CO6270308A2 - Derivados de 7-azaindol como inhibidores selectos de la 11 beta hidroxiesteroides deshidrogenasa de tipo 1 - Google Patents
Derivados de 7-azaindol como inhibidores selectos de la 11 beta hidroxiesteroides deshidrogenasa de tipo 1Info
- Publication number
- CO6270308A2 CO6270308A2 CO10053458A CO10053458A CO6270308A2 CO 6270308 A2 CO6270308 A2 CO 6270308A2 CO 10053458 A CO10053458 A CO 10053458A CO 10053458 A CO10053458 A CO 10053458A CO 6270308 A2 CO6270308 A2 CO 6270308A2
- Authority
- CO
- Colombia
- Prior art keywords
- derivatives
- hydroxiesteroids
- azaindol
- beta
- independently
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
Abstract
1.- Compuesto de formula I,donde R1 y R2 son independientemente entre si H, A, cicloalquilo, haloalquilo, Ar, heteroarilo o heterocicloalquilo,R3 y R4 son independientemente entre si H, A, Hal u OH,R5 y R6 son independientemente entre si H, A, haloalquilo o Hal,X es -(C)m-, -O-, S, S(O)- o -S(O)2-,Y es A, alcoxialquilo, cicloalquilo, ariloxilo, heteroariloxilo, fenilo o heteroarilo opcionalmente mono, di o trisustituidos por Hal, A, alquiloxilo C1-4, trifluorometilo, trifluorometoxilo, alquiloxicarbonilo C1-4, alquilcarbonilo C1-4 o alquiloxilo R7R8NC1-4,R7 y R8 son independientemente entre si alquilo C1-4 o cicloalquilo C4-7,n es 1 o 2 ym es 0 o 1,y las sales, derivados, profarmacos, solvatos y estereoisomeros de los mismos fisiologicamente aceptables, incluyendo mezclas de los mismos en todas las proporciones.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07291325 | 2007-11-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6270308A2 true CO6270308A2 (es) | 2011-04-20 |
Family
ID=40445347
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO10053458A CO6270308A2 (es) | 2007-11-05 | 2010-05-05 | Derivados de 7-azaindol como inhibidores selectos de la 11 beta hidroxiesteroides deshidrogenasa de tipo 1 |
Country Status (23)
Country | Link |
---|---|
US (1) | US8470849B2 (es) |
EP (1) | EP2247589B1 (es) |
JP (1) | JP5529743B2 (es) |
KR (1) | KR101624596B1 (es) |
CN (1) | CN101848910B (es) |
AU (1) | AU2008324525B2 (es) |
BR (1) | BRPI0819219B1 (es) |
CA (1) | CA2704803C (es) |
CO (1) | CO6270308A2 (es) |
CY (1) | CY1113645T1 (es) |
DK (1) | DK2247589T3 (es) |
EA (1) | EA019707B1 (es) |
EC (1) | ECSP10010231A (es) |
ES (1) | ES2400105T3 (es) |
HR (1) | HRP20130097T1 (es) |
IL (1) | IL205508A (es) |
MX (1) | MX2010004815A (es) |
PL (1) | PL2247589T3 (es) |
PT (1) | PT2247589E (es) |
SI (1) | SI2247589T1 (es) |
UA (1) | UA102379C2 (es) |
WO (1) | WO2009059666A1 (es) |
ZA (1) | ZA201004023B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2563780B1 (en) | 2010-04-29 | 2015-05-06 | The University Of Edinburgh | 3,3-disubstituted-(8-aza-bicyclo[3.2.1]oct-8-yl)-[5-(1h-pyrazol-4-yl)-thiophen-3-yl]-methanones as inhibitors of 11(beta)-hsd1 |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP3235813A1 (en) | 2016-04-19 | 2017-10-25 | Cidqo 2012, S.L. | Aza-tetra-cyclo derivatives |
CN106279154A (zh) * | 2016-08-02 | 2017-01-04 | 叶芳 | 一种7‑氮杂吲哚‑3‑甲醛的制备方法 |
WO2022006039A1 (en) * | 2020-06-30 | 2022-01-06 | The Regents Of The University Of California | Compositions and methods for modulating hair growth |
CN112390815B (zh) * | 2020-11-03 | 2022-07-26 | 浙江医药股份有限公司新昌制药厂 | 一种Lewis酸脱N-苄基制备d-生物素的制备方法 |
CN112409353A (zh) * | 2020-11-27 | 2021-02-26 | 苏州艾缇克药物化学有限公司 | 一种7-氮杂吲哚衍生物的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP0400684A2 (hu) * | 2000-12-22 | 2004-07-28 | Wyeth | 5-Hidroxitriptamin-6-ligandumként használható heterociklilindazol- és -azaindazol-származékok, előállításuk és ezeket tartalmazó gyógyszerkészítmények |
DE10252666A1 (de) * | 2002-11-11 | 2004-08-05 | Grünenthal GmbH | N-Piperidyl-cyclohexan-Derivate |
DE10337184A1 (de) * | 2003-08-13 | 2005-03-10 | Gruenenthal Gmbh | Substituierte 3-Pyrrolidin-Indol-Derivate |
ES2634841T3 (es) * | 2003-10-14 | 2017-09-29 | Pfizer Products Inc. | Derivados bicíclicos [3.1.0] como inhibidores del transportador de glicina |
WO2007050381A2 (en) * | 2005-10-24 | 2007-05-03 | Janssen Pharmaceutica, N.V. | 3-piperidin-4-yl-indole orl-1 receptor modulators |
US7638062B2 (en) | 2006-07-10 | 2009-12-29 | Cameron International Corporation | Ultra compact cyclonic flotation system |
-
2008
- 2008-10-01 MX MX2010004815A patent/MX2010004815A/es active IP Right Grant
- 2008-10-01 EA EA201000751A patent/EA019707B1/ru not_active IP Right Cessation
- 2008-10-01 PL PL08802728T patent/PL2247589T3/pl unknown
- 2008-10-01 WO PCT/EP2008/008309 patent/WO2009059666A1/en active Application Filing
- 2008-10-01 AU AU2008324525A patent/AU2008324525B2/en not_active Ceased
- 2008-10-01 KR KR1020107012222A patent/KR101624596B1/ko active IP Right Grant
- 2008-10-01 BR BRPI0819219-7A patent/BRPI0819219B1/pt active IP Right Grant
- 2008-10-01 US US12/741,254 patent/US8470849B2/en active Active
- 2008-10-01 CN CN2008801146395A patent/CN101848910B/zh active Active
- 2008-10-01 JP JP2010531433A patent/JP5529743B2/ja active Active
- 2008-10-01 DK DK08802728.9T patent/DK2247589T3/da active
- 2008-10-01 SI SI200830889T patent/SI2247589T1/sl unknown
- 2008-10-01 EP EP08802728A patent/EP2247589B1/en active Active
- 2008-10-01 UA UAA201006828A patent/UA102379C2/ru unknown
- 2008-10-01 PT PT88027289T patent/PT2247589E/pt unknown
- 2008-10-01 CA CA2704803A patent/CA2704803C/en active Active
- 2008-10-01 ES ES08802728T patent/ES2400105T3/es active Active
-
2010
- 2010-05-03 IL IL205508A patent/IL205508A/en active IP Right Grant
- 2010-05-05 CO CO10053458A patent/CO6270308A2/es not_active Application Discontinuation
- 2010-06-03 EC EC2010010231A patent/ECSP10010231A/es unknown
- 2010-06-04 ZA ZA2010/04023A patent/ZA201004023B/en unknown
-
2013
- 2013-02-05 HR HRP20130097AT patent/HRP20130097T1/hr unknown
- 2013-02-08 CY CY20131100113T patent/CY1113645T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ECSP10010231A (es) | 2010-07-30 |
BRPI0819219B1 (pt) | 2021-09-21 |
MX2010004815A (es) | 2010-05-27 |
SI2247589T1 (sl) | 2013-03-29 |
AU2008324525B2 (en) | 2014-09-18 |
WO2009059666A1 (en) | 2009-05-14 |
ES2400105T3 (es) | 2013-04-05 |
CN101848910B (zh) | 2013-12-04 |
IL205508A (en) | 2013-06-27 |
JP5529743B2 (ja) | 2014-06-25 |
PL2247589T3 (pl) | 2013-03-29 |
JP2011502135A (ja) | 2011-01-20 |
EA019707B1 (ru) | 2014-05-30 |
IL205508A0 (en) | 2010-12-30 |
EP2247589A1 (en) | 2010-11-10 |
DK2247589T3 (da) | 2013-01-21 |
CY1113645T1 (el) | 2016-06-22 |
US8470849B2 (en) | 2013-06-25 |
UA102379C2 (ru) | 2013-07-10 |
CA2704803A1 (en) | 2009-05-14 |
EP2247589B1 (en) | 2012-11-21 |
PT2247589E (pt) | 2013-02-20 |
AU2008324525A1 (en) | 2009-05-14 |
KR101624596B1 (ko) | 2016-05-26 |
CN101848910A (zh) | 2010-09-29 |
EA201000751A1 (ru) | 2010-12-30 |
BRPI0819219A2 (pt) | 2020-08-04 |
CA2704803C (en) | 2017-04-11 |
ZA201004023B (en) | 2011-03-30 |
US20100267761A1 (en) | 2010-10-21 |
HRP20130097T1 (hr) | 2013-02-28 |
KR20100094500A (ko) | 2010-08-26 |
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