JP2012504608A5 - - Google Patents
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- JP2012504608A5 JP2012504608A5 JP2011530057A JP2011530057A JP2012504608A5 JP 2012504608 A5 JP2012504608 A5 JP 2012504608A5 JP 2011530057 A JP2011530057 A JP 2011530057A JP 2011530057 A JP2011530057 A JP 2011530057A JP 2012504608 A5 JP2012504608 A5 JP 2012504608A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- pharmaceutical composition
- halogen
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 150000001875 compounds Chemical class 0.000 claims 20
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 229910052736 halogen Inorganic materials 0.000 claims 13
- 150000002367 halogens Chemical class 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 11
- 125000001424 substituent group Chemical group 0.000 claims 10
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 9
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 9
- -1 cyano, hydroxy Chemical group 0.000 claims 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 6
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 6
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims 6
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 6
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 4
- 125000001931 aliphatic group Chemical group 0.000 claims 4
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 4
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000003282 alkyl amino group Chemical group 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 208000030761 polycystic kidney disease Diseases 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10254108P | 2008-10-03 | 2008-10-03 | |
| US61/102,541 | 2008-10-03 | ||
| PCT/US2009/005435 WO2010039256A1 (en) | 2008-10-03 | 2009-10-02 | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015075248A Division JP6175465B2 (ja) | 2008-10-03 | 2015-04-01 | ２−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012504608A JP2012504608A (ja) | 2012-02-23 |
| JP2012504608A5 true JP2012504608A5 (enExample) | 2012-10-25 |
Family
ID=41402426
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011530057A Withdrawn JP2012504608A (ja) | 2008-10-03 | 2009-10-02 | ２−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
| JP2015075248A Expired - Fee Related JP6175465B2 (ja) | 2008-10-03 | 2015-04-01 | ２−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
| JP2017095022A Expired - Fee Related JP6297194B2 (ja) | 2008-10-03 | 2017-05-11 | ２−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
| JP2018028160A Pending JP2018087232A (ja) | 2008-10-03 | 2018-02-20 | ２−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015075248A Expired - Fee Related JP6175465B2 (ja) | 2008-10-03 | 2015-04-01 | ２−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
| JP2017095022A Expired - Fee Related JP6297194B2 (ja) | 2008-10-03 | 2017-05-11 | ２−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
| JP2018028160A Pending JP2018087232A (ja) | 2008-10-03 | 2018-02-20 | ２−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8309593B2 (enExample) |
| EP (2) | EP3078373A1 (enExample) |
| JP (4) | JP2012504608A (enExample) |
| KR (1) | KR101687039B1 (enExample) |
| CN (2) | CN102271678B (enExample) |
| CA (1) | CA2738768C (enExample) |
| IL (2) | IL211946A (enExample) |
| MX (1) | MX2011003517A (enExample) |
| RU (1) | RU2578947C2 (enExample) |
| WO (1) | WO2010039256A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008519840A (ja) | 2004-11-10 | 2008-06-12 | ジェンザイム・コーポレイション | 糖尿病の処置方法 |
| WO2007134086A2 (en) | 2006-05-09 | 2007-11-22 | Genzyme Corporation | Methods of treating fatty liver disease comprising inhibiting glucosphingolipid synthesis |
| EP2594562B1 (en) * | 2007-05-31 | 2016-07-20 | Genzyme Corporation | 2-acylaminopropanol-type glucosylceramide synthase inhibitors |
| KR101640263B1 (ko) * | 2007-10-05 | 2016-07-15 | 젠자임 코포레이션 | 세라마이드 유도체로 다낭성 신장질환을 치료하는 방법 |
| JP2011529500A (ja) * | 2008-07-28 | 2011-12-08 | ジェンザイム コーポレーション | 虚脱性糸球体症および他の糸球体疾患の処置のためのグルコシルセラミドシンターゼ阻害 |
| US8309593B2 (en) | 2008-10-03 | 2012-11-13 | Genzyme Corporation | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
| WO2013059119A1 (en) * | 2011-10-17 | 2013-04-25 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
| CN102702010B (zh) * | 2012-05-23 | 2014-09-17 | 北京大学 | 光敏感的功能化固载相及其制备方法和应用 |
| CA2906396A1 (en) | 2013-03-15 | 2014-09-25 | Concert Pharmaceuticals Inc. | Inhibitors of the enzyme udp-glucose: n-acyl-sphingosine glucosyltransferase |
| AU2014321397C1 (en) * | 2013-09-20 | 2019-08-01 | Biomarin Pharmaceutical Inc. | Glucosylceramide synthase inhibitors for the treatment of diseases |
| US20170129869A1 (en) * | 2014-07-03 | 2017-05-11 | Dr. Reddy's Laboratories Limited | Amorphous form of eliglustat hemitartarate |
| WO2016126572A2 (en) | 2015-02-02 | 2016-08-11 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
| EP3268355B1 (en) * | 2015-03-11 | 2019-06-12 | BioMarin Pharmaceutical Inc. | Glucosylceramide synthase inhibitors for the treatment of diseases |
| JP6895963B2 (ja) | 2015-11-18 | 2021-06-30 | ジェンザイム・コーポレーション | 多発性嚢胞腎のバイオマーカーおよびその使用 |
| JP6940515B2 (ja) | 2016-03-25 | 2021-09-29 | ジェンザイム・コーポレーション | タンパク質症のバイオマーカーおよびその使用 |
| WO2017204319A1 (ja) * | 2016-05-27 | 2017-11-30 | 公益財団法人野口研究所 | グルコシルセラミド合成酵素阻害剤 |
| US20200339587A1 (en) | 2017-12-21 | 2020-10-29 | Lysosomal Therapeutics Inc. | Crystalline substituted cyclohexyl pyrazolo[1,5-a]pyrimidinyl carboxamide compound and therapeutic uses thereof |
Family Cites Families (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1555654A (en) | 1977-06-25 | 1979-11-14 | Exxon Research Engineering Co | Agricultural burner apparatus |
| US4065562A (en) | 1975-12-29 | 1977-12-27 | Nippon Shinyaku Co., Ltd. | Method and composition for reducing blood glucose levels |
| NO154918C (no) | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
| GB2020278B (en) | 1978-05-03 | 1983-02-23 | Nippon Shinyaku Co Ltd | Moranoline dervitives |
| JPS568318A (en) | 1979-06-28 | 1981-01-28 | Janssen Pharmaceutica Nv | Non oral long acting composition of haloperidol and bromperidol derivative |
| GB8311286D0 (en) | 1983-04-26 | 1983-06-02 | Searle & Co | Carboxyalkyl peptide derivatives |
| EP0144290A3 (de) | 1983-12-01 | 1987-05-27 | Ciba-Geigy Ag | Substituierte Aethylendiaminderivate |
| US5041441A (en) | 1988-04-04 | 1991-08-20 | The Regents Of The University Of Michigan | Method of chemotherapy using 1-phenyl-2-decanoylamino-3-morpholino-1-propanol |
| JPH0416856A (ja) | 1990-05-10 | 1992-01-21 | Canon Inc | 正帯電性非磁性トナー |
| JPH04140984A (ja) | 1990-10-02 | 1992-05-14 | Canon Inc | スチルビデオカメラ |
| RU2005102C1 (ru) * | 1991-06-21 | 1993-12-30 | Институт геологии Карельского научного центра РАН | Способ получени декоративного стекла |
| US5302609A (en) | 1992-12-16 | 1994-04-12 | The Regents Of The University Of Michigan | Treatment of diabetic nephropathy |
| US5399567A (en) | 1993-05-13 | 1995-03-21 | Monsanto Company | Method of treating cholera |
| HUT73527A (en) | 1993-08-13 | 1996-08-28 | Seikagaku Kogyo Co Ltd | Remedy for nervous diseases |
| EP1008342A3 (en) | 1994-02-02 | 2004-12-29 | The Liposome Company, Inc. | Pharmaceutically active compounds and liposomes, and methods of use thereof |
| WO1995034530A1 (en) | 1994-06-10 | 1995-12-21 | Seikagaku Corporation | 2-acylaminopropanol compound and medicinal composition |
| US20030073680A1 (en) | 1995-09-20 | 2003-04-17 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| WO2001004108A1 (en) | 1999-07-09 | 2001-01-18 | Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US6255336B1 (en) | 1995-09-20 | 2001-07-03 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US5916911A (en) | 1995-09-20 | 1999-06-29 | The Regents Of The University Of Michigan | Amino ceramide--like compounds and therapeutic methods of use |
| JP3993908B2 (ja) | 1995-12-08 | 2007-10-17 | 生化学工業株式会社 | アミノアルコール誘導体及び該誘導体の製造方法 |
| NO965193L (no) | 1995-12-08 | 1997-06-09 | Seikagaku Kogyo Kk Seikagaku C | Aminalkoholderivat og fremgangsmåte for fremstilling derav |
| JP4140984B2 (ja) | 1995-12-20 | 2008-08-27 | 生化学工業株式会社 | 分化誘導作用を有する薬剤 |
| US5972928A (en) * | 1997-05-21 | 1999-10-26 | Johns Hopkins University | Methods for treatment of conditions associated with lactosylceramide |
| JP4036500B2 (ja) | 1997-05-23 | 2008-01-23 | 生化学工業株式会社 | アミノアルコール誘導体及びそれを含有する医薬 |
| JP4176170B2 (ja) | 1997-06-06 | 2008-11-05 | 生化学工業株式会社 | アミノアルコール誘導体を含む医薬及び異常増殖性疾患治療薬 |
| US6465488B1 (en) | 1997-12-11 | 2002-10-15 | Chancellor, Masters & Scholars Of The University Of Oxford | Inhibition of glycolipid biosynthesis |
| EP1098642B1 (en) | 1998-07-27 | 2007-04-04 | Johns Hopkins University | Diamino-propanol-compounds for treating ischemia |
| US6610703B1 (en) | 1998-12-10 | 2003-08-26 | G.D. Searle & Co. | Method for treatment of glycolipid storage diseases |
| GB0100889D0 (en) | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
| EP1384719A1 (en) | 1999-07-09 | 2004-01-28 | The Regents of The University of Michigan | Inhibitors of the glucosyl ceramide synthase enzyme useful for the treatment of cancers, sphingolipidosis and microbial infections |
| MXPA02000296A (es) * | 1999-07-09 | 2004-05-21 | Univ Michigan | Compuestos parecidos a aminoceramida y metodos de uso. |
| JP5009459B2 (ja) * | 1999-12-06 | 2012-08-22 | 生化学工業株式会社 | アミノアルコール誘導体及びそれを含有する医薬 |
| US6407064B2 (en) | 1999-12-06 | 2002-06-18 | Seikagaku Corporation | Aminoalcohol derivative and medicament comprising the same |
| US6235737B1 (en) | 2000-01-25 | 2001-05-22 | Peter Styczynski | Reduction of hair growth |
| AR028023A1 (es) | 2000-04-19 | 2003-04-23 | Borody Thomas J | Una composicion farmaceutica para el tratamiento de la hiperlipidemia y el uso de dicha composicion para la preparacion de medicamentos |
| CA2432908A1 (en) | 2000-12-20 | 2002-06-27 | Bristol-Myers Squibb Pharma Company | Diamines as modulators of chemokine receptor activity |
| CA2431679A1 (en) | 2000-12-29 | 2002-07-11 | Wyeth | Method for the regioselective preparation of substituted benzo[g]quinoline-3-carbonitriles and benzo[g]quinazolines |
| WO2002062777A2 (en) | 2001-01-10 | 2002-08-15 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US7148251B2 (en) | 2001-01-10 | 2006-12-12 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US20040260099A1 (en) | 2001-01-10 | 2004-12-23 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US20020198240A1 (en) | 2001-01-10 | 2002-12-26 | Shayman James A. | Amino ceramide - like compounds and therapeutic methods of use |
| PT2266968E (pt) | 2001-07-16 | 2013-02-25 | Genzyme Corp | Síntese de udp-glucose: inibidores de n-acil esfingosinaglucosiltransferase |
| WO2003045928A1 (en) | 2001-11-26 | 2003-06-05 | Genzyme Corporation | Diastereoselective synthesis of udp-glucose : n-acylsphingosine glucosyltransferase inhibitors |
| GB0229931D0 (en) | 2002-12-21 | 2003-01-29 | Astrazeneca Ab | Therapeutic agents |
| JPWO2003057874A1 (ja) | 2001-12-28 | 2005-05-19 | 住友製薬株式会社 | 腎疾患の疾患マーカー及びその利用 |
| ATE314370T1 (de) * | 2002-01-22 | 2006-01-15 | Warner Lambert Co | 2-(pyridin-2-ylamino)-pyrido(2,3-d)pyrimidin-7- one |
| EP1336411A1 (en) | 2002-02-14 | 2003-08-20 | Academisch Medisch Centrum bij de Universiteit van Amsterdam | Compositions and methods for improving enzyme replacement therapy of lysosomal storage diseases |
| JP2003238410A (ja) | 2002-02-21 | 2003-08-27 | Seibutsu Yuki Kagaku Kenkyusho:Kk | インスリン抵抗性解除剤 |
| US20060217560A1 (en) | 2002-04-29 | 2006-09-28 | Shayman James A | Amino ceramide-like compounds and therapeutic methods of use |
| US6916802B2 (en) | 2002-04-29 | 2005-07-12 | Genzyme Corporation | Amino ceramide-like compounds and therapeutic methods of use |
| US7985760B2 (en) | 2002-07-17 | 2011-07-26 | Actelion Pharmaceuticals Ltd. | Piperidinetriol derivatives as inhibitors of glycosyceramid synthase |
| BR0312947A (pt) | 2002-07-17 | 2007-07-10 | Biogen Idec Inc | terapias para insuficiência renal empregando-se interferon-beta |
| WO2004078194A1 (en) | 2003-02-28 | 2004-09-16 | Intermune, Inc. | Interferon drug therapy for the treatment of viral diseases and liver fibrosis |
| GB0313678D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compounds |
| EP1528056A1 (en) | 2003-10-29 | 2005-05-04 | Academisch Ziekenhuis bij de Universiteit van Amsterdam | Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors |
| WO2005039578A2 (en) | 2003-10-29 | 2005-05-06 | Macrozyme B.V. | Use of a deoxynojirimycin derivative or a pharmaceutically salt thereof |
| US20070270350A1 (en) | 2003-12-23 | 2007-11-22 | Musc Foundation For Research Development | Methods and Compositions for the Prevention and Treatment of Inflammatory Diseases or Conditions |
| GB0400812D0 (en) | 2004-01-14 | 2004-02-18 | Celltech R&D Ltd | Novel compounds |
| EP1576894A1 (en) | 2004-03-16 | 2005-09-21 | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO | The use of sphingolipids in the treatment and prevention of type 2 diabetes mellitus, insulin resistance and Metabolic Syndrome |
| ATE500752T1 (de) | 2004-03-16 | 2011-03-15 | Tno | Verwendung von sphingolipiden bei der behandlung und vorbeugung von typ-2-diabetes mellitus, insulinresistenz und metabolismussyndrom |
| US20070224200A1 (en) | 2004-05-07 | 2007-09-27 | Samer Elbawab | Gm3 Synthase as a Therapeutic Target in Microvascular Complications of Diabetes |
| WO2005123055A2 (en) | 2004-06-14 | 2005-12-29 | Musc Foundation For Research Development | Methods for treating inflammatory disorders |
| CA2581173A1 (en) | 2004-08-20 | 2006-03-02 | The Johns Hopkins University | Methods for treatment of angiogenesis |
| JP2008519840A (ja) | 2004-11-10 | 2008-06-12 | ジェンザイム・コーポレイション | 糖尿病の処置方法 |
| US20090088433A1 (en) * | 2005-01-26 | 2009-04-02 | Bertrand Leblond | Methods of using as analgesics 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds |
| US8389472B2 (en) | 2005-08-19 | 2013-03-05 | Amylin Pharmaceuticals, Llc | Exendin-4 to treat nonalcoholic steatohepatitis and nonalcoholic fatty liver disease |
| WO2007134086A2 (en) | 2006-05-09 | 2007-11-22 | Genzyme Corporation | Methods of treating fatty liver disease comprising inhibiting glucosphingolipid synthesis |
| WO2008011478A2 (en) | 2006-07-19 | 2008-01-24 | Allergan, Inc. | Methods for treating chronic pain using 3-aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds |
| WO2008011487A2 (en) | 2006-07-19 | 2008-01-24 | Allergan, Inc. | L-benzyl-l-hydr0xy-2, 3-diamin0-propyl amines and 3-benzyl-3-hydroxy-2-amino-propionicacid amides for chronic pain |
| GB0614947D0 (en) | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
| TWI389895B (zh) | 2006-08-21 | 2013-03-21 | Infinity Discovery Inc | 抑制ｂｃｌ蛋白質與結合夥伴間之交互作用的化合物及方法 |
| EP2117541A1 (en) * | 2007-02-09 | 2009-11-18 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
| EP2594562B1 (en) | 2007-05-31 | 2016-07-20 | Genzyme Corporation | 2-acylaminopropanol-type glucosylceramide synthase inhibitors |
| KR101640263B1 (ko) | 2007-10-05 | 2016-07-15 | 젠자임 코포레이션 | 세라마이드 유도체로 다낭성 신장질환을 치료하는 방법 |
| WO2009117150A2 (en) | 2008-03-20 | 2009-09-24 | Genzyme Corporation | Method of treating lupus with ceramide derivatives |
| JP2011529500A (ja) | 2008-07-28 | 2011-12-08 | ジェンザイム コーポレーション | 虚脱性糸球体症および他の糸球体疾患の処置のためのグルコシルセラミドシンターゼ阻害 |
| US8309593B2 (en) | 2008-10-03 | 2012-11-13 | Genzyme Corporation | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
-
2009
- 2009-10-02 US US13/122,135 patent/US8309593B2/en not_active Expired - Fee Related
- 2009-10-02 JP JP2011530057A patent/JP2012504608A/ja not_active Withdrawn
- 2009-10-02 WO PCT/US2009/005435 patent/WO2010039256A1/en not_active Ceased
- 2009-10-02 CN CN200980147488.8A patent/CN102271678B/zh not_active Expired - Fee Related
- 2009-10-02 KR KR1020117010056A patent/KR101687039B1/ko not_active Expired - Fee Related
- 2009-10-02 MX MX2011003517A patent/MX2011003517A/es active IP Right Grant
- 2009-10-02 CA CA2738768A patent/CA2738768C/en not_active Expired - Fee Related
- 2009-10-02 EP EP16162074.5A patent/EP3078373A1/en not_active Withdrawn
- 2009-10-02 RU RU2011117028/15A patent/RU2578947C2/ru not_active IP Right Cessation
- 2009-10-02 EP EP09741487.4A patent/EP2349255B1/en not_active Not-in-force
- 2009-10-02 CN CN201710483611.XA patent/CN107935983A/zh active Pending
-
2011
- 2011-03-27 IL IL211946A patent/IL211946A/en not_active IP Right Cessation
-
2012
- 2012-08-27 US US13/595,251 patent/US9272996B2/en not_active Expired - Fee Related
-
2015
- 2015-04-01 JP JP2015075248A patent/JP6175465B2/ja not_active Expired - Fee Related
- 2015-05-03 IL IL238583A patent/IL238583B/en not_active IP Right Cessation
-
2016
- 2016-01-21 US US15/003,207 patent/US9744153B2/en not_active Expired - Fee Related
-
2017
- 2017-05-11 JP JP2017095022A patent/JP6297194B2/ja not_active Expired - Fee Related
-
2018
- 2018-02-20 JP JP2018028160A patent/JP2018087232A/ja active Pending
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