JP5971830B1 - 置換された多環性ピリドン誘導体およびそのプロドラッグ - Google Patents

置換された多環性ピリドン誘導体およびそのプロドラッグ Download PDF

Info

Publication number
JP5971830B1
JP5971830B1 JP2016535247A JP2016535247A JP5971830B1 JP 5971830 B1 JP5971830 B1 JP 5971830B1 JP 2016535247 A JP2016535247 A JP 2016535247A JP 2016535247 A JP2016535247 A JP 2016535247A JP 5971830 B1 JP5971830 B1 JP 5971830B1
Authority
JP
Japan
Prior art keywords
group
substituent group
optionally substituted
compound
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016535247A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2016175224A1 (ja
Inventor
河井　真
真 河井
健嗣 富田
健嗣 富田
俊行 秋山
俊行 秋山
梓 岡野
梓 岡野
雅好 宮川
雅好 宮川
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57199167&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP5971830(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of JP5971830B1 publication Critical patent/JP5971830B1/ja
Publication of JPWO2016175224A1 publication Critical patent/JPWO2016175224A1/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2016535247A 2015-04-28 2016-04-27 置換された多環性ピリドン誘導体およびそのプロドラッグ Active JP5971830B1 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2015090909 2015-04-28
JP2015090909 2015-04-28
JP2015236844 2015-12-03
JP2015236844 2015-12-03
PCT/JP2016/063139 WO2016175224A1 (ja) 2015-04-28 2016-04-27 置換された多環性ピリドン誘導体およびそのプロドラッグ

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016135602A Division JP6697209B2 (ja) 2015-04-28 2016-07-08 置換された多環性ピリドン誘導体およびそのプロドラッグ

Publications (2)

Publication Number Publication Date
JP5971830B1 true JP5971830B1 (ja) 2016-08-17
JPWO2016175224A1 JPWO2016175224A1 (ja) 2017-05-18

Family

ID=57199167

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2016535247A Active JP5971830B1 (ja) 2015-04-28 2016-04-27 置換された多環性ピリドン誘導体およびそのプロドラッグ
JP2016135602A Active JP6697209B2 (ja) 2015-04-28 2016-07-08 置換された多環性ピリドン誘導体およびそのプロドラッグ
JP2020075767A Withdrawn JP2020125331A (ja) 2015-04-28 2020-04-22 置換された多環性ピリドン誘導体およびそのプロドラッグ

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2016135602A Active JP6697209B2 (ja) 2015-04-28 2016-07-08 置換された多環性ピリドン誘導体およびそのプロドラッグ
JP2020075767A Withdrawn JP2020125331A (ja) 2015-04-28 2020-04-22 置換された多環性ピリドン誘導体およびそのプロドラッグ

Country Status (38)

Country Link
US (5) US10392406B2 (enExample)
EP (4) EP3428170B1 (enExample)
JP (3) JP5971830B1 (enExample)
KR (3) KR101981912B1 (enExample)
CN (4) CN107709321A (enExample)
AU (1) AU2016256125B9 (enExample)
BR (1) BR112017022550B1 (enExample)
CA (1) CA2984130C (enExample)
CL (1) CL2017002711A1 (enExample)
CO (1) CO2017010384A2 (enExample)
CR (1) CR20170530A (enExample)
CY (2) CY2021006I2 (enExample)
DK (3) DK4219508T3 (enExample)
ES (3) ES2986814T3 (enExample)
FI (3) FI4219508T3 (enExample)
HK (1) HK1248673A1 (enExample)
HR (3) HRP20230215T1 (enExample)
HU (3) HUE061440T2 (enExample)
IL (1) IL255295B (enExample)
LT (3) LT3290424T (enExample)
LU (1) LUC00198I2 (enExample)
MD (1) MD3428170T2 (enExample)
MX (2) MX385402B (enExample)
MY (1) MY189144A (enExample)
NZ (1) NZ736259A (enExample)
PE (1) PE20180194A1 (enExample)
PH (1) PH12017501909B1 (enExample)
PL (3) PL4219508T3 (enExample)
PT (3) PT4219508T (enExample)
RS (3) RS64012B1 (enExample)
RU (1) RU2712275C9 (enExample)
SG (1) SG11201708721XA (enExample)
SI (3) SI4219508T1 (enExample)
SM (1) SMT202100102T1 (enExample)
TW (3) TW201825492A (enExample)
UA (1) UA123725C2 (enExample)
WO (1) WO2016175224A1 (enExample)
ZA (1) ZA201707111B (enExample)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017105750A (ja) * 2015-04-28 2017-06-15 塩野義製薬株式会社 置換された多環性ピリドン誘導体およびそのプロドラッグ
WO2017104691A1 (ja) * 2015-12-15 2017-06-22 塩野義製薬株式会社 キャップ依存的エンドヌクレアーゼ阻害剤及び抗インフルエンザ薬を組み合わせることを特徴とするインフルエンザ治療用医薬
JP2018024682A (ja) * 2016-06-20 2018-02-15 塩野義製薬株式会社 置換された多環性ピリドン誘導体の製造方法およびその結晶
WO2018030463A1 (ja) * 2016-08-10 2018-02-15 塩野義製薬株式会社 置換された多環性ピリドン誘導体およびそのプロドラッグを含有する医薬組成物
WO2019073775A1 (ja) * 2017-10-11 2019-04-18 ダイキン工業株式会社 不飽和基を有する環状カーボネートの製造方法及び新規環状カーボネート
CN110041327A (zh) * 2018-01-17 2019-07-23 银杏树药业(苏州)有限公司 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用
CN110637016A (zh) * 2018-01-17 2019-12-31 银杏树药业(苏州)有限公司 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用
CN111303147A (zh) * 2018-12-12 2020-06-19 银杏树药业(苏州)有限公司 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用
WO2021007506A1 (en) 2019-07-11 2021-01-14 Nanjing Zhengxiang Pharmaceuticals Co., Ltd. Compounds useful to treat influenza virus infections
CN112236146A (zh) * 2018-04-24 2021-01-15 盐野义制药株式会社 稳定性优良的固体制剂
CN113286793A (zh) * 2018-09-10 2021-08-20 共结晶制药公司 吡咯并吡嗪和吡啶并三嗪类流感病毒复制抑制剂
CN117285542A (zh) * 2023-09-26 2023-12-26 广西天铭药业有限公司 一种巴洛沙韦酯及其关键中间体的制备方法
US12583867B2 (en) 2019-05-08 2026-03-24 Jiangxi Caishi Pharmaceutical Technology Co., Ltd. Pyridone derivative crystal form and preparation method and application therefor
EP4660197A4 (en) * 2023-04-14 2026-05-20 Nanjing Cavendish Bio Engineering Tech Co Ltd POLYCYCLIC ACYLETHYL ESTER COMPOUND, AND ASSOCIATED PHARMACEUTICAL COMPOSITION AND USE

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3686201A4 (en) * 2017-09-18 2021-04-28 Sunshine Lake Pharma Co., Ltd. INFLUENCE VIRUS REPLICATION INHIBITOR AND ITS USES
US11286262B2 (en) * 2017-10-06 2022-03-29 Shionogi & Co., Ltd. Stereoselective process for preparing substituted polycyclic pyridone derivatives
TWI795462B (zh) 2017-11-17 2023-03-11 日商鹽野義製藥股份有限公司 光安定性及溶出性優異的醫藥製劑
CN109503625A (zh) * 2018-01-19 2019-03-22 赵蕾 一种多环吡啶酮化合物及其药物组合和用途
US10596171B2 (en) 2018-01-22 2020-03-24 Taigen Biotechnology Co., Ltd. Cap-dependent endonuclease inhibitors
CN108440564B (zh) * 2018-04-11 2019-08-06 安帝康（无锡）生物科技有限公司 被取代的多环氨基甲酰基吡啶酮衍生物及其前药
CN109956956B (zh) * 2018-05-15 2020-07-07 广东东阳光药业有限公司 一种并环吡啶酮化合物的制备方法
EP3815689A4 (en) 2018-06-27 2022-04-20 National University Corporation Hokkaido University ARENAVIRUS GROWTH INHIBITOR WITH POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE
WO2020015669A1 (zh) * 2018-07-17 2020-01-23 南京明德新药研发有限公司 抗流感病毒三并环衍生物
CN110317211B (zh) * 2018-07-27 2022-05-13 深圳市塔吉瑞生物医药有限公司 一种取代的多环性吡啶酮化合物及其前药
CN110872247A (zh) * 2018-08-29 2020-03-10 上海复星星泰医药科技有限公司 Xofluza含硫杂环化合物、其中间体及制备方法
MX2021003724A (es) * 2018-09-29 2021-05-14 Jiangsu Yahong Meditech Co Ltd Profarmaco de nitroxolina y su uso.
CN111057074B (zh) * 2018-10-17 2022-04-29 广东东阳光药业有限公司 流感病毒复制抑制剂及其用途
CA3123605A1 (en) * 2018-12-20 2020-06-25 Aimmune Therapeutics, Inc. Peanut oral immunotherapy dosing schedule for missed doses
CN109516998B (zh) * 2018-12-25 2021-06-25 深圳市华先医药科技有限公司 一种巴洛沙韦中间体的合成方法
CN111484508B (zh) * 2019-01-29 2022-11-25 北京四环制药有限公司 一种用于制备巴罗萨韦或其衍生物的化合物及其制备方法和其应用
WO2020181025A1 (en) 2019-03-05 2020-09-10 Assia Chemical Industries Ltd Solid state forms of baloxavir marboxil
AU2019433734B2 (en) * 2019-03-12 2025-08-28 Shionogi & Co., Ltd. Treating influenza using substituted polycyclic pyridone derivatives and prodrugs thereof in a subject having influenza and a complication risk factor
WO2020194024A1 (en) * 2019-03-22 2020-10-01 Shionogi & Co., Ltd. Treating influenza using substituted polycyclic pyridone derivatives and prodrugs thereof in a subject having influenza and a severe influenza condition
EP3714889A1 (en) 2019-03-29 2020-09-30 F. Hoffmann-La Roche AG Baloxavir for the prevention of transmission of influenza virus
CN109912624B (zh) * 2019-04-11 2021-05-11 杭州科巢生物科技有限公司 一种巴洛沙韦酯关键母核中间体的合成方法
CN111825699B (zh) * 2019-04-15 2023-02-21 上海复星星泰医药科技有限公司 含硫杂环化合物及其制备方法
RU2720305C1 (ru) 2019-05-07 2020-04-28 Андрей Александрович Иващенко Замещенный 3,4,12,12а-тетрагидро-1Н-[1,4]оксазино[3,4-c]пиридо[2,1-f] [1,2,4]триазин-6,8-дион, фармацевтическая композиция, способы их получения и применения
CN110105372B (zh) * 2019-06-05 2022-05-10 南京焕然生物科技有限公司 一种r-7-(苄氧基)-四氢-1h-恶嗪并吡啶并-三嗪-6,8-二酮的制备方法
US20210069204A1 (en) * 2019-08-13 2021-03-11 F. Hoffmann-La Roche Ag Dosage of baloxavir marboxil for pediatric patients
AU2019461218C1 (en) 2019-08-13 2026-04-30 F. Hoffmann-La Roche Ag Improved dosage of baloxavir marboxil for pediatric patients
WO2021057834A1 (zh) * 2019-09-27 2021-04-01 广东东阳光药业有限公司 一种酯化合物的晶型及其制备方法
CN111057070A (zh) * 2019-10-30 2020-04-24 浙江工业大学 一种巴洛沙韦关键中间体的合成方法
CN112779304B (zh) * 2019-11-06 2023-11-03 广东东阳光药业股份有限公司 一种并环吡啶酮化合物的制备方法
CN115175913B (zh) * 2019-11-13 2023-11-28 南京知和医药科技有限公司 取代的双三环化合物及其药物组合物和用途
CN115135646B (zh) * 2019-12-23 2024-05-17 石家庄迪斯凯威医药科技有限公司 取代的多环化合物及其药物组合物和用途
CN113045589B (zh) * 2019-12-27 2024-08-23 广东东阳光药业股份有限公司 流感病毒复制抑制剂及其用途
CN112898346B (zh) * 2020-01-23 2023-11-10 南京知和医药科技有限公司 水溶性多环化合物及其药物组合物和用途
MX2022008901A (es) 2020-01-24 2022-08-16 Regeneron Pharma Conjugados de proteinas-compuestos antivirales.
CN112940009A (zh) * 2020-02-03 2021-06-11 南京知和医药科技有限公司 一种磺酸多环化合物及其药物组合物和用途
CN112876510A (zh) * 2020-02-10 2021-06-01 石家庄迪斯凯威医药科技有限公司 一种磷酸酯类多环化合物及其药物组合物和用途
CN111233891B (zh) * 2020-03-04 2021-05-04 江苏柯菲平医药股份有限公司 一种稠环吡啶酮衍生物及其制备方法和用途
CN113527296B (zh) * 2020-03-13 2025-03-07 北京凯因科技股份有限公司 一种流感病毒抑制剂
WO2021180147A1 (zh) * 2020-03-13 2021-09-16 北京凯因科技股份有限公司 一种流感病毒抑制剂
WO2021209563A1 (en) 2020-04-16 2021-10-21 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
CN113620948B (zh) * 2020-05-06 2022-11-25 太景医药研发(北京)有限公司 帽依赖性核酸内切酶抑制剂
RU2745985C1 (ru) * 2020-05-07 2021-04-05 Андрей Александрович Иващенко Антикоронавирусный терапевтический агент - замещенный 7-гидрокси-3,4,12,12а-тетрагидро-1H-[1,4]оксазино[3,4-c]пиридо[2,1-f][1,2,4]триазин-6,8-дион для профилактики и лечения COVID-19
US12516070B2 (en) 2020-05-21 2026-01-06 Cisen Pharmaceutical Co., Ltd Fused ring derivatives and use thereof in pharmacy
CN111875619B (zh) * 2020-07-30 2021-06-25 深圳市新阳唯康科技有限公司 巴洛沙韦酯的晶型及其制备方法
CN113683613B (zh) * 2020-09-08 2023-06-09 知和(山东)大药厂有限公司 一种多环吡啶肟基化合物及其药物组合物和用途
CN112079848A (zh) * 2020-09-24 2020-12-15 广东莱佛士制药技术有限公司 巴洛沙韦关键中间体的合成方法
CN112409379B (zh) * 2020-09-28 2023-07-28 长沙晶易医药科技股份有限公司 氘代的二氢二苯并硫杂卓化合物以及包含该化合物的药物组合物
CN114478575A (zh) * 2020-11-12 2022-05-13 上海迪赛诺生物医药有限公司 一种巴洛沙韦酯晶型d及其制备方法
WO2022107755A1 (ja) 2020-11-17 2022-05-27 塩野義製薬株式会社 新規アクリジニウム塩およびその製造方法
CN114539285B (zh) * 2020-11-25 2025-10-17 上海迪赛诺生物医药有限公司 一种玛巴洛沙韦的制备方法
WO2022128934A1 (en) 2020-12-15 2022-06-23 Synthon B.V. Solid forms of baloxavir, salts of baloxavir and cocrystals of baloxavir
CN114671889A (zh) * 2020-12-24 2022-06-28 江苏威凯尔医药科技有限公司 一种取代三环吡啶酮衍生物的晶型及其制备方法
JP2024054430A (ja) * 2020-12-28 2024-04-17 塩野義製薬株式会社 Ｄｐ１アンタゴニストおよびキャップ依存性エンドヌクレアーゼ阻害剤からなるウイルス性気道感染症治療用医薬
CN112724156B (zh) * 2020-12-30 2022-05-10 深圳市坤健创新药物研究院 一种多环吡啶酮衍生物和药物组合物及其应用
WO2022148434A1 (zh) * 2021-01-08 2022-07-14 辉诺生物医药科技（杭州）有限公司 吡啶酮多并环类衍生物及其应用
TW202308646A (zh) * 2021-05-10 2023-03-01 大陸商南京征祥醫藥有限公司 治療流感化合物的晶型及應用
WO2023286078A1 (en) * 2021-07-13 2023-01-19 Natco Pharma Limited An improved process for the preparation of an intermediate of baloxavir morboxil
US20250230161A1 (en) * 2021-08-11 2025-07-17 Merck Sharp & Dohme Llc Polycyclic cap-dependent endonuclease inhibitors for treating or preventing influenza
CN113960192B (zh) * 2021-10-08 2023-06-30 江苏正济药业股份有限公司 一种巴洛沙韦中间体有关物质及其制备方法与应用
CN118317964A (zh) * 2021-11-17 2024-07-09 辰欣药业股份有限公司 一种稠环衍生物的晶型及其制备方法
CN114014874B (zh) * 2021-12-20 2023-04-28 中国科学院上海药物研究所 一种玛巴洛沙韦中间体的制备方法
CN115947737B (zh) * 2022-01-26 2023-11-28 南京赛弗斯医药科技有限公司 一种含硒化合物及其用途
CN117343079B (zh) * 2022-07-05 2024-08-20 山东如至生物医药科技有限公司 一种新型抗流感病毒化合物及其药物组合物和用途
CN117003766B (zh) * 2022-10-08 2024-02-02 石家庄迪斯凯威医药科技有限公司 一种抗流感病毒衍生物及其用途
WO2024109707A1 (zh) * 2022-11-21 2024-05-30 合肥医工医药股份有限公司 稠环吡啶酮衍生物及其制备方法和用途
CN116284046B (zh) * 2023-02-22 2025-11-11 山东新华制药股份有限公司 巴洛沙韦衍生物及其制备方法和应用
EP4788681A2 (en) 2023-10-05 2026-08-12 F. Hoffmann-La Roche AG Process for manufacturing baloxavir marboxil
WO2025152855A1 (zh) * 2024-01-16 2025-07-24 上海翊石医药科技有限公司 用于治疗流感的化合物及其制备方法
CN121127476A (zh) * 2024-03-18 2025-12-12 石药集团中奇制药技术（石家庄）有限公司 多环吡啶酮衍生物及其用途
CN118561867B (zh) * 2024-05-27 2025-04-18 安徽贝克制药股份有限公司 一种帽状依赖性核酸内切酶抑制剂及其制备方法和其应用
CN119119081A (zh) * 2024-06-12 2024-12-13 南京卡文迪许生物工程技术有限公司 一种酰乙酯多环化合物的制备方法
CN121627717A (zh) * 2024-09-07 2026-03-10 南京卡文迪许生物工程技术有限公司 酰乙酯多环化合物的产业化制备方法及其中间体化合物
CN119841849B (zh) * 2024-09-26 2025-08-15 浙江大学 一种吡啶酮类化合物、合成方法及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010147068A1 (ja) * 2009-06-15 2010-12-23 塩野義製薬株式会社 置換された多環性カルバモイルピリドン誘導体
WO2012039414A1 (ja) * 2010-09-24 2012-03-29 塩野義製薬株式会社 置換された多環性カルバモイルピリドン誘導体のプロドラッグ

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2280435A (en) 1993-07-29 1995-02-01 Merck & Co Inc Anti-viral agent
US5475109A (en) 1994-10-17 1995-12-12 Merck & Co., Inc. Dioxobutanoic acid derivatives as inhibitors of influenza endonuclease
KR100663147B1 (ko) * 2002-02-19 2007-02-28 오노 야꾸힝 고교 가부시키가이샤 축합 피리다진 유도체 화합물 및 이를 유효 성분으로서함유하는 약제
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
US7291733B2 (en) * 2003-10-10 2007-11-06 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted tricyclic heterocycles and their uses
CA2634499A1 (en) 2004-12-23 2006-06-29 Virochem Pharma Inc. Hydroxydihydropyridopy razine-1,8-diones and methods for inhibiting hiv integrase
DK3187225T3 (da) * 2005-04-28 2022-02-28 Viiv Healthcare Co Polycyklisk carbamoylpyridonderivat med hiv-integrasehæmmende aktivitet
TW200800988A (en) 2005-10-27 2008-01-01 Shionogi & Amp Co Ltd Polycyclic carbamoylpyridone derivative having HIV integrase inhibitory activity
TWI518084B (zh) * 2009-03-26 2016-01-21 鹽野義製藥股份有限公司 哌喃酮與吡啶酮衍生物之製造方法
WO2011129095A1 (ja) * 2010-04-12 2011-10-20 塩野義製薬株式会社 インテグラーゼ阻害活性を有するピリドン誘導体
US8278541B2 (en) * 2011-01-12 2012-10-02 Trick Percussion Products, Inc. Drum pedal with optical sensor
US8859290B2 (en) 2011-07-22 2014-10-14 Rutgers, The State University Of New Jersey Inhibitors of influenza endonuclease activity and tools for their discovery
AU2012321762A1 (en) * 2011-10-12 2014-04-17 Shionogi & Co., Ltd. Polycyclic pyridone derivative having integrase-inhibiting activity
US20130102601A1 (en) 2011-10-21 2013-04-25 F. Hoffmann-La Roche Ltd Pyrimidin-4-one derivatives and their use in the treatment, amelioration or prevention of a viral disease
US20130102600A1 (en) 2011-10-21 2013-04-25 F. Hoffmann-La Roche Ltd Heteroaryl hydroxamic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease
HK1204987A1 (en) 2012-05-23 2015-12-11 Savira Pharmaceuticals Gmbh 7-oxo-4,7 -dihydro- pyrazolo [1, 5 -a]pyrimidine derivatives which are useful in the treatment, amelioration or prevention of a viral disease
BR112014029016A8 (pt) 2012-05-23 2018-01-09 European Molecular Biology Laboratory derivados de ácido 7-oxo-tiazolopiridina carbônico e seu uso no tratamento, melhora ou prevenção de uma doença viral
WO2014024056A1 (en) * 2012-08-06 2014-02-13 Daiichi Sankyo Company, Limited Pyrrolidine derivatives with antibacterial properties
HK1211289A1 (en) 2012-08-06 2016-05-20 Savira Pharmaceuticals Gmbh Dihydroxypyrimidine carbonic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease
WO2014043252A2 (en) 2012-09-11 2014-03-20 Rutgers, The State University Of New Jersey Therapeutic hydroxypyridinones, hydroxypyrimidinones and hydroxypyridazinones
WO2014074926A1 (en) 2012-11-09 2014-05-15 Rutgers, The State University Of New Jersey Therapeutic hydroxyquinolones
EA030003B1 (ru) * 2012-12-21 2018-06-29 Джилид Сайэнс, Инк. Полициклическое карбамоилпиридоновое соединение и его фармацевтическое применение для лечения вич-инфекции
HK1211287A1 (en) 2013-01-08 2016-05-20 Savira Pharmaceuticals Gmbh Pyridone derivatives and their use in the treatment, amelioration or prevention of a viral disease
EA201591291A1 (ru) 2013-01-08 2015-12-30 Савира Фармасьютикалз Гмбх Производные пиримидона и их применение в лечении, облегчении или профилактике вирусного заболевания
CN104903319B (zh) 2013-01-08 2017-05-31 萨维拉制药有限公司 萘啶酮衍生物及其在治疗、改善或预防病毒疾病中的用途
AU2014318837B2 (en) 2013-09-12 2019-05-30 Janssen Biopharma, Inc. Pyridazinone compounds and uses thereof
CN105764904B (zh) 2013-09-12 2020-02-11 詹森生物制药有限公司 氮杂-吡啶酮化合物及其用途
CN104016983B (zh) * 2013-10-08 2018-11-02 上海创诺制药有限公司 吡咯并三嗪类衍生物及其制法和用途
CA2953862A1 (en) 2014-07-07 2016-01-14 F. Hoffmann-La Roche Ag Dihydropyridopyrazine-1,8-diones and their use in the treatment, amelioration or prevention of viral diseases
EP3166943A1 (en) 2014-07-07 2017-05-17 Savira Pharmaceuticals GmbH Pyridopyrazine compounds and their use in the treatment, amelioration or prevention of influenza
CN107709321A (zh) * 2015-04-28 2018-02-16 盐野义制药株式会社 经取代的多环性吡啶酮衍生物及其前药
US20170081331A1 (en) 2015-09-18 2017-03-23 F. Hoffmann-La Roche Ag Pyrazolopyrazines and their use in the treatment, amelioration or prevention of a viral disease
US9988390B2 (en) 2015-10-30 2018-06-05 F. Hoffmann-La Roche Ag Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
HK1254961A1 (en) 2015-12-15 2019-08-02 Shionogi & Co., Ltd. Medicine for treating influenza characterized by comprising combination of cap-dependent endonuclease inhibitor with anti-influenza drug
WO2017109088A1 (en) 2015-12-23 2017-06-29 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
JP6806413B2 (ja) 2016-02-03 2021-01-06 塩野義製薬株式会社 多環性ピリドン誘導体およびそのプロドラッグ
ES2881776T3 (es) 2016-03-08 2021-11-30 Novartis Ag Compuestos tricíclicos útiles para tratar las infecciones por ortomixovirus
WO2017158151A1 (en) 2016-03-18 2017-09-21 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
WO2017158147A1 (en) 2016-03-18 2017-09-21 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
WO2017223231A1 (en) 2016-06-21 2017-12-28 Alios Biopharma, Inc. (s)-8-(benzhydryl )-6-isopropyl-3,5-dioxo- 5, 6,7,8,-tetrahydro-3h-pyrazino-[1,2-b]pyridazin-yl-isobutyrate antiviral agent for use in treating influenza
US10759814B2 (en) * 2016-08-10 2020-09-01 Shionogi & Co., Ltd. Pharmaceutical compositions containing substituted polycyclic pyridone derivatives and prodrug thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010147068A1 (ja) * 2009-06-15 2010-12-23 塩野義製薬株式会社 置換された多環性カルバモイルピリドン誘導体
WO2012039414A1 (ja) * 2010-09-24 2012-03-29 塩野義製薬株式会社 置換された多環性カルバモイルピリドン誘導体のプロドラッグ

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017105750A (ja) * 2015-04-28 2017-06-15 塩野義製薬株式会社 置換された多環性ピリドン誘導体およびそのプロドラッグ
WO2017104691A1 (ja) * 2015-12-15 2017-06-22 塩野義製薬株式会社 キャップ依存的エンドヌクレアーゼ阻害剤及び抗インフルエンザ薬を組み合わせることを特徴とするインフルエンザ治療用医薬
JPWO2017104691A1 (ja) * 2015-12-15 2018-04-05 塩野義製薬株式会社 キャップ依存的エンドヌクレアーゼ阻害剤及び抗インフルエンザ薬を組み合わせることを特徴とするインフルエンザ治療用医薬
JP2018024682A (ja) * 2016-06-20 2018-02-15 塩野義製薬株式会社 置換された多環性ピリドン誘導体の製造方法およびその結晶
US10759814B2 (en) 2016-08-10 2020-09-01 Shionogi & Co., Ltd. Pharmaceutical compositions containing substituted polycyclic pyridone derivatives and prodrug thereof
WO2018030463A1 (ja) * 2016-08-10 2018-02-15 塩野義製薬株式会社 置換された多環性ピリドン誘導体およびそのプロドラッグを含有する医薬組成物
US11306106B2 (en) 2016-08-10 2022-04-19 Shionogi & Co., Ltd. Pharmaceutical compositions containing substituted polycyclic pyridone derivatives and prodrug thereof
WO2019073775A1 (ja) * 2017-10-11 2019-04-18 ダイキン工業株式会社 不飽和基を有する環状カーボネートの製造方法及び新規環状カーボネート
US11718599B2 (en) 2017-10-11 2023-08-08 Daikin Industries, Ltd. Method for producing cyclic carbonate having unsaturated group, and novel cyclic carbonate
JPWO2019073775A1 (ja) * 2017-10-11 2020-04-23 ダイキン工業株式会社 不飽和基を有する環状カーボネートの製造方法及び新規環状カーボネート
CN110637016A (zh) * 2018-01-17 2019-12-31 银杏树药业(苏州)有限公司 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用
CN110041327A (zh) * 2018-01-17 2019-07-23 银杏树药业(苏州)有限公司 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用
CN111848614A (zh) * 2018-01-17 2020-10-30 江西彩石医药科技有限公司 吡啶酮衍生物及抗流感病毒药物组合物
CN111848616A (zh) * 2018-01-17 2020-10-30 江西彩石医药科技有限公司 吡啶酮衍生物及其用于制备抗流感病毒药物的用途
CN111848615A (zh) * 2018-01-17 2020-10-30 江西彩石医药科技有限公司 吡啶酮衍生物及包含其的抗流感病毒药物组合物
CN111848615B (zh) * 2018-01-17 2022-05-17 江西彩石医药科技有限公司 吡啶酮衍生物及包含其的抗流感病毒药物组合物
EP3753936A4 (en) * 2018-01-17 2022-03-23 Jiangxi Caishi Pharmaceutical Technology Co., Ltd. PYRIDONE DERIVATIVE, COMPOSITION THEREOF AND USE THEREOF AS AN AGAINST FLU MEDICATION
CN111848614B (zh) * 2018-01-17 2021-11-23 江西彩石医药科技有限公司 吡啶酮衍生物及抗流感病毒药物组合物
CN111848616B (zh) * 2018-01-17 2021-11-23 江西彩石医药科技有限公司 吡啶酮衍生物及其用于制备抗流感病毒药物的用途
CN110041327B (zh) * 2018-01-17 2022-01-21 江西彩石医药科技有限公司 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用
CN112236146A (zh) * 2018-04-24 2021-01-15 盐野义制药株式会社 稳定性优良的固体制剂
CN113286793A (zh) * 2018-09-10 2021-08-20 共结晶制药公司 吡咯并吡嗪和吡啶并三嗪类流感病毒复制抑制剂
CN113286793B (zh) * 2018-09-10 2024-04-05 共结晶制药公司 吡咯并吡嗪和吡啶并三嗪类流感病毒复制抑制剂
CN111303147A (zh) * 2018-12-12 2020-06-19 银杏树药业(苏州)有限公司 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用
CN111303147B (zh) * 2018-12-12 2024-07-02 江西彩石医药科技有限公司 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用
US12583867B2 (en) 2019-05-08 2026-03-24 Jiangxi Caishi Pharmaceutical Technology Co., Ltd. Pyridone derivative crystal form and preparation method and application therefor
WO2021007506A1 (en) 2019-07-11 2021-01-14 Nanjing Zhengxiang Pharmaceuticals Co., Ltd. Compounds useful to treat influenza virus infections
EP4660197A4 (en) * 2023-04-14 2026-05-20 Nanjing Cavendish Bio Engineering Tech Co Ltd POLYCYCLIC ACYLETHYL ESTER COMPOUND, AND ASSOCIATED PHARMACEUTICAL COMPOSITION AND USE
CN117285542A (zh) * 2023-09-26 2023-12-26 广西天铭药业有限公司 一种巴洛沙韦酯及其关键中间体的制备方法

Also Published As

Publication number Publication date
PT3428170T (pt) 2021-03-02
RU2017137518A (ru) 2019-05-28
NZ757062A (en) 2021-05-28
SG11201708721XA (en) 2017-11-29
HRP20241039T1 (hr) 2024-11-08
US10392406B2 (en) 2019-08-27
ES2938877T3 (es) 2023-04-17
SI3290424T1 (sl) 2023-03-31
JP2020125331A (ja) 2020-08-20
FI3290424T3 (fi) 2024-02-26
JPWO2016175224A1 (ja) 2017-05-18
EP3428170A1 (en) 2019-01-16
US20240327424A1 (en) 2024-10-03
EP4219508A1 (en) 2023-08-02
MD3428170T2 (ro) 2021-06-30
BR112017022550A2 (pt) 2018-07-17
ZA201707111B (en) 2019-01-30
CY1123920T1 (el) 2021-06-25
US20190112315A1 (en) 2019-04-18
KR20170131651A (ko) 2017-11-29
KR20190002742A (ko) 2019-01-08
HUE061440T2 (hu) 2023-06-28
LT3290424T (lt) 2023-03-10
DK3428170T3 (da) 2021-03-01
RS61381B1 (sr) 2021-02-26
FIC20240038I1 (fi) 2024-11-12
IL255295B (en) 2019-08-29
RS64012B1 (sr) 2023-03-31
SI4219508T1 (sl) 2024-09-30
PT3290424T (pt) 2023-02-22
BR112017022550B1 (pt) 2021-02-23
UA123725C2 (uk) 2021-05-26
IL255295A0 (en) 2017-12-31
KR20190049916A (ko) 2019-05-09
PH12017501909B1 (en) 2022-04-08
LT3428170T (lt) 2021-02-10
MX2021006404A (es) 2022-08-02
EP3290424B1 (en) 2023-01-04
US10633397B2 (en) 2020-04-28
HUE052739T2 (hu) 2021-05-28
SMT202100102T1 (it) 2021-03-15
TWI671298B (zh) 2019-09-11
MX394421B (es) 2025-03-24
PT4219508T (pt) 2024-08-05
RU2712275C9 (ru) 2020-03-19
LUC00198I2 (enExample) 2024-10-04
TWI625330B (zh) 2018-06-01
EP4219508B1 (en) 2024-06-05
CR20170530A (es) 2018-01-25
KR101981912B1 (ko) 2019-05-23
TW201811789A (zh) 2018-04-01
TW201825492A (zh) 2018-07-16
CA2984130A1 (en) 2016-11-03
CY2021006I1 (el) 2021-06-25
RS65734B1 (sr) 2024-08-30
DK3290424T3 (da) 2023-02-06
EP4424314A3 (en) 2025-02-19
NZ736259A (en) 2019-09-27
JP6697209B2 (ja) 2020-05-20
MX385402B (es) 2025-03-18
KR101981880B1 (ko) 2019-05-23
AU2016256125B2 (en) 2020-01-30
EP3290424A1 (en) 2018-03-07
EP3428170B1 (en) 2021-01-06
US20200283455A1 (en) 2020-09-10
CA2984130C (en) 2021-07-20
LT4219508T (lt) 2024-08-26
CL2017002711A1 (es) 2018-04-27
HK1259624A1 (en) 2019-12-06
US20230287004A1 (en) 2023-09-14
EP4424314A2 (en) 2024-09-04
AU2016256125A1 (en) 2017-11-02
MY189144A (en) 2022-01-28
ES2986814T3 (es) 2024-11-12
DK4219508T3 (da) 2024-08-05
RU2712275C2 (ru) 2020-01-28
CN112876473A (zh) 2021-06-01
RU2017137518A3 (enExample) 2019-07-17
CN112940010B (zh) 2021-11-02
WO2016175224A1 (ja) 2016-11-03
HRP20230215T1 (hr) 2023-04-14
EP3290424A4 (en) 2018-03-07
PL3290424T3 (pl) 2023-05-08
JP2017105750A (ja) 2017-06-15
HUE067891T2 (hu) 2024-11-28
PL4219508T3 (pl) 2024-10-28
SI3428170T1 (sl) 2021-03-31
CY2021006I2 (el) 2021-06-25
HRP20210241T1 (hr) 2021-04-02
CN113004304A (zh) 2021-06-22
CN113004304B (zh) 2022-03-18
MX2017013809A (es) 2018-03-15
AU2016256125B9 (en) 2020-02-20
CN112940010A (zh) 2021-06-11
FI4219508T3 (fi) 2024-08-02
KR102409779B1 (ko) 2022-06-16
TW201702245A (zh) 2017-01-16
CO2017010384A2 (es) 2017-12-15
PE20180194A1 (es) 2018-01-26
ES2857906T3 (es) 2021-09-29
CN107709321A (zh) 2018-02-16
PH12017501909A1 (en) 2018-03-05
PL3428170T3 (pl) 2021-05-31
HK1248673A1 (zh) 2018-10-19
US20180118760A1 (en) 2018-05-03

Similar Documents

Publication Publication Date Title
JP6697209B2 (ja) 置換された多環性ピリドン誘導体およびそのプロドラッグ
JP6267397B1 (ja) 置換された多環性ピリドン誘導体およびそのプロドラッグを含有する医薬組成物
JP7095945B2 (ja) 多環性ピリドン誘導体およびそのプロドラッグ
JP6323860B2 (ja) キャップ依存的エンドヌクレアーゼ阻害剤及び抗インフルエンザ薬を組み合わせることを特徴とするインフルエンザ治療用医薬
JP2019059697A (ja) 置換された多環性ピリダジン誘導体およびそのプロドラッグ
NZ757062B2 (en) Substituted polycyclic pyridone derivatives and prodrugs thereof

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160607

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160607

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20160607

TRDD Decision of grant or rejection written
A975 Report on accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A971005

Effective date: 20160630

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20160705

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20160708

R150 Certificate of patent or registration of utility model

Ref document number: 5971830

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R153 Grant of patent term extension

Free format text: JAPANESE INTERMEDIATE CODE: R153

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R153 Grant of patent term extension

Free format text: JAPANESE INTERMEDIATE CODE: R153

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R153 Grant of patent term extension

Free format text: JAPANESE INTERMEDIATE CODE: R153

R153 Grant of patent term extension

Free format text: JAPANESE INTERMEDIATE CODE: R153