 |
| MD20140130A2 (ro) | 2012-06-29 | 2015-04-30 | Pfizer Inc. | 4-(amino-substituite)-7H-pirolo[2,3-d]pirimidine noi ca inhibitori de LRRK2 |
| TW201412740A (zh) | 2012-09-20 | 2014-04-01 | Bayer Pharma AG | 經取代之吡咯并嘧啶胺基苯并噻唑酮 |
| CN103664993B (zh) * | 2012-09-25 | 2016-05-25 | 韩冰 | 一类治疗缺血性脑损伤的化合物及其用途 |
| CN103012428A (zh) * | 2013-01-08 | 2013-04-03 | 中国药科大学 | 4-(五元杂环并嘧啶/吡啶取代)氨基-1H-3-吡唑甲酰胺类CDK/Aurora双重抑制剂及其用途 |
| EP2951187A1 (en) | 2013-02-01 | 2015-12-09 | Bayer Pharma Aktiengesellschaft | Substituted thienopyrimidines and pharmaceutical use thereof |
| US9675612B2 (en) | 2013-03-06 | 2017-06-13 | Bayer Pharma Aktiengesellschaft | Substituted thiazolopyrimidines |
| WO2015092592A1 (en) | 2013-12-17 | 2015-06-25 | Pfizer Inc. | Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors |
| MD20160112A2 (ro) | 2014-04-25 | 2017-06-30 | Pfizer Inc. | Compuşi heteroaromatici şi utilizarea lor ca liganzi ai dopaminei D1 |
| FR3037956B1 (fr) * | 2015-06-23 | 2017-08-04 | Servier Lab | Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CN105061461B (zh) * | 2015-08-18 | 2017-06-30 | 沈阳药科大学 | 含有苄胺结构的四氢苯并[4,5]噻吩并[2,3‑d]嘧啶类化合物及其应用 |
| CN105061460B (zh) * | 2015-08-18 | 2017-06-30 | 沈阳药科大学 | 含有硫醚结构的四氢苯并[4,5]噻吩并[2,3‑d]嘧啶类化合物及其应用 |
| RU2722149C1 (ru) | 2015-09-14 | 2020-05-27 | Пфайзер Инк. | Новые производные имидазо[4,5-c] хинолинов и имидазо[4,5-c][1,5] нафтиридинов в качестве ингибиторов LRRK2 |
| US9630968B1 (en) | 2015-12-23 | 2017-04-25 | Arqule, Inc. | Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof |
| FR3046792B1 (fr) * | 2016-01-19 | 2018-02-02 | Les Laboratoires Servier | Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CN106243124B (zh) * | 2016-07-29 | 2018-03-09 | 湖北民族学院 | 一种噻吩并嘧啶脲类化合物及其制备方法和应用 |
| BR112019003504A2 (pt) | 2016-08-24 | 2019-05-21 | Arqule, Inc. | compostos de amino-pirrolopirimidinona e métodos de uso dos mesmos |
| CN106810512B (zh) * | 2017-01-18 | 2019-09-10 | 江苏省中医药研究院 | Idh2突变体抑制剂及其用途 |
| TW201920193A (zh) * | 2017-08-15 | 2019-06-01 | 美商艾伯維有限公司 | 大環ｍｅｌ-１抑制劑以及使用方法 |
| CN111818917A (zh) * | 2017-08-15 | 2020-10-23 | 艾伯维公司 | 大环mcl-1抑制剂和使用方法 |
| US20200255451A1 (en) * | 2017-08-15 | 2020-08-13 | Abbvie Inc. | Macrocyclic mcl-1 inhibitors and methods of use |
| PL4021452T3 (pl) * | 2019-08-26 | 2024-05-06 | Chemwerth Inc | Podstawione związki (7h-pirolo[2,3-d]pirymidyn-4-ylo)aminowe przydatne jako inhibitory jak1 |
| CN112500421B (zh) * | 2020-12-15 | 2021-08-24 | 河南科技大学第一附属医院 | 一种可用于杀菌消毒的苯并吡喃脲类化合物的制备方法及应用 |
| TW202413367A (zh) * | 2022-08-19 | 2024-04-01 | 財團法人國家衛生研究院 | Ｔａｍ受體抑制劑 |
| TW202508595A (zh) | 2023-05-04 | 2025-03-01 | 美商銳新醫藥公司 | 用於ｒａｓ相關疾病或病症之組合療法 |
| WO2025034702A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Rmc-6291 for use in the treatment of ras protein-related disease or disorder |
| WO2025080946A2 (en) | 2023-10-12 | 2025-04-17 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4008726A1 (de) * | 1990-03-19 | 1991-09-26 | Basf Ag | Thieno(2,3-d)pyrimidinderivate |
| HU230302B1 (hu) * | 2000-10-20 | 2015-12-28 | Eisai R&D Management Co., Ltd. | Nitrogéntartalmú aromás származékok és ezeket tartalmazó gyógyászati készítmények |
| DE10141212A1 (de) | 2001-08-22 | 2003-03-06 | Bayer Ag | Neue 4-Aminofuropyrimidine und ihre Verwendung |
| JP2005508904A (ja) | 2001-09-11 | 2005-04-07 | スミスクライン ビーチャム コーポレーション | 血管新生阻害剤としてのフロ−及びチエノピリミジン誘導体 |
| US6814324B2 (en) * | 2002-07-03 | 2004-11-09 | Segway Systems, Llc | Releasably latchable leader block in tape threading apparatus for data storage systems and method therefor |
| BRPI0317717B8 (pt) | 2002-12-24 | 2021-05-25 | Astrazeneca Ab | composto, composição farmacêutica, e uso de um composto |
| ATE437872T1 (de) * | 2003-10-14 | 2009-08-15 | Univ Arizona | Proteinkinaseinhibitoren |
| US20050165029A1 (en) | 2004-01-13 | 2005-07-28 | Ambit Biosciences Corporation | Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases |
| KR20050091462A (ko) | 2004-03-12 | 2005-09-15 | 한국과학기술연구원 | 푸로피리미딘 화합물 및 이를 포함하는 ｄｄｒ2 티로신키나아제 활성 저해제 |
| HRP20080120T5 (hr) | 2004-05-14 | 2012-07-31 | Millennium@Pharmaceuticals | Spojevi i postupci za inhibiciju napredovanja mitoze s pomoću inhibicije aurora kinaze |
| WO2006004658A2 (en) | 2004-06-29 | 2006-01-12 | Amgen Inc. | Furanopyrimidines |
| EP1781653A1 (en) | 2004-07-05 | 2007-05-09 | Astex Therapeutics Limited | 3,4-disubstituted pyrazoles as cyclin dependent kinases (cdk) or aurora kinase or glycogen synthase 3 (gsk-3) inhibitors |
| CN101160316A (zh) * | 2004-07-16 | 2008-04-09 | 苏内西斯医药公司 | 适合用作aurora激酶抑制剂的噻吩并嘧啶 |
| ATE485300T1 (de) | 2004-07-16 | 2010-11-15 | Sunesis Pharmaceuticals Inc | Als aurora-kinase-inhibitoren nutzbare thienopyrimidine |
| JP2009502801A (ja) | 2005-07-22 | 2009-01-29 | サネシス ファーマシューティカルズ， インコーポレイテッド | Ａｕｒｏｒａキナーゼインヒビターとして有用なピラゾロピリミジン |
| DE102005037499A1 (de) * | 2005-08-09 | 2007-02-15 | Merck Patent Gmbh | Pyrazolderivate |
| RU2008120850A (ru) * | 2005-10-28 | 2009-12-10 | Айрм Ллк (Bm) | Соединения и композиции в качестве ингибиторов протеинкиназ |
| KR20080083680A (ko) | 2005-12-23 | 2008-09-18 | 스미스클라인 비참 코포레이션 | 오로라 키나제의 아자인돌 억제제 |
-
2009
- 2009-04-22 CA CA2722220A patent/CA2722220C/en active Active
- 2009-04-22 CN CN200980115577.4A patent/CN102014627B/zh active Active
- 2009-04-22 ES ES09739460.5T patent/ES2616255T3/es active Active
- 2009-04-22 US US12/428,044 patent/US8138194B2/en active Active
- 2009-04-22 AU AU2009241469A patent/AU2009241469B2/en not_active Ceased
- 2009-04-22 WO PCT/US2009/041382 patent/WO2009134658A2/en not_active Ceased
- 2009-04-22 PL PL09739460T patent/PL2276346T3/pl unknown
- 2009-04-22 EP EP09739460.5A patent/EP2276346B1/en active Active
- 2009-04-22 JP JP2011507540A patent/JP5502072B2/ja active Active
- 2009-04-22 KR KR1020107025018A patent/KR101667822B1/ko active Active
- 2009-04-22 DK DK09739460.5T patent/DK2276346T3/en active
- 2009-04-29 TW TW098114168A patent/TWI363627B/zh active
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