JP2017105750A5 - - Google Patents
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- JP2017105750A5 JP2017105750A5 JP2016135602A JP2016135602A JP2017105750A5 JP 2017105750 A5 JP2017105750 A5 JP 2017105750A5 JP 2016135602 A JP2016135602 A JP 2016135602A JP 2016135602 A JP2016135602 A JP 2016135602A JP 2017105750 A5 JP2017105750 A5 JP 2017105750A5
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- JP
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- Prior art keywords
- substituted
- substituent group
- group
- alkyl
- carbocyclic
- Prior art date
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- 125000001424 substituent group Chemical group 0.000 claims 59
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 125000002837 carbocyclic group Chemical group 0.000 claims 14
- 125000000623 heterocyclic group Chemical group 0.000 claims 14
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 125000003282 alkyl amino group Chemical group 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical group 0.000 claims 6
- 125000001188 haloalkyl group Chemical group 0.000 claims 4
- 125000005343 heterocyclic alkyl group Chemical group 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- -1 carbocyclic alkyl Chemical group 0.000 claims 3
- 125000004665 trialkylsilyl group Chemical group 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000005195 alkyl amino carbonyloxy group Chemical group 0.000 claims 2
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 2
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- DYMRYCZRMAHYKE-UHFFFAOYSA-N n-diazonitramide Chemical compound [O-][N+](=O)N=[N+]=[N-] DYMRYCZRMAHYKE-UHFFFAOYSA-N 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 125000004437 phosphorous atom Chemical group 0.000 claims 2
- 229910052698 phosphorus Inorganic materials 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000004450 alkenylene group Chemical group 0.000 claims 1
- 125000005194 alkoxycarbonyloxy group Chemical group 0.000 claims 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 1
- 125000005094 alkyl carbonyl amino alkyl group Chemical group 0.000 claims 1
- 125000005103 alkyl silyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 0 C[C@](COCC1)([N-]N(C=C2)C3=C(*)C2=O)N1C3=O Chemical compound C[C@](COCC1)([N-]N(C=C2)C3=C(*)C2=O)N1C3=O 0.000 description 6
- ACXQROFICZTSKE-UHFFFAOYSA-N Fc1ccc(Cc2ccccc2SC2)c2c1 Chemical compound Fc1ccc(Cc2ccccc2SC2)c2c1 ACXQROFICZTSKE-UHFFFAOYSA-N 0.000 description 5
- SZVMKELHQQKXDC-CUJSYCCXSA-N C[C@@H](COC[C@H]1N([C@@H]2c3ccccc3SCc3cc(F)ccc23)N(C=CC2=O)C3=C2O)N1C3=O Chemical compound C[C@@H](COC[C@H]1N([C@@H]2c3ccccc3SCc3cc(F)ccc23)N(C=CC2=O)C3=C2O)N1C3=O SZVMKELHQQKXDC-CUJSYCCXSA-N 0.000 description 1
- KEAPVRQCXJSAQQ-YADHBBJMSA-N OC(C(C=C1)=O)=C(C(N2[C@H]3CCCC2)=O)N1N3[C@@H]1c(cccc2)c2SCc2cc(F)ccc12 Chemical compound OC(C(C=C1)=O)=C(C(N2[C@H]3CCCC2)=O)N1N3[C@@H]1c(cccc2)c2SCc2cc(F)ccc12 KEAPVRQCXJSAQQ-YADHBBJMSA-N 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015090909 | 2015-04-28 | ||
| JP2015090909 | 2015-04-28 | ||
| JP2015236844 | 2015-12-03 | ||
| JP2015236844 | 2015-12-03 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016535247A Division JP5971830B1 (ja) | 2015-04-28 | 2016-04-27 | 置換された多環性ピリドン誘導体およびそのプロドラッグ |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020075767A Division JP2020125331A (ja) | 2015-04-28 | 2020-04-22 | 置換された多環性ピリドン誘導体およびそのプロドラッグ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017105750A JP2017105750A (ja) | 2017-06-15 |
| JP2017105750A5 true JP2017105750A5 (enExample) | 2019-04-25 |
| JP6697209B2 JP6697209B2 (ja) | 2020-05-20 |
Family
ID=57199167
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016135602A Active JP6697209B2 (ja) | 2015-04-28 | 2016-07-08 | 置換された多環性ピリドン誘導体およびそのプロドラッグ |
| JP2020075767A Withdrawn JP2020125331A (ja) | 2015-04-28 | 2020-04-22 | 置換された多環性ピリドン誘導体およびそのプロドラッグ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020075767A Withdrawn JP2020125331A (ja) | 2015-04-28 | 2020-04-22 | 置換された多環性ピリドン誘導体およびそのプロドラッグ |
Country Status (36)
Families Citing this family (82)
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| ES2938877T3 (es) * | 2015-04-28 | 2023-04-17 | Shionogi & Co | Derivados de piridona policíclicos sustituidos y profármacos de los mismos |
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| NZ791086A (en) * | 2016-08-10 | 2025-08-29 | Shionogi & Co | Substituted polycyclic pyridone derivative and pharmaceutical composition containing prodrug thereof |
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| US11718599B2 (en) | 2017-10-11 | 2023-08-08 | Daikin Industries, Ltd. | Method for producing cyclic carbonate having unsaturated group, and novel cyclic carbonate |
| TWI795462B (zh) | 2017-11-17 | 2023-03-11 | 日商鹽野義製藥股份有限公司 | 光安定性及溶出性優異的醫藥製劑 |
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| EP3815689A4 (en) | 2018-06-27 | 2022-04-20 | National University Corporation Hokkaido University | ARENAVIRUS GROWTH INHIBITOR COMPRISING A POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE |
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