|
US3361742A
(en)
|
1964-12-07 |
1968-01-02 |
Hoffmann La Roche |
5-oxo-1h-pyrrolo-[2, 1-c][1, 4]-benzodiazepin-2-crylamides
|
|
US3523941A
(en)
|
1967-03-06 |
1970-08-11 |
Hoffmann La Roche |
Benzodiazepine compounds and process for their preparation
|
|
US3524849A
(en)
|
1967-10-27 |
1970-08-18 |
Hoffmann La Roche |
Process for the preparation of pyrrolo-benzodiazepine acrylamides and intermediates useful therein
|
|
IL33558A
(en)
|
1968-12-30 |
1973-10-25 |
Fujisawa Pharmaceutical Co |
Antibiotic pyrrolo-benzodiazepine compound,its derivatives and processes for their production
|
|
JPS4843755B1
(enExample)
|
1969-06-26 |
1973-12-20 |
|
|
|
DE1965304A1
(de)
|
1968-12-30 |
1970-07-23 |
Fujisawa Pharmaceutical Co |
Benzdiazepinon-Verbindungen und Verfahren zu ihrer Herstellung
|
|
JPS6053033B2
(ja)
|
1976-12-28 |
1985-11-22 |
財団法人微生物化学研究会 |
新制癌抗生物質マゼスラマイシン及びその製造方法
|
|
JPS585916B2
(ja)
|
1977-12-27 |
1983-02-02 |
株式会社ミドリ十字 |
新規ベンゾジアゼピン系化合物
|
|
JPS5615289A
(en)
|
1979-07-17 |
1981-02-14 |
Green Cross Corp:The |
Novel benzodiazepinnbased compound 3
|
|
JPS57131791A
(en)
|
1980-12-31 |
1982-08-14 |
Fujisawa Pharmaceut Co Ltd |
Benzodiazepine derivative and its preparation
|
|
CA1185602A
(en)
|
1981-02-27 |
1985-04-16 |
Emilio Kyburz |
Imidazodiazepines
|
|
CA1184175A
(en)
|
1981-02-27 |
1985-03-19 |
Walter Hunkeler |
Imidazodiazepines
|
|
CA1173441A
(en)
|
1981-02-27 |
1984-08-28 |
Hoffmann-La Roche Limited |
Imidazodiazepines
|
|
JPS58180487A
(ja)
|
1982-04-16 |
1983-10-21 |
Kyowa Hakko Kogyo Co Ltd |
抗生物質ｄｃ−８１およびその製造法
|
|
US4427588A
(en)
|
1982-11-08 |
1984-01-24 |
Bristol-Myers Company |
Process for conversion of oxotomaymycin to tomaymycin
|
|
US4427587A
(en)
|
1982-11-10 |
1984-01-24 |
Bristol-Myers Company |
Total synthesis of antitumor antibiotics BBM-2040A and BBM-2040B
|
|
JPS59152329A
(ja)
|
1983-02-17 |
1984-08-31 |
Green Cross Corp:The |
局所障害抑制剤
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
FR2586683B1
(fr)
|
1985-08-29 |
1988-07-01 |
Centre Nat Rech Scient |
Nouveaux derives de neothramycine, leur procede de preparation et leur application en tant que medicaments
|
|
US5583024A
(en)
|
1985-12-02 |
1996-12-10 |
The Regents Of The University Of California |
Recombinant expression of Coleoptera luciferase
|
|
JP2660201B2
(ja)
|
1988-08-05 |
1997-10-08 |
塩野義製薬株式会社 |
新規ピロロ［１，４］ベンゾジアゼピン誘導体および老人性痴呆薬
|
|
FR2676230B1
(fr)
|
1991-05-07 |
1993-08-27 |
Centre Nat Rech Scient |
Nouveaux derives de pyrrolo [1,4]-benzodiazepines, leur procede de preparation et medicaments les contenant.
|
|
GB9205051D0
(en)
|
1992-03-09 |
1992-04-22 |
Cancer Res Campaign Tech |
Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them
|
|
FR2696176B1
(fr)
|
1992-09-28 |
1994-11-10 |
Synthelabo |
Dérivés de pipéridine, leur préparation et leur application en thérapeutique.
|
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
GB9316162D0
(en)
|
1993-08-04 |
1993-09-22 |
Zeneca Ltd |
Fungicides
|
|
ATE195933T1
(de)
|
1994-03-10 |
2000-09-15 |
Searle & Co |
L-n6-(1-iminoethyl)lysin - derivate und ihre verwendung als no-synthase - inhibitoren
|
|
JPH08336393A
(ja)
|
1995-04-13 |
1996-12-24 |
Mitsubishi Chem Corp |
光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法
|
|
EP1754995B1
(en)
|
1998-07-08 |
2012-04-04 |
E Ink Corporation |
Methods for achieving improved color in microencapsulted electrophoretic devices
|
|
GB9818730D0
(en)
|
1998-08-27 |
1998-10-21 |
Univ Portsmouth |
Collections of compounds
|
|
GB9818732D0
(en)
|
1998-08-27 |
1998-10-21 |
Univ Portsmouth |
Collection of compounds
|
|
GB9818731D0
(en)
|
1998-08-27 |
1998-10-21 |
Univ Portsmouth |
Compounds
|
|
CA2341471C
(en)
|
1998-08-27 |
2009-04-07 |
Spirogen Limited |
Pyrrolbenzodiazepines
|
|
US6909006B1
(en)
|
1999-08-27 |
2005-06-21 |
Spirogen Limited |
Cyclopropylindole derivatives
|
|
CN1315805C
(zh)
|
2000-09-19 |
2007-05-16 |
斯皮罗根公司 |
Cc－1065和多卡米新的非手性类似物的组合物及其使用方法
|
|
US6362331B1
(en)
|
2001-03-30 |
2002-03-26 |
Council Of Scientific And Industrial Research |
Process for the preparation of antitumor agents
|
|
EP1401850A1
(en)
*
|
2001-06-20 |
2004-03-31 |
Nuevolution A/S |
Nucleoside derivatives for library preparation
|
|
US6660856B2
(en)
|
2002-03-08 |
2003-12-09 |
Kaohsiung Medical University |
Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine analogues
|
|
DK1545613T3
(da)
|
2002-07-31 |
2011-11-14 |
Seattle Genetics Inc |
Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom
|
|
US20040138269A1
(en)
|
2002-10-11 |
2004-07-15 |
Sugen, Inc. |
Substituted pyrroles as kinase inhibitors
|
|
GB0226593D0
(en)
|
2002-11-14 |
2002-12-24 |
Consultants Ltd |
Compounds
|
|
ATE421967T1
(de)
|
2003-03-31 |
2009-02-15 |
Council Scient Ind Res |
Nichtvernetzende pyrroloä2,1-cüä1, 4übenzodiazepine als potentielle antitumor- agentien und ihre herstellung
|
|
GB0321295D0
(en)
|
2003-09-11 |
2003-10-15 |
Spirogen Ltd |
Synthesis of protected pyrrolobenzodiazepines
|
|
WO2005040170A2
(en)
|
2003-10-22 |
2005-05-06 |
Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto
|
|
GB0416511D0
(en)
|
2003-10-22 |
2004-08-25 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
CN107213469A
(zh)
|
2003-11-06 |
2017-09-29 |
西雅图基因公司 |
能够与配体偶联的单甲基缬氨酸化合物
|
|
WO2005079479A2
(en)
|
2004-02-17 |
2005-09-01 |
Absalus, Inc. |
Super-humanized antibodies against respiratory syncytial virus
|
|
EP1718667B1
(en)
|
2004-02-23 |
2013-01-09 |
Genentech, Inc. |
Heterocyclic self-immolative linkers and conjugates
|
|
CA2558195C
(en)
|
2004-03-01 |
2012-11-06 |
Spirogen Limited |
11-hydroxy-5h-pyrrolo[2,1-c][1,4]benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepines
|
|
GB0404574D0
(en)
|
2004-03-01 |
2004-04-07 |
Spirogen Ltd |
Amino acids
|
|
GB0404578D0
(en)
|
2004-03-01 |
2004-04-07 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
GB0404577D0
(en)
|
2004-03-01 |
2004-04-07 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
DE102004010943A1
(de)
|
2004-03-03 |
2005-09-29 |
Degussa Ag |
Verfahren zur Herstellung von N-geschützten 4-Ketprolinderivaten
|
|
US7528126B2
(en)
|
2004-03-09 |
2009-05-05 |
Spirogen Limited |
Pyrrolobenzodiazepines
|
|
FR2869231B1
(fr)
|
2004-04-27 |
2008-03-14 |
Sod Conseils Rech Applic |
Composition therapeutique contenant au moins un derive de la pyrrolobenzodiazepine et la fludarabine
|
|
GB0410725D0
(en)
|
2004-05-13 |
2004-06-16 |
Spirogen Ltd |
Pyrrolobenzodiazepine therapeutic agents
|
|
KR101270829B1
(ko)
|
2004-09-23 |
2013-06-07 |
제넨테크, 인크. |
시스테인 유전자조작 항체 및 접합체
|
|
EP1831418A2
(en)
|
2004-12-24 |
2007-09-12 |
Showa Denko Kabushiki Kaisha |
Production method of thermoelectric semiconductor alloy, thermoelectric conversion module and thermoelectric power generating device
|
|
CN101203241B
(zh)
|
2005-04-19 |
2012-02-22 |
西雅图基因公司 |
人源化抗-cd70结合物和其应用
|
|
NZ563136A
(en)
|
2005-04-21 |
2009-11-27 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
US8637664B2
(en)
|
2005-10-05 |
2014-01-28 |
Spirogen Sarl |
Alkyl 4- [4- (5-oxo-2,3,5, 11a-tetrahydo-5H-pyrrolo [2, 1-c] [1,4] benzodiazepine-8-yloxy)-butyrylamino]-1H-pyrrole-2-carboxylate derivatives and related compounds for the treatment of a proliferative disease
|
|
US20070154906A1
(en)
|
2005-10-05 |
2007-07-05 |
Spirogen Ltd. |
Methods to identify therapeutic candidates
|
|
SI1813614T1
(sl)
|
2006-01-25 |
2012-01-31 |
Sanofi 174 |
Citotoksična sredstva, ki obsegajo nove tomajmicinske derivate
|
|
NZ574215A
(en)
|
2006-07-18 |
2012-07-27 |
Sanofi Aventis |
Antagonist antibody against epha2 for the treatment of cancer
|
|
US10144736B2
(en)
*
|
2006-07-20 |
2018-12-04 |
Gilead Sciences, Inc. |
Substituted pteridines useful for the treatment and prevention of viral infections
|
|
EP1914242A1
(en)
|
2006-10-19 |
2008-04-23 |
Sanofi-Aventis |
Novel anti-CD38 antibodies for the treatment of cancer
|
|
WO2008050140A2
(en)
|
2006-10-27 |
2008-05-02 |
Spirogen Limited |
Compounds for treatment of parasitic infection
|
|
DK2099823T4
(da)
|
2006-12-01 |
2022-05-09 |
Seagen Inc |
Målbindingsmiddelvarianter og anvendelser deraf
|
|
JP2008291207A
(ja)
*
|
2007-04-27 |
2008-12-04 |
Kyowa Hakko Kirin Co Ltd |
塩基性アミノ酸を有するらせん状ポリマー
|
|
AR066476A1
(es)
|
2007-05-08 |
2009-08-19 |
Genentech Inc |
Anticuerpos anti-muc16 disenados con cisteina y conjugaods de anticuerpos y farmacos
|
|
SI2019104T1
(sl)
|
2007-07-19 |
2013-12-31 |
Sanofi |
Citotoksična sredstva, ki obsegajo nove tomaimicinske derivate, in njihova terapevtska uporaba
|
|
GB0716799D0
(en)
*
|
2007-08-31 |
2007-10-10 |
Univ Kent Canterbury |
Improvements in or relating to radio-labelled peptides
|
|
CA2698541C
(en)
|
2007-10-19 |
2018-01-09 |
Genentech, Inc. |
Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates
|
|
GB0722087D0
(en)
|
2007-11-09 |
2007-12-19 |
Spirogen Ltd |
Polyamides
|
|
GB0722088D0
(en)
|
2007-11-09 |
2007-12-19 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
DK2265283T3
(da)
|
2008-03-18 |
2014-10-20 |
Seattle Genetics Inc |
Auristatin-lægemiddel-linker-konjugater
|
|
GB0813432D0
(en)
|
2008-07-22 |
2008-08-27 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
GB0819097D0
(en)
|
2008-10-17 |
2008-11-26 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
GB0819095D0
(en)
|
2008-10-17 |
2008-11-26 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
US20110077365A1
(en)
*
|
2008-12-29 |
2011-03-31 |
Gilbert Yu |
Preparation of organosilicon-containing triazoles
|
|
SG173152A1
(en)
|
2009-02-05 |
2011-08-29 |
Immunogen Inc |
Novel benzodiazepine derivatives
|
|
CN101492494A
(zh)
*
|
2009-03-05 |
2009-07-29 |
浙江大学 |
整合素配体环肽类似物及其环化方法
|
|
FR2949469A1
(fr)
|
2009-08-25 |
2011-03-04 |
Sanofi Aventis |
Derives anticancereux, leur preparation et leur application en therapeutique
|
|
JP5640983B2
(ja)
*
|
2009-09-16 |
2014-12-17 |
アステラス製薬株式会社 |
グリシン化合物
|
|
EP2480230A4
(en)
|
2009-09-24 |
2015-06-10 |
Seattle Genetics Inc |
DR5 Ligand-HEILMITTELKONJUGATE
|
|
US9040526B2
(en)
|
2010-02-09 |
2015-05-26 |
Bristol-Myers Squibb Company |
Benzylpyrrolidinone derivatives as modulators of chemokine receptor activity
|
|
WO2011130615A2
(en)
|
2010-04-15 |
2011-10-20 |
Dr. Reddy's Laboratories Ltd. |
Preparation of lacosamide
|
|
ES2623057T3
(es)
|
2010-04-15 |
2017-07-10 |
Medimmune Limited |
Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas
|
|
WO2011130598A1
(en)
|
2010-04-15 |
2011-10-20 |
Spirogen Limited |
Pyrrolobenzodiazepines and conjugates thereof
|
|
KR101772354B1
(ko)
|
2010-04-15 |
2017-08-28 |
시애틀 지네틱스, 인크. |
표적화된 피롤로벤조디아제핀 접합체
|
|
GB201006340D0
(en)
|
2010-04-15 |
2010-06-02 |
Spirogen Ltd |
Synthesis method and intermediates
|
|
WO2012109164A1
(en)
*
|
2011-02-07 |
2012-08-16 |
Rempex Pharmaceuticals, Inc. |
Boron containing polybasic bacterial efflux pump inhibitors and therapeutics uses thereof
|
|
KR20190089048A
(ko)
|
2011-02-15 |
2019-07-29 |
이뮤노젠 아이엔씨 |
컨쥬게이트의 제조방법
|
|
WO2013041606A1
(en)
|
2011-09-20 |
2013-03-28 |
Spirogen Sàrl |
Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates
|
|
BR112014008888A2
(pt)
*
|
2011-10-14 |
2017-04-18 |
Seattle Genetics Inc |
pirrolobenzodiazepinas
|
|
MX358757B
(es)
|
2011-10-14 |
2018-09-03 |
Seattle Genetics Inc |
Pirrolobenzodiazepinas y conjugados dirigidos.
|
|
WO2013055987A1
(en)
|
2011-10-14 |
2013-04-18 |
Spirogen Sàrl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
US9526798B2
(en)
|
2011-10-14 |
2016-12-27 |
Seattle Genetics, Inc. |
Pyrrolobenzodiazepines and targeted conjugates
|
|
US9388187B2
(en)
|
2011-10-14 |
2016-07-12 |
Medimmune Limited |
Pyrrolobenzodiazepines
|
|
EP2751076B1
(en)
|
2011-10-14 |
2018-04-25 |
MedImmune Limited |
Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines
|
|
EP2852413A4
(en)
*
|
2012-02-16 |
2016-04-27 |
Univ Toledo |
XENOANTIGEN WITH VACCINES AGAINST CANCER AND MANUFACTURING PROCESS THEREFOR
|
|
FR2989085A1
(fr)
*
|
2012-04-05 |
2013-10-11 |
Commissariat Energie Atomique |
Radiotraceurs, procedes de preparation et applications
|
|
NZ701290A
(en)
|
2012-04-30 |
2016-08-26 |
Medimmune Ltd |
Pyrrolobenzodiazepines
|
|
KR101960130B1
(ko)
|
2012-04-30 |
2019-03-19 |
메디뮨 리미티드 |
피롤로벤조디아제핀
|
|
IN2014DN10652A
(enExample)
|
2012-07-09 |
2015-09-11 |
Genentech Inc |
|
|
TW201406785A
(zh)
|
2012-07-09 |
2014-02-16 |
Genentech Inc |
抗ｃｄ２２抗體及免疫結合物
|
|
BR112015002193A2
(pt)
|
2012-08-02 |
2017-07-04 |
Genentech Inc |
anticorpos anti-etbr e imunoconjugados
|
|
WO2014057120A1
(en)
|
2012-10-12 |
2014-04-17 |
Adc Therapeutics Sàrl |
Pyrrolobenzodiazepine-antibody conjugates
|
|
WO2014057118A1
(en)
|
2012-10-12 |
2014-04-17 |
Adc Therapeutics Sarl |
Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
|
|
PL2906251T3
(pl)
|
2012-10-12 |
2018-02-28 |
Adc Therapeutics Sa |
Koniugaty pirolobenzodiazepina-przeciwciało anty-CD22
|
|
AU2013328673B2
(en)
|
2012-10-12 |
2017-07-13 |
Medimmune Limited |
Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
|
|
HRP20190366T1
(hr)
|
2012-10-12 |
2019-04-19 |
Medimmune Limited |
Pirolobenzodiazepini i njihovi konjugati
|
|
KR101645905B1
(ko)
|
2012-10-12 |
2016-08-04 |
스피로즌 살 |
피롤로벤조디아제핀 및 그의 컨주게이트
|
|
ES2680153T3
(es)
|
2012-10-12 |
2018-09-04 |
Adc Therapeutics Sa |
Conjugados de anticuerpos anti-PSMA-pirrolobenzodiazepinas
|
|
HRP20181646T2
(hr)
|
2012-10-12 |
2019-08-09 |
Adc Therapeutics Sa |
Konjugati pirolobenzodiazepin - anti-psma protutijela
|
|
HRP20171264T1
(hr)
|
2012-10-12 |
2017-10-20 |
Adc Therapeutics Sa |
Konjugati protutijela anti-her2-pirolobenzodiazepina
|
|
WO2014057117A1
(en)
|
2012-10-12 |
2014-04-17 |
Adc Therapeutics Sàrl |
Pyrrolobenzodiazepine-antibody conjugates
|
|
MX364328B
(es)
|
2012-10-12 |
2019-04-23 |
Medimmune Ltd |
Conjugados del anticuerpo pirrolobenzodiazepina.
|
|
CN105246894A
(zh)
|
2012-12-21 |
2016-01-13 |
斯皮罗根有限公司 |
用于治疗增殖性和自身免疫疾病的非对称吡咯并苯并二氮杂卓二聚物
|
|
AU2013366493B2
(en)
|
2012-12-21 |
2017-08-24 |
Medimmune Limited |
Pyrrolobenzodiazepines and conjugates thereof
|
|
RU2019109456A
(ru)
|
2013-02-22 |
2019-04-10 |
ЭББВИ СТЕМСЕНТРКС ЭлЭлСи |
Новые конъюгаты антител и их применения
|
|
JP6445519B2
(ja)
|
2013-03-13 |
2018-12-26 |
メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ |
ピロロベンゾジアゼピン及びそのコンジュゲート
|
|
EP2968585B1
(en)
|
2013-03-13 |
2018-07-18 |
Medimmune Limited |
Pyrrolobenzodiazepines and conjugates thereof
|
|
WO2014140862A2
(en)
|
2013-03-13 |
2014-09-18 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
WO2014174111A1
(en)
|
2013-04-26 |
2014-10-30 |
Pierre Fabre Medicament |
Axl antibody-drug conjugate and its use for the treatment of cancer
|
|
EP3054984A1
(en)
|
2013-10-11 |
2016-08-17 |
Medimmune Limited |
Pyrrolobenzodiazepine-antibody conjugates
|
|
US9950078B2
(en)
|
2013-10-11 |
2018-04-24 |
Medimmune Limited |
Pyrrolobenzodiazepine-antibody conjugates
|
|
EP3054986B1
(en)
|
2013-10-11 |
2019-03-20 |
Medimmune Limited |
Pyrrolobenzodiazepine-antibody conjugates
|
|
GB201317982D0
(en)
|
2013-10-11 |
2013-11-27 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
US10010624B2
(en)
|
2013-10-11 |
2018-07-03 |
Medimmune Limited |
Pyrrolobenzodiazepine-antibody conjugates
|
|
GB201317981D0
(en)
|
2013-10-11 |
2013-11-27 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
MX381017B
(es)
|
2013-12-16 |
2025-03-12 |
Genentech Inc |
Compuestos peptidomiméticos y conjugados anticuerpo-fármaco de estos.
|
|
GB201406767D0
(en)
|
2014-04-15 |
2014-05-28 |
Cancer Rec Tech Ltd |
Humanized anti-Tn-MUC1 antibodies anf their conjugates
|