JP2013506715A5 - - Google Patents
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- JP2013506715A5 JP2013506715A5 JP2012533248A JP2012533248A JP2013506715A5 JP 2013506715 A5 JP2013506715 A5 JP 2013506715A5 JP 2012533248 A JP2012533248 A JP 2012533248A JP 2012533248 A JP2012533248 A JP 2012533248A JP 2013506715 A5 JP2013506715 A5 JP 2013506715A5
- Authority
- JP
- Japan
- Prior art keywords
- nitrogen
- oxygen
- membered
- ring
- sulfur
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24909509P | 2009-10-06 | 2009-10-06 | |
| US61/249,095 | 2009-10-06 | ||
| PCT/US2010/051517 WO2011044157A1 (en) | 2009-10-06 | 2010-10-05 | Heterocyclic compounds useful as pdk1 inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016155272A Division JP2016188253A (ja) | 2009-10-06 | 2016-08-08 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013506715A JP2013506715A (ja) | 2013-02-28 |
| JP2013506715A5 true JP2013506715A5 (enExample) | 2013-11-14 |
| JP6016635B2 JP6016635B2 (ja) | 2016-10-26 |
Family
ID=43857093
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012533248A Expired - Fee Related JP6016635B2 (ja) | 2009-10-06 | 2010-10-05 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
| JP2016155272A Withdrawn JP2016188253A (ja) | 2009-10-06 | 2016-08-08 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
| JP2018106041A Pending JP2018145196A (ja) | 2009-10-06 | 2018-06-01 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
| JP2020149736A Withdrawn JP2020203925A (ja) | 2009-10-06 | 2020-09-07 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
| JP2022177407A Pending JP2023002840A (ja) | 2009-10-06 | 2022-11-04 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016155272A Withdrawn JP2016188253A (ja) | 2009-10-06 | 2016-08-08 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
| JP2018106041A Pending JP2018145196A (ja) | 2009-10-06 | 2018-06-01 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
| JP2020149736A Withdrawn JP2020203925A (ja) | 2009-10-06 | 2020-09-07 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
| JP2022177407A Pending JP2023002840A (ja) | 2009-10-06 | 2022-11-04 | Ｐｄｋ１インヒビターとして有用な複素環式化合物 |
Country Status (27)
| Country | Link |
|---|---|
| US (6) | US9546165B2 (enExample) |
| EP (3) | EP2485731B1 (enExample) |
| JP (5) | JP6016635B2 (enExample) |
| KR (3) | KR101947307B1 (enExample) |
| CN (1) | CN102665718B (enExample) |
| AR (2) | AR078540A1 (enExample) |
| AU (3) | AU2010303567B2 (enExample) |
| BR (1) | BR112012007747B8 (enExample) |
| CA (1) | CA2776690C (enExample) |
| CY (1) | CY1118143T1 (enExample) |
| DK (2) | DK3070077T3 (enExample) |
| ES (2) | ES2712875T3 (enExample) |
| HR (1) | HRP20160967T1 (enExample) |
| HU (2) | HUE028082T2 (enExample) |
| IL (4) | IL295518B2 (enExample) |
| IN (1) | IN2012DN03883A (enExample) |
| LT (1) | LT2485731T (enExample) |
| MX (2) | MX389288B (enExample) |
| PH (1) | PH12012500674A1 (enExample) |
| PL (1) | PL2485731T4 (enExample) |
| PT (1) | PT2485731T (enExample) |
| RS (1) | RS55101B1 (enExample) |
| RU (2) | RU2017109664A (enExample) |
| SI (1) | SI2485731T1 (enExample) |
| SM (1) | SMT201600275B (enExample) |
| TW (1) | TWI525093B (enExample) |
| WO (1) | WO2011044157A1 (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2921576T3 (es) | 2008-12-19 | 2022-08-29 | Vertex Pharma | Compuestos útiles como inhibidores de la quinasa ATR |
| EP2485731B1 (en) | 2009-10-06 | 2016-05-11 | Millennium Pharmaceuticals, Inc. | Heterocyclic compounds useful as pdk1 inhibitors |
| EP2569286B1 (en) * | 2010-05-12 | 2014-08-20 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
| EP2569313A1 (en) | 2010-05-12 | 2013-03-20 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| US9334244B2 (en) | 2010-05-12 | 2016-05-10 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| ES2587232T3 (es) | 2010-07-20 | 2016-10-21 | Vestaron Corporation | Triazinas y pirimidinas insecticidas |
| US9181264B2 (en) | 2010-09-16 | 2015-11-10 | Hutchison Medipharma Limited | Fused heteroaryls and their uses |
| WO2012135631A1 (en) | 2011-03-30 | 2012-10-04 | Arrien Pharmaeuticals Llc | Substituted 5-(pyrazin-2-yl)-1h-pyrazolo [3, 4-b] pyridine and pyrazolo [3, 4-b] pyridine derivatives as protein kinase inhibitors |
| WO2012149106A1 (en) | 2011-04-29 | 2012-11-01 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
| EP3878851A1 (en) | 2011-09-30 | 2021-09-15 | Vertex Pharmaceuticals Incorporated | Process for making compounds useful as inhibitors of atr kinase |
| RU2018108589A (ru) | 2011-09-30 | 2019-02-25 | Вертекс Фармасьютикалз Инкорпорейтед | Лечение рака поджелудочной железы и немелкоклеточного рака легкого ингибиторами atr |
| CN103159741B (zh) * | 2011-12-19 | 2016-08-24 | 天津市国际生物医药联合研究院 | 一类酪氨酸激酶抑制剂的制备和用途 |
| PT2833973T (pt) | 2012-04-05 | 2017-12-21 | Vertex Pharma | Compostos úteis como inibidores da cinase atr e terapias de combinação dos mesmos |
| CN102627632B (zh) * | 2012-04-16 | 2014-06-18 | 中国科学院广州生物医药与健康研究院 | 一种胺基喹唑啉衍生物及其制备方法和用途 |
| PE20142258A1 (es) | 2012-04-25 | 2015-01-15 | Takeda Pharmaceutical | Compuesto heterociclico nitrogenado |
| KR20150008891A (ko) * | 2012-05-08 | 2015-01-23 | 앤빌 엘엘씨 | 알파 7 니코틴성 아세틸콜린 수용기 알로스테릭 조절제, 그의 유도체 및 그의 용도 |
| EP2873669A4 (en) | 2012-07-13 | 2015-11-25 | Takeda Pharmaceutical | HETEROCYCLIC CONNECTION |
| WO2014052669A1 (en) | 2012-09-26 | 2014-04-03 | The Regents Of The University Of California | Modulation of ire1 |
| WO2014055756A1 (en) | 2012-10-04 | 2014-04-10 | Vertex Pharmaceuticals Incorporated | Method for measuring atr inhibition mediated increases in dna damage |
| US9834520B2 (en) | 2013-03-14 | 2017-12-05 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| KR20150135332A (ko) | 2013-03-14 | 2015-12-02 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 미토콘드리아 알데히드 탈수소효소-2 조절인자들 및 이들의 사용 방법 |
| JP6327483B2 (ja) * | 2013-05-31 | 2018-05-23 | 日産化学工業株式会社 | 複素環アミド化合物 |
| WO2015002231A1 (ja) | 2013-07-03 | 2015-01-08 | 武田薬品工業株式会社 | 複素環化合物 |
| JP6411342B2 (ja) | 2013-07-03 | 2018-10-24 | 武田薬品工業株式会社 | アミド化合物 |
| US20160159808A1 (en) | 2013-07-24 | 2016-06-09 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| AU2014337064B2 (en) | 2013-10-18 | 2019-03-14 | Celgene Quanticel Research, Inc. | Bromodomain inhibitors |
| US20160264570A1 (en) * | 2013-11-15 | 2016-09-15 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv | Method of blocking transmission of malarial parasite |
| KR102254957B1 (ko) | 2013-11-22 | 2021-05-25 | 씨엘 바이오사이언시즈 엘엘씨 | 골다공증 치료 및 예방을 위한 가스트린 길항제(ｅｇ ｙｆ476, 네타제피드) |
| CN104130256B (zh) * | 2014-08-01 | 2016-08-24 | 上海毕得医药科技有限公司 | 一种吡啶并[3,4-d]嘧啶-4（3H）-酮衍生物的制备方法 |
| WO2016064957A1 (en) * | 2014-10-22 | 2016-04-28 | Bristol-Myers Squibb Company | Bicyclic heteroaryl amine compounds as pi3k inhibitors |
| CA2967125C (en) | 2014-11-14 | 2022-10-25 | Nerviano Medical Sciences S.R.L. | 6-amino-7-bicyclo-7-deaza-purine derivatives as protein kinase inhibitors |
| AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| EP3325100A4 (en) | 2015-07-17 | 2019-02-20 | Memorial Sloan-Kettering Cancer Center | COMBINATION THERAPY WITH PDK1 AND PI3K INHIBITORS |
| CN105130980B (zh) * | 2015-09-09 | 2018-05-22 | 沈阳药科大学 | N-3-苯并咪唑噻唑胺类衍生物及其制备方法与应用 |
| CN108137586B (zh) * | 2015-09-14 | 2021-04-13 | 辉瑞大药厂 | 作为LRRK2抑制剂的新颖咪唑并[4,5-c]喹啉和咪唑并[4,5-c][1,5]萘啶衍生物 |
| EP3355926B1 (en) | 2015-09-30 | 2025-12-24 | Vertex Pharmaceuticals Inc. | Combination of dna damaging agents and atr inhibitors for use in a method for treating cancer using |
| KR101753652B1 (ko) * | 2015-10-21 | 2017-07-05 | 한국화학연구원 | N-아릴-1h-피라졸로피리딘-3-아민 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 melk 관련 질환의 예방 또는 치료용 약학적 조성물 |
| KR101753654B1 (ko) | 2015-10-21 | 2017-07-05 | 한국화학연구원 | 3-(4-(피페라진-1-일)벤즈아미도)-1h-피라졸로피리딘 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 melk 관련 질환의 예방 또는 치료용 약학적 조성물 |
| CA3002907A1 (en) | 2015-10-23 | 2017-04-27 | Sunesis Pharmaceuticals, Inc. | Heterocyclic pdk1 inhibitors for use to treat cancer |
| US9630968B1 (en) | 2015-12-23 | 2017-04-25 | Arqule, Inc. | Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof |
| AU2017241524B2 (en) | 2016-03-28 | 2021-07-08 | Incyte Corporation | Pyrrolotriazine compounds as TAM inhibitors |
| WO2017184462A1 (en) | 2016-04-18 | 2017-10-26 | Celgene Quanticel Research, Inc. | Therapeutic compounds |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| SG11201901197PA (en) | 2016-08-24 | 2019-03-28 | Arqule Inc | Amino-pyrrolopyrimidinone compounds and methods of use thereof |
| EP3558971B1 (en) | 2016-12-22 | 2022-02-23 | Global Blood Therapeutics, Inc. | Histone methyltransferase inhibitors |
| JP6420021B1 (ja) * | 2017-03-10 | 2018-11-07 | 大塚化学株式会社 | 反応生成物及びゴム組成物 |
| CN110997671A (zh) * | 2017-06-09 | 2020-04-10 | 全球血液疗法股份有限公司 | 作为组蛋白甲基转移酶抑制剂的氮杂吲哚化合物 |
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| BR112020014516A2 (pt) | 2018-01-26 | 2020-12-08 | Bristol-Myers Squibb Company | Aminopirrolotriazinas como inibidores de quinase |
| CN109087534A (zh) * | 2018-10-09 | 2018-12-25 | 王业宝 | 一种基于车辆行驶轨迹的交通冲突检测方法 |
| US11780857B2 (en) * | 2019-04-17 | 2023-10-10 | EWHA University—Industry Collaboration Foundation | Probe compounds for amino alcohols, and simultaneous fluorescence and circular dichroism analysis method |
| CN110066221B (zh) * | 2019-05-16 | 2022-03-08 | 海门瑞一医药科技有限公司 | 一种环丙基甲胺的制备方法 |
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| US20240116962A1 (en) * | 2020-12-31 | 2024-04-11 | Tsinghua University | Pyridine-2-amine derivative and pharmaceutical composition and use thereof |
| AR127972A1 (es) * | 2021-12-17 | 2024-03-13 | Pi Industries Ltd | Novedosos compuestos de piridina carboxamida bicíclica sustituida fusionada para combatir hongos fitopatogénicos |
| IL313857A (en) * | 2021-12-24 | 2024-08-01 | Psylo Pty Ltd | Substances, medicines containing them and their uses |
| WO2024040241A1 (en) | 2022-08-19 | 2024-02-22 | Viracta Therapeutics, Inc. | Pharmaceutical formulations, processes for preparation, and methods of use |
| WO2024040242A1 (en) | 2022-08-19 | 2024-02-22 | Viracta Therapeutics, Inc. | Combinations of pdk1 inhibitors and kinase inhibitors |
| KR20250175338A (ko) * | 2023-04-21 | 2025-12-16 | 카이메라 쎄라퓨틱스 인코포레이티드 | Tyk2 분해제 및 이의 용도 |
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| WO2025076290A1 (en) * | 2023-10-05 | 2025-04-10 | Purdue Research Foundation | 5-6-5/6-bisaryl compounds as flt3 inhibitors |
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-
2010
- 2010-10-05 EP EP10822550.9A patent/EP2485731B1/en active Active
- 2010-10-05 CA CA2776690A patent/CA2776690C/en active Active
- 2010-10-05 EP EP16167938.6A patent/EP3070077B1/en active Active
- 2010-10-05 ES ES16167938T patent/ES2712875T3/es active Active
- 2010-10-05 US US13/499,835 patent/US9546165B2/en active Active
- 2010-10-05 KR KR1020177034734A patent/KR101947307B1/ko not_active Expired - Fee Related
- 2010-10-05 IL IL295518A patent/IL295518B2/en unknown
- 2010-10-05 ES ES10822550.9T patent/ES2586856T3/es active Active
- 2010-10-05 HR HRP20160967TT patent/HRP20160967T1/hr unknown
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