EA201300080A1 - Дипиридильные производные, пригодные для лечения заболеваний, индуцированных киназами - Google Patents
Дипиридильные производные, пригодные для лечения заболеваний, индуцированных киназамиInfo
- Publication number
- EA201300080A1 EA201300080A1 EA201300080A EA201300080A EA201300080A1 EA 201300080 A1 EA201300080 A1 EA 201300080A1 EA 201300080 A EA201300080 A EA 201300080A EA 201300080 A EA201300080 A EA 201300080A EA 201300080 A1 EA201300080 A1 EA 201300080A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- treatment
- diseases
- dipyridil
- kinase
- derivatives suitable
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 102000001253 Protein Kinase Human genes 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108060006633 protein kinase Proteins 0.000 abstract 2
- 102000021527 ATP binding proteins Human genes 0.000 abstract 1
- 108091011108 ATP binding proteins Proteins 0.000 abstract 1
- ROFVEXUMMXZLPA-UHFFFAOYSA-N Bipyridyl Chemical group N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108091005735 TGF-beta receptors Proteins 0.000 abstract 1
- 102000016715 Transforming Growth Factor beta Receptors Human genes 0.000 abstract 1
- 230000033228 biological regulation Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 229940043355 kinase inhibitor Drugs 0.000 abstract 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A—HUMAN NECESSITIES
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- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- AIDS & HIV (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Настоящее изобретение относится к новым дипиридильным производным формулы (I) и к применению таких соединений, при котором играет роль ингибирование, регуляция и/или модуляция передачи сигналов с помощью АТФ-связывающих белков, подобных киназам, в частности к ингибиторам TGF-бета рецепторных киназ, и к применению таких соединений для лечения заболеваний, индуцированных киназами, в частности для лечения опухолей.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10006927 | 2010-07-05 | ||
PCT/EP2011/002788 WO2012003912A1 (en) | 2010-07-05 | 2011-06-07 | Bipyridyl derivatives useful for the treatment of kinase - induced diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201300080A1 true EA201300080A1 (ru) | 2013-06-28 |
Family
ID=44259587
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201300080A EA201300080A1 (ru) | 2010-07-05 | 2011-06-07 | Дипиридильные производные, пригодные для лечения заболеваний, индуцированных киназами |
Country Status (15)
Country | Link |
---|---|
US (2) | US8846931B2 (ru) |
EP (1) | EP2590946B1 (ru) |
JP (1) | JP5886842B2 (ru) |
KR (1) | KR20130131293A (ru) |
CN (1) | CN102971293A (ru) |
AR (1) | AR082109A1 (ru) |
AU (1) | AU2011276193B2 (ru) |
BR (1) | BR112012033658A2 (ru) |
CA (1) | CA2804285C (ru) |
EA (1) | EA201300080A1 (ru) |
ES (1) | ES2535656T3 (ru) |
IL (1) | IL223978A (ru) |
MX (1) | MX2012014537A (ru) |
SG (1) | SG186871A1 (ru) |
WO (1) | WO2012003912A1 (ru) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
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NZ587051A (en) | 2008-01-04 | 2012-12-21 | Intellikine Llc | Isoquinolinone derivatives, compositions and methods of inhibiting phosphatidyl inositol-3 kinase (pi3 kinase) |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
CA2824197C (en) | 2011-01-10 | 2020-02-25 | Michael Martin | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
JP6457942B2 (ja) * | 2012-10-05 | 2019-01-23 | ライジェル ファーマシューティカルズ, インコーポレイテッド | Gdf−8阻害剤 |
GB201312800D0 (en) | 2013-07-17 | 2013-08-28 | Heptares Therapeutics Ltd | mGlu5 modulators |
TN2016000270A1 (en) | 2014-01-14 | 2017-10-06 | Millennium Pharm Inc | Heteroaryls and uses thereof. |
WO2015108881A1 (en) | 2014-01-14 | 2015-07-23 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
CN104004762B (zh) * | 2014-05-20 | 2016-03-30 | 南京医科大学附属南京儿童医院 | Tgf-r反义序列及其在制备抗气道炎症反应药物中的应用 |
WO2016133838A1 (en) * | 2015-02-20 | 2016-08-25 | Rigel Pharmaceuticals, Inc. | Gdf-8 inhibitors |
AU2017281797A1 (en) | 2016-06-24 | 2019-01-24 | Infinity Pharmaceuticals, Inc. | Combination therapies |
JP7132937B2 (ja) * | 2017-03-15 | 2022-09-07 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Hpk1の阻害剤としてのアザインドール |
NZ762856A (en) | 2017-10-05 | 2020-07-31 | Fulcrum Therapeutics Inc | P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
JP7268049B2 (ja) | 2018-03-08 | 2023-05-02 | インサイト・コーポレイション | PI3K-γ阻害剤としてのアミノピラジンジオール化合物 |
US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
EP4087657A1 (en) | 2020-01-08 | 2022-11-16 | Synthis Therapeutics, Inc. | Alk5 inhibitor conjugates and uses thereof |
IL307274A (en) * | 2021-03-29 | 2023-11-01 | Arbutus Biopharma Corp | Disubstituted 1-aryl-1'-heteroaryl compounds, disubstituted 1,1'-biheteroaryl compounds, and methods of using them |
Family Cites Families (20)
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GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
WO2000061186A1 (en) | 1999-04-08 | 2000-10-19 | Arch Development Corporation | Use of anti-vegf antibody to enhance radiation in cancer therapy |
TW200417547A (en) * | 2002-07-31 | 2004-09-16 | Smithkline Beecham Corp | Compounds |
GB0218876D0 (en) * | 2002-08-13 | 2002-09-25 | Merck Sharp & Dohme | Therapeutic agents |
JP2006521357A (ja) | 2003-03-24 | 2006-09-21 | メルク エンド カムパニー インコーポレーテッド | ナトリウムチャンネル遮断薬としてのビアリール置換6員複素環化合物 |
US20050014753A1 (en) | 2003-04-04 | 2005-01-20 | Irm Llc | Novel compounds and compositions as protein kinase inhibitors |
US7504401B2 (en) | 2003-08-29 | 2009-03-17 | Locus Pharmaceuticals, Inc. | Anti-cancer agents and uses thereof |
DK1836169T5 (da) | 2004-12-28 | 2023-10-09 | Atnx Spv Llc | Sammensætninger og fremgangsmåder til behandling af celleproliferationslidelser |
RU2384331C2 (ru) | 2005-12-05 | 2010-03-20 | Пфайзер Продактс Инк. | Способ лечения аномального роста клеток |
US20070191371A1 (en) | 2006-02-14 | 2007-08-16 | Kalypsys, Inc. | Heterocyclic modulators of ppar |
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JP5564251B2 (ja) | 2006-06-29 | 2014-07-30 | キネックス ファーマシューティカルズ, エルエルシー | キナーゼカスケードを調節するためのビアリール組成物および方法 |
PT2041071E (pt) | 2006-06-29 | 2014-09-23 | Kinex Pharmaceuticals Llc | Composições de biarilo e processos para a regulação de uma cascata de cinases |
WO2008008059A1 (en) | 2006-07-12 | 2008-01-17 | Locus Pharmaceuticals, Inc. | Anti-cancer agents ans uses thereof |
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JP4751856B2 (ja) | 2007-07-03 | 2011-08-17 | 本田技研工業株式会社 | 車体側部構造 |
US20090069288A1 (en) | 2007-07-16 | 2009-03-12 | Breinlinger Eric C | Novel therapeutic compounds |
WO2009024825A1 (en) | 2007-08-21 | 2009-02-26 | Astrazeneca Ab | 2-pyrazinylbenzimidazole derivatives as receptor tyrosine kinase inhibitors |
AU2009203693B2 (en) * | 2008-01-11 | 2012-06-07 | Novartis Ag | Pyrimidines as kinase inhibitors |
US8343966B2 (en) * | 2008-01-11 | 2013-01-01 | Novartis Ag | Organic compounds |
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2011
- 2011-06-07 MX MX2012014537A patent/MX2012014537A/es not_active Application Discontinuation
- 2011-06-07 SG SG2012096525A patent/SG186871A1/en unknown
- 2011-06-07 JP JP2013517056A patent/JP5886842B2/ja not_active Expired - Fee Related
- 2011-06-07 CA CA2804285A patent/CA2804285C/en not_active Expired - Fee Related
- 2011-06-07 WO PCT/EP2011/002788 patent/WO2012003912A1/en active Application Filing
- 2011-06-07 BR BR112012033658A patent/BR112012033658A2/pt not_active IP Right Cessation
- 2011-06-07 KR KR1020137002690A patent/KR20130131293A/ko not_active Application Discontinuation
- 2011-06-07 CN CN2011800330966A patent/CN102971293A/zh active Pending
- 2011-06-07 EP EP11724136.4A patent/EP2590946B1/en not_active Not-in-force
- 2011-06-07 EA EA201300080A patent/EA201300080A1/ru unknown
- 2011-06-07 ES ES11724136.4T patent/ES2535656T3/es active Active
- 2011-06-07 US US13/808,369 patent/US8846931B2/en not_active Expired - Fee Related
- 2011-06-07 AU AU2011276193A patent/AU2011276193B2/en not_active Ceased
- 2011-07-05 AR ARP110102395A patent/AR082109A1/es not_active Application Discontinuation
-
2012
- 2012-12-27 IL IL223978A patent/IL223978A/en active IP Right Grant
-
2014
- 2014-07-29 US US14/445,227 patent/US9051307B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2535656T3 (es) | 2015-05-13 |
US9051307B2 (en) | 2015-06-09 |
AU2011276193A1 (en) | 2013-02-21 |
CA2804285A1 (en) | 2012-01-12 |
US20130102608A1 (en) | 2013-04-25 |
BR112012033658A2 (pt) | 2016-11-29 |
WO2012003912A1 (en) | 2012-01-12 |
AU2011276193A8 (en) | 2013-05-02 |
JP2013530192A (ja) | 2013-07-25 |
SG186871A1 (en) | 2013-02-28 |
AU2011276193B2 (en) | 2015-01-22 |
MX2012014537A (es) | 2013-02-21 |
IL223978A (en) | 2017-10-31 |
US20140336201A1 (en) | 2014-11-13 |
EP2590946B1 (en) | 2015-02-18 |
JP5886842B2 (ja) | 2016-03-16 |
CA2804285C (en) | 2019-05-14 |
US8846931B2 (en) | 2014-09-30 |
CN102971293A (zh) | 2013-03-13 |
EP2590946A1 (en) | 2013-05-15 |
AR082109A1 (es) | 2012-11-14 |
KR20130131293A (ko) | 2013-12-03 |
WO2012003912A8 (en) | 2012-03-08 |
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