JP2013506715A5 - - Google Patents
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- JP2013506715A5 JP2013506715A5 JP2012533248A JP2012533248A JP2013506715A5 JP 2013506715 A5 JP2013506715 A5 JP 2013506715A5 JP 2012533248 A JP2012533248 A JP 2012533248A JP 2012533248 A JP2012533248 A JP 2012533248A JP 2013506715 A5 JP2013506715 A5 JP 2013506715A5
- Authority
- JP
- Japan
- Prior art keywords
- nitrogen
- oxygen
- membered
- ring
- sulfur
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24909509P | 2009-10-06 | 2009-10-06 | |
| US61/249,095 | 2009-10-06 | ||
| PCT/US2010/051517 WO2011044157A1 (en) | 2009-10-06 | 2010-10-05 | Heterocyclic compounds useful as pdk1 inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016155272A Division JP2016188253A (ja) | 2009-10-06 | 2016-08-08 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013506715A JP2013506715A (ja) | 2013-02-28 |
| JP2013506715A5 true JP2013506715A5 (enExample) | 2013-11-14 |
| JP6016635B2 JP6016635B2 (ja) | 2016-10-26 |
Family
ID=43857093
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012533248A Expired - Fee Related JP6016635B2 (ja) | 2009-10-06 | 2010-10-05 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
| JP2016155272A Withdrawn JP2016188253A (ja) | 2009-10-06 | 2016-08-08 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
| JP2018106041A Pending JP2018145196A (ja) | 2009-10-06 | 2018-06-01 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
| JP2020149736A Withdrawn JP2020203925A (ja) | 2009-10-06 | 2020-09-07 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
| JP2022177407A Pending JP2023002840A (ja) | 2009-10-06 | 2022-11-04 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016155272A Withdrawn JP2016188253A (ja) | 2009-10-06 | 2016-08-08 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
| JP2018106041A Pending JP2018145196A (ja) | 2009-10-06 | 2018-06-01 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
| JP2020149736A Withdrawn JP2020203925A (ja) | 2009-10-06 | 2020-09-07 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
| JP2022177407A Pending JP2023002840A (ja) | 2009-10-06 | 2022-11-04 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
Country Status (27)
| Country | Link |
|---|---|
| US (6) | US9546165B2 (enExample) |
| EP (3) | EP3070077B1 (enExample) |
| JP (5) | JP6016635B2 (enExample) |
| KR (3) | KR20120087936A (enExample) |
| CN (1) | CN102665718B (enExample) |
| AR (2) | AR078540A1 (enExample) |
| AU (3) | AU2010303567B2 (enExample) |
| BR (1) | BR112012007747B8 (enExample) |
| CA (1) | CA2776690C (enExample) |
| CY (1) | CY1118143T1 (enExample) |
| DK (2) | DK2485731T3 (enExample) |
| ES (2) | ES2586856T3 (enExample) |
| HR (1) | HRP20160967T1 (enExample) |
| HU (2) | HUE028082T2 (enExample) |
| IL (4) | IL302896A (enExample) |
| IN (1) | IN2012DN03883A (enExample) |
| LT (1) | LT2485731T (enExample) |
| MX (2) | MX353257B (enExample) |
| PH (1) | PH12012500674A1 (enExample) |
| PL (1) | PL2485731T4 (enExample) |
| PT (1) | PT2485731T (enExample) |
| RS (1) | RS55101B1 (enExample) |
| RU (2) | RU2017109664A (enExample) |
| SI (1) | SI2485731T1 (enExample) |
| SM (1) | SMT201600275B (enExample) |
| TW (1) | TWI525093B (enExample) |
| WO (1) | WO2011044157A1 (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0924084B1 (pt) | 2008-12-19 | 2021-12-21 | Vertex Pharmaceuticals Incorporated | Derivados de pirazina e composição farmacêutica que os compreende |
| AU2010303567B2 (en) | 2009-10-06 | 2016-06-09 | Millennium Pharmaceuticals, Inc | Heterocyclic compounds useful as PDK1 inhibitors |
| AU2011253025A1 (en) | 2010-05-12 | 2012-11-29 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| US9062008B2 (en) * | 2010-05-12 | 2015-06-23 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| EP2569287B1 (en) | 2010-05-12 | 2014-07-09 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
| CN103052628B (zh) | 2010-07-20 | 2016-05-18 | 韦斯塔隆公司 | 三嗪类和嘧啶类杀虫剂 |
| US9181264B2 (en) | 2010-09-16 | 2015-11-10 | Hutchison Medipharma Limited | Fused heteroaryls and their uses |
| US8791112B2 (en) * | 2011-03-30 | 2014-07-29 | Arrien Pharmaceuticals Llc | Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-B] pyridine and pyrazolo [3, 4-B] pyridine derivatives as protein kinase inhibitors |
| WO2012149106A1 (en) | 2011-04-29 | 2012-11-01 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
| SG10201606774UA (en) | 2011-09-30 | 2016-10-28 | Vertex Pharma | Processes for making compounds useful as inhibitors of atr kinase |
| IN2014CN02501A (enExample) | 2011-09-30 | 2015-06-26 | Vertex Pharma | |
| CN103159741B (zh) * | 2011-12-19 | 2016-08-24 | 天津市国际生物医药联合研究院 | 一类酪氨酸激酶抑制剂的制备和用途 |
| US20140044802A1 (en) | 2012-04-05 | 2014-02-13 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase and combination therapies thereof |
| CN102627632B (zh) * | 2012-04-16 | 2014-06-18 | 中国科学院广州生物医药与健康研究院 | 一种胺基喹唑啉衍生物及其制备方法和用途 |
| MY173949A (en) | 2012-04-25 | 2020-02-28 | Takeda Pharmaceuticals Co | Nitrogenated heterocyclic compound |
| AU2013259565A1 (en) * | 2012-05-08 | 2014-11-13 | Anvyl Llc | Alpha 7 nicotinic acetylcholine receptor allosteric modulators, their derivatives and uses thereof |
| US9527841B2 (en) | 2012-07-13 | 2016-12-27 | Takeda Pharmaceutical Company Limited | Substituted pyrido[2,3-b]pyrazines as phosphodiesterase 2A inhibitors |
| MX2015003874A (es) | 2012-09-26 | 2015-12-16 | Univ California | Modulacion de ire1. |
| DK2904406T3 (en) | 2012-10-04 | 2018-06-18 | Vertex Pharma | METHOD OF DETERMINING THE ATR INHIBITION, INCREASED DNA DAMAGE |
| JP6280912B2 (ja) | 2013-03-14 | 2018-02-14 | 武田薬品工業株式会社 | 複素環化合物 |
| WO2014160185A2 (en) * | 2013-03-14 | 2014-10-02 | The Board Of Trustees Of The Leland Stanford Junior University | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof |
| US9708314B2 (en) * | 2013-05-31 | 2017-07-18 | Nissan Chemical Industries, Ltd. | Heterocyclic amide compound |
| WO2015002231A1 (ja) | 2013-07-03 | 2015-01-08 | 武田薬品工業株式会社 | 複素環化合物 |
| ES2950424T3 (es) | 2013-07-03 | 2023-10-09 | Takeda Pharmaceuticals Co | Compuesto de amida |
| JPWO2015012328A1 (ja) | 2013-07-24 | 2017-03-02 | 武田薬品工業株式会社 | 複素環化合物 |
| DK3290407T3 (da) | 2013-10-18 | 2020-03-23 | Celgene Quanticel Res Inc | Bromodomæneinhibitorer |
| WO2015073804A2 (en) * | 2013-11-15 | 2015-05-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method of blocking transmission of malarial parasite |
| CA2929858C (en) | 2013-11-22 | 2022-03-29 | CL BioSciences LLC | Gastrin antagonists (eg yf476, netazepide) for treatment and prevention of osteoporosis |
| CN104130256B (zh) * | 2014-08-01 | 2016-08-24 | 上海毕得医药科技有限公司 | 一种吡啶并[3,4-d]嘧啶-4（3H）-酮衍生物的制备方法 |
| ES2807785T3 (es) * | 2014-10-22 | 2021-02-24 | Bristol Myers Squibb Co | Compuestos de heteroarilamina bicíclicos como inhibidores de pi3k |
| KR102562866B1 (ko) | 2014-11-14 | 2023-08-04 | 네르비아노 메디칼 사이언시스 에스.알.엘. | 단백질 키나아제 억제제로서의 6-아미노-7-바이사이클로-7-데아자-퓨린 유도체 |
| AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| CA2992945A1 (en) | 2015-07-17 | 2017-01-26 | Memorial Sloan-Kettering Cancer Center | Combination therapy using pdk1 and pi3k inhibitors |
| CN105130980B (zh) * | 2015-09-09 | 2018-05-22 | 沈阳药科大学 | N-3-苯并咪唑噻唑胺类衍生物及其制备方法与应用 |
| CN108137586B (zh) * | 2015-09-14 | 2021-04-13 | 辉瑞大药厂 | 作为LRRK2抑制剂的新颖咪唑并[4,5-c]喹啉和咪唑并[4,5-c][1,5]萘啶衍生物 |
| KR102678021B1 (ko) | 2015-09-30 | 2024-06-26 | 버텍스 파마슈티칼스 인코포레이티드 | Dna 손상제와 병용되는, atr 저해제를 포함하는 암 치료용 약제학적 조성물 |
| KR101753652B1 (ko) * | 2015-10-21 | 2017-07-05 | 한국화학연구원 | N-아릴-1h-피라졸로피리딘-3-아민 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 melk 관련 질환의 예방 또는 치료용 약학적 조성물 |
| KR101753654B1 (ko) | 2015-10-21 | 2017-07-05 | 한국화학연구원 | 3-(4-(피페라진-1-일)벤즈아미도)-1h-피라졸로피리딘 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 melk 관련 질환의 예방 또는 치료용 약학적 조성물 |
| PL3364971T3 (pl) * | 2015-10-23 | 2021-05-31 | Sunesis Pharmaceuticals, Inc. | Heterocykliczne inhibitory PDK1 do zastosowania w leczeniu nowotworu |
| US9630968B1 (en) | 2015-12-23 | 2017-04-25 | Arqule, Inc. | Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof |
| CN114456176B (zh) | 2016-03-28 | 2024-08-30 | 因赛特公司 | 作为tam抑制剂的吡咯并三嗪化合物 |
| WO2017184462A1 (en) | 2016-04-18 | 2017-10-26 | Celgene Quanticel Research, Inc. | Therapeutic compounds |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| SG11201901197PA (en) | 2016-08-24 | 2019-03-28 | Arqule Inc | Amino-pyrrolopyrimidinone compounds and methods of use thereof |
| EP4063358B1 (en) | 2016-12-22 | 2024-05-22 | Global Blood Therapeutics, Inc. | Histone methyltransferase inhibitors |
| JP6420021B1 (ja) * | 2017-03-10 | 2018-11-07 | 大塚化学株式会社 | 反応生成物及びゴム組成物 |
| BR112019025770A2 (pt) * | 2017-06-09 | 2020-06-23 | Global Blood Therapeutics, Inc. | Compostos de azaindol como inibidores de histona metiltransferase |
| WO2019094779A1 (en) * | 2017-11-09 | 2019-05-16 | Sunesis Pharmaceuticals, Inc. | Pharmaceutical formulations, processes for preparation, and methods of use |
| EA202091777A1 (ru) | 2018-01-26 | 2020-10-14 | Бристол-Маерс Сквибб Компани | Аминопирролотриазины в качестве ингибиторов киназы |
| CN109087534A (zh) * | 2018-10-09 | 2018-12-25 | 王业宝 | 一种基于车辆行驶轨迹的交通冲突检测方法 |
| US11780857B2 (en) * | 2019-04-17 | 2023-10-10 | EWHA University—Industry Collaboration Foundation | Probe compounds for amino alcohols, and simultaneous fluorescence and circular dichroism analysis method |
| CN110066221B (zh) * | 2019-05-16 | 2022-03-08 | 海门瑞一医药科技有限公司 | 一种环丙基甲胺的制备方法 |
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| EP4067354B1 (en) * | 2019-11-25 | 2025-10-22 | Daewoong Pharmaceutical Co., Ltd. | Novel triazolopyridine derivative and pharmaceutical composition comprising same |
| EP4253383A4 (en) * | 2020-12-31 | 2024-07-17 | Tsinghua University | PYRIDINE-2-AMINE DERIVATIVE, PHARMACEUTICAL COMPOSITION AND ASSOCIATED USE |
| AR127972A1 (es) * | 2021-12-17 | 2024-03-13 | Pi Industries Ltd | Novedosos compuestos de piridina carboxamida bicíclica sustituida fusionada para combatir hongos fitopatogénicos |
| WO2023115165A1 (en) * | 2021-12-24 | 2023-06-29 | Psylo Pty Ltd | Compounds |
| WO2024040241A1 (en) | 2022-08-19 | 2024-02-22 | Viracta Therapeutics, Inc. | Pharmaceutical formulations, processes for preparation, and methods of use |
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| EP4698169A2 (en) * | 2023-04-21 | 2026-02-25 | Kymera Therapeutics, Inc. | Tyk2 degraders and uses thereof |
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-
2010
- 2010-10-05 AU AU2010303567A patent/AU2010303567B2/en not_active Ceased
- 2010-10-05 EP EP16167938.6A patent/EP3070077B1/en active Active
- 2010-10-05 IL IL302896A patent/IL302896A/en unknown
- 2010-10-05 DK DK10822550.9T patent/DK2485731T3/en active
- 2010-10-05 RS RS20160640A patent/RS55101B1/sr unknown
- 2010-10-05 RU RU2017109664A patent/RU2017109664A/ru unknown
- 2010-10-05 JP JP2012533248A patent/JP6016635B2/ja not_active Expired - Fee Related
- 2010-10-05 HU HUE10822550A patent/HUE028082T2/en unknown
- 2010-10-05 WO PCT/US2010/051517 patent/WO2011044157A1/en not_active Ceased
- 2010-10-05 PT PT108225509T patent/PT2485731T/pt unknown
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