MX389288B - Compuestos heterocíclicos útiles como inhibidores de proteína cinasa-1 dependiente de 3-fosfoinositido (pdk1). - Google Patents

Compuestos heterocíclicos útiles como inhibidores de proteína cinasa-1 dependiente de 3-fosfoinositido (pdk1).

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Publication number
MX389288B
MX389288B MX2017008225A MX2017008225A MX389288B MX 389288 B MX389288 B MX 389288B MX 2017008225 A MX2017008225 A MX 2017008225A MX 2017008225 A MX2017008225 A MX 2017008225A MX 389288 B MX389288 B MX 389288B
Authority
MX
Mexico
Prior art keywords
pdk1
inhibitors
compounds useful
phosphoinositide
protein kinase
Prior art date
Application number
MX2017008225A
Other languages
English (en)
Spanish (es)
Inventor
Daniel Erlanson
Daniel Scott
Deping Wang
Edward Yin- Shiang LIN
Gnanasambandam Kumaravel
Jermaine Thomas
Joseph Arndt
Kevin Guckian
Vloten Kurt Van
Lei Zhang
Lihong Sun
Timothy Chan
Wen- Cherng Lee
Original Assignee
Millennium Pharm Inc
Sunesis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc, Sunesis Pharmaceuticals Inc filed Critical Millennium Pharm Inc
Publication of MX389288B publication Critical patent/MX389288B/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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