JP5875083B2 - 増殖性疾患治療用ピロロベンゾジアゼピン - Google Patents

増殖性疾患治療用ピロロベンゾジアゼピン Download PDF

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JP5875083B2
JP5875083B2 JP2013505172A JP2013505172A JP5875083B2 JP 5875083 B2 JP5875083 B2 JP 5875083B2 JP 2013505172 A JP2013505172 A JP 2013505172A JP 2013505172 A JP2013505172 A JP 2013505172A JP 5875083 B2 JP5875083 B2 JP 5875083B2
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JP2013523897A5 (enExample
JP2013523897A (ja
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ハワード，フィリップ，ウィルソン
マスターソン，ルーク
ティベルギーン，アルノー
ジェフリー，スコット
バーク，パトリック
センター，ピーター
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MedImmune Ltd
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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  • Bioinformatics & Cheminformatics (AREA)
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  • Immunology (AREA)
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  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Cell Biology (AREA)
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  • Rheumatology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
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  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Emergency Medicine (AREA)
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JP2013505172A 2010-04-15 2011-04-15 増殖性疾患治療用ピロロベンゾジアゼピン Active JP5875083B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32445310P 2010-04-15 2010-04-15
US61/324,453 2010-04-15
PCT/US2011/032668 WO2011130616A1 (en) 2010-04-15 2011-04-15 Pyrrolobenzodiazepines used to treat proliferative diseases

Publications (3)

Publication Number Publication Date
JP2013523897A JP2013523897A (ja) 2013-06-17
JP2013523897A5 JP2013523897A5 (enExample) 2014-05-29
JP5875083B2 true JP5875083B2 (ja) 2016-03-02

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JP2013505172A Active JP5875083B2 (ja) 2010-04-15 2011-04-15 増殖性疾患治療用ピロロベンゾジアゼピン

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Country Link
US (2) US8697688B2 (enExample)
EP (2) EP2789622B1 (enExample)
JP (1) JP5875083B2 (enExample)
KR (1) KR101687054B1 (enExample)
CN (1) CN102971329B (enExample)
AU (1) AU2011239525B2 (enExample)
BR (1) BR112012026410B8 (enExample)
CA (1) CA2795353C (enExample)
ES (1) ES2623057T3 (enExample)
MX (2) MX368648B (enExample)
NZ (1) NZ602933A (enExample)
WO (1) WO2011130616A1 (enExample)
ZA (1) ZA201207357B (enExample)

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CA3014224C (en) 2009-02-05 2022-05-24 Immunogen, Inc. Condensed benzodiazepine-indoline derivatives and processes to prepare said derivatives
CN103068405A (zh) 2010-04-15 2013-04-24 西雅图基因公司 靶向吡咯并苯并二氮杂卓结合物
MX368648B (es) 2010-04-15 2019-10-09 Seattle Genetics Inc Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas.
SI2675480T1 (sl) 2011-02-15 2019-05-31 Immunogen, Inc. Metode priprave konjugatov
US20130058947A1 (en) 2011-09-02 2013-03-07 Stem Centrx, Inc Novel Modulators and Methods of Use
US9399641B2 (en) 2011-09-20 2016-07-26 Medimmune Limited Pyrrolobenzodiazepines as unsymmetrical dimeric PBD compounds for inclusion in targeted conjugates
CA2850375C (en) 2011-10-14 2019-07-02 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
AU2012322934B2 (en) 2011-10-14 2016-09-08 Medimmune Limited Pyrrolobenzodiazepines
CA2850264C (en) 2011-10-14 2019-11-05 Medimmune Limited Pyrrolobenzodiazepines
CA2850373C (en) 2011-10-14 2019-07-16 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
CA2858806A1 (en) 2011-12-23 2013-06-27 Innate Pharma Enzymatic conjugation of polypeptides
RU2691698C2 (ru) 2012-02-24 2019-06-17 ЭББВИ СТЕМСЕНТРКС ЭлЭлСи Антитела против sez6 и способы их применения
CN104520324A (zh) 2012-02-24 2015-04-15 施特姆森特Rx股份有限公司 Dll3调节剂及其使用方法
EP2852664B1 (en) 2012-05-18 2017-09-06 Medical Research Council Methods of incorporating an amino acid comprising a bcn group into a polypeptide using an orthogonal codon encoding it and an orthorgonal pylrs synthase.
EP2872894B1 (en) 2012-07-13 2019-04-17 Innate Pharma Screening of conjugated antibodies
KR101995620B1 (ko) 2012-10-12 2019-07-03 에이디씨 테라퓨틱스 에스에이 피롤로벤조디아제핀-항체 컨주게이트
WO2014057118A1 (en) * 2012-10-12 2014-04-17 Adc Therapeutics Sarl Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
BR112015008238A2 (pt) 2012-10-12 2017-11-28 Adc Therapeutics Sarl conjugados de pirrolbenzodiazepina-anticorpo anti-cd22
EP2906249B1 (en) 2012-10-12 2018-06-27 MedImmune Limited Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
EP2906297B1 (en) 2012-10-12 2017-12-06 ADC Therapeutics SA Pyrrolobenzodiazepine-antibody conjugates
PT2906253T (pt) * 2012-10-12 2018-11-05 Medimmune Ltd Conjugados de anticorpo anti-psma de pirrolobenzodiazepina
DK2906298T3 (en) * 2012-10-12 2018-12-17 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
PT2906252T (pt) * 2012-10-12 2017-09-19 Medimmune Ltd Conjugados de anticorpo anti-her2 de pirrolobenzodiazepina
DK2839860T3 (da) 2012-10-12 2019-06-17 Medimmune Ltd Pyrrolobenzodiazepiner og konjugater deraf
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