TWI363627B - Fused bicyclic pyrimidine compounds as aurora kinase inhibitors - Google Patents

Fused bicyclic pyrimidine compounds as aurora kinase inhibitors Download PDF

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Publication number
TWI363627B
TWI363627B TW098114168A TW98114168A TWI363627B TW I363627 B TWI363627 B TW I363627B TW 098114168 A TW098114168 A TW 098114168A TW 98114168 A TW98114168 A TW 98114168A TW I363627 B TWI363627 B TW I363627B
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TW
Taiwan
Prior art keywords
compound
group
monocyclic
membered
bicyclic
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TW098114168A
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English (en)
Chinese (zh)
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TW200948365A (en
Inventor
Selvaraj Mohane Coumar
Tsu An Hsu
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Nat Health Research Institutes
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Publication of TWI363627B publication Critical patent/TWI363627B/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
TW098114168A 2008-04-30 2009-04-29 Fused bicyclic pyrimidine compounds as aurora kinase inhibitors TWI363627B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4906308P 2008-04-30 2008-04-30

Publications (2)

Publication Number Publication Date
TW200948365A TW200948365A (en) 2009-12-01
TWI363627B true TWI363627B (en) 2012-05-11

Family

ID=41255689

Family Applications (1)

Application Number Title Priority Date Filing Date
TW098114168A TWI363627B (en) 2008-04-30 2009-04-29 Fused bicyclic pyrimidine compounds as aurora kinase inhibitors

Country Status (12)

Country Link
US (1) US8138194B2 (enExample)
EP (1) EP2276346B1 (enExample)
JP (1) JP5502072B2 (enExample)
KR (1) KR101667822B1 (enExample)
CN (1) CN102014627B (enExample)
AU (1) AU2009241469B2 (enExample)
CA (1) CA2722220C (enExample)
DK (1) DK2276346T3 (enExample)
ES (1) ES2616255T3 (enExample)
PL (1) PL2276346T3 (enExample)
TW (1) TWI363627B (enExample)
WO (1) WO2009134658A2 (enExample)

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Also Published As

Publication number Publication date
CA2722220A1 (en) 2009-11-05
WO2009134658A3 (en) 2009-12-30
EP2276346A2 (en) 2011-01-26
EP2276346B1 (en) 2016-11-23
PL2276346T3 (pl) 2017-07-31
KR20100132067A (ko) 2010-12-16
KR101667822B1 (ko) 2016-10-19
CN102014627B (zh) 2014-10-29
HK1151694A1 (en) 2012-02-10
AU2009241469B2 (en) 2015-05-07
US20090275533A1 (en) 2009-11-05
CA2722220C (en) 2016-06-07
TW200948365A (en) 2009-12-01
JP5502072B2 (ja) 2014-05-28
DK2276346T3 (en) 2017-02-27
EP2276346A4 (en) 2011-08-24
CN102014627A (zh) 2011-04-13
JP2011522789A (ja) 2011-08-04
US8138194B2 (en) 2012-03-20
ES2616255T3 (es) 2017-06-12
AU2009241469A1 (en) 2009-11-05
WO2009134658A2 (en) 2009-11-05

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