JP2013506715A5 - - Google Patents
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- JP2013506715A5 JP2013506715A5 JP2012533248A JP2012533248A JP2013506715A5 JP 2013506715 A5 JP2013506715 A5 JP 2013506715A5 JP 2012533248 A JP2012533248 A JP 2012533248A JP 2012533248 A JP2012533248 A JP 2012533248A JP 2013506715 A5 JP2013506715 A5 JP 2013506715A5
- Authority
- JP
- Japan
- Prior art keywords
- nitrogen
- oxygen
- membered
- ring
- sulfur
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24909509P | 2009-10-06 | 2009-10-06 | |
| US61/249,095 | 2009-10-06 | ||
| PCT/US2010/051517 WO2011044157A1 (en) | 2009-10-06 | 2010-10-05 | Heterocyclic compounds useful as pdk1 inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016155272A Division JP2016188253A (ja) | 2009-10-06 | 2016-08-08 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013506715A JP2013506715A (ja) | 2013-02-28 |
| JP2013506715A5 true JP2013506715A5 (enExample) | 2013-11-14 |
| JP6016635B2 JP6016635B2 (ja) | 2016-10-26 |
Family
ID=43857093
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012533248A Expired - Fee Related JP6016635B2 (ja) | 2009-10-06 | 2010-10-05 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
| JP2016155272A Withdrawn JP2016188253A (ja) | 2009-10-06 | 2016-08-08 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
| JP2018106041A Pending JP2018145196A (ja) | 2009-10-06 | 2018-06-01 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
| JP2020149736A Withdrawn JP2020203925A (ja) | 2009-10-06 | 2020-09-07 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
| JP2022177407A Pending JP2023002840A (ja) | 2009-10-06 | 2022-11-04 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016155272A Withdrawn JP2016188253A (ja) | 2009-10-06 | 2016-08-08 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
| JP2018106041A Pending JP2018145196A (ja) | 2009-10-06 | 2018-06-01 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
| JP2020149736A Withdrawn JP2020203925A (ja) | 2009-10-06 | 2020-09-07 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
| JP2022177407A Pending JP2023002840A (ja) | 2009-10-06 | 2022-11-04 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
Country Status (27)
| Country | Link |
|---|---|
| US (6) | US9546165B2 (enExample) |
| EP (3) | EP3070077B1 (enExample) |
| JP (5) | JP6016635B2 (enExample) |
| KR (3) | KR20120087936A (enExample) |
| CN (1) | CN102665718B (enExample) |
| AR (2) | AR078540A1 (enExample) |
| AU (3) | AU2010303567B2 (enExample) |
| BR (1) | BR112012007747B8 (enExample) |
| CA (1) | CA2776690C (enExample) |
| CY (1) | CY1118143T1 (enExample) |
| DK (2) | DK2485731T3 (enExample) |
| ES (2) | ES2712875T3 (enExample) |
| HR (1) | HRP20160967T1 (enExample) |
| HU (2) | HUE028082T2 (enExample) |
| IL (4) | IL302896A (enExample) |
| IN (1) | IN2012DN03883A (enExample) |
| LT (1) | LT2485731T (enExample) |
| MX (2) | MX353257B (enExample) |
| PH (1) | PH12012500674A1 (enExample) |
| PL (1) | PL2485731T4 (enExample) |
| PT (1) | PT2485731T (enExample) |
| RS (1) | RS55101B1 (enExample) |
| RU (2) | RU2017109664A (enExample) |
| SI (1) | SI2485731T1 (enExample) |
| SM (1) | SMT201600275B (enExample) |
| TW (1) | TWI525093B (enExample) |
| WO (1) | WO2011044157A1 (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG172248A1 (en) | 2008-12-19 | 2011-07-28 | Vertex Pharma | Pyrazine derivatives useful as inhibitors of atr kinase |
| MX353257B (es) | 2009-10-06 | 2018-01-05 | Millennium Pharmaceuticals Inc Star | Compuestos heterociclicos utiles como inhibidores de proteina cinasa-1 dependiente de 3-fosfoinositido (pdk1). |
| EP2569287B1 (en) | 2010-05-12 | 2014-07-09 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
| JP2013529200A (ja) * | 2010-05-12 | 2013-07-18 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｒキナーゼ阻害剤として有用な化合物 |
| MX2012013081A (es) | 2010-05-12 | 2013-05-09 | Vertex Pharma | Compuestos utiles como inhibidores de cinasa atr. |
| CA2803687C (en) | 2010-07-20 | 2019-04-30 | Vestaron Corporation | Insecticidal triazines and pyrimidines |
| US9181264B2 (en) | 2010-09-16 | 2015-11-10 | Hutchison Medipharma Limited | Fused heteroaryls and their uses |
| US8791112B2 (en) | 2011-03-30 | 2014-07-29 | Arrien Pharmaceuticals Llc | Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-B] pyridine and pyrazolo [3, 4-B] pyridine derivatives as protein kinase inhibitors |
| US10457659B2 (en) | 2011-04-29 | 2019-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
| SG10201602515QA (en) | 2011-09-30 | 2016-05-30 | Vertex Pharma | Treating pancreatic cancer and non-small cell lung cancer with atr inhibitors |
| PT2940017T (pt) | 2011-09-30 | 2019-10-31 | Vertex Pharma | Processos para a produção de compostos úteis como inibidores de atr quinase |
| CN103159741B (zh) * | 2011-12-19 | 2016-08-24 | 天津市国际生物医药联合研究院 | 一类酪氨酸激酶抑制剂的制备和用途 |
| NZ700580A (en) | 2012-04-05 | 2016-07-29 | Vertex Pharma | Compounds useful as inhibitors of atr kinase and combination therapies thereof |
| CN102627632B (zh) * | 2012-04-16 | 2014-06-18 | 中国科学院广州生物医药与健康研究院 | 一种胺基喹唑啉衍生物及其制备方法和用途 |
| CA2869730A1 (en) | 2012-04-25 | 2013-10-31 | Takeda Pharmaceutical Company Limited | Nitrogenated heterocyclic compound |
| AU2013259565A1 (en) * | 2012-05-08 | 2014-11-13 | Anvyl Llc | Alpha 7 nicotinic acetylcholine receptor allosteric modulators, their derivatives and uses thereof |
| EP2873669A4 (en) | 2012-07-13 | 2015-11-25 | Takeda Pharmaceutical | HETEROCYCLIC CONNECTION |
| WO2014052669A1 (en) | 2012-09-26 | 2014-04-03 | The Regents Of The University Of California | Modulation of ire1 |
| WO2014055756A1 (en) | 2012-10-04 | 2014-04-10 | Vertex Pharmaceuticals Incorporated | Method for measuring atr inhibition mediated increases in dna damage |
| US9834520B2 (en) | 2013-03-14 | 2017-12-05 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| KR20150135332A (ko) | 2013-03-14 | 2015-12-02 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 미토콘드리아 알데히드 탈수소효소-2 조절인자들 및 이들의 사용 방법 |
| EP3006444B1 (en) * | 2013-05-31 | 2017-09-27 | Nissan Chemical Industries, Ltd. | Heterocyclic amide compound |
| US10472376B2 (en) | 2013-07-03 | 2019-11-12 | Takeda Pharmaceutical Company Limited | Amide compound |
| WO2015002231A1 (ja) | 2013-07-03 | 2015-01-08 | 武田薬品工業株式会社 | 複素環化合物 |
| WO2015012328A1 (ja) | 2013-07-24 | 2015-01-29 | 武田薬品工業株式会社 | 複素環化合物 |
| CA3148196A1 (en) | 2013-10-18 | 2015-04-23 | Celgene Quanticel Research, Inc. | Bromodomain inhibitors |
| WO2015073804A2 (en) * | 2013-11-15 | 2015-05-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method of blocking transmission of malarial parasite |
| JP6502939B2 (ja) | 2013-11-22 | 2019-04-17 | シーエル バイオサイエンシズ リミティド ライアビリティ カンパニー | 骨粗鬆症の処置及び予防のためのガストリン拮抗薬 |
| CN104130256B (zh) * | 2014-08-01 | 2016-08-24 | 上海毕得医药科技有限公司 | 一种吡啶并[3,4-d]嘧啶-4（3H）-酮衍生物的制备方法 |
| ES2807785T3 (es) * | 2014-10-22 | 2021-02-24 | Bristol Myers Squibb Co | Compuestos de heteroarilamina bicíclicos como inhibidores de pi3k |
| AU2015345054B2 (en) | 2014-11-14 | 2020-03-05 | Nerviano Medical Sciences S.R.L. | 6-amino-7-bicyclo-7-deaza-purine derivatives as protein kinase inhibitors |
| AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| CA2992945A1 (en) | 2015-07-17 | 2017-01-26 | Memorial Sloan-Kettering Cancer Center | Combination therapy using pdk1 and pi3k inhibitors |
| CN105130980B (zh) * | 2015-09-09 | 2018-05-22 | 沈阳药科大学 | N-3-苯并咪唑噻唑胺类衍生物及其制备方法与应用 |
| WO2017046675A1 (en) * | 2015-09-14 | 2017-03-23 | Pfizer Inc. | Novel imidazo [4,5-c] quinoline and imidazo [4,5-c][1,5] naphthyridine derivatives as lrrk2 inhibitors |
| EP3355926B1 (en) | 2015-09-30 | 2025-12-24 | Vertex Pharmaceuticals Inc. | Combination of dna damaging agents and atr inhibitors for use in a method for treating cancer using |
| KR101753652B1 (ko) * | 2015-10-21 | 2017-07-05 | 한국화학연구원 | N-아릴-1h-피라졸로피리딘-3-아민 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 melk 관련 질환의 예방 또는 치료용 약학적 조성물 |
| KR101753654B1 (ko) | 2015-10-21 | 2017-07-05 | 한국화학연구원 | 3-(4-(피페라진-1-일)벤즈아미도)-1h-피라졸로피리딘 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 melk 관련 질환의 예방 또는 치료용 약학적 조성물 |
| BR112018008025A2 (pt) | 2015-10-23 | 2018-10-23 | Sunesis Pharmaceuticals, Inc. | inibidores de pdk1 heterocíclicos para uso no trata-mento de câncer |
| US9630968B1 (en) | 2015-12-23 | 2017-04-25 | Arqule, Inc. | Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof |
| HUE064656T2 (hu) | 2016-03-28 | 2024-04-28 | Incyte Corp | Pirrolotriazin vegyületek mint TAM inhibitorok |
| AU2017252276A1 (en) | 2016-04-18 | 2018-11-15 | Celgene Quanticel Research, Inc. | Therapeutic compounds |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| US11020398B2 (en) | 2016-08-24 | 2021-06-01 | Arqule, Inc. | Amino-pyrrolopyrimidinone compounds and methods of use thereof |
| EP3558971B1 (en) | 2016-12-22 | 2022-02-23 | Global Blood Therapeutics, Inc. | Histone methyltransferase inhibitors |
| JP6420021B1 (ja) * | 2017-03-10 | 2018-11-07 | 大塚化学株式会社 | 反応生成物及びゴム組成物 |
| BR112019025770A2 (pt) * | 2017-06-09 | 2020-06-23 | Global Blood Therapeutics, Inc. | Compostos de azaindol como inibidores de histona metiltransferase |
| US20190175589A1 (en) * | 2017-11-09 | 2019-06-13 | Sunesis Pharmaceuticals, Inc. | Pharmaceutical formulations, processes for preparation, and methods of use |
| JP7307734B2 (ja) | 2018-01-26 | 2023-07-12 | ブリストル－マイヤーズ スクイブ カンパニー | キナーゼ阻害剤としてのアミノピロロトリアジン |
| CN109087534A (zh) * | 2018-10-09 | 2018-12-25 | 王业宝 | 一种基于车辆行驶轨迹的交通冲突检测方法 |
| KR102293339B1 (ko) * | 2019-04-17 | 2021-08-25 | 이화여자대학교 산학협력단 | 아미노알코올을 포함하는 아민 화합물에 대한 형광 및/또는 원편광 이색성 센서용 신규 프로브 화합물, 및 이를 이용한 형광 및 원편광 이색성 동시 분석 방법 |
| CN110066221B (zh) * | 2019-05-16 | 2022-03-08 | 海门瑞一医药科技有限公司 | 一种环丙基甲胺的制备方法 |
| WO2021064141A1 (en) * | 2019-10-02 | 2021-04-08 | Tolremo Therapeutics Ag | Inhibitors of dual specificity tyrosine phosphorylation regulated kinase 1b |
| EP4067354B1 (en) * | 2019-11-25 | 2025-10-22 | Daewoong Pharmaceutical Co., Ltd. | Novel triazolopyridine derivative and pharmaceutical composition comprising same |
| JP2024502083A (ja) * | 2020-12-31 | 2024-01-17 | 清華大学 | ピリジン－２－アミン誘導体、その医薬組成物、及び使用 |
| AR127972A1 (es) * | 2021-12-17 | 2024-03-13 | Pi Industries Ltd | Novedosos compuestos de piridina carboxamida bicíclica sustituida fusionada para combatir hongos fitopatogénicos |
| IL313857A (en) * | 2021-12-24 | 2024-08-01 | Psylo Pty Ltd | Substances, medicines containing them and their uses |
| WO2024040242A1 (en) | 2022-08-19 | 2024-02-22 | Viracta Therapeutics, Inc. | Combinations of pdk1 inhibitors and kinase inhibitors |
| WO2024040241A1 (en) | 2022-08-19 | 2024-02-22 | Viracta Therapeutics, Inc. | Pharmaceutical formulations, processes for preparation, and methods of use |
| WO2024220937A2 (en) * | 2023-04-21 | 2024-10-24 | Kymera Therapeutics, Inc. | Tyk2 degraders and uses thereof |
| CN117603068A (zh) * | 2023-08-01 | 2024-02-27 | 常州寅盛药业有限公司 | 一种氨甲环酸的制备方法 |
| WO2025076290A1 (en) * | 2023-10-05 | 2025-04-10 | Purdue Research Foundation | 5-6-5/6-bisaryl compounds as flt3 inhibitors |
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-
2010
- 2010-10-05 MX MX2012004114A patent/MX353257B/es active IP Right Grant
- 2010-10-05 JP JP2012533248A patent/JP6016635B2/ja not_active Expired - Fee Related
- 2010-10-05 MX MX2017008225A patent/MX389288B/es unknown
- 2010-10-05 RU RU2017109664A patent/RU2017109664A/ru unknown
- 2010-10-05 PH PH1/2012/500674A patent/PH12012500674A1/en unknown
- 2010-10-05 ES ES16167938T patent/ES2712875T3/es active Active
- 2010-10-05 EP EP16167938.6A patent/EP3070077B1/en active Active
- 2010-10-05 HU HUE10822550A patent/HUE028082T2/en unknown
- 2010-10-05 WO PCT/US2010/051517 patent/WO2011044157A1/en not_active Ceased
- 2010-10-05 KR KR1020127011581A patent/KR20120087936A/ko not_active Ceased
- 2010-10-05 EP EP18207990.5A patent/EP3466929B1/en active Active
- 2010-10-05 PL PL10822550T patent/PL2485731T4/pl unknown
- 2010-10-05 BR BR112012007747A patent/BR112012007747B8/pt not_active IP Right Cessation
- 2010-10-05 US US13/499,835 patent/US9546165B2/en active Active
- 2010-10-05 HU HUE16167938A patent/HUE043536T2/hu unknown
- 2010-10-05 LT LTEP10822550.9T patent/LT2485731T/lt unknown
- 2010-10-05 RS RS20160640A patent/RS55101B1/sr unknown
- 2010-10-05 KR KR1020197003115A patent/KR102097664B1/ko not_active Expired - Fee Related
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