UA102379C2 - Производные 7-азаиндола как селективные ингибиторы бета-гидроксистероида дегидрогеназы 1 типа - Google Patents

Производные 7-азаиндола как селективные ингибиторы бета-гидроксистероида дегидрогеназы 1 типа

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Publication number
UA102379C2
UA102379C2 UAA201006828A UAA201006828A UA102379C2 UA 102379 C2 UA102379 C2 UA 102379C2 UA A201006828 A UAA201006828 A UA A201006828A UA A201006828 A UAA201006828 A UA A201006828A UA 102379 C2 UA102379 C2 UA 102379C2
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Ukraine
Prior art keywords
beta
selective inhibitors
azaindole derivatives
hydroxysteroiddehydrogenase
type
Prior art date
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UAA201006828A
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English (en)
Ukrainian (uk)
Inventor
Денис Карниато
Юрген Шутц
Дидье Роше
Софи Халлакоу-Бозек
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Мерк Патент Гмбх
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Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of UA102379C2 publication Critical patent/UA102379C2/ru

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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Pulmonology (AREA)
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  • Dermatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)

Abstract

Данное изобретение касается производных 7-азаиндола формулы I как селективных ингибиторов энзима бета-гидроксистероида дегидрогеназы типа 1 (11β-HSD-1) и использования таких соединений для лечения и предотвращения метаболического синдрома, сахарного диабета, резистентности к инсулину, ожирения, расстройства липидного обмена, глаукомы, остеопороза, когнитивных расстройств, беспокойства, депрессии, иммунным расстройств, артериальной гипертензии и других болезней и патологическим состояний.I
UAA201006828A 2007-11-05 2008-10-01 Производные 7-азаиндола как селективные ингибиторы бета-гидроксистероида дегидрогеназы 1 типа UA102379C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07291325 2007-11-05
PCT/EP2008/008309 WO2009059666A1 (en) 2007-11-05 2008-10-01 7-azaindole derivatives as selective 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors

Publications (1)

Publication Number Publication Date
UA102379C2 true UA102379C2 (ru) 2013-07-10

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ID=40445347

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201006828A UA102379C2 (ru) 2007-11-05 2008-10-01 Производные 7-азаиндола как селективные ингибиторы бета-гидроксистероида дегидрогеназы 1 типа

Country Status (23)

Country Link
US (1) US8470849B2 (ru)
EP (1) EP2247589B1 (ru)
JP (1) JP5529743B2 (ru)
KR (1) KR101624596B1 (ru)
CN (1) CN101848910B (ru)
AU (1) AU2008324525B2 (ru)
BR (1) BRPI0819219B1 (ru)
CA (1) CA2704803C (ru)
CO (1) CO6270308A2 (ru)
CY (1) CY1113645T1 (ru)
DK (1) DK2247589T3 (ru)
EA (1) EA019707B1 (ru)
EC (1) ECSP10010231A (ru)
ES (1) ES2400105T3 (ru)
HR (1) HRP20130097T1 (ru)
IL (1) IL205508A (ru)
MX (1) MX2010004815A (ru)
PL (1) PL2247589T3 (ru)
PT (1) PT2247589E (ru)
SI (1) SI2247589T1 (ru)
UA (1) UA102379C2 (ru)
WO (1) WO2009059666A1 (ru)
ZA (1) ZA201004023B (ru)

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WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
JP5899202B2 (ja) 2010-04-29 2016-04-06 ザ ユニバーシティ オブ エディンバラ １１β−ＨＳＤ１の阻害剤としての３，３−二置換−（８−アザ−ビシクロ［３．２．１］オクタ−８−イル）−［５−（１Ｈ−ピラゾール−４−イル）−チオフェン−３−イル］−メタノン類
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP3235813A1 (en) 2016-04-19 2017-10-25 Cidqo 2012, S.L. Aza-tetra-cyclo derivatives
CN106279154A (zh) * 2016-08-02 2017-01-04 叶芳 一种7‑氮杂吲哚‑3‑甲醛的制备方法
EP4172158A4 (en) * 2020-06-30 2024-01-10 The Regents of the University of California COMPOSITIONS AND METHODS FOR MODULATING HAIR GROWTH
CN112390815B (zh) * 2020-11-03 2022-07-26 浙江医药股份有限公司新昌制药厂 一种Lewis酸脱N-苄基制备d-生物素的制备方法
CN112409353A (zh) * 2020-11-27 2021-02-26 苏州艾缇克药物化学有限公司 一种7-氮杂吲哚衍生物的制备方法

Family Cites Families (6)

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CA2432654A1 (en) * 2000-12-22 2002-07-04 Wyeth Heterocyclindazole and azaindazole compounds as 5-hydroxytryptamine-6 ligands
DE10252666A1 (de) * 2002-11-11 2004-08-05 Grünenthal GmbH N-Piperidyl-cyclohexan-Derivate
DE10337184A1 (de) * 2003-08-13 2005-03-10 Gruenenthal Gmbh Substituierte 3-Pyrrolidin-Indol-Derivate
ES2634841T3 (es) * 2003-10-14 2017-09-29 Pfizer Products Inc. Derivados bicíclicos [3.1.0] como inhibidores del transportador de glicina
JP2009515833A (ja) * 2005-10-24 2009-04-16 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ３−ピペリジン−４−イル−インドールｏｒｌ−１受容体モジュレーター
US7638062B2 (en) 2006-07-10 2009-12-29 Cameron International Corporation Ultra compact cyclonic flotation system

Also Published As

Publication number Publication date
US20100267761A1 (en) 2010-10-21
CN101848910A (zh) 2010-09-29
CO6270308A2 (es) 2011-04-20
WO2009059666A1 (en) 2009-05-14
ES2400105T3 (es) 2013-04-05
DK2247589T3 (da) 2013-01-21
BRPI0819219B1 (pt) 2021-09-21
CN101848910B (zh) 2013-12-04
PL2247589T3 (pl) 2013-03-29
IL205508A0 (en) 2010-12-30
PT2247589E (pt) 2013-02-20
SI2247589T1 (sl) 2013-03-29
US8470849B2 (en) 2013-06-25
EP2247589A1 (en) 2010-11-10
JP5529743B2 (ja) 2014-06-25
CA2704803A1 (en) 2009-05-14
EP2247589B1 (en) 2012-11-21
IL205508A (en) 2013-06-27
MX2010004815A (es) 2010-05-27
KR20100094500A (ko) 2010-08-26
AU2008324525A1 (en) 2009-05-14
JP2011502135A (ja) 2011-01-20
HRP20130097T1 (hr) 2013-02-28
ECSP10010231A (es) 2010-07-30
CY1113645T1 (el) 2016-06-22
ZA201004023B (en) 2011-03-30
KR101624596B1 (ko) 2016-05-26
AU2008324525B2 (en) 2014-09-18
BRPI0819219A2 (pt) 2020-08-04
EA201000751A1 (ru) 2010-12-30
CA2704803C (en) 2017-04-11
EA019707B1 (ru) 2014-05-30

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