JP2012526842A5 - - Google Patents
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- Publication number
- JP2012526842A5 JP2012526842A5 JP2012511009A JP2012511009A JP2012526842A5 JP 2012526842 A5 JP2012526842 A5 JP 2012526842A5 JP 2012511009 A JP2012511009 A JP 2012511009A JP 2012511009 A JP2012511009 A JP 2012511009A JP 2012526842 A5 JP2012526842 A5 JP 2012526842A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- alkyl
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 8
- -1 Nitro, cyano, cyclopropyl Chemical group 0.000 claims 6
- 150000001768 cations Chemical class 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 230000003287 optical effect Effects 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 claims 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- 125000000538 pentafluorophenyl group Chemical group FC1=C(F)C(F)=C(*)C(F)=C1F 0.000 claims 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/466,170 US7928067B2 (en) | 2009-05-14 | 2009-05-14 | Compositions and methods for treating ischemia and ischemia-reperfusion injury |
| US12/466,170 | 2009-05-14 | ||
| PCT/US2010/034701 WO2010132657A1 (en) | 2009-05-14 | 2010-05-13 | Compositions and methods for treating ischemia and ischemia-reperfusion injury |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013257143A Division JP5767307B2 (ja) | 2009-05-14 | 2013-12-12 | 虚血および虚血・再灌流障害を治療するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012526842A JP2012526842A (ja) | 2012-11-01 |
| JP2012526842A5 true JP2012526842A5 (enExample) | 2013-06-27 |
| JP5570590B2 JP5570590B2 (ja) | 2014-08-13 |
Family
ID=42244916
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012511009A Active JP5570590B2 (ja) | 2009-05-14 | 2010-05-13 | 虚血および虚血・再灌流障害を治療するための組成物および方法 |
| JP2013257143A Active JP5767307B2 (ja) | 2009-05-14 | 2013-12-12 | 虚血および虚血・再灌流障害を治療するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013257143A Active JP5767307B2 (ja) | 2009-05-14 | 2013-12-12 | 虚血および虚血・再灌流障害を治療するための組成物および方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US7928067B2 (enExample) |
| EP (1) | EP2429519B1 (enExample) |
| JP (2) | JP5570590B2 (enExample) |
| KR (1) | KR101636395B1 (enExample) |
| CN (1) | CN102802622B (enExample) |
| AU (1) | AU2010249001B2 (enExample) |
| BR (1) | BRPI1012182A2 (enExample) |
| CA (1) | CA2761798C (enExample) |
| DK (1) | DK2429519T3 (enExample) |
| ES (1) | ES2470673T3 (enExample) |
| IL (2) | IL216349A (enExample) |
| MX (2) | MX2011012095A (enExample) |
| NZ (1) | NZ596364A (enExample) |
| PL (1) | PL2429519T3 (enExample) |
| SG (1) | SG176062A1 (enExample) |
| WO (1) | WO2010132657A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8541396B2 (en) | 2009-04-24 | 2013-09-24 | National University Of Singapore | Morpholin-4-ium 4 methoxyphenyl (morpholino) phosphinodithioate (GYY4137) as a novel vasodilator agent |
| US7928067B2 (en) | 2009-05-14 | 2011-04-19 | Ischemix Llc | Compositions and methods for treating ischemia and ischemia-reperfusion injury |
| WO2012067947A1 (en) | 2010-11-18 | 2012-05-24 | Ischemix Llc | Lipoyl compounds and their use for treating ischemic injury |
| EP2540292A1 (en) * | 2011-06-28 | 2013-01-02 | Nestec S.A. | DHA and EPA in the reduction of oxidative stress |
| US10531655B2 (en) | 2011-12-02 | 2020-01-14 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
| KR101873773B1 (ko) | 2012-05-11 | 2018-08-02 | 주식회사 젬백스앤카엘 | 류마티즘 관절염 예방 또는 치료 조성물 |
| KR20210025132A (ko) | 2012-05-11 | 2021-03-08 | 주식회사 젬백스앤카엘 | 항염증 활성을 갖는 펩티드 및 이를 포함하는 조성물 |
| WO2014010971A1 (ko) | 2012-07-11 | 2014-01-16 | 주식회사 카엘젬백스 | 세포 투과성 펩티드, 그를 포함한 컨쥬게이트 및 그를 포함한 조성물 |
| KR102258864B1 (ko) | 2013-04-19 | 2021-06-01 | 주식회사 젬백스앤카엘 | 허혈성 손상 치료 및 예방용 조성물 |
| RU2677277C2 (ru) | 2013-06-07 | 2019-01-16 | Джемвакс Энд Каэл Ко., Лтд. | Биологические маркеры, которые могут быть использованы в иммунотерапии рака |
| JP6495899B2 (ja) | 2013-06-21 | 2019-04-03 | ジェムバックス アンド カエル カンパニー，リミティド | ホルモン分泌調節剤、及びそれを含む組成物 |
| CA2926183C (en) | 2013-10-23 | 2018-07-03 | Gemvax & Kael Co., Ltd. | Composition for treating and preventing benign prostatic hyperplasia |
| JP6553605B2 (ja) | 2013-11-22 | 2019-07-31 | ジェムバックス アンド カエル カンパニー，リミティド | 血管新生抑制活性を有するペプチド、及びそれを含む組成物 |
| ES2809251T3 (es) | 2013-12-17 | 2021-03-03 | Gemvax & Kael Co Ltd | Composición para tratar cáncer de próstata |
| WO2015156649A1 (ko) | 2014-04-11 | 2015-10-15 | 주식회사 젬백스앤카엘 | 섬유증 억제 활성을 가지는 펩티드 및 이를 포함하는 조성물 |
| US10662223B2 (en) | 2014-04-30 | 2020-05-26 | Gemvax & Kael Co., Ltd. | Composition for organ, tissue, or cell transplantation, kit, and transplantation method |
| WO2015174948A1 (en) | 2014-05-14 | 2015-11-19 | Ischemix, LLC | Formulations comprising lipoyl compounds |
| CN104095835A (zh) * | 2014-06-20 | 2014-10-15 | 广州军区广州总医院 | 对羟基苄叉丙酮在制备预防和/或治疗肝缺血/再灌注损伤药物中的应用 |
| KR102413243B1 (ko) | 2014-12-23 | 2022-06-27 | 주식회사 젬백스앤카엘 | 안질환 치료 펩티드 및 이를 포함하는 안질환 치료용 조성물 |
| ES2799511T3 (es) | 2015-02-27 | 2020-12-18 | Gemvax & Kael Co Ltd | Péptido para prevenir la pérdida de audición, y composición que lo comprende |
| EP3318265B1 (en) | 2015-07-02 | 2021-08-18 | Gemvax & Kael Co., Ltd. | Peptide having anti-viral effect and composition containing same |
| KR20180123512A (ko) | 2016-04-07 | 2018-11-16 | 주식회사 젬백스앤카엘 | 텔로머라제 활성 증가 및 텔로미어 연장 효능을 가지는 펩티드 및 이를 포함하는 조성물 |
| CN106083800A (zh) * | 2016-06-13 | 2016-11-09 | 崔坤峰 | 氯普噻吨的药物组合物及对脑缺血再灌注损伤的保护作用 |
| KR20190062502A (ko) * | 2016-10-05 | 2019-06-05 | 미토브리지, 인크. | 급성 신장 손상을 치료하는 방법 |
| EP4282411A1 (en) * | 2017-04-25 | 2023-11-29 | Ischemix LLC | Lipoyl-glu-ala for the treatment of neurodegenerative damage caused by traumatic brain injury |
| KR102139678B1 (ko) | 2017-11-24 | 2020-07-31 | 전북대학교 산학협력단 | N-아세틸 또는 n-아실 아미노산을 포함하는 아토피 또는 가려움증 치료용 조성물 |
| KR102112949B1 (ko) | 2019-02-12 | 2020-05-19 | 남현규 | 복합 효모 발효로 불용 단백질을 가용화하여 화장품원료를 추출하는 화장품원료 제조방법 |
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| US7928067B2 (en) * | 2009-05-14 | 2011-04-19 | Ischemix Llc | Compositions and methods for treating ischemia and ischemia-reperfusion injury |
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| US20150329519A1 (en) | 2014-05-14 | 2015-11-19 | Ischemix, LLC | Formulations Comprising Lipoyl Compounds |
| WO2015174948A1 (en) | 2014-05-14 | 2015-11-19 | Ischemix, LLC | Formulations comprising lipoyl compounds |
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2009
- 2009-05-14 US US12/466,170 patent/US7928067B2/en active Active
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2010
- 2010-05-13 NZ NZ596364A patent/NZ596364A/xx not_active IP Right Cessation
- 2010-05-13 MX MX2011012095A patent/MX2011012095A/es active IP Right Grant
- 2010-05-13 DK DK10720092.5T patent/DK2429519T3/da active
- 2010-05-13 ES ES10720092.5T patent/ES2470673T3/es active Active
- 2010-05-13 CA CA2761798A patent/CA2761798C/en active Active
- 2010-05-13 BR BRPI1012182A patent/BRPI1012182A2/pt not_active Application Discontinuation
- 2010-05-13 JP JP2012511009A patent/JP5570590B2/ja active Active
- 2010-05-13 MX MX2013004034A patent/MX347460B/es unknown
- 2010-05-13 KR KR1020117029417A patent/KR101636395B1/ko active Active
- 2010-05-13 PL PL10720092T patent/PL2429519T3/pl unknown
- 2010-05-13 EP EP10720092.5A patent/EP2429519B1/en active Active
- 2010-05-13 SG SG2011083862A patent/SG176062A1/en unknown
- 2010-05-13 CN CN201080031479.5A patent/CN102802622B/zh active Active
- 2010-05-13 AU AU2010249001A patent/AU2010249001B2/en not_active Ceased
- 2010-05-13 US US13/319,839 patent/US8772250B2/en active Active
- 2010-05-13 WO PCT/US2010/034701 patent/WO2010132657A1/en not_active Ceased
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2011
- 2011-03-04 US US13/041,001 patent/US8772249B2/en active Active
- 2011-11-14 IL IL216349A patent/IL216349A/en active IP Right Grant
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2013
- 2013-12-12 JP JP2013257143A patent/JP5767307B2/ja active Active
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2014
- 2014-05-21 US US14/283,844 patent/US20140274917A1/en not_active Abandoned
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2015
- 2015-03-19 IL IL237820A patent/IL237820A/en active IP Right Grant
- 2015-10-20 US US14/918,175 patent/US9540417B2/en active Active