CY1113645T1 - Παραγωγα 7-αζαϊνδολης ως επιλεκτικοι αναστολεις 11-βητα-υδροξυστεροειδους δεϋδρογενασης τυπου 1 - Google Patents

Παραγωγα 7-αζαϊνδολης ως επιλεκτικοι αναστολεις 11-βητα-υδροξυστεροειδους δεϋδρογενασης τυπου 1

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Publication number
CY1113645T1
CY1113645T1 CY20131100113T CY131100113T CY1113645T1 CY 1113645 T1 CY1113645 T1 CY 1113645T1 CY 20131100113 T CY20131100113 T CY 20131100113T CY 131100113 T CY131100113 T CY 131100113T CY 1113645 T1 CY1113645 T1 CY 1113645T1
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CY
Cyprus
Prior art keywords
beta
selective inhibitors
hydroxyhydrogenate
azandol
derivative
Prior art date
Application number
CY20131100113T
Other languages
English (en)
Inventor
Denis Carniato
Melanie Schultz
Didier Roche
Sophie Hallakou-Bozec
Original Assignee
Merck Patent Gmbh
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Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of CY1113645T1 publication Critical patent/CY1113645T1/el

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P13/00—Drugs for disorders of the urinary system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P27/00—Drugs for disorders of the senses
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    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Organic Chemistry (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Diabetes (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
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  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται στα παράγωγα 7-αζαϊνδόλης του χημικού τύπου (I) ως επιλεκτικούς αναστολείς του ενζύμου 11-βητα- υδροξυστεροειδούς δεϋδρογενάσης τύπου 1 (11β-HSD-1) και στη χρήση αυτών των ενώσεων για την αντιμετώπιση και την πρόληψη του μεταβολικού συνδρόμου, του διαβήτη, της αντίστασης στην ινσουλίνη, της παχυσαρκίας, των διαταραχών των λιπιδίων, του γλαυκώματος, της οστεοπόρωσης, των νοητικών διαταραχών, του άγχους, της κατάθλιψης, των διαταραχών του ανοσοποιητικού, της υπέρτασης και άλλων ασθενειών και παθήσεων.
CY20131100113T 2007-11-05 2013-02-08 Παραγωγα 7-αζαϊνδολης ως επιλεκτικοι αναστολεις 11-βητα-υδροξυστεροειδους δεϋδρογενασης τυπου 1 CY1113645T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07291325 2007-11-05
EP08802728A EP2247589B1 (en) 2007-11-05 2008-10-01 7-azaindole derivatives as selective 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors

Publications (1)

Publication Number Publication Date
CY1113645T1 true CY1113645T1 (el) 2016-06-22

Family

ID=40445347

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131100113T CY1113645T1 (el) 2007-11-05 2013-02-08 Παραγωγα 7-αζαϊνδολης ως επιλεκτικοι αναστολεις 11-βητα-υδροξυστεροειδους δεϋδρογενασης τυπου 1

Country Status (23)

Country Link
US (1) US8470849B2 (el)
EP (1) EP2247589B1 (el)
JP (1) JP5529743B2 (el)
KR (1) KR101624596B1 (el)
CN (1) CN101848910B (el)
AU (1) AU2008324525B2 (el)
BR (1) BRPI0819219B1 (el)
CA (1) CA2704803C (el)
CO (1) CO6270308A2 (el)
CY (1) CY1113645T1 (el)
DK (1) DK2247589T3 (el)
EA (1) EA019707B1 (el)
EC (1) ECSP10010231A (el)
ES (1) ES2400105T3 (el)
HR (1) HRP20130097T1 (el)
IL (1) IL205508A (el)
MX (1) MX2010004815A (el)
PL (1) PL2247589T3 (el)
PT (1) PT2247589E (el)
SI (1) SI2247589T1 (el)
UA (1) UA102379C2 (el)
WO (1) WO2009059666A1 (el)
ZA (1) ZA201004023B (el)

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WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
JP5899202B2 (ja) 2010-04-29 2016-04-06 ザ ユニバーシティ オブ エディンバラ １１β−ＨＳＤ１の阻害剤としての３，３−二置換−（８−アザ−ビシクロ［３．２．１］オクタ−８−イル）−［５−（１Ｈ−ピラゾール−４−イル）−チオフェン−３−イル］−メタノン類
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP3235813A1 (en) 2016-04-19 2017-10-25 Cidqo 2012, S.L. Aza-tetra-cyclo derivatives
CN106279154A (zh) * 2016-08-02 2017-01-04 叶芳 一种7‑氮杂吲哚‑3‑甲醛的制备方法
EP4172158A4 (en) * 2020-06-30 2024-01-10 The Regents of the University of California COMPOSITIONS AND METHODS FOR MODULATING HAIR GROWTH
CN112390815B (zh) * 2020-11-03 2022-07-26 浙江医药股份有限公司新昌制药厂 一种Lewis酸脱N-苄基制备d-生物素的制备方法
CN112409353A (zh) * 2020-11-27 2021-02-26 苏州艾缇克药物化学有限公司 一种7-氮杂吲哚衍生物的制备方法

Family Cites Families (6)

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CA2432654A1 (en) * 2000-12-22 2002-07-04 Wyeth Heterocyclindazole and azaindazole compounds as 5-hydroxytryptamine-6 ligands
DE10252666A1 (de) * 2002-11-11 2004-08-05 Grünenthal GmbH N-Piperidyl-cyclohexan-Derivate
DE10337184A1 (de) * 2003-08-13 2005-03-10 Gruenenthal Gmbh Substituierte 3-Pyrrolidin-Indol-Derivate
ES2634841T3 (es) * 2003-10-14 2017-09-29 Pfizer Products Inc. Derivados bicíclicos [3.1.0] como inhibidores del transportador de glicina
JP2009515833A (ja) * 2005-10-24 2009-04-16 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ３−ピペリジン−４−イル−インドールｏｒｌ−１受容体モジュレーター
US7638062B2 (en) 2006-07-10 2009-12-29 Cameron International Corporation Ultra compact cyclonic flotation system

Also Published As

Publication number Publication date
US20100267761A1 (en) 2010-10-21
CN101848910A (zh) 2010-09-29
CO6270308A2 (es) 2011-04-20
WO2009059666A1 (en) 2009-05-14
ES2400105T3 (es) 2013-04-05
DK2247589T3 (da) 2013-01-21
BRPI0819219B1 (pt) 2021-09-21
CN101848910B (zh) 2013-12-04
PL2247589T3 (pl) 2013-03-29
IL205508A0 (en) 2010-12-30
UA102379C2 (ru) 2013-07-10
PT2247589E (pt) 2013-02-20
SI2247589T1 (sl) 2013-03-29
US8470849B2 (en) 2013-06-25
EP2247589A1 (en) 2010-11-10
JP5529743B2 (ja) 2014-06-25
CA2704803A1 (en) 2009-05-14
EP2247589B1 (en) 2012-11-21
IL205508A (en) 2013-06-27
MX2010004815A (es) 2010-05-27
KR20100094500A (ko) 2010-08-26
AU2008324525A1 (en) 2009-05-14
JP2011502135A (ja) 2011-01-20
HRP20130097T1 (hr) 2013-02-28
ECSP10010231A (es) 2010-07-30
ZA201004023B (en) 2011-03-30
KR101624596B1 (ko) 2016-05-26
AU2008324525B2 (en) 2014-09-18
BRPI0819219A2 (pt) 2020-08-04
EA201000751A1 (ru) 2010-12-30
CA2704803C (en) 2017-04-11
EA019707B1 (ru) 2014-05-30

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