JP2017105750A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017105750A5 JP2017105750A5 JP2016135602A JP2016135602A JP2017105750A5 JP 2017105750 A5 JP2017105750 A5 JP 2017105750A5 JP 2016135602 A JP2016135602 A JP 2016135602A JP 2016135602 A JP2016135602 A JP 2016135602A JP 2017105750 A5 JP2017105750 A5 JP 2017105750A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- substituent group
- group
- alkyl
- carbocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001424 substituent group Chemical group 0.000 claims 59
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 125000002837 carbocyclic group Chemical group 0.000 claims 14
- 125000000623 heterocyclic group Chemical group 0.000 claims 14
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 125000003282 alkyl amino group Chemical group 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical group 0.000 claims 6
- 125000001188 haloalkyl group Chemical group 0.000 claims 4
- 125000005343 heterocyclic alkyl group Chemical group 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- -1 carbocyclic alkyl Chemical group 0.000 claims 3
- 125000004665 trialkylsilyl group Chemical group 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000005195 alkyl amino carbonyloxy group Chemical group 0.000 claims 2
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 2
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- DYMRYCZRMAHYKE-UHFFFAOYSA-N n-diazonitramide Chemical compound [O-][N+](=O)N=[N+]=[N-] DYMRYCZRMAHYKE-UHFFFAOYSA-N 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 125000004437 phosphorous atom Chemical group 0.000 claims 2
- 229910052698 phosphorus Inorganic materials 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000004450 alkenylene group Chemical group 0.000 claims 1
- 125000005194 alkoxycarbonyloxy group Chemical group 0.000 claims 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 1
- 125000005094 alkyl carbonyl amino alkyl group Chemical group 0.000 claims 1
- 125000005103 alkyl silyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 0 C[C@](COCC1)([N-]N(C=C2)C3=C(*)C2=O)N1C3=O Chemical compound C[C@](COCC1)([N-]N(C=C2)C3=C(*)C2=O)N1C3=O 0.000 description 6
- ACXQROFICZTSKE-UHFFFAOYSA-N Fc1ccc(Cc2ccccc2SC2)c2c1 Chemical compound Fc1ccc(Cc2ccccc2SC2)c2c1 ACXQROFICZTSKE-UHFFFAOYSA-N 0.000 description 5
- SZVMKELHQQKXDC-CUJSYCCXSA-N C[C@@H](COC[C@H]1N([C@@H]2c3ccccc3SCc3cc(F)ccc23)N(C=CC2=O)C3=C2O)N1C3=O Chemical compound C[C@@H](COC[C@H]1N([C@@H]2c3ccccc3SCc3cc(F)ccc23)N(C=CC2=O)C3=C2O)N1C3=O SZVMKELHQQKXDC-CUJSYCCXSA-N 0.000 description 1
- KEAPVRQCXJSAQQ-YADHBBJMSA-N OC(C(C=C1)=O)=C(C(N2[C@H]3CCCC2)=O)N1N3[C@@H]1c(cccc2)c2SCc2cc(F)ccc12 Chemical compound OC(C(C=C1)=O)=C(C(N2[C@H]3CCCC2)=O)N1N3[C@@H]1c(cccc2)c2SCc2cc(F)ccc12 KEAPVRQCXJSAQQ-YADHBBJMSA-N 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015090909 | 2015-04-28 | ||
| JP2015090909 | 2015-04-28 | ||
| JP2015236844 | 2015-12-03 | ||
| JP2015236844 | 2015-12-03 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016535247A Division JP5971830B1 (ja) | 2015-04-28 | 2016-04-27 | 置換された多環性ピリドン誘導体およびそのプロドラッグ |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020075767A Division JP2020125331A (ja) | 2015-04-28 | 2020-04-22 | 置換された多環性ピリドン誘導体およびそのプロドラッグ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017105750A JP2017105750A (ja) | 2017-06-15 |
| JP2017105750A5 true JP2017105750A5 (enExample) | 2019-04-25 |
| JP6697209B2 JP6697209B2 (ja) | 2020-05-20 |
Family
ID=57199167
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016135602A Active JP6697209B2 (ja) | 2015-04-28 | 2016-07-08 | 置換された多環性ピリドン誘導体およびそのプロドラッグ |
| JP2020075767A Withdrawn JP2020125331A (ja) | 2015-04-28 | 2020-04-22 | 置換された多環性ピリドン誘導体およびそのプロドラッグ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020075767A Withdrawn JP2020125331A (ja) | 2015-04-28 | 2020-04-22 | 置換された多環性ピリドン誘導体およびそのプロドラッグ |
Country Status (36)
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20230215T1 (hr) * | 2015-04-28 | 2023-04-14 | Shionogi & Co., Ltd. | Supstituirani policiklički derivati piridona i njihov predlijek |
| SG10201911957QA (en) * | 2015-12-15 | 2020-02-27 | Shionogi & Co | Medicine for treating influenza characterized by comprising combination of cap-dependent endonuclease inhibitor with anti-influenza drug |
| AU2017282305B2 (en) | 2016-06-20 | 2021-06-10 | Shionogi & Co., Ltd. | Method for producing substituted polycyclic pyridone derivative and crystal of same |
| UA125218C2 (uk) * | 2016-08-10 | 2022-02-02 | Сіоногі Енд Ко., Лтд. | Фармацевтичні композиції, що містять заміщені поліциклічні піридонові похідні та їх проліки |
| AU2018331172B2 (en) * | 2017-09-18 | 2022-12-01 | Sunshine Lake Pharma Co., Ltd. | Influenza virus replication inhibitor and use thereof |
| WO2019070059A1 (ja) * | 2017-10-06 | 2019-04-11 | 塩野義製薬株式会社 | 置換された多環性ピリドン誘導体の立体選択的な製造方法 |
| WO2019073775A1 (ja) * | 2017-10-11 | 2019-04-18 | ダイキン工業株式会社 | 不飽和基を有する環状カーボネートの製造方法及び新規環状カーボネート |
| TWI795462B (zh) * | 2017-11-17 | 2023-03-11 | 日商鹽野義製藥股份有限公司 | 光安定性及溶出性優異的醫藥製劑 |
| CA3088926A1 (en) * | 2018-01-17 | 2019-07-25 | Jiangxi Caishi Pharmaceutical Technology Co., Ltd. | Pyridone derivative, composition and use as antiviral drug thereof |
| CN109503625A (zh) * | 2018-01-19 | 2019-03-22 | 赵蕾 | 一种多环吡啶酮化合物及其药物组合和用途 |
| US10596171B2 (en) * | 2018-01-22 | 2020-03-24 | Taigen Biotechnology Co., Ltd. | Cap-dependent endonuclease inhibitors |
| CN108440564B (zh) * | 2018-04-11 | 2019-08-06 | 安帝康（无锡）生物科技有限公司 | 被取代的多环氨基甲酰基吡啶酮衍生物及其前药 |
| WO2019208540A1 (ja) * | 2018-04-24 | 2019-10-31 | 塩野義製薬株式会社 | 安定性に優れた固形製剤 |
| EP3785716A4 (en) * | 2018-04-24 | 2022-03-02 | Shionogi & Co., Ltd | SOLID FORMULATION WITH EXCELLENT STABILITY |
| CN109956956B (zh) * | 2018-05-15 | 2020-07-07 | 广东东阳光药业有限公司 | 一种并环吡啶酮化合物的制备方法 |
| JP7307412B2 (ja) | 2018-06-27 | 2023-07-12 | 国立大学法人北海道大学 | 多環性カルバモイルピリドン誘導体を含有するアレナウイルス増殖阻害剤 |
| WO2020015669A1 (zh) * | 2018-07-17 | 2020-01-23 | 南京明德新药研发有限公司 | 抗流感病毒三并环衍生物 |
| CN110317211B (zh) * | 2018-07-27 | 2022-05-13 | 深圳市塔吉瑞生物医药有限公司 | 一种取代的多环性吡啶酮化合物及其前药 |
| CN110872247A (zh) * | 2018-08-29 | 2020-03-10 | 上海复星星泰医药科技有限公司 | Xofluza含硫杂环化合物、其中间体及制备方法 |
| TWI844564B (zh) * | 2018-09-10 | 2024-06-11 | 美商共結晶製藥公司 | 流感病毒複製之抑制劑 |
| MX2021003724A (es) * | 2018-09-29 | 2021-05-14 | Jiangsu Yahong Meditech Co Ltd | Profarmaco de nitroxolina y su uso. |
| CN111057074B (zh) * | 2018-10-17 | 2022-04-29 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其用途 |
| EP3897681A4 (en) * | 2018-12-20 | 2022-10-26 | Société des Produits Nestlé S.A. | DOSING SCHEDULE APPLICABLE FOR ORAL IMMUNOTHERAPY AGAINST PEANUT FOR MISSED DOSES |
| CN109516998B (zh) * | 2018-12-25 | 2021-06-25 | 深圳市华先医药科技有限公司 | 一种巴洛沙韦中间体的合成方法 |
| CN111484508B (zh) * | 2019-01-29 | 2022-11-25 | 北京四环制药有限公司 | 一种用于制备巴罗萨韦或其衍生物的化合物及其制备方法和其应用 |
| EP3934758A1 (en) | 2019-03-05 | 2022-01-12 | Assia Chemical Industries Ltd | Solid state forms of baloxavir marboxil |
| MX2021010884A (es) * | 2019-03-12 | 2022-01-19 | Shionogi & Co | Tratamiento de la influenza con derivados de piridona policiclica sustituida y profarmacos de los mismos en un sujeto que tiene influenza y factor de riesgo de complicacion. |
| WO2020194024A1 (en) * | 2019-03-22 | 2020-10-01 | Shionogi & Co., Ltd. | Treating influenza using substituted polycyclic pyridone derivatives and prodrugs thereof in a subject having influenza and a severe influenza condition |
| EP3714889A1 (en) | 2019-03-29 | 2020-09-30 | F. Hoffmann-La Roche AG | Baloxavir for the prevention of transmission of influenza virus |
| CN109912624B (zh) * | 2019-04-11 | 2021-05-11 | 杭州科巢生物科技有限公司 | 一种巴洛沙韦酯关键母核中间体的合成方法 |
| CN111825699B (zh) * | 2019-04-15 | 2023-02-21 | 上海复星星泰医药科技有限公司 | 含硫杂环化合物及其制备方法 |
| RU2720305C1 (ru) * | 2019-05-07 | 2020-04-28 | Андрей Александрович Иващенко | Замещенный 3,4,12,12а-тетрагидро-1Н-[1,4]оксазино[3,4-c]пиридо[2,1-f] [1,2,4]триазин-6,8-дион, фармацевтическая композиция, способы их получения и применения |
| CN111909174B (zh) * | 2019-05-08 | 2022-01-21 | 江西彩石医药科技有限公司 | 吡啶酮衍生物的晶型及制备方法和应用 |
| CN110105372B (zh) * | 2019-06-05 | 2022-05-10 | 南京焕然生物科技有限公司 | 一种r-7-(苄氧基)-四氢-1h-恶嗪并吡啶并-三嗪-6,8-二酮的制备方法 |
| CN114907378A (zh) * | 2019-07-11 | 2022-08-16 | 南京征祥医药有限公司 | 可用于治疗流感病毒感染的化合物 |
| WO2021028024A1 (en) * | 2019-08-13 | 2021-02-18 | F. Hoffmann-La Roche Ag | Improved dosage of baloxavir marboxil for pediatric patients |
| US20210069204A1 (en) * | 2019-08-13 | 2021-03-11 | F. Hoffmann-La Roche Ag | Dosage of baloxavir marboxil for pediatric patients |
| WO2021057834A1 (zh) * | 2019-09-27 | 2021-04-01 | 广东东阳光药业有限公司 | 一种酯化合物的晶型及其制备方法 |
| CN111057070A (zh) * | 2019-10-30 | 2020-04-24 | 浙江工业大学 | 一种巴洛沙韦关键中间体的合成方法 |
| CN112779304B (zh) * | 2019-11-06 | 2023-11-03 | 广东东阳光药业股份有限公司 | 一种并环吡啶酮化合物的制备方法 |
| WO2021093860A1 (zh) * | 2019-11-13 | 2021-05-20 | 南京知和医药科技有限公司 | 取代的双三环化合物及其药物组合物和用途 |
| CN118480041A (zh) * | 2019-12-23 | 2024-08-13 | 石家庄迪斯凯威医药科技有限公司 | 取代的多环化合物及其药物组合物和用途 |
| CN113045589B (zh) * | 2019-12-27 | 2024-08-23 | 广东东阳光药业股份有限公司 | 流感病毒复制抑制剂及其用途 |
| CN112898346B (zh) * | 2020-01-23 | 2023-11-10 | 南京知和医药科技有限公司 | 水溶性多环化合物及其药物组合物和用途 |
| IL294989A (en) * | 2020-01-24 | 2022-09-01 | Regeneron Pharma | Conjugated protein-antiviral compounds |
| CN112940009A (zh) * | 2020-02-03 | 2021-06-11 | 南京知和医药科技有限公司 | 一种磺酸多环化合物及其药物组合物和用途 |
| CN112876510A (zh) * | 2020-02-10 | 2021-06-01 | 石家庄迪斯凯威医药科技有限公司 | 一种磷酸酯类多环化合物及其药物组合物和用途 |
| CN111233891B (zh) * | 2020-03-04 | 2021-05-04 | 江苏柯菲平医药股份有限公司 | 一种稠环吡啶酮衍生物及其制备方法和用途 |
| CN113527296B (zh) * | 2020-03-13 | 2025-03-07 | 北京凯因科技股份有限公司 | 一种流感病毒抑制剂 |
| WO2021180147A1 (zh) * | 2020-03-13 | 2021-09-16 | 北京凯因科技股份有限公司 | 一种流感病毒抑制剂 |
| US20230218644A1 (en) | 2020-04-16 | 2023-07-13 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
| CN113620948B (zh) * | 2020-05-06 | 2022-11-25 | 太景医药研发(北京)有限公司 | 帽依赖性核酸内切酶抑制剂 |
| RU2745985C1 (ru) * | 2020-05-07 | 2021-04-05 | Андрей Александрович Иващенко | Антикоронавирусный терапевтический агент - замещенный 7-гидрокси-3,4,12,12а-тетрагидро-1H-[1,4]оксазино[3,4-c]пиридо[2,1-f][1,2,4]триазин-6,8-дион для профилактики и лечения COVID-19 |
| US12516070B2 (en) | 2020-05-21 | 2026-01-06 | Cisen Pharmaceutical Co., Ltd | Fused ring derivatives and use thereof in pharmacy |
| CN111875619B (zh) * | 2020-07-30 | 2021-06-25 | 深圳市新阳唯康科技有限公司 | 巴洛沙韦酯的晶型及其制备方法 |
| CN113683613B (zh) * | 2020-09-08 | 2023-06-09 | 知和(山东)大药厂有限公司 | 一种多环吡啶肟基化合物及其药物组合物和用途 |
| CN112079848A (zh) * | 2020-09-24 | 2020-12-15 | 广东莱佛士制药技术有限公司 | 巴洛沙韦关键中间体的合成方法 |
| CN112409379B (zh) * | 2020-09-28 | 2023-07-28 | 长沙晶易医药科技股份有限公司 | 氘代的二氢二苯并硫杂卓化合物以及包含该化合物的药物组合物 |
| CN114478575A (zh) * | 2020-11-12 | 2022-05-13 | 上海迪赛诺生物医药有限公司 | 一种巴洛沙韦酯晶型d及其制备方法 |
| CN116783167A (zh) | 2020-11-17 | 2023-09-19 | 盐野义制药株式会社 | 新颖吖啶鎓盐及其制造方法 |
| CN114539285B (zh) * | 2020-11-25 | 2025-10-17 | 上海迪赛诺生物医药有限公司 | 一种玛巴洛沙韦的制备方法 |
| WO2022128934A1 (en) * | 2020-12-15 | 2022-06-23 | Synthon B.V. | Solid forms of baloxavir, salts of baloxavir and cocrystals of baloxavir |
| CN114671889A (zh) * | 2020-12-24 | 2022-06-28 | 江苏威凯尔医药科技有限公司 | 一种取代三环吡啶酮衍生物的晶型及其制备方法 |
| JP2024054430A (ja) * | 2020-12-28 | 2024-04-17 | 塩野義製薬株式会社 | Ｄｐ１アンタゴニストおよびキャップ依存性エンドヌクレアーゼ阻害剤からなるウイルス性気道感染症治療用医薬 |
| CN112724156B (zh) * | 2020-12-30 | 2022-05-10 | 深圳市坤健创新药物研究院 | 一种多环吡啶酮衍生物和药物组合物及其应用 |
| AU2022205484B2 (en) * | 2021-01-08 | 2024-12-05 | Phaeno Therapeutics Co., Ltd. | Pyridone multiple-membered ring derivatives and use thereof |
| TW202308646A (zh) * | 2021-05-10 | 2023-03-01 | 大陸商南京征祥醫藥有限公司 | 治療流感化合物的晶型及應用 |
| WO2023286078A1 (en) * | 2021-07-13 | 2023-01-19 | Natco Pharma Limited | An improved process for the preparation of an intermediate of baloxavir morboxil |
| US20250230161A1 (en) * | 2021-08-11 | 2025-07-17 | Merck Sharp & Dohme Llc | Polycyclic cap-dependent endonuclease inhibitors for treating or preventing influenza |
| CN113960192B (zh) * | 2021-10-08 | 2023-06-30 | 江苏正济药业股份有限公司 | 一种巴洛沙韦中间体有关物质及其制备方法与应用 |
| WO2023088370A1 (zh) * | 2021-11-17 | 2023-05-25 | 辰欣药业股份有限公司 | 一种稠环衍生物的晶型及其制备方法 |
| CN114014874B (zh) * | 2021-12-20 | 2023-04-28 | 中国科学院上海药物研究所 | 一种玛巴洛沙韦中间体的制备方法 |
| CN115947737B (zh) * | 2022-01-26 | 2023-11-28 | 南京赛弗斯医药科技有限公司 | 一种含硒化合物及其用途 |
| CN117343079B (zh) * | 2022-07-05 | 2024-08-20 | 山东如至生物医药科技有限公司 | 一种新型抗流感病毒化合物及其药物组合物和用途 |
| CN117003766B (zh) * | 2022-10-08 | 2024-02-02 | 石家庄迪斯凯威医药科技有限公司 | 一种抗流感病毒衍生物及其用途 |
| CN118056834A (zh) * | 2022-11-21 | 2024-05-21 | 合肥医工医药股份有限公司 | 稠环吡啶酮衍生物及其制备方法和用途 |
| CN116284046B (zh) * | 2023-02-22 | 2025-11-11 | 山东新华制药股份有限公司 | 巴洛沙韦衍生物及其制备方法和应用 |
| CN118496239A (zh) * | 2023-04-14 | 2024-08-16 | 南京卡文迪许生物工程技术有限公司 | 一种酰乙酯多环化合物及其药物组合物和用途 |
| WO2025073819A2 (en) | 2023-10-05 | 2025-04-10 | F. Hoffmann-La Roche Ag | Process for manufacturing baloxavir marboxil |
| WO2025152855A1 (zh) * | 2024-01-16 | 2025-07-24 | 上海翊石医药科技有限公司 | 用于治疗流感的化合物及其制备方法 |
| CN121127476A (zh) * | 2024-03-18 | 2025-12-12 | 石药集团中奇制药技术（石家庄）有限公司 | 多环吡啶酮衍生物及其用途 |
| CN118561867B (zh) * | 2024-05-27 | 2025-04-18 | 安徽贝克制药股份有限公司 | 一种帽状依赖性核酸内切酶抑制剂及其制备方法和其应用 |
| CN119841849B (zh) * | 2024-09-26 | 2025-08-15 | 浙江大学 | 一种吡啶酮类化合物、合成方法及其应用 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2280435A (en) | 1993-07-29 | 1995-02-01 | Merck & Co Inc | Anti-viral agent |
| US5475109A (en) | 1994-10-17 | 1995-12-12 | Merck & Co., Inc. | Dioxobutanoic acid derivatives as inhibitors of influenza endonuclease |
| PL372171A1 (en) * | 2002-02-19 | 2005-07-11 | Ono Pharmaceutical Co, Ltd. | Fused pyridazine derivative compounds and drugs containing the compounds as the active ingredient |
| TW200510425A (en) | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| US7291733B2 (en) * | 2003-10-10 | 2007-11-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted tricyclic heterocycles and their uses |
| WO2006066414A1 (en) | 2004-12-23 | 2006-06-29 | Virochem Pharma Inc. | Hydroxydihydropyridopy razine-1,8-diones and methods for inhibiting hiv integrase |
| DK1874117T3 (da) * | 2005-04-28 | 2013-09-23 | Viiv Healthcare Co | Polycyklisk carbamoylpyridonderivat med hiv-integrasehæmmende aktivitet |
| JP5131689B2 (ja) | 2005-10-27 | 2013-01-30 | 塩野義製薬株式会社 | Ｈｉｖインテグラーゼ阻害活性を有する多環性カルバモイルピリドン誘導体 |
| TWI518084B (zh) * | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| PL2444400T3 (pl) * | 2009-06-15 | 2018-08-31 | Shionogi & Co., Ltd. | Podstawiona policykliczna pochodna karbamoilopirydonowa |
| US9216995B2 (en) | 2010-04-12 | 2015-12-22 | Shionogi & Co., Ltd. | Pyridone derivative having integrase inhibitory activity |
| US8987441B2 (en) * | 2010-09-24 | 2015-03-24 | Shionogi & Co., Ltd. | Substituted polycyclic carbamoyl pyridone derivative prodrug |
| US8278541B2 (en) * | 2011-01-12 | 2012-10-02 | Trick Percussion Products, Inc. | Drum pedal with optical sensor |
| US8859290B2 (en) | 2011-07-22 | 2014-10-14 | Rutgers, The State University Of New Jersey | Inhibitors of influenza endonuclease activity and tools for their discovery |
| AU2012321762A1 (en) * | 2011-10-12 | 2014-04-17 | Shionogi & Co., Ltd. | Polycyclic pyridone derivative having integrase-inhibiting activity |
| US20130102600A1 (en) | 2011-10-21 | 2013-04-25 | F. Hoffmann-La Roche Ltd | Heteroaryl hydroxamic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| US20130102601A1 (en) | 2011-10-21 | 2013-04-25 | F. Hoffmann-La Roche Ltd | Pyrimidin-4-one derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| CN104334563B (zh) | 2012-05-23 | 2017-03-08 | 萨维拉制药有限公司 | 7‑氧代‑噻唑并吡啶碳酸衍生物和它们在治疗、改善或预防病毒疾病中的用途 |
| HK1204987A1 (en) | 2012-05-23 | 2015-12-11 | Savira Pharmaceuticals Gmbh | 7-oxo-4,7 -dihydro- pyrazolo [1, 5 -a]pyrimidine derivatives which are useful in the treatment, amelioration or prevention of a viral disease |
| CA2879245A1 (en) | 2012-08-06 | 2014-02-13 | Savira Pharmaceuticals Gmbh | Dihydroxypyrimidine carbonic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| US9573938B2 (en) | 2012-09-11 | 2017-02-21 | Rutgers, The State University Of New Jersey | Therapeutic hydroxypyridinones, hydroxypyrimidinones and hydroxypyridazinones |
| WO2014074926A1 (en) | 2012-11-09 | 2014-05-15 | Rutgers, The State University Of New Jersey | Therapeutic hydroxyquinolones |
| SI2822954T1 (sl) * | 2012-12-21 | 2016-07-29 | Gilead Sciences, Inc. | Policiklične karbamoilpiridonske spojine in njihova farmacevtska uporaba |
| HK1211288A1 (en) | 2013-01-08 | 2016-05-20 | Savira Pharmaceuticals Gmbh | Naphthyridinone derivatives and their use in the treatment,amelioration or prevention of a viral disease |
| MX2015008288A (es) | 2013-01-08 | 2016-06-02 | Savira Pharmaceuticals Gmbh | Derivados de piridona y su uso en el tratamiento, mejora o prevencion de una enfermedad viral. |
| AU2014204889A1 (en) | 2013-01-08 | 2015-06-11 | European Molecular Biology Laboratory | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| CN105722831B (zh) | 2013-09-12 | 2019-08-06 | 艾丽奥斯生物制药有限公司 | 哒嗪酮化合物及其用途 |
| AU2014318832B2 (en) | 2013-09-12 | 2018-11-29 | Janssen Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| CN104016983B (zh) * | 2013-10-08 | 2018-11-02 | 上海创诺制药有限公司 | 吡咯并三嗪类衍生物及其制法和用途 |
| CN107001355A (zh) | 2014-07-07 | 2017-08-01 | 萨维拉制药有限公司 | 吡啶并吡嗪化合物和它们在治疗、改善或预防流感中的用途 |
| CN107074880A (zh) | 2014-07-07 | 2017-08-18 | 萨维拉制药有限公司 | 二氢吡啶并吡嗪‑1,8‑二酮和它们在治疗、改善或预防病毒疾病中的用途 |
| HRP20230215T1 (hr) * | 2015-04-28 | 2023-04-14 | Shionogi & Co., Ltd. | Supstituirani policiklički derivati piridona i njihov predlijek |
| US20170081331A1 (en) | 2015-09-18 | 2017-03-23 | F. Hoffmann-La Roche Ag | Pyrazolopyrazines and their use in the treatment, amelioration or prevention of a viral disease |
| TW201726678A (zh) | 2015-10-30 | 2017-08-01 | 赫孚孟拉羅股份公司 | 嘧啶酮衍生物及其於治療、改善或預防病毒性疾病之用途 |
| SG10201911957QA (en) * | 2015-12-15 | 2020-02-27 | Shionogi & Co | Medicine for treating influenza characterized by comprising combination of cap-dependent endonuclease inhibitor with anti-influenza drug |
| WO2017109088A1 (en) | 2015-12-23 | 2017-06-29 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| JP6806413B2 (ja) | 2016-02-03 | 2021-01-06 | 塩野義製薬株式会社 | 多環性ピリドン誘導体およびそのプロドラッグ |
| US10858366B2 (en) | 2016-03-08 | 2020-12-08 | Novartis Ag | Tricyclic compounds useful to treat orthomyxovirus infections |
| WO2017158151A1 (en) | 2016-03-18 | 2017-09-21 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| WO2017158147A1 (en) | 2016-03-18 | 2017-09-21 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| WO2017223231A1 (en) | 2016-06-21 | 2017-12-28 | Alios Biopharma, Inc. | (s)-8-(benzhydryl )-6-isopropyl-3,5-dioxo- 5, 6,7,8,-tetrahydro-3h-pyrazino-[1,2-b]pyridazin-yl-isobutyrate antiviral agent for use in treating influenza |
-
2016
- 2016-04-27 HR HRP20241039TT patent/HRP20241039T1/hr unknown
- 2016-04-27 WO PCT/JP2016/063139 patent/WO2016175224A1/ja not_active Ceased
- 2016-04-27 AU AU2016256125A patent/AU2016256125B9/en active Active
- 2016-04-27 LT LTEP23150186.7T patent/LT4219508T/lt unknown
- 2016-04-27 ES ES23150186T patent/ES2986814T3/es active Active
- 2016-04-27 KR KR1020177031140A patent/KR101981880B1/ko active Active
- 2016-04-27 CA CA2984130A patent/CA2984130C/en active Active
- 2016-04-27 PL PL23150186.7T patent/PL4219508T3/pl unknown
- 2016-04-27 SI SI201631834T patent/SI4219508T1/sl unknown
- 2016-04-27 ES ES18189193T patent/ES2857906T3/es active Active
- 2016-04-27 CR CR20170530A patent/CR20170530A/es unknown
- 2016-04-27 DK DK23150186.7T patent/DK4219508T3/da active
- 2016-04-27 HK HK18104684.3A patent/HK1248673A1/zh unknown
- 2016-04-27 SI SI201631075T patent/SI3428170T1/sl unknown
- 2016-04-27 CN CN202110197031.0A patent/CN112876473A/zh active Pending
- 2016-04-27 CN CN201680037827.7A patent/CN107709321A/zh active Pending
- 2016-04-27 EP EP23150186.7A patent/EP4219508B1/en active Active
- 2016-04-27 BR BR112017022550-6A patent/BR112017022550B1/pt active IP Right Grant
- 2016-04-27 SM SM20210102T patent/SMT202100102T1/it unknown
- 2016-04-27 RS RS20210119A patent/RS61381B1/sr unknown
- 2016-04-27 LT LTEP18189193.8T patent/LT3428170T/lt unknown
- 2016-04-27 PE PE2017002333A patent/PE20180194A1/es unknown
- 2016-04-27 UA UAA201710501A patent/UA123725C2/uk unknown
- 2016-04-27 HU HUE16786500A patent/HUE061440T2/hu unknown
- 2016-04-27 MX MX2017013809A patent/MX385402B/es unknown
- 2016-04-27 EP EP24172424.4A patent/EP4424314A3/en active Pending
- 2016-04-27 PL PL18189193T patent/PL3428170T3/pl unknown
- 2016-04-27 EP EP18189193.8A patent/EP3428170B1/en active Active
- 2016-04-27 NZ NZ73625916A patent/NZ736259A/en unknown
- 2016-04-27 KR KR1020187037812A patent/KR101981912B1/ko active Active
- 2016-04-27 RU RU2017137518A patent/RU2712275C9/ru active
- 2016-04-27 HU HUE18189193A patent/HUE052739T2/hu unknown
- 2016-04-27 HU HUE23150186A patent/HUE067891T2/hu unknown
- 2016-04-27 EP EP16786500.5A patent/EP3290424B1/en active Active
- 2016-04-27 DK DK18189193.8T patent/DK3428170T3/da active
- 2016-04-27 FI FIEP23150186.7T patent/FI4219508T3/fi active
- 2016-04-27 SG SG11201708721XA patent/SG11201708721XA/en unknown
- 2016-04-27 CN CN202110162320.7A patent/CN112940010B/zh active Active
- 2016-04-27 US US15/569,191 patent/US10392406B2/en active Active
- 2016-04-27 RS RS20240797A patent/RS65734B1/sr unknown
- 2016-04-27 PT PT231501867T patent/PT4219508T/pt unknown
- 2016-04-27 PT PT167865005T patent/PT3290424T/pt unknown
- 2016-04-27 PT PT181891938T patent/PT3428170T/pt unknown
- 2016-04-27 MD MDE20190845T patent/MD3428170T2/ro not_active IP Right Cessation
- 2016-04-27 FI FIEP16786500.5T patent/FI3290424T3/fi active
- 2016-04-28 TW TW107110667A patent/TW201825492A/zh unknown
- 2016-04-28 TW TW105113329A patent/TWI625330B/zh active
- 2016-04-28 TW TW106145446A patent/TWI671298B/zh active
- 2016-07-08 JP JP2016135602A patent/JP6697209B2/ja active Active
-
2017
- 2017-10-11 CO CONC2017/0010384A patent/CO2017010384A2/es unknown
- 2017-10-19 ZA ZA2017/07111A patent/ZA201707111B/en unknown
- 2017-10-25 CL CL2017002711A patent/CL2017002711A1/es unknown
- 2017-10-26 IL IL255295A patent/IL255295B/en active IP Right Grant
-
2018
- 2018-12-17 US US16/221,733 patent/US10633397B2/en active Active
-
2020
- 2020-03-23 US US16/826,623 patent/US20200283455A1/en not_active Abandoned
- 2020-04-22 JP JP2020075767A patent/JP2020125331A/ja not_active Withdrawn
-
2021
- 2021-02-11 HR HRP20210241TT patent/HRP20210241T1/hr unknown
- 2021-03-04 CY CY2021006C patent/CY2021006I2/el unknown
- 2021-03-04 LU LU00198C patent/LUC00198I2/fr unknown
-
2024
- 2024-11-12 FI FIC20240038C patent/FIC20240038I1/fi unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017105750A5 (enExample) | ||
| JP2017137291A5 (enExample) | ||
| RU2017137518A (ru) | Замещенные полициклические производные пиридона и их пролекарства | |
| JP2015534574A5 (enExample) | ||
| JP2013531029A5 (enExample) | ||
| CY1117062T1 (el) | Ενωση κυκλικης αμινης και ακαρεοκτονο | |
| JP2013147496A5 (ja) | 有機金属錯体 | |
| CO6251243A2 (es) | Nuevos inhibidores macrocíclicos de la replicación del virus de hepatitis c | |
| JP2017119663A5 (enExample) | ||
| JP2011530500A5 (enExample) | ||
| AR084976A1 (es) | Compuestos de bifenileno sustituidos y metodos de uso de los mismos para el tratamiento de enfermedades virales | |
| CY1117374T1 (el) | Παραγωγα ιμιδαζοπυριδινης, διαδικασια για την παρασκευη αυτων και θεραπευτικη χρηση αυτων | |
| AR082201A1 (es) | Bencenosulfonamidas utiles como inhibidores del canal de sodio | |
| CY1118572T1 (el) | Παραγωγο κυκλοαλκανιου | |
| RU2014140735A (ru) | ПРОИЗВОДНЫЕ ПИРАЗОЛО[1, 5-a]ПИРИМИДИНА, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ СОЕДИНЕНИЯ, И СПОСОБЫ ИХ ПРИМЕНЕНИЯ | |
| RU2016137000A (ru) | Микробиоцидно активные бензоксаборолы | |
| MX344276B (es) | Compuesto de piperidina novedoso o sal del mismo. | |
| ES2637167T3 (es) | Compuestos de tetrahidro-pirido-piridina y tetrahidro-pirido-pirimidina y su uso como moduladores de los receptores de C5a | |
| EA201170096A1 (ru) | Замещенные производные пиримидона | |
| JP2013010749A5 (ja) | カルバゾール化合物 | |
| CO6270308A2 (es) | Derivados de 7-azaindol como inhibidores selectos de la 11 beta hidroxiesteroides deshidrogenasa de tipo 1 | |
| AR087909A1 (es) | Composiciones farmaceuticas | |
| JP2014526533A5 (enExample) | ||
| MX2014013074A (es) | Compuestos de n- (tetrazol-5-il) - y n- (triazol-5-il) arilcarboxamida sustituidos y su uso como herbicidas. | |
| RU2016135922A (ru) | Терапевтические соединения и композиции |