JP2014528466A5 - - Google Patents

Info

Publication number

JP2014528466A5

JP2014528466A5 JP2014535095A JP2014535095A JP2014528466A5 JP 2014528466 A5 JP2014528466 A5 JP 2014528466A5 JP 2014535095 A JP2014535095 A JP 2014535095A JP 2014535095 A JP2014535095 A JP 2014535095A JP 2014528466 A5 JP2014528466 A5 JP 2014528466A5

Authority

JP

Japan

Prior art keywords

unit

formula

attachment

point

group

Prior art date

2012-10-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 150000001875 compounds Chemical class 0.000 claims 8
• 239000003446 ligand Substances 0.000 claims 7
• 125000005647 linker group Chemical group 0.000 claims 6
• 125000000217 alkyl group Chemical group 0.000 claims 4
• 125000003118 aryl group Chemical group 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 4
• 229940079593 drug Drugs 0.000 claims 4
• 125000005843 halogen group Chemical group 0.000 claims 4
• -1 where Chemical compound 0.000 claims 4
• 125000002947 alkylene group Chemical group 0.000 claims 3
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
• 229910052760 oxygen Inorganic materials 0.000 claims 3
• 125000001424 substituent group Chemical group 0.000 claims 3
• 229910052717 sulfur Inorganic materials 0.000 claims 3
• OMRPLUKQNWNZAV-CONSDPRKSA-N (6as)-3-[3-[[(6as)-2-methoxy-8-(4-methoxyphenyl)-11-oxo-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]propoxy]-8-(4-aminophenyl)-2-methoxy-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-11-one Chemical group C1=CC(OC)=CC=C1C1=CN2C(=O)C3=CC(OC)=C(OCCCOC=4C(=CC=5C(=O)N6C=C(C[C@H]6C=NC=5C=4)C=4C=CC(N)=CC=4)OC)C=C3N=C[C@@H]2C1 OMRPLUKQNWNZAV-CONSDPRKSA-N 0.000 claims 2
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
• 150000001768 cations Chemical class 0.000 claims 2
• 125000000623 heterocyclic group Chemical group 0.000 claims 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• 125000006850 spacer group Chemical group 0.000 claims 2
• ALBODLTZUXKBGZ-JUUVMNCLSA-N (2s)-2-amino-3-phenylpropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CC1=CC=CC=C1 ALBODLTZUXKBGZ-JUUVMNCLSA-N 0.000 claims 1
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 108010016626 Dipeptides Proteins 0.000 claims 1
• 150000001413 amino acids Chemical group 0.000 claims 1
• 125000004432 carbon atom Chemical group C* 0.000 claims 1
• 125000001309 chloro group Chemical group Cl* 0.000 claims 1
• 229960002173 citrulline Drugs 0.000 claims 1
• IBAHLNWTOIHLKE-UHFFFAOYSA-N cyano cyanate Chemical compound N#COC#N IBAHLNWTOIHLKE-UHFFFAOYSA-N 0.000 claims 1
• 125000004093 cyano group Chemical group *C#N 0.000 claims 1
• 125000001153 fluoro group Chemical group F* 0.000 claims 1
• 125000005842 heteroatom Chemical group 0.000 claims 1
• 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
• 229910052757 nitrogen Inorganic materials 0.000 claims 1
• 125000005704 oxymethylene group Chemical group [H]C([H])([*:2])O[*:1] 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 239000012453 solvate Substances 0.000 claims 1