ATE240316T1 - Heteroaromatische amide als inhibitoren von faktor xa - Google Patents
Heteroaromatische amide als inhibitoren von faktor xaInfo
- Publication number
- ATE240316T1 ATE240316T1 AT99967352T AT99967352T ATE240316T1 AT E240316 T1 ATE240316 T1 AT E240316T1 AT 99967352 T AT99967352 T AT 99967352T AT 99967352 T AT99967352 T AT 99967352T AT E240316 T1 ATE240316 T1 AT E240316T1
- Authority
- AT
- Austria
- Prior art keywords
- factor
- inhibitors
- heteroaromatic amides
- heteroaromatic
- amides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11345298P | 1998-12-23 | 1998-12-23 | |
| PCT/US1999/029887 WO2000039117A1 (en) | 1998-12-23 | 1999-12-15 | HETEROROAROMATIC AMIDES AS INHIBITOR OF FACTOR Xa |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE240316T1 true ATE240316T1 (de) | 2003-05-15 |
Family
ID=22349511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99967352T ATE240316T1 (de) | 1998-12-23 | 1999-12-15 | Heteroaromatische amide als inhibitoren von faktor xa |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1140905B1 (de) |
| JP (1) | JP2002533453A (de) |
| AT (1) | ATE240316T1 (de) |
| AU (1) | AU2364600A (de) |
| CA (1) | CA2358095A1 (de) |
| DE (1) | DE69907963T2 (de) |
| ES (1) | ES2196917T3 (de) |
| WO (1) | WO2000039117A1 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU8270298A (en) | 1997-06-26 | 1999-01-19 | Eli Lilly And Company | Antithrombotic agents |
| WO1999000126A1 (en) | 1997-06-26 | 1999-01-07 | Eli Lilly And Company | Antithrombotic agents |
| EP1007037A4 (de) | 1997-06-26 | 2004-10-06 | Lilly Co Eli | Antithrombose mittel |
| CA2294042A1 (en) | 1997-06-26 | 1999-01-07 | David Kent Herron | Antithrombotic agents |
| PL341044A1 (en) | 1997-12-19 | 2001-03-26 | Schering Ag | Derivatives of orthoantranilic amide as anticoagulants |
| ATE326453T1 (de) | 1998-12-23 | 2006-06-15 | Lilly Co Eli | Antithrombotische amide |
| ES2226485T3 (es) | 1998-12-23 | 2005-03-16 | Eli Lilly And Company | Amidas aromaticas. |
| ATE261941T1 (de) | 1998-12-24 | 2004-04-15 | Lilly Co Eli | Heterocyclische amide als inhibitoren von faktor xa |
| DE60022508T2 (de) | 1999-06-14 | 2006-06-08 | Eli Lilly And Co., Indianapolis | Inhibitoren von serin proteasen |
| AU776053B2 (en) * | 2000-03-31 | 2004-08-26 | Astellas Pharma Inc. | Diazepan derivatives or salts thereof |
| TWI290136B (en) | 2000-04-05 | 2007-11-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
| DE10023492A1 (de) * | 2000-05-09 | 2001-11-22 | Schering Ag | Aza- und Polyazanthranylamide und deren Verwendung als Arzneimittel |
| GB0030303D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030305D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030306D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030304D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| IL153278A0 (en) * | 2000-06-21 | 2003-07-06 | Hoffmann La Roche | Benzothiazole derivatives |
| AU2001280438A1 (en) | 2000-07-27 | 2002-02-13 | Eli Lilly And Company | Substituted heterocyclic amides |
| ES2248380T3 (es) | 2000-08-17 | 2006-03-16 | Eli Lilly And Company | Agentes antitromboticos. |
| KR100863923B1 (ko) | 2000-11-22 | 2008-10-17 | 아스텔라스세이야쿠 가부시키가이샤 | 치환된 벤젠 유도체 또는 이의 염 및 이를 포함하는 의약 조성물 |
| US7163938B2 (en) | 2000-11-28 | 2007-01-16 | Eli Lilly And Company | Substituted carboxamides |
| US6878714B2 (en) | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
| US20030134836A1 (en) | 2001-01-12 | 2003-07-17 | Amgen Inc. | Substituted arylamine derivatives and methods of use |
| US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US7102009B2 (en) | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
| US6864255B2 (en) | 2001-04-11 | 2005-03-08 | Amgen Inc. | Substituted triazinyl amide derivatives and methods of use |
| US7365205B2 (en) | 2001-06-20 | 2008-04-29 | Daiichi Sankyo Company, Limited | Diamine derivatives |
| EP1456175A1 (de) | 2001-12-07 | 2004-09-15 | Eli Lilly And Company | Substituierte heterozyklische karboxamide mit antithrombotischer aktivität |
| US7307088B2 (en) | 2002-07-09 | 2007-12-11 | Amgen Inc. | Substituted anthranilic amide derivatives and methods of use |
| US7262194B2 (en) | 2002-07-26 | 2007-08-28 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| HUE025683T2 (hu) | 2002-12-03 | 2016-04-28 | Pharmacyclics Llc | VIIA faktor inhibitor 2-(2-hidroxi-bifenil-3-il)-1H-benzoimidazol-5-karboxamidin-származékok |
| TWI287010B (en) * | 2003-06-12 | 2007-09-21 | Euro Celtique Sa | Therapeutic agents useful for treating pain |
| NZ544009A (en) | 2003-07-24 | 2009-07-31 | Euro Celtique Sa | Heteroaryl-tetrahydropiperidyl compounds useful for treating or preventing pain |
| ES2340168T3 (es) | 2003-08-01 | 2010-05-31 | Euro-Celtique S.A. | Agentes terapeuticos utiles para tratar el dolor. |
| EP1664041B1 (de) | 2003-09-22 | 2008-07-02 | Euro-Celtique S.A. | Zur behandlung von schmerzen geeignete phenylcarbonsäureamidverbindungen |
| PL1664016T3 (pl) | 2003-09-22 | 2009-04-30 | Euro Celtique Sa | Środki terapeutyczne przydatne do leczenia bólu |
| SE0401343D0 (sv) * | 2004-05-25 | 2004-05-25 | Astrazeneca Ab | Therapeutic compounds: Pyridine N oxide as scaffold |
| US8247556B2 (en) | 2005-10-21 | 2012-08-21 | Amgen Inc. | Method for preparing 6-substituted-7-aza-indoles |
| HUE043536T2 (hu) * | 2009-10-06 | 2019-08-28 | Millennium Pharm Inc | PDK1 inhibitorként alkalmazható heterociklusos vegyületek |
| JP2019142776A (ja) * | 2016-06-24 | 2019-08-29 | 石原産業株式会社 | Ｎ−（４−ピリジル）ベンズアミド化合物又はその塩を有効成分として含有する有害生物防除剤 |
| MX2022001004A (es) * | 2019-08-21 | 2022-02-21 | Kalvista Pharmaceuticals Ltd | Inhibidores de enzimas. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA928276B (en) * | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
| AU8270298A (en) * | 1997-06-26 | 1999-01-19 | Eli Lilly And Company | Antithrombotic agents |
-
1999
- 1999-12-15 WO PCT/US1999/029887 patent/WO2000039117A1/en active IP Right Grant
- 1999-12-15 DE DE69907963T patent/DE69907963T2/de not_active Expired - Fee Related
- 1999-12-15 CA CA002358095A patent/CA2358095A1/en not_active Abandoned
- 1999-12-15 AT AT99967352T patent/ATE240316T1/de not_active IP Right Cessation
- 1999-12-15 ES ES99967352T patent/ES2196917T3/es not_active Expired - Lifetime
- 1999-12-15 EP EP99967352A patent/EP1140905B1/de not_active Expired - Lifetime
- 1999-12-15 JP JP2000591028A patent/JP2002533453A/ja not_active Withdrawn
- 1999-12-15 AU AU23646/00A patent/AU2364600A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000039117A1 (en) | 2000-07-06 |
| EP1140905B1 (de) | 2003-05-14 |
| DE69907963D1 (de) | 2003-06-18 |
| CA2358095A1 (en) | 2000-07-06 |
| DE69907963T2 (de) | 2004-05-19 |
| AU2364600A (en) | 2000-07-31 |
| ES2196917T3 (es) | 2003-12-16 |
| JP2002533453A (ja) | 2002-10-08 |
| EP1140905A1 (de) | 2001-10-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69907963D1 (de) | Heteroaromatische amide als inhibitoren von faktor xa | |
| ATE326453T1 (de) | Antithrombotische amide | |
| ATE374765T1 (de) | Substituierte heterocyclische amide | |
| DE69919212D1 (de) | Aromatische amiden | |
| DE69915687D1 (de) | Heterocyclische amide als inhibitoren von faktor xa | |
| ATE297203T1 (de) | Antithrombotische mitteln | |
| DE69831868D1 (en) | Antithrombosemittel | |
| ATE269312T1 (de) | N-(amidinophenyl)-n'-(subst.)-3h-2,4- benzodiazepin-3-on derivative als faktor xa inhibitoren | |
| EE200100485A (et) | Uudsed ühendid ja kompositsioonid proteaasi inhibiitoritena | |
| RS51444B (sr) | JEDINJENJA KOJA SADRŽE LAKTAM I NJIHOVI DERIVATI KAO INHIBITORI FAKTORA Xa | |
| FI950309A0 (fi) | Proliiniamidijohdannaisia | |
| TR200401962T4 (tr) | Heteroaromatik karboksamid türevleri ve bunların IKK-2 enziminin inhibitörleri olarak kullanımı | |
| DE60135485D1 (de) | Monozyklische oder bizyklische carbozyklen und heterozyklen als hemmer von factor xa | |
| EA200200510A1 (ru) | 4-карбоксиамино-2-этил-1,2,3,4-тетрагидрохинолин в кристаллической форме как ингибитор сетр | |
| ATE316962T1 (de) | Pyrimidin-derivate als selective inhibitoren von cox-2 | |
| ATE303384T1 (de) | 1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren | |
| DE60114640D1 (en) | Antithrombosemittel | |
| ATE373636T1 (de) | Amidderivate als inhibitoren der enzymatischen aktivität von renin | |
| ATE348800T1 (de) | 4'-methansulfonylbiphenylderivate als hochselektive cyclooxygenase-2-inhibitoren | |
| ATE239034T1 (de) | Mechanismus-orientierte inhibitoren der dipeptidylpeptidase i | |
| ATE396177T1 (de) | Neue kristalline formen eines faktor xa inhibitors | |
| ATE286395T1 (de) | Antithrombotische mittel | |
| DE60137451D1 (de) | N-substituierte Amide als NK1 Rezeptor Antagonisten | |
| SE0102058D0 (sv) | New Salts II | |
| ATE268768T1 (de) | Antithrombosemittel |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |