JP5875083B2 - 増殖性疾患治療用ピロロベンゾジアゼピン - Google Patents

増殖性疾患治療用ピロロベンゾジアゼピン Download PDF

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JP5875083B2
JP5875083B2 JP2013505172A JP2013505172A JP5875083B2 JP 5875083 B2 JP5875083 B2 JP 5875083B2 JP 2013505172 A JP2013505172 A JP 2013505172A JP 2013505172 A JP2013505172 A JP 2013505172A JP 5875083 B2 JP5875083 B2 JP 5875083B2
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JP2013523897A (ja
JP2013523897A5 (enExample
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ハワード，フィリップ，ウィルソン
マスターソン，ルーク
ティベルギーン，アルノー
ジェフリー，スコット
バーク，パトリック
センター，ピーター
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MedImmune Ltd
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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  • Immunology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
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  • Cardiology (AREA)
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  • Biomedical Technology (AREA)
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JP2013505172A 2010-04-15 2011-04-15 増殖性疾患治療用ピロロベンゾジアゼピン Active JP5875083B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32445310P 2010-04-15 2010-04-15
US61/324,453 2010-04-15
PCT/US2011/032668 WO2011130616A1 (en) 2010-04-15 2011-04-15 Pyrrolobenzodiazepines used to treat proliferative diseases

Publications (3)

Publication Number Publication Date
JP2013523897A JP2013523897A (ja) 2013-06-17
JP2013523897A5 JP2013523897A5 (enExample) 2014-05-29
JP5875083B2 true JP5875083B2 (ja) 2016-03-02

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JP2013505172A Active JP5875083B2 (ja) 2010-04-15 2011-04-15 増殖性疾患治療用ピロロベンゾジアゼピン

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Country Link
US (2) US8697688B2 (enExample)
EP (2) EP2789622B1 (enExample)
JP (1) JP5875083B2 (enExample)
KR (1) KR101687054B1 (enExample)
CN (1) CN102971329B (enExample)
AU (1) AU2011239525B2 (enExample)
BR (1) BR112012026410B8 (enExample)
CA (1) CA2795353C (enExample)
ES (1) ES2623057T3 (enExample)
MX (2) MX339185B (enExample)
NZ (1) NZ602933A (enExample)
WO (1) WO2011130616A1 (enExample)
ZA (1) ZA201207357B (enExample)

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* Cited by examiner, † Cited by third party
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GB0819095D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
CN102365021B (zh) 2009-02-05 2015-07-15 伊缪诺金公司 新型苯并二氮杂*衍生物
ES2623057T3 (es) 2010-04-15 2017-07-10 Medimmune Limited Pirrolobenzodiazepinas usadas para tratar enfermedades proliferativas
JP5870400B2 (ja) 2010-04-15 2016-03-01 シアトル ジェネティクス，インコーポレーテッド 標的化ピロロベンゾジアゼピンコンジュゲート
KR20140010076A (ko) 2011-02-15 2014-01-23 이뮤노젠 아이엔씨 세포독성 벤조다이아제핀 유도체
US20130058947A1 (en) 2011-09-02 2013-03-07 Stem Centrx, Inc Novel Modulators and Methods of Use
SG11201400770SA (en) 2011-09-20 2014-04-28 Spirogen Sarl Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates
MX358757B (es) 2011-10-14 2018-09-03 Seattle Genetics Inc Pirrolobenzodiazepinas y conjugados dirigidos.
SG11201401021TA (en) 2011-10-14 2014-08-28 Spirogen Sarl Pyrrolobenzodiazepines
US9526798B2 (en) 2011-10-14 2016-12-27 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
CN103998449A (zh) * 2011-10-14 2014-08-20 斯皮罗根有限公司 吡咯并苯并二氮杂卓
AU2012356894B2 (en) 2011-12-23 2018-01-18 Araris Biotech Ltd. Enzymatic conjugation of polypeptides
SG10201801444WA (en) 2012-02-24 2018-04-27 Abbvie Stemcentrx Llc Anti sez6 antibodies and methods of use
RU2014138474A (ru) 2012-02-24 2016-04-10 СтемСентРкс, Инк. Новые модуляторы и способы применения
JP6343604B2 (ja) 2012-05-18 2018-06-13 メディカル リサーチ カウンシル ＢＣＮ基を含むアミノ酸をコードする直交性コドンと、直交性ＰｙｌＲＳ合成酵素とを使用して、ＢＣＮ基を含むアミノ酸をポリペプチドに取り込む方法
WO2014009426A2 (en) 2012-07-13 2014-01-16 Innate Pharma Screening of conjugated antibodies
NZ707486A (en) * 2012-10-12 2018-09-28 Adc Therapeutics Sa Pyrrolobenzodiazepine - anti-psma antibody conjugates
ES2738310T3 (es) 2012-10-12 2020-01-21 Medimmune Ltd Pirrolobenzodiazepinas y conjugados de las mismas
US9931414B2 (en) 2012-10-12 2018-04-03 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
WO2014057118A1 (en) * 2012-10-12 2014-04-17 Adc Therapeutics Sarl Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
BR112015008251B1 (pt) * 2012-10-12 2023-09-26 Medimmune Limited Pirrolobenzodiazepinas, conjugados destas, composição e composição farmacêutica compreendendo os conjugados, uso dos conjugados para o tratamento de uma doença proliferativa e método para preparar os conjugados
ES2649990T3 (es) * 2012-10-12 2018-01-16 Medimmune Limited Conjugados de anticuerpos anti-CD22-pirrolobenzodiazepinas
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