CN102971329A - 用于治疗增殖性疾病的吡咯并苯并二氮杂卓 - Google Patents
用于治疗增殖性疾病的吡咯并苯并二氮杂卓 Download PDFInfo
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- CN102971329A CN102971329A CN2011800282426A CN201180028242A CN102971329A CN 102971329 A CN102971329 A CN 102971329A CN 2011800282426 A CN2011800282426 A CN 2011800282426A CN 201180028242 A CN201180028242 A CN 201180028242A CN 102971329 A CN102971329 A CN 102971329A
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Abstract
Description
L428 | 786-O | HEL | HL-60 | MCF-7 | |
IC50(nm) | <0.00001 | <0.00001 | <0.00001 | <0.00001 | 0.03 |
IC50(nM) | Caki-1 | 786-O | TF1a | MCF-7 |
11 | 0.06 | 0.1 | 0.07 | 0.2 |
18 | 0.6 | 1 | 0.7 | 2 |
IC50(nM) | 786-O | Caki-1 | MCF-7 | BxPC-3 | HL-60 | HEL |
11 | 0.85 | 0.4 | 7 | 3 | 0.1 | 0.06 |
Claims (78)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32445310P | 2010-04-15 | 2010-04-15 | |
US61/324,453 | 2010-04-15 | ||
PCT/US2011/032668 WO2011130616A1 (en) | 2010-04-15 | 2011-04-15 | Pyrrolobenzodiazepines used to treat proliferative diseases |
Publications (2)
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ZA201207357B (en) | 2015-07-29 |
US9732084B2 (en) | 2017-08-15 |
KR20130040889A (ko) | 2013-04-24 |
WO2011130616A1 (en) | 2011-10-20 |
BR112012026410B1 (pt) | 2020-12-01 |
NZ602933A (en) | 2014-09-26 |
KR101687054B1 (ko) | 2016-12-15 |
JP5875083B2 (ja) | 2016-03-02 |
MX2012011899A (es) | 2013-02-15 |
US20140066435A1 (en) | 2014-03-06 |
US8697688B2 (en) | 2014-04-15 |
EP2789622A1 (en) | 2014-10-15 |
AU2011239525A1 (en) | 2012-11-01 |
BR112012026410A8 (pt) | 2017-12-12 |
CA2795353A1 (en) | 2011-10-20 |
AU2011239525B2 (en) | 2015-04-09 |
ES2623057T3 (es) | 2017-07-10 |
EP2558475A1 (en) | 2013-02-20 |
CA2795353C (en) | 2018-01-09 |
BR112012026410B8 (pt) | 2023-01-31 |
BR112012026410A2 (pt) | 2016-09-20 |
US20130059800A1 (en) | 2013-03-07 |
EP2789622B1 (en) | 2017-03-01 |
JP2013523897A (ja) | 2013-06-17 |
MX368648B (es) | 2019-10-09 |
HK1202536A1 (zh) | 2015-10-02 |
CN102971329B (zh) | 2016-06-29 |
MX339185B (es) | 2016-05-16 |
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