JP2013523897A5 - - Google Patents
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- JP2013523897A5 JP2013523897A5 JP2013505172A JP2013505172A JP2013523897A5 JP 2013523897 A5 JP2013523897 A5 JP 2013523897A5 JP 2013505172 A JP2013505172 A JP 2013505172A JP 2013505172 A JP2013505172 A JP 2013505172A JP 2013523897 A5 JP2013523897 A5 JP 2013523897A5
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- JP
- Japan
- Prior art keywords
- unit
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- binding site
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- conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 125000005647 linker group Chemical group 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000006850 spacer group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 239000004474 valine Substances 0.000 claims 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 1
- LJCZNYWLQZZIOS-UHFFFAOYSA-N 2,2,2-trichlorethoxycarbonyl chloride Chemical compound ClC(=O)OCC(Cl)(Cl)Cl LJCZNYWLQZZIOS-UHFFFAOYSA-N 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 108010016626 Dipeptides Proteins 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 claims 1
- 235000013477 citrulline Nutrition 0.000 claims 1
- 229960002173 citrulline Drugs 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 0 CC1C2C(*)(C3CC3)C(C)C(C)C12 Chemical compound CC1C2C(*)(C3CC3)C(C)C(C)C12 0.000 description 4
- UMCLKVKQVOAZAT-UHFFFAOYSA-N CC(CC(N1CCC(NCCOC(C)(C)CCOCC(C)(C)C)=O)=O)C1=O Chemical compound CC(CC(N1CCC(NCCOC(C)(C)CCOCC(C)(C)C)=O)=O)C1=O UMCLKVKQVOAZAT-UHFFFAOYSA-N 0.000 description 1
- IZGVOANXLNJMDM-UHFFFAOYSA-N CC1=CCNCC1 Chemical compound CC1=CCNCC1 IZGVOANXLNJMDM-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32445310P | 2010-04-15 | 2010-04-15 | |
| US61/324,453 | 2010-04-15 | ||
| PCT/US2011/032668 WO2011130616A1 (en) | 2010-04-15 | 2011-04-15 | Pyrrolobenzodiazepines used to treat proliferative diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013523897A JP2013523897A (ja) | 2013-06-17 |
| JP2013523897A5 true JP2013523897A5 (enExample) | 2014-05-29 |
| JP5875083B2 JP5875083B2 (ja) | 2016-03-02 |
Family
ID=43971498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013505172A Active JP5875083B2 (ja) | 2010-04-15 | 2011-04-15 | 増殖性疾患治療用ピロロベンゾジアゼピン |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8697688B2 (enExample) |
| EP (2) | EP2789622B1 (enExample) |
| JP (1) | JP5875083B2 (enExample) |
| KR (1) | KR101687054B1 (enExample) |
| CN (1) | CN102971329B (enExample) |
| AU (1) | AU2011239525B2 (enExample) |
| BR (1) | BR112012026410B8 (enExample) |
| CA (1) | CA2795353C (enExample) |
| ES (1) | ES2623057T3 (enExample) |
| MX (2) | MX339185B (enExample) |
| NZ (1) | NZ602933A (enExample) |
| WO (1) | WO2011130616A1 (enExample) |
| ZA (1) | ZA201207357B (enExample) |
Families Citing this family (174)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0819095D0 (en) | 2008-10-17 | 2008-11-26 | Spirogen Ltd | Pyrrolobenzodiazepines |
| CN102365021B (zh) | 2009-02-05 | 2015-07-15 | 伊缪诺金公司 | 新型苯并二氮杂*衍生物 |
| ES2623057T3 (es) | 2010-04-15 | 2017-07-10 | Medimmune Limited | Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas |
| JP5870400B2 (ja) | 2010-04-15 | 2016-03-01 | シアトル ジェネティクス，インコーポレーテッド | 標的化ピロロベンゾジアゼピンコンジュゲート |
| KR20140010076A (ko) | 2011-02-15 | 2014-01-23 | 이뮤노젠 아이엔씨 | 세포독성 벤조다이아제핀 유도체 |
| US20130058947A1 (en) | 2011-09-02 | 2013-03-07 | Stem Centrx, Inc | Novel Modulators and Methods of Use |
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2011
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- 2011-04-15 JP JP2013505172A patent/JP5875083B2/ja active Active
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- 2011-04-15 KR KR1020127029495A patent/KR101687054B1/ko active Active
- 2011-04-15 EP EP14173641.3A patent/EP2789622B1/en active Active
- 2011-04-15 CN CN201180028242.6A patent/CN102971329B/zh active Active
- 2011-04-15 WO PCT/US2011/032668 patent/WO2011130616A1/en not_active Ceased
- 2011-04-15 CA CA2795353A patent/CA2795353C/en active Active
- 2011-04-15 AU AU2011239525A patent/AU2011239525B2/en active Active
- 2011-04-15 MX MX2012011899A patent/MX339185B/es active IP Right Grant
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