MX339185B - Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas. - Google Patents

Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas.

Info

Publication number
MX339185B
MX339185B MX2012011899A MX2012011899A MX339185B MX 339185 B MX339185 B MX 339185B MX 2012011899 A MX2012011899 A MX 2012011899A MX 2012011899 A MX2012011899 A MX 2012011899A MX 339185 B MX339185 B MX 339185B
Authority
MX
Mexico
Prior art keywords
pyrrolobenzodiazepines
proliferative diseases
treat proliferative
monomer unit
double bond
Prior art date
Application number
MX2012011899A
Other languages
English (en)
Other versions
MX2012011899A (es
Inventor
Philip Wilson Howard
Luke Masterson
Arnaud Tiberghien
Scott Jeffrey
Patrick Burke
Peter Senter
Original Assignee
Seattle Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seattle Genetics Inc filed Critical Seattle Genetics Inc
Publication of MX2012011899A publication Critical patent/MX2012011899A/es
Publication of MX339185B publication Critical patent/MX339185B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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  • Health & Medical Sciences (AREA)
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  • Endocrinology (AREA)
  • Dermatology (AREA)
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  • Neurology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
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Abstract

Dímeros de pirrolobenzodiazepina que tiene un doble enlace C2-C3 y un grupo arilo en la posición C2 en una unidad monomérica, y un doble enlace C2-C3 y también un doble o triple enlace conjugados en la posición C2, o un grupo alquilo en la posición C2 en la otra unidad monomérica, y conjugados de estos compuestos.
MX2012011899A 2010-04-15 2011-04-15 Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas. MX339185B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32445310P 2010-04-15 2010-04-15
PCT/US2011/032668 WO2011130616A1 (en) 2010-04-15 2011-04-15 Pyrrolobenzodiazepines used to treat proliferative diseases

Publications (2)

Publication Number Publication Date
MX2012011899A MX2012011899A (es) 2013-02-15
MX339185B true MX339185B (es) 2016-05-16

Family

ID=43971498

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2012011899A MX339185B (es) 2010-04-15 2011-04-15 Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas.
MX2015001565A MX368648B (es) 2010-04-15 2011-04-15 Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2015001565A MX368648B (es) 2010-04-15 2011-04-15 Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas.

Country Status (14)

Country Link
US (2) US8697688B2 (es)
EP (2) EP2558475A1 (es)
JP (1) JP5875083B2 (es)
KR (1) KR101687054B1 (es)
CN (1) CN102971329B (es)
AU (1) AU2011239525B2 (es)
BR (1) BR112012026410B8 (es)
CA (1) CA2795353C (es)
ES (1) ES2623057T3 (es)
HK (1) HK1202536A1 (es)
MX (2) MX339185B (es)
NZ (1) NZ602933A (es)
WO (1) WO2011130616A1 (es)
ZA (1) ZA201207357B (es)

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NZ602933A (en) 2010-04-15 2014-09-26 Seattle Genetics Inc Pyrrolobenzodiazepines used to treat proliferative diseases
BR112012026801B8 (pt) 2010-04-15 2021-05-25 Medimmune Ltd conjugados de pirrolobenzodiazepina direcionados, composição farmacêutica, uso dos mesmos para tratamento de uma doença proliferativa ou autoimune e ligante de medicamento
WO2012112708A1 (en) 2011-02-15 2012-08-23 Immunogen, Inc. Cytotoxic benzodiazepine derivatives and methods of preparation
US20130058947A1 (en) 2011-09-02 2013-03-07 Stem Centrx, Inc Novel Modulators and Methods of Use
CA2849039C (en) * 2011-09-20 2018-09-18 Spirogen Sarl Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates
CA2850264C (en) 2011-10-14 2019-11-05 Spirogen Sarl Pyrrolobenzodiazepines
WO2013055990A1 (en) 2011-10-14 2013-04-18 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
AU2012322613B2 (en) 2011-10-14 2016-04-21 Medimmune Limited Pyrrolobenzodiazepines and targeted conjugates
EA028457B1 (ru) 2011-10-14 2017-11-30 Медимьюн Лимитед Пирролобензодиазепины
CA2858806A1 (en) 2011-12-23 2013-06-27 Innate Pharma Enzymatic conjugation of polypeptides
JP6401060B2 (ja) 2012-02-24 2018-10-03 アッヴィ・ステムセントルクス・エル・エル・シー 抗ｓｅｚ６抗体及び使用方法
PE20190658A1 (es) 2012-02-24 2019-05-08 Abbvie Stemcentrx Llc Moduladores y metodos de empleo novedosos
IN2014DN09922A (es) 2012-05-18 2015-08-14 Medical Res Council
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WO2014057114A1 (en) * 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-anti-psma antibody conjugates
MX2015004423A (es) * 2012-10-12 2015-10-29 Adc Therapeutics Sàrl Conjugados del anticuerpo pirrolobenzodiazepina - anti-her2.
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