|
US3361742A
(en)
|
1964-12-07 |
1968-01-02 |
Hoffmann La Roche |
5-oxo-1h-pyrrolo-[2, 1-c][1, 4]-benzodiazepin-2-crylamides
|
|
US3523941A
(en)
|
1967-03-06 |
1970-08-11 |
Hoffmann La Roche |
Benzodiazepine compounds and process for their preparation
|
|
US3524849A
(en)
|
1967-10-27 |
1970-08-18 |
Hoffmann La Roche |
Process for the preparation of pyrrolo-benzodiazepine acrylamides and intermediates useful therein
|
|
JPS4843755B1
(enExample)
|
1969-06-26 |
1973-12-20 |
|
|
|
FR2027356A1
(en)
|
1968-12-30 |
1970-09-25 |
Fujisawa Pharmaceutical Co |
Benzodiazepinone antibiotics
|
|
IL33558A
(en)
|
1968-12-30 |
1973-10-25 |
Fujisawa Pharmaceutical Co |
Antibiotic pyrrolo-benzodiazepine compound,its derivatives and processes for their production
|
|
JPS6053033B2
(ja)
|
1976-12-28 |
1985-11-22 |
財団法人微生物化学研究会 |
新制癌抗生物質マゼスラマイシン及びその製造方法
|
|
JPS585916B2
(ja)
|
1977-12-27 |
1983-02-02 |
株式会社ミドリ十字 |
新規ベンゾジアゼピン系化合物
|
|
JPS5615289A
(en)
|
1979-07-17 |
1981-02-14 |
Green Cross Corp:The |
Novel benzodiazepinnbased compound 3
|
|
JPS57131791A
(en)
|
1980-12-31 |
1982-08-14 |
Fujisawa Pharmaceut Co Ltd |
Benzodiazepine derivative and its preparation
|
|
CA1185602A
(en)
|
1981-02-27 |
1985-04-16 |
Emilio Kyburz |
Imidazodiazepines
|
|
CA1173441A
(en)
|
1981-02-27 |
1984-08-28 |
Hoffmann-La Roche Limited |
Imidazodiazepines
|
|
CA1184175A
(en)
|
1981-02-27 |
1985-03-19 |
Walter Hunkeler |
Imidazodiazepines
|
|
JPS58180487A
(ja)
|
1982-04-16 |
1983-10-21 |
Kyowa Hakko Kogyo Co Ltd |
抗生物質dc−81およびその製造法
|
|
US4427588A
(en)
|
1982-11-08 |
1984-01-24 |
Bristol-Myers Company |
Process for conversion of oxotomaymycin to tomaymycin
|
|
US4427587A
(en)
|
1982-11-10 |
1984-01-24 |
Bristol-Myers Company |
Total synthesis of antitumor antibiotics BBM-2040A and BBM-2040B
|
|
JPS59152329A
(ja)
|
1983-02-17 |
1984-08-31 |
Green Cross Corp:The |
局所障害抑制剤
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
FR2586683B1
(fr)
|
1985-08-29 |
1988-07-01 |
Centre Nat Rech Scient |
Nouveaux derives de neothramycine, leur procede de preparation et leur application en tant que medicaments
|
|
US5583024A
(en)
|
1985-12-02 |
1996-12-10 |
The Regents Of The University Of California |
Recombinant expression of Coleoptera luciferase
|
|
JP2660201B2
(ja)
|
1988-08-05 |
1997-10-08 |
塩野義製薬株式会社 |
新規ピロロ[1,4]ベンゾジアゼピン誘導体および老人性痴呆薬
|
|
FR2676230B1
(fr)
|
1991-05-07 |
1993-08-27 |
Centre Nat Rech Scient |
Nouveaux derives de pyrrolo [1,4]-benzodiazepines, leur procede de preparation et medicaments les contenant.
|
|
GB9205051D0
(en)
|
1992-03-09 |
1992-04-22 |
Cancer Res Campaign Tech |
Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them
|
|
FR2696176B1
(fr)
|
1992-09-28 |
1994-11-10 |
Synthelabo |
Dérivés de pipéridine, leur préparation et leur application en thérapeutique.
|
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
GB9316162D0
(en)
|
1993-08-04 |
1993-09-22 |
Zeneca Ltd |
Fungicides
|
|
WO1995024382A1
(en)
|
1994-03-10 |
1995-09-14 |
G.D. Searle & Co. |
L-n6-(1-iminoethyl)lysine derivatives useful as nitric oxide synthase inhibitors
|
|
JPH08336393A
(ja)
|
1995-04-13 |
1996-12-24 |
Mitsubishi Chem Corp |
光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法
|
|
US20020113770A1
(en)
|
1998-07-08 |
2002-08-22 |
Joseph M. Jacobson |
Methods for achieving improved color in microencapsulated electrophoretic devices
|
|
GB9818731D0
(en)
|
1998-08-27 |
1998-10-21 |
Univ Portsmouth |
Compounds
|
|
ES2244210T3
(es)
|
1998-08-27 |
2005-12-01 |
Spirogen Limited |
Pirrolobenzodiazepinas.
|
|
GB9818730D0
(en)
|
1998-08-27 |
1998-10-21 |
Univ Portsmouth |
Collections of compounds
|
|
GB9818732D0
(en)
|
1998-08-27 |
1998-10-21 |
Univ Portsmouth |
Collection of compounds
|
|
US6909006B1
(en)
|
1999-08-27 |
2005-06-21 |
Spirogen Limited |
Cyclopropylindole derivatives
|
|
ATE310724T1
(de)
|
2000-09-19 |
2005-12-15 |
Taiho Pharmaceutical Co Ltd |
Zusammensetzungen und verfahren zur verwendung achirale analoge von cc1065 und den duocarmycinen
|
|
US6362331B1
(en)
|
2001-03-30 |
2002-03-26 |
Council Of Scientific And Industrial Research |
Process for the preparation of antitumor agents
|
|
EP1401850A1
(en)
*
|
2001-06-20 |
2004-03-31 |
Nuevolution A/S |
Nucleoside derivatives for library preparation
|
|
US6660856B2
(en)
|
2002-03-08 |
2003-12-09 |
Kaohsiung Medical University |
Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine analogues
|
|
DK1545613T3
(da)
|
2002-07-31 |
2011-11-14 |
Seattle Genetics Inc |
Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom
|
|
US20040138269A1
(en)
|
2002-10-11 |
2004-07-15 |
Sugen, Inc. |
Substituted pyrroles as kinase inhibitors
|
|
GB0226593D0
(en)
|
2002-11-14 |
2002-12-24 |
Consultants Ltd |
Compounds
|
|
WO2006113909A2
(en)
|
2005-04-19 |
2006-10-26 |
Seattle Genetics, Inc. |
Humanized anti-cd70 binding agents and uses thereof
|
|
US6884799B2
(en)
|
2003-03-31 |
2005-04-26 |
Council Of Scientific And Industrial Research |
Non-cross-linking pyrrolo[2,1-c][1,4]benzodiazepines and process thereof
|
|
GB0321295D0
(en)
|
2003-09-11 |
2003-10-15 |
Spirogen Ltd |
Synthesis of protected pyrrolobenzodiazepines
|
|
GB0416511D0
(en)
|
2003-10-22 |
2004-08-25 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
CA2543318C
(en)
|
2003-10-22 |
2013-01-08 |
B. Rao Vishnuvajjala |
Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto
|
|
PL2489364T3
(pl)
|
2003-11-06 |
2015-06-30 |
Seattle Genetics Inc |
Związki monometylowaliny zdolne do sprzęgania do przeciwciał
|
|
US20050288491A1
(en)
|
2004-02-17 |
2005-12-29 |
Wilson David S |
Super-humanized antibodies against respiratory syncytial virus
|
|
EP1718667B1
(en)
|
2004-02-23 |
2013-01-09 |
Genentech, Inc. |
Heterocyclic self-immolative linkers and conjugates
|
|
GB0404578D0
(en)
|
2004-03-01 |
2004-04-07 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
PT2270010E
(pt)
|
2004-03-01 |
2012-03-12 |
Spirogen Ltd |
Derivados de 11-hidroxi-5h-pirrolo[2,1-c][1,4]benzodiazepin- 5-ona como intermediários chave para a preparação de pirrolobenzodiazepinas substituídas em c2
|
|
GB0404574D0
(en)
|
2004-03-01 |
2004-04-07 |
Spirogen Ltd |
Amino acids
|
|
GB0404577D0
(en)
|
2004-03-01 |
2004-04-07 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
DE102004010943A1
(de)
|
2004-03-03 |
2005-09-29 |
Degussa Ag |
Verfahren zur Herstellung von N-geschützten 4-Ketprolinderivaten
|
|
EP1723152B1
(en)
|
2004-03-09 |
2015-02-11 |
Spirogen Sàrl |
Pyrrolobenzodiazepines
|
|
FR2869231B1
(fr)
|
2004-04-27 |
2008-03-14 |
Sod Conseils Rech Applic |
Composition therapeutique contenant au moins un derive de la pyrrolobenzodiazepine et la fludarabine
|
|
GB0410725D0
(en)
|
2004-05-13 |
2004-06-16 |
Spirogen Ltd |
Pyrrolobenzodiazepine therapeutic agents
|
|
BRPI0516284A
(pt)
|
2004-09-23 |
2008-09-02 |
Genentech Inc |
anticorpo construìdo com cisteìna, método de selecionar anticorpos, compostos conjugados de droga-anticorpo, composição farmacêutica, método para matar ou inibir a proliferação de células de tumor, métodos de inibir a proliferação celular e o crescimento de células de tumor, artigo manufaturado e método para produzir um composto
|
|
RU2364643C2
(ru)
|
2004-12-24 |
2009-08-20 |
Сова Денко К.К. |
Способ получения термоэлектрического полупроводникового сплава, модуль термоэлектрического преобразования и термоэлектрическое устройство генерации электроэнергии
|
|
US7612062B2
(en)
|
2005-04-21 |
2009-11-03 |
Spirogen Limited |
Pyrrolobenzodiazepines
|
|
ATE427949T1
(de)
|
2005-10-05 |
2009-04-15 |
Spirogen Ltd |
4-a4-(5-oxo-2,3,5,11a-tetrahydro-5h-pyrrolo a2, 1-cua1,4ubenzodiazepin-8-yloxy)-butyrylaminou-1 - pyrrol-2-carbonsaurealkylesterderivate und verwandte verbindung zur behandlung einer proliferativen erkrankung
|
|
US20070154906A1
(en)
|
2005-10-05 |
2007-07-05 |
Spirogen Ltd. |
Methods to identify therapeutic candidates
|
|
ATE527262T1
(de)
|
2006-01-25 |
2011-10-15 |
Sanofi Sa |
Neue tomaymycin derivate enhaltende zytotoxische mittel
|
|
USRE47123E1
(en)
|
2006-07-18 |
2018-11-13 |
Sanofi |
EPHA2 receptor antagonist antibodies
|
|
US10144736B2
(en)
*
|
2006-07-20 |
2018-12-04 |
Gilead Sciences, Inc. |
Substituted pteridines useful for the treatment and prevention of viral infections
|
|
EP1914242A1
(en)
|
2006-10-19 |
2008-04-23 |
Sanofi-Aventis |
Novel anti-CD38 antibodies for the treatment of cancer
|
|
WO2008050140A2
(en)
|
2006-10-27 |
2008-05-02 |
Spirogen Limited |
Compounds for treatment of parasitic infection
|
|
US8455622B2
(en)
|
2006-12-01 |
2013-06-04 |
Seattle Genetics, Inc. |
Variant target binding agents and uses thereof
|
|
JP2008291207A
(ja)
*
|
2007-04-27 |
2008-12-04 |
Kyowa Hakko Kirin Co Ltd |
塩基性アミノ酸を有するらせん状ポリマー
|
|
CN101687037B
(zh)
|
2007-05-08 |
2013-07-10 |
健泰科生物技术公司 |
半胱氨酸改造的抗muc16抗体和抗体药物偶联物
|
|
SI2019104T1
(sl)
|
2007-07-19 |
2013-12-31 |
Sanofi |
Citotoksična sredstva, ki obsegajo nove tomaimicinske derivate, in njihova terapevtska uporaba
|
|
GB0716799D0
(en)
*
|
2007-08-31 |
2007-10-10 |
Univ Kent Canterbury |
Improvements in or relating to radio-labelled peptides
|
|
ES2450755T3
(es)
|
2007-10-19 |
2014-03-25 |
Genentech, Inc. |
Anticuerpos anti-TENB2 modificados por ingeniería genética con cisteína, y conjugados de anticuerpo y fármaco
|
|
GB0722088D0
(en)
|
2007-11-09 |
2007-12-19 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
GB0722087D0
(en)
|
2007-11-09 |
2007-12-19 |
Spirogen Ltd |
Polyamides
|
|
ES2647927T3
(es)
|
2008-03-18 |
2017-12-27 |
Seattle Genetics, Inc. |
Conjugados enlazadores del fármaco auriestatina
|
|
GB0813432D0
(en)
|
2008-07-22 |
2008-08-27 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
GB0819095D0
(en)
|
2008-10-17 |
2008-11-26 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
GB0819097D0
(en)
|
2008-10-17 |
2008-11-26 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
US20110077365A1
(en)
*
|
2008-12-29 |
2011-03-31 |
Gilbert Yu |
Preparation of organosilicon-containing triazoles
|
|
IL271761B
(en)
|
2009-02-05 |
2022-09-01 |
Immunogen Inc |
(12as)-8-methoxy-9-benzyloxy-11,12,12a,13-tetrahydro-6h-indolo[2,1-c][1,4]benzodiazepin-6-one, 4-benzyloxy-5-methoxy-2-nitrobenzoic acid and processes for preparing the same
|
|
CN101492494A
(zh)
|
2009-03-05 |
2009-07-29 |
浙江大学 |
整合素配体环肽类似物及其环化方法
|
|
FR2949469A1
(fr)
|
2009-08-25 |
2011-03-04 |
Sanofi Aventis |
Derives anticancereux, leur preparation et leur application en therapeutique
|
|
JP5640983B2
(ja)
*
|
2009-09-16 |
2014-12-17 |
アステラス製薬株式会社 |
グリシン化合物
|
|
JP2013505944A
(ja)
|
2009-09-24 |
2013-02-21 |
シアトル ジェネティックス, インコーポレイテッド |
Dr5リガンド薬物結合体
|
|
ES2449379T3
(es)
|
2010-02-09 |
2014-03-19 |
Bristol-Myers Squibb Company |
Derivados de bencilpirrolidinona como moduladores de la actividad de receptores de quimiocinas
|
|
MX2012011900A
(es)
|
2010-04-15 |
2013-03-21 |
Seattle Genetics Inc |
Conjugados de pirrolobenzodiazepina diana.
|
|
NZ602241A
(en)
|
2010-04-15 |
2015-03-27 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
EP2558475A1
(en)
|
2010-04-15 |
2013-02-20 |
Spirogen Sàrl |
Pyrrolobenzodiazepines used to treat proliferative diseases
|
|
GB201006340D0
(en)
|
2010-04-15 |
2010-06-02 |
Spirogen Ltd |
Synthesis method and intermediates
|
|
WO2011130615A2
(en)
|
2010-04-15 |
2011-10-20 |
Dr. Reddy's Laboratories Ltd. |
Preparation of lacosamide
|
|
PL2673281T3
(pl)
*
|
2011-02-07 |
2016-10-31 |
|
Zawierające bor wielozasadowe inhibitory pomp usuwających substancje z komórek bakteryjnych oraz ich zastosowania terapeutyczne
|
|
CN113896731A
(zh)
|
2011-02-15 |
2022-01-07 |
伊缪诺金公司 |
细胞毒性苯并二氮杂䓬衍生物
|
|
KR101860174B1
(ko)
*
|
2011-09-20 |
2018-05-21 |
메디뮨 리미티드 |
표적 접합체 내의 내포를 위한 비대칭 이량체 pbd 화합물로서 피롤로벤조디아제핀
|
|
BR112014009070B1
(pt)
|
2011-10-14 |
2021-11-23 |
Medimmune Limited |
Método de síntese e intermediários úteis na preparação de pirrolobenzo-diazepinas
|
|
BR112014008888A2
(pt)
*
|
2011-10-14 |
2017-04-18 |
Seattle Genetics Inc |
pirrolobenzodiazepinas
|
|
CN103997893B
(zh)
|
2011-10-14 |
2019-04-12 |
西雅图基因公司 |
吡咯并苯并二氮杂卓和靶向结合物
|
|
CN103987384A
(zh)
|
2011-10-14 |
2014-08-13 |
西雅图基因公司 |
吡咯并苯并二氮杂卓和靶向结合物
|
|
CN103998449A
(zh)
|
2011-10-14 |
2014-08-20 |
斯皮罗根有限公司 |
吡咯并苯并二氮杂卓
|
|
PL2750713T3
(pl)
|
2011-10-14 |
2016-03-31 |
Medimmune Ltd |
Pirolobenzodiazepiny i ich koniugaty
|
|
EP2852413A4
(en)
*
|
2012-02-16 |
2016-04-27 |
Univ Toledo |
XENOANTIGEN WITH VACCINES AGAINST CANCER AND MANUFACTURING PROCESS THEREFOR
|
|
FR2989085A1
(fr)
*
|
2012-04-05 |
2013-10-11 |
Commissariat Energie Atomique |
Radiotraceurs, procedes de preparation et applications
|
|
JP6157596B2
(ja)
|
2012-04-30 |
2017-07-05 |
メドイミューン・リミテッドMedImmune Limited |
ピロロベンゾジアゼピン
|
|
CN104540827B
(zh)
|
2012-04-30 |
2018-03-23 |
Ucl商业有限公司 |
吡咯并苯并二氮杂卓
|
|
CA2873884A1
(en)
|
2012-07-09 |
2014-01-16 |
Genentech, Inc. |
Immunoconjugates comprising anti-cd79b antibodies
|
|
HK1209043A1
(en)
|
2012-07-09 |
2016-03-24 |
基因泰克公司 |
Immunoconjugates comprising anti-cd22 antibodies
|
|
CN104717979A
(zh)
|
2012-08-02 |
2015-06-17 |
基因泰克公司 |
抗etbr抗体和免疫偶联物
|
|
JP6367204B2
(ja)
|
2012-10-12 |
2018-08-01 |
メドイミューン・リミテッドMedImmune Limited |
結合用のピロロベンゾジアゼピン誘導体の合成および中間体
|
|
WO2014057120A1
(en)
|
2012-10-12 |
2014-04-17 |
Adc Therapeutics Sàrl |
Pyrrolobenzodiazepine-antibody conjugates
|
|
WO2014057118A1
(en)
|
2012-10-12 |
2014-04-17 |
Adc Therapeutics Sarl |
Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
|
|
HRP20171916T1
(hr)
|
2012-10-12 |
2018-02-09 |
Adc Therapeutics Sa |
Konjugati protutijelo anti-cd22 - pirolobenzodiazepin
|
|
US9931415B2
(en)
|
2012-10-12 |
2018-04-03 |
Medimmune Limited |
Pyrrolobenzodiazepine-antibody conjugates
|
|
PT3470086T
(pt)
|
2012-10-12 |
2021-02-01 |
Medimmune Ltd |
Pirrolobenzodiazepinas e conjugados das mesmas
|
|
HRP20181646T2
(hr)
|
2012-10-12 |
2019-08-09 |
Adc Therapeutics Sa |
Konjugati pirolobenzodiazepin - anti-psma protutijela
|
|
JP2016502504A
(ja)
|
2012-10-12 |
2016-01-28 |
エイディーシー・セラピューティクス・エス・アー・エール・エルAdc Therapeutics Sarl |
ピロロベンゾジアゼピン−抗体結合体
|
|
SMT201900017T1
(it)
|
2012-10-12 |
2019-02-28 |
Medimmune Ltd |
Coniugati pirrolobenzodiazepina-anticorpo
|
|
US10736903B2
(en)
|
2012-10-12 |
2020-08-11 |
Medimmune Limited |
Pyrrolobenzodiazepine-anti-PSMA antibody conjugates
|
|
CA2885340C
(en)
|
2012-10-12 |
2016-11-08 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
BR112015014669B1
(pt)
|
2012-12-21 |
2023-09-26 |
Medimmune Limited |
Compostos pirrolobenzodiazepinas, conjugados compreendendo os mesmos e uso destes para tratar uma doença proliferativa
|
|
AU2013366490B9
(en)
|
2012-12-21 |
2018-02-01 |
Medimmune Limited |
Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases
|
|
KR20160037130A
(ko)
|
2013-02-22 |
2016-04-05 |
스템센트알엑스 인코포레이티드 |
신규한 항체 접합체 및 이의 용도
|
|
CN105142674B
(zh)
|
2013-03-13 |
2018-11-13 |
麦迪穆有限责任公司 |
吡咯并苯并二氮杂卓和其结合物
|
|
NZ712035A
(en)
|
2013-03-13 |
2019-06-28 |
Medimmune Ltd |
Pyrrolobenzodiazepines and conjugates thereof
|
|
EA027910B1
(ru)
|
2013-03-13 |
2017-09-29 |
Медимьюн Лимитед |
Пирролобензодиазепины и их конъюгаты
|
|
JP2016518382A
(ja)
|
2013-04-26 |
2016-06-23 |
ピエール、ファーブル、メディカマン |
Axl抗体薬物複合体および癌の治療のためのその使用
|
|
EP3054985B1
(en)
|
2013-10-11 |
2018-12-26 |
Medimmune Limited |
Pyrrolobenzodiazepine-antibody conjugates
|
|
GB201317981D0
(en)
|
2013-10-11 |
2013-11-27 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
EP3054986B1
(en)
|
2013-10-11 |
2019-03-20 |
Medimmune Limited |
Pyrrolobenzodiazepine-antibody conjugates
|
|
EP3054983B1
(en)
|
2013-10-11 |
2019-03-20 |
Medimmune Limited |
Pyrrolobenzodiazepine-antibody conjugates
|
|
GB201317982D0
(en)
|
2013-10-11 |
2013-11-27 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
WO2015052533A1
(en)
|
2013-10-11 |
2015-04-16 |
Spirogen Sàrl |
Pyrrolobenzodiazepine-antibody conjugates
|
|
HK1222577A1
(zh)
|
2013-12-16 |
2017-07-07 |
Genentech Inc. |
擬肽化合物及其抗體藥物偶聯物
|
|
GB201406767D0
(en)
|
2014-04-15 |
2014-05-28 |
Cancer Rec Tech Ltd |
Humanized anti-Tn-MUC1 antibodies anf their conjugates
|