AR109007A2 - Compuesto de oxazol y composición farmacéutica - Google Patents

Compuesto de oxazol y composición farmacéutica

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Publication number
AR109007A2
AR109007A2 ARP170101905A ARP170101905A AR109007A2 AR 109007 A2 AR109007 A2 AR 109007A2 AR P170101905 A ARP170101905 A AR P170101905A AR P170101905 A ARP170101905 A AR P170101905A AR 109007 A2 AR109007 A2 AR 109007A2
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AR
Argentina
Prior art keywords
oxazol
methoxyphenyl
propan
ylmethyl
phenyl
Prior art date
Application number
ARP170101905A
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English (en)
Inventor
Tomonori Shibaata
Hidetaka Hiyama
Junpei Haruta
Hideki Kitagaki
Tetsuyuki Uno
Norifumi Sato
Masaya Kato
Minoru Okada
Original Assignee
Otsuka Pharma Co Ltd
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Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of AR109007A2 publication Critical patent/AR109007A2/es

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    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Un compuesto de oxazol representado por la fórmula (1), en donde R¹ es un grupo fenilo que tiene dos sustituyentes seleccionados entre los siguientes (1-2), (1-3), (1-4), y (1-5): (1-2) grupos alcoxi C₁₋₆ sustituidos con halógeno o no sustituidos, (1-3) grupos alqueniloxi C₂₋₆, (1-4) grupos alquiniloxi C₂₋₆, (1-5) grupos cicloalquilo C₃₋₈-alcoxi C₁₋₆; R² es un grupo fenilo o un grupo piridilo, cada uno de los cuales puede tener de uno a dos sustituyentes seleccionados entre los siguientes (2-2), (2-3), (2-4), y (2-5): (2-2) grupos alcoxi C₁₋₆ sustituidos con halógeno o no sustituidos, (2-3) grupos alquilo C₁₋₆ sustituidos con halógeno o no sustituidos, (2-4) grupos alqueniloxi C₂₋₆, (2-5) átomos de halógeno; W es un grupo divalente representado por la fórmula (i): fórmula (i) -Y¹-A¹- en donde A¹ es un grupo alquileno C₁₋₆ que puede tener uno o más sustituyentes seleccionados del grupo constituido por grupos hidroxilo y grupos alcoxicarbonilo C₁₋₆, e Y¹ es -C(=O)-, o -C(=O)-N(R³)-, en donde R³ es un átomo de hidrógeno; caracterizado porque el compuesto de oxazol se selecciona de entre los siguientes compuestos (1) a (385): (1) N-[2-(3-benciloxi-4-metoxifenil)oxazol-4-ilmetil]-2-etoxibenzamida, (2) N-[2-(3-hidroxi-4-metoxifenil)-oxazol-4-ilmetil]-2-etoxibenzamida, (3) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-2-etoxibenzamida, (4) N-{2-[4-metoxi-3-(2,2,2-trifluoroetoxi)fenil]oxazol-4-ilmetil}-2-etoxibenzamida, (5) N-[2-(3-butoxi-4-metoxifenil)oxazol-4-ilmetil]-2-etoxi-benzamida, (6) N-[2-(3-ciclopentiloxi-4-metoxifenil)oxazol-4-ilmetil]-2-etoxibenzamida, (7) N-{2-[3-(3-hidroxipropoxi)-4-metoxifenil]oxazol-4-ilmetil}-2-etoxibenzamida, (8) N-[2-(4-metoxi-3-(2-propiniloxi)fenil)oxazol-4-ilmetil]-2-etoxibenzamida, (9) N-[2-(3-etoxi-4-metoxifenil)oxazol-4-ilmetil]-2-etoxibenzamida, (10) N-[2-(4-metoxi-3-(2-oxiranilmetoxi)fenil)oxazol-4-ilmetil]-2-etoxibenzamida, (11) N-[2-(4-metoxi-3-propoxifenil)oxazol-4-ilmetil]-2-etoxi-benzamida, (12) N-[2-(3-isopropoxi-4-metoxifenil)oxazol-4-ilmetil]-2-etoxi-benzamida, (13) N-[2-(3-(3-buteniloxi)-4-metoxifenil)oxazol-4-ilmetil]-2-etoxibenzamida, (14) N-[2-(3-isobutoxi-4-metoxifenil)oxazol-4-ilmetil]-2-etoxi-benzamida, (15) N-{2-[4-metoxi-3-(3,3,3-trifluoropropoxi)fenil]oxazol-4-ilmetil}-2-etoxibenzamida, (16) N-[2-(3-benciloxi-4-metoxifenil)oxazol-4-ilmetil]-3-metil-picolinamida, (17) N-[2-(3-hidroxi-4-metoxifenil)oxazol-4-ilmetil]-3-metilpicolinamida, (18) N-[2-(3-ciclopentiloxi-4-metoxifenil)oxazol-4-ilmetil]-3-metilpicolinamida, (19) N-{2-[4-metoxi-3-(2,2,2-trifluoro-etoxi)fenil]oxazol-4-ilmetil}-3-metilpicolinamida, (20) N-[2-(3-etoxi-4-metoxifenil)oxazol-4-ilmetil]-3-metilpicolinamida, (21) N-[2-(3-aliloxi-4-metoxifenil)oxazol-4-ilmetil]-3-metilpicolinamida, (22) N-{2-[3-(indan-2-iloxi)-4-metoxifenil]oxazol-4-ilmetil}-3-metil-picolinamida, (23) N-[2-(3-benciloxi-4-metoxifenil)-oxazol-4-ilmetil]-2-trifluorometilbenzamida, (24) N-[2-(3-hidroxi-4-metoxifenil)oxazol-4-ilmetil]-2-trifluorometilbenzamida, (25) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-2-trifluorometilbenzamida, (26) N-{2-[3-(3-hidroxipropoxi)-4-metoxifenil]oxazol-4-ilmetil}-2-trifluorometilbenzamida, (27) N-[2-(3-benciloxi-4-metoxifenil)oxazol-4-ilmetil]-3-etoxipicolinamida, (28) N-[2-(3-hidroxi-4-metoxifenil)-oxazol-4-ilmetil]-3-etoxipicolinamida, (29) N-[2-(3-ciclopentiloxi-4-metoxifenil)-oxazol-4-ilmetil]-3-etoxipicolinamida, (30) N-[2-(3-benciloxi-4-metoxifenil)oxazol-4-ilmetil]-2-(2,2,2-trifluoroetoxi)benzamida, (31) N-[2-(3-hidroxi-4-metoxifenil)oxazol-4-ilmetil]-2-(2,2,2-trifluoroetoxi)-benzamida, (32) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-2-(2,2,2-trifluoroetoxi)benzamida, (33) N-[2-(3-benciloxi-4-metoxifenil)oxazol-4-ilmetil]-2-metoxibenzamida, (34) N-[2-(3-hidroxi-4-metoxifenil)oxazol-4-ilmetil]-2-metoxibenzamida, (35) N-[2-(3-ciclopentiloxi-4-metoxifenil)-oxazol-4-ilmetil]-2-metoxibenzamida, (36) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-3-metilpicolinamida, (37) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-2-isopropoxibenzamida, (38) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-2-metilbenzamida, (39) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-2-etilbenzamida, (40) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-2-clorobenzamida, (41) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-5-fluoro-2-metoxibenzamida, (42) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-4-fluoro-2-metoxibenzamida, (43) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-2-fluoro-6-metoxibenzamida, (44) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-2-metilsulfanilbenzamida, (45) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-3-hidroxipicolinamida, (46) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-2-metoxibenzamida, (47) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-2-trifluorometoxibenzamida, (48) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-2-propoxibenzamida, (49) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-pirazina-2-carboxamida, (50) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-3-etoxipicolinamida, (51) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-2-butoxibenzamida, (52) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-2-isobutoxibenzamida, (53) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-3-isopropoxipicolinamida, (54) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-2-etilsulfanilbenzamida, (55) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-1-óxidopicolinamida, (56) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-2,6-dimetoxibenzamida, (57) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-3-metoxipicolinamida, (58) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-3-isobutoxipicolinamida, (59) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-2-metilnicotinamida, (60) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-2-metano-sulfonilbenzamida, (61) N-2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-3-propoxipicolinamida, (62) N-[2-(3-isobutoxi-4-metoxifenil)oxazol-4-ilmetil]-3-metilpicolinamida, (63) N-[2-(3-isobutoxi-4-metoxifenil)oxazol-4-ilmetil]-2-metoxi-benzamida, (64) N-[2-(3-isobutoxi-4-metoxifenil)oxazol-4-ilmetil]-2-metil-sulfanilbenzamida, (65) N-[2-(3-isobutoxi-4-metoxifenil)oxazol-4-ilmetil]-3-etoxi-picolinamida, (66) N-[2-(3-isobutoxi-4-metoxifenil)oxazol-4-ilmetil]-2-metoxi-4-fluorobenzamida, (67) N-[2-(3-isobutoxi-4-metoxifenil)oxazol-4-ilmetil]-2-iso-propoxibenzamida, (68) N-[2-(3-isobutoxi-4-metoxifenil)oxazol-4-ilmetil]-2-fluoro-6-metoxibenzamida, (69) N-[2-(3-isobutoxi-4-metoxifenil)oxazol-4-ilmetil]-3-metoxi-picolinamida, (70) N-[2-(3-isobutoxi-4-metoxifenil)oxazol-4-ilmetil]-3-isobutoxi-picolinamida, (71) N-[2-(3-isobutoxi-4-metoxifenil)oxazol-4-ilmetil]-2-propoxibenzamida, (72) N-[2-(3-isobutoxi-4-metoxifenil)oxazol-4-ilmetil]-2-butoxibenzamida, (73) N-[2-(3-isobutoxi-4-metoxifenil)oxazol-4-ilmetil]-2-iso-butoxibenzamida, (74) N-[2-(3-isobutoxi-4-metoxifenil)oxazol-4-ilmetil]-3-iso-propoxipicolinamida, (75) N-[2-(3-isobutoxi-4-metoxifenil)oxazol-4-ilmetil]-2-metil-nicotinamida, (76) N-{2-[4-metoxi-3-(2,2,2-trifluoroetoxi)fenil]oxazol-4-ilmetil}-3-metoxi-picolinamida, (77) N-{2-[4-metoxi-3-(2,2,2-trifluoroetoxi)fenil]oxazol-4-il-metil}-3-etoxipicolinamida, (78) N-{2-[4-metoxi-3-(2,2,2-trifluoroetoxi)fenil]oxazol-4-il-metil}-2-metoxibenzamida, (79) N-{2-[4-metoxi-3-(2,2,2-trifluoroetoxi)fenil]oxazol-4-il-metil}-2-metilobenzamida, (80) N-{2-[4-metoxi-3-(2,2,2-trifluoroetoxi)fenil]oxazol-4-il-metil}-2-propoxibenzamida, (81) N-{2-[4-metoxi-3-(2,2,2-trifluoroetoxi)fenil]oxazol-4-il-metil}-2-isopropoxibenzamida, (82) N-{2-[4-metoxi-3-(2,2,2-trifluoroetoxi)fenil]oxazol-4-il-metil}-4-cloro-2-metoxibenzamida, (83) N-{2-[3-ciclopropilmetoxi-4-(2,2,2-trifluoroetoxi)fenil]oxazol-4-ilmetil}-2-etoxibenzamida (84) N-{2-[3-ciclopropilmetoxi-4-(2,2,2-trifluoroetoxi)fenil]oxazol-4-il-metil}-3-metilpicolina, (85) N-[2-(3,4-dietoxifenil)oxazol-4-ilmetil]-2-propoxibenzamida, (86) N-[2-(3,4-dietoxifenil)oxazol-4-ilmetil]-2-trifluorometilbenzamida, (87) N-[2-(3,4-dietoxifenil)oxazol-4-ilmetil]picolinamida, (88)N-[2-(3,4-dietoxifenil)oxazol-4-ilmetil]-2-etoxibenzamida, (89)N-[2-(3,4-dietoxifenil)oxazol-4-ilmetil]-4-etoxibenzamida, (90) N-[2-(3,4-dietoxifenil)oxazol-4-ilmetil]-5-metoxi-2-trifluoro-metoxibenzamida, (91) N-[2-(3,4-dietoxifenil)oxazol-4-ilmetil]-3-etoxibenzamida, (92) N-[2-(3,4-dimetoxifenil)oxazol-4-ilmetil]-2-etoxibenzamida, (93) N-[2-(3,4-dimetoxifenil)oxazol-4-ilmetil]-2-etilbenzamida, (94) N-[2-(3,4-dimetoxifenil)oxazol-4-ilmetil]-3-metilpicolinamida, (95) N-[2-(3,4-dimetoxifenil)oxazol-4-ilmetil]-3-metoxipicolinamida, (96) N-[2-(3-benciloxi-4-difluorometoxifenil)oxazol-4-ilmetil]-3-metilpicolinamida, (97) N-[2-(4-difluorometoxi-3-hidroxifenil)oxazol-4-ilmetil]-3-etil-picolinamida, (98) N-[2-(3-ciclopropilmetoxi-4-difluorometoxifenil)oxazol-4-ilmetil]-3-metilopicolinamida, (99) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]isoquinolina-1-carboxamida, (100) 2-[2-(3-benciloxi-4-metoxifenil)oxazol-4-ilmetilo]-3-(2-etoxi-fenil)-3-oxopropionato, (101) 1-(2-etoxifenil)-3-[2-(3-hidroxi-4-metoxifenil)-oxazol-4-il]propan-1-ona, (102) 3-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-il]-1-(2-etoxifenil)-propan-1-ona, (103) 3-[2-(3-etoxi-4-metoxifenil)oxazol-4-il]-1-(2-etoxifenil)-propan-1-ona, (104) 3-[2-(3-aliloxi-4-metoxifenil)oxazol-4-il]-1-(2-etoxifenil)propan-1-ona, (105) 3-[2-(3-ciclopentiloxi-4-metoxifenil)oxazol-4-il]-1-(2-etoxi-fenil)propan-1-ona, (106) 3-[2-(3-isobutoxi-4-metoxifenil)oxazol-4-il]-1-(2-etoxi-fenil)-propan-1-ona, (107) 1-(2-etoxifenil)-3-[2-(4-metoxi-3-propoxifenil)oxazol-4-il]propan-1-ona, (108) 3-[2-(3-(3-buteniloxi)-4-metoxifenil)oxazol-4-il]-1-(2-etoxifenil)propan-1-ona, (109) 3-[2-(3-butoxi-4-metoxifenil)oxazol-4-il]-1-(2-etoxifenil)-propan-1-ona, (110) 1-(2-etoxifenil)-3-[2-(4-metoxi-3-(2-propeniloxi)fenil)oxazol-4-il]propan-1-ona, (111) 1-(2-etoxifenil)-3-[2-(3-isopropoxi-4-metoxifenil)oxazol-4-il]propan-1-ona, (112) 1-(2-etoxifenil)-3-{2-[4-metoxi-3-(2,2,2-trifluoroetoxi)-fenil]oxazol-4-il}propan-1-ona, (113) 3-[2-(3-ciclohexilmetoxi-4-metoxifenil)oxazol-4-il]-1-(2-etoxifenil)propan-1-ona, (114) 3-[2-(3-ciclopentilmetoxi-4-metoxifenil)oxazo1-4-il]-1-(2-etoxifenil)propan-1-ona, (115) 1-(2-etoxifenil)-3-[2-(4-metoxi-3-(4-penteniloxi)fenil)-oxazol-4-il]propan-1-ona, (116) 3-[2-(3-ciclobutilmetoxi-4-metoxifenil)oxazol-4-il]-1-(2-etoxifenil)propan-1-ona, (117) 1-(2-etoxifenil)-3-{2-[4-metoxi-3-(3-metil-2-buteniloxi)-fenil]-oxazol-4-il}propan-1-ona, (118) 3-{2-[3-(2-ciclohexeniloxi)-4-metoxifenil]oxazol-4-il}-1-(2-etoxifenil)propan-1-ona, (119) 1-(2-etoxifenil)-3-[2-(4-metoxi-3-fenetiloxifenil)oxazol-4-il]propan-1-ona, (120) 1-(2-etoxifenil)-3-{2-[4-metoxi-3-(3-fenilpropoxi)fenilo]-oxazol-4-il}propan-1-ona, (121) 3-{2-[3-(2-ciclopropiletoxi)-4-metoxifenil]oxazol-4-il}-1-(2-etoxifenil)propan-1-ona, (122) 3-{2-[3-(2-ciclopentiletoxi)-4-metoxifenil]oxazol-4-il}-1-(2-etoxifenil)propan-1-ona, (123) 3-{2-[3-ciclopropilmetoxi-4-(2,2,2-trifluoroetoxi)-fenil]-oxazol-4-il}-1-(3-metoxipiridin-2-il)propan-1-ona, (124) 2-[2-(3-benciloxi-4-metoxifenil)oxazol-4-ilmetil]-3-(3-metoxi-piridin-2-il)-3-oxopropionato, (125) 3-[2-(3-hidroxi-4-metoxifenil)oxazol-4-il]-3-(3-metoxipiridin-2-il)propan-1-ona, (126) 3-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-il]-3-(3-metoxi-piridin-2-il)propan-1-ona, (127) 3-[2-(3-isobutoxi-4-metoxifenil)oxazol-4-il]-3-(3-metoxi-piridin-2-il)propan-1-ona, (128) 3-[2-(3-ciclopentiloxi-4-metoxifenil)oxazol-4-il]-1-(3-metoxipiridin-2-il)propan-1-ona, (129) 1-(3-metoxipiridin-2-il)-3-{2-[4-metoxi-3-(2,2,2-trifluoroetoxi)fenil]oxazol-4-il}propan-1-ona, (130) 2-[2-(3-benciloxi-4-metoxifenil)oxazol-4-ilmetil]-3-(3-etoxipiridin-2-il)-3-oxopropionato, (131) 1-(3-etoxipiridin-2-il)-3-[2-(3-hidroxi-4-metoxifenil)oxazol-4-il]propan-1-ona, (132) 3-[2-(3-ciclopentiloxi-4-metoxifenil)oxazol-4-il]-1-(3-etoxipiridin-2-il)propan-1-ona, (133) 3-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-il]-1-(3-etoxipiridin-2-il)propan-1-ona, (134) 1-(3-etoxipiridin-2-il)-3-[2-(3-isobutoxi-4-metoxifenil)-oxazol-4-il]propan-1-ona, (135) 2-[2-(3-benciloxi-4-metoxifenil)oxazol-4-ilmetil]-3-(3-metilpiridin-2-il)-3-oxo-propionato, (136) 3-[2-(3-hidroxi-4-metoxifenil)oxazol-4-il]-1-(3-metilpiridin-2-il)-propan-1-ona, (137) 3-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-il]-1-(3-metilpiridin-2-il)propan-1-ona, (138) 3-[2-(3-etoxi-4-metoxifenil)oxazol-4-il]-1-(3-metilpiridin-2-il)propan-1-ona, (139) 3-[2-(3-isopropoxi-4-metoxifenil)oxazol-4-il]-1-(3-metilpiridin-2-il)propan-1-ona, (140) 3-[2-(3-aliloxi-4-metoxifenil)oxazol-4-il]-1-(3-metilpiridin-2-il)propan-1-ona, (141) 3-[2-(3-ciclobutilmetoxi-4-metoxifenil)oxazol-4-il]-1-(3-metilpiridin-2-il)propan-1-ona, (142) 3-[2-(3-isobutoxi-4-metoxifenil)oxazol-4-il]-1-(3-metilpiridin-2-il)propan-1-ona, (143) 3-[2-(4-metoxi-3-propoxifenil)oxazol-4-il]-1-(3-metilpridin-2-il)propan-1-ona, (144) 3-[2-(3-ciclopentiloxi-4-metoxifenil)oxazol-4-il]-1-(3-metilpiridina-2-il)propan-1-ona, (145) 3-[2-(4-metoxi-3-(2-propeniloxi)fenil)oxazol-4-il]-1-(3-metilpiridin-2-il)propan-1-ona, (146) 3-[2-(3-(3-buteniloxi)-4-metoxifenil)oxazol-4-il]-1-(3-metilpiridin-2-il)propan-1-ona, (147) 3-[2-(3-butoxi-4-metoxifenil)oxazol-4-il]-1-(3-metilpiridin-2-il)propan-1-ona, (148) 3-[2-(3-ciclohexilmetoxi-4-metoxifenil)oxazol-4-il]-1-(3-metilpiridin-2-il)propan-1-ona, (149) 3-[2-(4-metoxi-3-(4-penteniloxi)fenil)oxazol-4-il]-1-(3-metilpiridin-2-il)propan-1-ona, (150) 3-[2-(4-metoxi-3-fenetiloxifenil)oxazol-4-il]-1-(3-metilpiridin-2-il)propan-1-ona, (151) 3-{2-[4-metoxi-3-(3-fenilpropoxi)fenil]oxazol-4-il}-1-(3-metilpiridin-2-il)propan-1-ona, (152) 3-[2-(3-ciclopentilmetoxi-4-metoxifenil)oxazol-4-il]-1-(3-metilpiridin-2-il)propan-1-ona, (153) 3-{2-[3-(2-ciclopropiletoxi)-4-metoxifenil]oxazol-4-il}-1-(3-metilpiridin-2-il)propan-1-ona, (154) 3-{2-[3-(2-ciclopentiletoxi)-4-metoxifenil]oxazol-4-il}-1-(3-metilpiridin-2-il)propan-1-ona, (155) 3-{2-[4-metoxi-3-(2,2,2-trifluoroetoxi)fenil]oxazol-4-il}-1-(3-metilpiridin-2-il)propan-1-ona, (156) 3-{2-[4-metoxi-3-(3-metil-2-buteniloxi)fenil]oxazol-4-il}-1-(3-metilpiridin-2-il)propan-1-ona, (157) 3-{2-[3-(2-ciclohexeniloxi)-4-metoxifenil]oxazol-4-il}-1-(3-metilpiridin-2-il)propan-1-ona, (158) 3-[2-(3-ciclohexiloxi-4-metoxifenil)oxazol-4-il]-1-(3-metilpiridin-2-il)propan-1-ona, (159) 3-{2-[3-(indan-2-iloxi)-4-metoxifenil]oxazol-4-il}-1-(3-metilpiridin-2-il)propan-1-ona, (160) 2-[2-(3-benciloxi-4-metoxifenil)oxazol-4-ilmetil]-3-oxo-3-piridin-2-ilpropionato, (161) 3-[2-(3-hidroxi-4-metoxifenil)oxazol-4-il]-1-(piridin-2-il)propan-1-ona, (162) 3-[2-(3-ciclobutilmetoxi-4-metoxifenil)oxazol-4-il]-1-(piridin-2-il)propan-1-ona, (163) 3-[2-(4-metoxi-3-(4-penteniloxi)fenil)oxazol-4-il]-1-(piridin-2-il)propan-1-ona, (164) 1-(2-aliloxifenil)-3-[2-(3-benciloxi-4-metoxifenil)oxazol-4-il]propan-1-ona, (165) 3-[2-(3-hidroxi-4-metoxifenil)-oxazol-4-il]-1-(2-hidroxifenil)propan-1-ona, (166) 3-[2-(3-aliloxi-4-metoxifenil)oxazol-4-il]-1-(2-aliloxifenil)propan-1-ona, (167) 2-[2-(3-benciloxi-4-metoxifenil)oxazol-4-ilmetil]-3-(2-metoxifenil)-3-oxopropionato, (168) 3-[2-(3-hidroxi-4-metoxifenil)oxazol-4-il]-1-(2-metoxifenil)propan-1-ona, (169) 3-[2-(3-isopropoxi-4-metoxifenil)-oxazol-4-il]-1-(2-metoxifenil)propan-1-ona, (170) 3-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-il]-1-(2-metoxifenil)propan-1-ona, (171) 3-[2-(3-ciclopentiloxi-4-metoxifenil)oxazol-4-il]-1-(2-metoxi-fenil)propan-1-ona, (172) 3-[2-(3-etoxi-4-metoxifenil)oxazol-4-il]-1-(2-metoxifenil)-propan-1-ona, (173) 3-[2-(3-isobutoxi-4-metoxifenil)oxazol-4-il]-1-(2-metoxi-fenil)-propan-1-ona, (174) 3-[2-(3-aliloxi-4-metoxifenil)oxazol-4-il]-1-(2-metoxifenil)-propan-1-ona, (175) 1-(2-metoxifenil)-3-{2-[4-metoxi-3-(2,2,2-trifluoroetoxi)-fenil]oxazol-4-il}propan-1-ona, (176) 3-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-il]-1-(2-hidroxifenil)propan-1-ona, (177) 1-(2-aliloxifenil)-3-[2-(3-ciclopropilmetoxi-4-metoxifenil)-oxazol-4-il]propan-1-ona, (178) 1-(2-aliloxifenil)-3-[2-(3,4-dietoxifenil)oxazol-4-il]propan-1-ona, (179) 1-(2-clorofenil)-3-[2-(3-ciclopropilmetoxi-4-metoxifenil)-oxazol-4-il]propan-1-ona, (180) 2-[2-(3,4-dietoxifenil)oxazol-4-ilmetil]-3-(3-metilpiridin-2-il)-3-oxopropionato, (181) 3-[2-(3,4-dietoxifenil)oxazol-4-il]-1-(3-metilpiridin-2-il)propan-1-ona, (182) 3-[2-(3,4-dietoxifenil)oxazol-4-il]-1-(2-etoxifenil)propan-1-ona, (183) 3-[2-(3,4-dietoxifenil)oxazol-4-il]-1-(3-etoxipiridin-2-il)-propan-1-ona, (184) 3-[2-(3,4-dietoxifenil)oxazol-4-il]-1-(3-etoxifenil)propan-1-ona, (185) 3-[2-(3,4-dietoxifenil)oxazol-4-il]-1-(4-etoxifenil)propan-1-ona, (186) 2-[2-(3,4-bisbenciloxifenil)oxazol-4-ilmetil]-3-(3-metilpiridin-2-il)-3-oxopropionato, (187) 3-[2-(3,4-dihidroxifenil)oxazol-4-ilmetil]-1-(3-metilpiridin-2-il)-propan-1-ona, (188) 3-{2-[3,4-bis-(2,2,2-trifluoroetoxi)fenil]oxazol-4-il}-1-(3-metilpiridin-2-il)-propan-1-ona, (189) 1-(2-aliloxifenil)-3-[2-(3-etoxi-4-metoxifenil)oxazol-4-il]propan-1-ona, (190) 3-[2-(4-benciloxi-3-etoxifenil)oxazol-4-il]-1-(2-etoxifenil)propan-1-ona, (191) 3-[2-(3-etoxi-4-hidroxifenil)oxazol-4-il]-1-(2-etoxi-fenil)-propan-1-ona, (192) 3-[2-(3-etoxi-4-isopropoxifenil)oxazol-4-il]-1-(2-etoxifenil)-propan-1-ona, (194) 3-[2-(3-hidroxi-4-metoxifenil)oxazol-4-il]-1-(2-propoxifenil)propan-1-ona, (195) 3-[2-(3-etoxi-4-metoxifenil)oxazol-4-il]-1-(2-propoxifenil)propan-1-ona, (196) 3-[2-(3-ciclopentiloxi-4-metoxifenil)-oxazol-4-il]-1-(2-propoxifenil)propan-1-ona, (197) 3-[2-(3-isopropoxi-4-metoxifenil)oxazol-4-il]-1-(2-propoxifenil)propan-1-ona, (198) 3-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazo1-4-il]-1-(2-propoxifenil)propan-1-ona, (199) 3-[2-(3-(3-buteniloxi)-4-metoxifenil)oxazol-4-il]-1-(2-propoxi-fenil)-propan-1-ona, (200) 3-[2-(3-aliloxi-4-metoxifenil)oxazol-4-il]-1-(2-propoxifenil)propan-1-ona, (201) 3-[2-(3-ciclobutilmetoxi-4-metoxifenil)oxazol-4-il]-1-(2-propoxifenil)propan-1-ona, (203) 3-{2-[4-metoxi-3-(2,2,2-trifluoroetoxi)fenil]oxazol-4-il}-1-(2-propoxifenil)propan-1-ona, (205) 3-[2-(3,4-dietoxifenil)oxazol-4-il]-1-(2-propoxi-fenil)propan-1-ona, (207) 3-[2-(3-hidroxi-4-metoxifenil)-oxazol-4-il]-1-(2-isoprepoxifenil)propan-1-ona, (208) 3-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-il]-1-(2-isopropoxifenil)propan-1-ona, (209) 3-[2-(3-etoxi-4-metoxifenil)oxazol-4-il]-1-(2-isopropoxifenil)propan-1-ona, (210) 3-[2-(3-isopropoxi-4-metoxifenil)oxazol-4-il]-1-(2-isopropoxi-fenil)propan-1-ona, (211) 3-[2-(3-aliloxi-4-metoxifenil)oxazol-4-il]-1-(2-isopropoxi-fenil)-propan-1-ona, (212) 3-[2-(3-(3-buteniloxi)-4-metoxifenil)oxazol-4-il]-1-(2-isopropoxifenil)propan-1-ona, (213) 1-(2-isopropoxifenil)-3-{2-[4-metoxi-3-(2,2,2-trifluoroetoxi)fenil]oxazol-4-il}-propan-1-ona, (214) 3-[2-(3-ciclobutilmetoxi-4-metoxifenil)oxazol-4-il]-1-(2-isopropoxifenil)propan-1-ona, (216) 3-[2-(3,4-dietoxifenil)oxazol-4-il]-1-(2-isopropoxi-fenil)propan-1-ona, (218) 3-[2-(3,4-dietoxifenil)oxazol-4-il]-1-o-tolilpropan-1-ona, (220) 3-[2-(3-hidroxi-4-metoxifenil)oxazol-4-il]-1-o-tolilpropan-1-ona, (221) 3-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-il]-1-o-tolilpropan-1-ona, (223) 1-(2-hidroxifenil)-3-[2-(3-isopropoxi-4-metoxifenil)-oxazol-4-il]propan-1-ona, (224) 1-(2-aliloxifenil)-3-[2-(3-isopropoxi-4-metoxifenil)oxazol-4-il]propan-1-ona, (225) 3-[2-(3-etoxi-4-metoxifenil)oxazol-4-il]-1-o-tolilpropan-1-ona, (226) 3-[2-(3-aliloxi-4-metoxifenil)oxazol-4-il]-1-o-tolilpropan-1-ona, (227) 3-[2-(3-isopropoxi-4-metoxifenil)oxazol-4-il]-1-o-tolilpropan-1-ona, (228) 3-[2-(3-benciloxi-4-difluorometoxifenil)oxazol-4-il]-1-(2-etoxifenil)-propan-1-ona, (229) 3-[2-(4-difluorometoxi-3-hidroxifenil)oxazol-4-il]-1-(2-etoxifenil)-propan-1-ona, (230) 3-[2-(4-difluorometoxi-3-isopropoxifenil)oxazol-4-il]-1-(2-etoxi-fenil)-propan-1-ona, (231) 3-[2-(3-benciloxi-4-metoxifenil)oxazol-4-il]-1-(2-metoximetoxifenil)propan-1-ona, (232) 3-[2-(3-hidroxi-4-metoxifenil)oxazol-4-il]-1-(2-metoxi-metoxifenilo)propan-1-ona, (233) 3-[2-(3-isopropoxi-4-metoxifenil)oxazol-4-il]-1-(2-metoximetoxifenil)propan-1-ona, (234) 3-[2-(3-etoxi-4-metoxifenil)oxazol-4-il]-1-[2-(2,2,2-trifluoroetoxi)fenil]propan-1-ona, (235) 3-[2-(3-etoxi-4-metoxifenil)oxazol-4-il]-1-(2-trifluorometoxi-fenil)-propan-1-ona, (236) 3-[2-(3,4-dietoxifenil)oxazol-4-il]-1-pirrolidin-1-il-propan-1-ona, (237) 3-[2-(3,4-dietoxifenil)oxazol-4-il]-1-(3-hidroxipirrolidin-1-il)propan-1-ona, (238) 3-[2-(4-benciloxi-3-metoxifenil)-oxazol-4-il]-1-pirrolidin-1-ilpropan-1-ona, (239) 3-[2-(4-hidroxi-3-metoxifenil)oxazol-4-il]-1-pirrolidin-1-ilpropan-1-ona, (240) 3-[2-(4-etoxi-3-metoxifenil)oxazol-4-il]-1-pirrolidin-1-ilpropan-1-ona, (241) N-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-ilmetil]-N-metil-2-trifluorometil-benzamida, (242) N-[2-(3,4-dimetoxifenil)oxazol-4-ilmetil]-2-etoxi-N-metilbenzamida, (243) N-{2-[2-(3,4-dimetoxifenil)oxazol-4-il]etil}-2-etoxibenzamida, (244) N-(2-oxo-2-feniletil)-2-(3,4-dietoxifenil)oxazol-4-carboxamida, (245) 1-(4-{4-[2-(3,4-dietoxifenil)oxazol-4-carbonil]piperazin-1-il}fenil)etanona, (246) 4-(2-(3,4-dietoxi-fenil)oxazol-4-il)-1-(4-metoxifenil)piperazina, (247) 4-(2-(3,4-dietoxifenil)-oxazol-4-il)-1-(4-hidroxifenil)piperazina, (248) N-fenetil-2-(3,4-dimetoxifenil)oxazol-4-carboxamida, (249) N-(2-(pirrolidin-1-il)etil)-2-(3,4-dimetoxifenil)oxazol-4-carboxamida, (250) 2-[2-(3,4-dietoxifenil)-oxazol-4-il]-N-(2-etoxifenil)acetamida, (251) 2-[2-(3,4-dietoxifenil)oxazol-4-il]-N-(3-hidroxipiridin-2-il)acetamida, (252) 4-[2-(3,4-dietoxifenil)oxazol-4-ilmetil]piperazin-2-ona, (253) 4-[2-(3,4-dietoxifenil)oxazol-4-ilmetil]morfolina, (254) 2-[2-(3,4-dietoxifenil)oxazol-4-ilmetilsulfanil]-piridina, (255) 2-[2-(3,4-dietoxifenil)oxazol-4-ilmetanosulfonil]piridina, (256) N-[2-(3,4-dietoxifenil)oxazol-4-ilmetil]-2-metilbencenosulfonamida, (257) 2-(3-ciclopropilmetoxi-4-metoxifenil)-4-[3-(2-etoxifenil)propil]oxazol, (258) 2-(3-hidroxi-4-metoxifenil)-4-(3-o-tolilpropil)oxazol, (259) 2-(3-ciclopropilmetoxi-4-metoxifenil)-4-(3-o-tolilpropil)oxazol, (260) 3-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-il]-1-(2-etoxifenil)propan-1-ol, (261) 3-[2-(3-isopropoxi-4-metoxifenil)oxazol-4-il]-2,2-dimetil-1-(3-metilpiridin-2-il)propan-1-ona, (262) 3-(3-metoxipiridin-2-il)-2-{2-[4-metoxi-3-(2,2,2-trifluoroetoxi)-fenil]oxazol-4-ilmetil}-3-oxopropionato, (263) 2-{2-[4-metoxi-3-(2,2,2-trifluoroetoxi)-fenil]-oxazol-4-ilmetil}-2-metil-3-(3-metilpiridin-2-il)-3-oxopropionato, (264) 1-(3-metoxipiridin-2-il)-3-{2-[4-metoxi-3-(2,2,2-trifluoroetoxi)fenil]oxazol-4-il}-2-metilpropan-1-ona, (265) 1-(3-metoxipiridin-2-il)-3-{2-[4-metoxi-3-(2,2,2-trifluoroetoxi)-fenil]oxazol-4-il}-2,2-dimetilpropan-1-ona, (266) 3-[2-(3-benciloxi-4-metoxifenil)oxazol-4-il]-1-(2-hidroxifenil)propan-1-ona como, (267) 3-[2-(3-benciloxi-4-metoxi-fenil)oxazol-4-il]-1-(2-difluorometoxifenil)propan-1-ona, (268) 3-[2-(3-benciloxi-4-metoxifenil)oxazol-4-il]-1-[2-(2-fluoro-etoxi)fenil]propan-1-ona, (269) 3-[2-(3-benciloxi-4-metoxifenil)oxazol-4-il]-1-[2-(2,2-di-fluoroetoxi)fenil]propan-1-ona, (270) 1-(2-difluorometoxifenil)-3-[2-(3-hidroxi-4-metoxifenil)-oxazol-4-il]propan-1-ona, (271) 1-[2-(2-fluoroetoxi)fenil]-3-[2-(3-hidroxi-4-metoxifenil)-oxazol-4-il]propan-1-ona, (272) 1-[2-(2,2-difluoroetoxi)fenil]-3-[2-(3-hidroxi-4-metoxi-fenil)oxazol-4-il]propan-1-ona, (273) 1-(2-difluorometoxifenil)-3-[2-(3-isopropoxi-4-metoxifenil)oxazol-4-il]propan-1-ona, (274) 1-(2-difluorometoxifenil)-3-[2-(3-etoxi-4-metoxifenil)oxazol-4-il]propan-1-ona, (275) 1-(2-fluoroetoxifenil)-3-[2-(3-isopropoxi-4-metoxifenil)oxazol-4-il]propan-1-ona, (276) 3-[2-(3-but-3-eniloxi-4-metoxifenil)oxazol-4-il]-1-[2-(2-fluoroetoxi)fenil]propan-1-ona, (277) 1-[2-(2-fluoroetoxi)fenil]-3-[2-(3-isobutoxi-4-metoxifenil)oxazol-4-il]propan-1-ona, (278) 1-[2-(2,2-difluoroetoxi)fenil]-3-[2-(3-isopropoxi-4-metoxifenil)oxazol-4-il]propan-1-ona, (279) 1-[2-(2,2-difluoroetoxi)fenil]-3-[2-(3-propoxi-4-metoxifenil)oxazol-4-il]propan-1-ona, (280) 1-[2-(2,2-difluoroetoxi)fenil]-3-[2-(3-etoxi-4-metoxifenil)oxazol-4-il]propan-1-ona, (281) 3-[2-(3-aliloxi-4-metoxifenil)oxazol-4-il]-1-[2-(2,2-difluoroetoxi)fenil]propan-1-ona, (282) 3-[2-(3-but-3-eniloxi-4-metoxifenil)oxazol-4-il]-1-[2-(2,2-difluoroetoxi)fenil]propan-1-ona, (283) 3-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-il]-1-[2-(2,2-difluoroetoxi)fenil]propan-1-ona, (284) 3-{2-[3-(2,2-difluoroetoxi)-4-metoxifenil]oxazol-4-il}-1-[2-(2,2-difluoroetoxi)fenil]propan-1-ona, (285) 1-[2-(2,2-difluoroetoxi)fenil]-3-[2-(3-isobutoxi-4-metoxifenil)oxazol-4-il]propan-1-ona, (286) 3-[2-(3,4-dietoxifenil)oxazol-4-il]-1-(2-metoximetoxi-fenil)propan-1-ona, (287) 3-[2-(3,4-dietoxifenil)oxazol-4-il]-1-(2-hidroxifenil)propan-1-ona, (288) 3-[2-(3,4-dietoxifeniloxazol-4-il)-1-(2-difluorametoxifenil)propan-1-ona, (289) 3-[2-(3,4-dietoxifenil)oxazol-4-il]-1-[2-(2-fluoroetoxi)-fenilo]propan-1-ona, (290) 3-[2-(3,4-dietoxifenil)oxazol-4-il]-1-[2-(2,2-difluoroetoxi)-fenil]propan-1-ona, (291) 2-{3-[2-(3-isopropoxi-4-metoxifenil)oxazol-4-il]propionil}fenilo, (292) 3-[2-(3,4-dietoxifenil)oxazol-4-il]-1-(2-trifluoro-metoxifenil)propan-1-ona, (293) 3-[2-(3-ciclopropilmetoxi-4-metoxifenil)oxazol-4-il]-1-(2-trifluoro-metoxifenil)propan-1-ona, (294) 3-[2-(3,4-dietoxifenil)oxazol-4-il]-1-(2,5-dimetoxifenil)-propan-1-ona, (295) 3-[2-(3,4-dietoxifenil)oxazol-4-il]-1-(2-etoxi-5-metilfenil)-propan-1-ona, (296) 3-[2-(3,4-dietoxifenil)oxazol-4-il]-1-(2,4-dimetilfenil)-propan-1-ona, (297) 3-[2-(3,4-dietoxifenil)oxazol-4-il]-1-(2,5-dimetilfenil)-propan-1-ona, (298) 3-[2-(3,4-dietoxifenil)oxazol-4-il]-1-(2-etoxi-4-metilfenil)-propan-1-ona, (299) 3-[2-(3,4-dietoxifenil)oxazol-4-il]-1-(2-etoxi-4-fluorofenil)-propan-1-ona, (300) 3-[2-(3,4-dietoxifenil)oxazol-4-il]-1-(2-metoximetilfenil)-propan-1-ona, (301) 3-[2-(3,4-dietoxifenil)oxazol-4-il]-1-(2-etilofenil)propan-1-ona, (302) 3-[2-(3,4-dietoxifenil)oxazol-4-il]-1-(2,3-dimetoxifenil)-propan-1-ona, (303) 3-[2-(3,4-dietoxifenil)oxazol-4-il]-1-(2-etoxi-3-metilfenil)-propan-1-ona, (304) 1-(2-etoxi-4-fluorofenil)-3-[2-(3-etoxi-4-metoxifenil)oxazol-4-il]propan-1-ona, (305) 3-[2-(3-etoxi-4-metoxifenil)oxazol-4-il]-1-(4-fluoro-2-isopropoxi-fenil)propan-1-ona, (306) 1-(2-etoxi-5-metilofenil)-3-[2-(3-isopropoxi-4-metoxifenil)oxazol-4-il]-propan-1-ona, (307) 1-(2-etoxi-4-metilfenil)-3-[2-(3-isopropoxi-4-metoxifenil)oxazol-4-il]-propan-1-ona, (308) 3-[2-(3-difluorometoxi-4-metoxifenil)oxazol-4-il]-1-(3-metilpiridin-2-il)propan-1-ona, (309) 3-{2-[3-(2,2-difluoroetoxi)-4-metoxifenil]oxazol-4-il}-1-(3-metilpiridin-2-il)propan-1-ona, (310) 3-{2-[3-(2-fluoroetoxi)-4-metoxifenil]oxazol-4-il}-1-(3-metil-piridin-2-il)propan-1-ona, (311) 3-[2-(3-sec-butoxi-4-metoxifenil)-oxazol-4-il]-1-(3-metilpiridin-2-il)propan-1-ona, (312) 3-{2-[3-(1-etilopropoxi)-4-metoxi-fenil]oxazol-4-il}-1-(3-metilpiridin-2-il)propan-1-ona, (313) 3-[2-(3-difluorometoxi-4-metoxifenil)oxazol-4-il]-1-(2-etoxifenil)propan-1-ona, (314) 3-{2-[3-(2,2-difluoroetoxi)-4-metoxifenil]oxazol-4-il}-1-(2-etoxifeni1)propan-1-ona, (315) 1-(2-etoxifenil)-3-{2-[3-(2-fluoroetoxi)-4-metoxifenil]oxazol-4-il}propan-1-ona, (316) 2-{2-[4-benciloxi-3-(2,2-difluoroetoxi)fenil]-oxazol-4-ilmetil}-3-(3-metilpiridin-2-il)-3-oxo-propionato, (317) 3-{2-[3-(2,2-difluoroetoxi)-4-hidroxifenil]oxazol-4-il}-1-(3-metilpiridin-2-il)propan-1-ona, (318) 3-{2-[3-(2,2-difluoroetoxi)-4-etoxifenil]oxazo1-4-il}-1-(3-metilpiridin-2-il)-propan-1-ona, (319) 3-{2-[3-(2,2-difluoroetoxi)-4-isopropoxifenil]oxazol-4-il}-1-(3-metilpiridin-2-il)propan-1-ona, (320) N-[2-(3-benciloxi-4-metoxifenil)oxazol-4-ilmetil]-2-difluorometoxi-benzamida, (321) 2-difluorometoxi-N-[2-(3-hidroxi-4-metoxifenil)oxazol-4-ilmetil]-benzamida, (322) N-[2-(3-aliloxi-4-metoxifenil)-oxazol-4-ilmetil]-2-difluorometoxibenzamida, (323) 2-difluorometoxi-N-[2-(3-isopropoxi-4-metoxifenil)oxazol-4-ilmetil]benzamida, (324) N-{2-[3-(1-etilpropoxi)-4-metoxifenil]oxazol-4-ilmetil}-3-metilpicolinamida, (325) 2-etoxi-N-{2-[3-(1-etilpropoxi)-4-metoxifenil]oxazol-4-ilmetil}benzamida, (326) 2-[2-(3-benciloxi-4-difluorometoxifenil)oxazol-4-ilmetil]-3-(3-metilpiridin-2-il)-3-oxopropionato, (327) 3-[2-(4-difluorometoxi-3-hidroxifenil)oxazol-4-il]-1-(3-metilpiridin-2-il)propan-1-ona, (328) 3-[2-(3-ciclopropilmetoxi-4-difluorometoxifenil)oxazol-4-il]-1-(3-metilpiridin-2-il)propan-1-ona, (329) 3-[2-(4-difluorometoxi-3-propoxifenil)-oxazol-4-il]-1-(3-metilpiridin-2-il)propan-1-ona, (330) 3-[2-(3-aliloxi-4-difluorometoxifenil)-oxazol-4-il]-1-(3-metilpiridin-2-il)propan-1-ona, (331) 3-[2-(3-but-3-eniloxi-4-difluoro-metoxifenil)-oxazol-4-il]-1-(3-metilpiridin-2-il)-propan-1-ona, (332) 3-[2-(4-difluorometoxi-3-isopropoxifenil)oxazol-4-il]-1-(3-metil-piridin-2-il)propan-1
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