EA027386B1 - Пирролобензодиазепины - Google Patents
Пирролобензодиазепины Download PDFInfo
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- EA027386B1 EA027386B1 EA201490554A EA201490554A EA027386B1 EA 027386 B1 EA027386 B1 EA 027386B1 EA 201490554 A EA201490554 A EA 201490554A EA 201490554 A EA201490554 A EA 201490554A EA 027386 B1 EA027386 B1 EA 027386B1
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- EA
- Eurasian Patent Office
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- YUOCYTRGANSSRY-UHFFFAOYSA-N pyrrolo[2,3-i][1,2]benzodiazepine Chemical class C1=CN=NC2=C3C=CN=C3C=CC2=C1 YUOCYTRGANSSRY-UHFFFAOYSA-N 0.000 title description 4
- -1 methoxy, ethoxy Chemical group 0.000 claims abstract description 91
- 125000001424 substituent group Chemical group 0.000 claims abstract description 52
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Classifications
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| CN103987718A (zh) | 2011-09-20 | 2014-08-13 | 斯皮罗根有限公司 | 作为非对称二聚体pbd化合物用于内含在靶向结合物中的吡咯并苯并二氮杂卓 |
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| CN113631560B (zh) | 2019-03-15 | 2025-02-18 | 麦迪穆有限责任公司 | 氮杂环丁烷并苯并二氮杂䓬二聚体和用于治疗癌症的包含它们的缀合物 |
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- 2012-10-12 JP JP2014535095A patent/JP6117801B2/ja active Active
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- 2012-10-12 EP EP12772780.8A patent/EP2751110B1/en not_active Not-in-force
- 2012-10-12 AU AU2012322932A patent/AU2012322932B2/en not_active Ceased
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| WO2010043880A1 (en) * | 2008-10-17 | 2010-04-22 | Spirogen Limited | Unsymmetrical pyrrolobenzodiazepine-dimers for treatment of proliferative diseases |
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|---|---|
| US20140234346A1 (en) | 2014-08-21 |
| EA201490554A1 (ru) | 2015-06-30 |
| CN103998449A (zh) | 2014-08-20 |
| US9388187B2 (en) | 2016-07-12 |
| CN110183470A (zh) | 2019-08-30 |
| JP2014528466A (ja) | 2014-10-27 |
| AU2012322932A1 (en) | 2014-05-29 |
| EP2751110A1 (en) | 2014-07-09 |
| EP2751110B1 (en) | 2017-04-19 |
| JP6117801B2 (ja) | 2017-04-19 |
| BR112014008981A2 (pt) | 2017-05-02 |
| CA2850264C (en) | 2019-11-05 |
| CA2850264A1 (en) | 2013-04-18 |
| AU2012322932B2 (en) | 2016-11-10 |
| WO2013053871A1 (en) | 2013-04-18 |
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