JP5875083B2 - 増殖性疾患治療用ピロロベンゾジアゼピン - Google Patents

増殖性疾患治療用ピロロベンゾジアゼピン Download PDF

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JP5875083B2
JP5875083B2 JP2013505172A JP2013505172A JP5875083B2 JP 5875083 B2 JP5875083 B2 JP 5875083B2 JP 2013505172 A JP2013505172 A JP 2013505172A JP 2013505172 A JP2013505172 A JP 2013505172A JP 5875083 B2 JP5875083 B2 JP 5875083B2
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JP2013523897A5 (enExample
JP2013523897A (ja
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ハワード，フィリップ，ウィルソン
マスターソン，ルーク
ティベルギーン，アルノー
ジェフリー，スコット
バーク，パトリック
センター，ピーター
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MedImmune Ltd
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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  • Diabetes (AREA)
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  • Pulmonology (AREA)
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  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
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  • Gynecology & Obstetrics (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
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  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
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JP2013505172A 2010-04-15 2011-04-15 増殖性疾患治療用ピロロベンゾジアゼピン Active JP5875083B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32445310P 2010-04-15 2010-04-15
US61/324,453 2010-04-15
PCT/US2011/032668 WO2011130616A1 (en) 2010-04-15 2011-04-15 Pyrrolobenzodiazepines used to treat proliferative diseases

Publications (3)

Publication Number Publication Date
JP2013523897A JP2013523897A (ja) 2013-06-17
JP2013523897A5 JP2013523897A5 (enExample) 2014-05-29
JP5875083B2 true JP5875083B2 (ja) 2016-03-02

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JP2013505172A Active JP5875083B2 (ja) 2010-04-15 2011-04-15 増殖性疾患治療用ピロロベンゾジアゼピン

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Country Link
US (2) US8697688B2 (enExample)
EP (2) EP2789622B1 (enExample)
JP (1) JP5875083B2 (enExample)
KR (1) KR101687054B1 (enExample)
CN (1) CN102971329B (enExample)
AU (1) AU2011239525B2 (enExample)
BR (1) BR112012026410B8 (enExample)
CA (1) CA2795353C (enExample)
ES (1) ES2623057T3 (enExample)
MX (2) MX339185B (enExample)
NZ (1) NZ602933A (enExample)
WO (1) WO2011130616A1 (enExample)
ZA (1) ZA201207357B (enExample)

Families Citing this family (168)

* Cited by examiner, † Cited by third party
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GB0819095D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
CN105198908B (zh) 2009-02-05 2019-12-24 伊缪诺金公司 新型苯并二氮杂*衍生物
ES2623057T3 (es) 2010-04-15 2017-07-10 Medimmune Limited Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas
CN103068405A (zh) 2010-04-15 2013-04-24 西雅图基因公司 靶向吡咯并苯并二氮杂卓结合物
PT2675480T (pt) 2011-02-15 2019-04-15 Immunogen Inc Métodos para preparação de conjugados
US20130058947A1 (en) 2011-09-02 2013-03-07 Stem Centrx, Inc Novel Modulators and Methods of Use
CN103987718A (zh) * 2011-09-20 2014-08-13 斯皮罗根有限公司 作为非对称二聚体pbd化合物用于内含在靶向结合物中的吡咯并苯并二氮杂卓
CA2850373C (en) 2011-10-14 2019-07-16 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
CA2850375C (en) 2011-10-14 2019-07-02 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
CN103998450B (zh) 2011-10-14 2017-03-08 麦迪穆有限责任公司 吡咯并苯并二氮杂卓
CN103998449A (zh) * 2011-10-14 2014-08-20 斯皮罗根有限公司 吡咯并苯并二氮杂卓
US9717803B2 (en) 2011-12-23 2017-08-01 Innate Pharma Enzymatic conjugation of polypeptides
PL2817338T3 (pl) 2012-02-24 2017-12-29 Abbvie Stemcentrx Llc Modulatory DLL3 i sposoby zastosowania
CN108383909B (zh) 2012-02-24 2021-08-24 艾伯维施特姆森特克斯有限责任公司 抗sez6抗体及使用方法
JP6343604B2 (ja) 2012-05-18 2018-06-13 メディカル リサーチ カウンシル ＢＣＮ基を含むアミノ酸をコードする直交性コドンと、直交性ＰｙｌＲＳ合成酵素とを使用して、ＢＣＮ基を含むアミノ酸をポリペプチドに取り込む方法
EP2872894B1 (en) 2012-07-13 2019-04-17 Innate Pharma Screening of conjugated antibodies
WO2014057120A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-antibody conjugates
HRP20182129T1 (hr) * 2012-10-12 2019-02-08 Adc Therapeutics Sa Konjugati protutijelo - pirolobenzodiazepin
WO2014057118A1 (en) * 2012-10-12 2014-04-17 Adc Therapeutics Sarl Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
LT2906251T (lt) * 2012-10-12 2017-12-11 Adc Therapeutics Sa Pirolobenzodiazepino-anti-cd22 antikūno konjugatai
CN104703630A (zh) 2012-10-12 2015-06-10 斯皮罗根有限公司 吡咯并苯并二氮杂卓及其结合物
ES2680153T3 (es) 2012-10-12 2018-09-04 Adc Therapeutics Sa Conjugados de anticuerpos anti-PSMA-pirrolobenzodiazepinas
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